• Journal of Dental Anesthesia and Pain Medicine
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• 제21권6호
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• pp.479-506
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• 2021

Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge of its efficacy and safety in treating NP. The objective of this review was to evaluate the effectiveness of cannabis-based medications in individuals with chronic NP. Methods: Randomized placebo-controlled trials using tetrahydrocannabinol (THC), cannabidiol (CBD), cannabidivarin (CBDV), or synthetic cannabinoids for NP treatment were included. The MEDLINE, Cochrane Library, EMBASE, and Web of Science databases were examined. The primary outcome was the NP intensity. The risk of bias analysis was based on the Cochrane handbook. Results: The search of databases up to 2/1/2021 yielded 379 records with 17 RCTs included (861 patients with NP). Meta-analysis showed that there was a significant reduction in pain intensity for THC/CBD by -6.624 units (P < .001), THC by -8.681 units (P < .001), and dronabinol by -6.0 units (P = .008) compared to placebo on a 0-100 scale. CBD, CBDV, and CT-3 showed no significant differences. Patients taking THC/CBD were 1.756 times more likely to achieve a 30% reduction in pain (P = .008) and 1.422 times more likely to achieve a 50% reduction (P = .37) than placebo. Patients receiving THC had a 21% higher improvement in pain intensity (P = .005) and were 1.855 times more likely to achieve a 30% reduction in pain than placebo (P < .001). Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality. Further research is needed for CBD, dronabinol, CT-3, and CBDV.

• 플랜트 저널
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• 제7권2호
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• pp.44-51
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• 2011

Given the fact that the entire bituminous coal used for a boiler is imported, the supply of coal is often affected by the rise of international coal price. Moreover, coal suppliers have been diversified due to the competition among power generation companies for reducing costs and inexpensive sub-bituminous coal is used. As a result, boilers combustion conditions have been deviated from the initial boiler design. This requires the selection of adequate excessive air ratio for different combustion conditions to enhance the efficiency of boiler operation. The boiler efficiency has been identified through an examination on the change of excessive air ratio by mixed fuel in unit 8 of Dangjin power plant complex. In addition, an excessive air ratio was calculated based on the examination result. According to the study result, the adequate excessive air ratio was 13% when Macquarie and Powder river were mixed at a ratio of 5:5 and when Sonoma and Megaprima persada were mixed at a ratio of 5:5. When BHP Billiton and Powder river were mixed at a ratio of 4:6 and Centennial and Batubara were mixed at a ratio of 3:7, the adequate excessive air ratio was 11%.

• 한국유체기계학회 논문집
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• 제20권2호
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• pp.17-25
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• 2017

Prediction of performance and operating characteristics of a state-of-the-art ultra-supercritical (USC) steam turbine is an important issue in many ways. Theoretical and empirical correlation equations, developed a few decades ago, have been widely used in commercial programs for a prediction of performance. To improve of these correlation equations and apply them to the high pressure turbine of a USC steam turbine, computational fluid dynamic analysis was carried out and correlation equations to calculate efficiency variation of each stage were made. Both fluid dynamic characteristic and thermodynamic performance was analyzed for the development of the correlation equations. In particular, the impact of flow addition through an overload valve (OLV) between stages was examined throughly. The trend of pressure drop due to the flow mixing by the OLV flow addition was analyzed and an efficiency correlation equation considering the OLV flow was also made.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권6호
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• pp.403-408
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• 2020

Trigeminal neuralgia (TN) involves chronic neuropathic pain, characterized by attacks of repeating short episodes of unilateral shock-like pain, which are abrupt in onset and termination. Anticonvulsants, such as carbamazepine, are the gold standard first-line drugs for pharmacological treatment. Microvascular decompression (MVD) surgery is often the course of action if pharmacological management with anticonvulsants is unsuccessful. MVD surgery is an effective therapy in approximately 83% of cases. However, persistent neuropathic pain after MVD surgery may require reintroduction of pharmacotherapy. This case report presents two patients with persistent pain after MVD requiring reintroduction of pharmacological therapy. Although MVD is successful for patients with failed pharmacological management, it is an invasive procedure and requires hospitalization of the patient. About one-third of patients suffer from recurrent TN after MVD. Often, alternative treatment protocols, including the reintroduction of medications, may be necessary to achieve improvement. This case report presents two cases of post-MVD recurrent pain. Further research is lacking on the success rates of subsequent medication therapy after MVD has proven less effective in managing TN.

• 전기저널
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• 통권445호
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• pp.45-51
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• 2014

• JSTS:Journal of Semiconductor Technology and Science
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• 제9권4호
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• pp.225-232
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• 2009

An analytical compact model for the asymmetric lightly doped Double Gate (DG) MOSFET is presented. The model is developed using the Lambert Function and a 2-dimensional (2-D) parabolic electrostatic potential approximation. Compact models of the net charge and channel current of the DG-MOSFET are derived in section 2. Results for the channel potential and current are compared with 2-D numerical data for a lightly doped DG MOSFET in section 3, showing very good agreement.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2002년도 춘계학술대회 논문집
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• pp.39-40
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• 2002

대기 중 초미세입자 (0.1 마이크론 이하)들을 최근 건강 위해성에 대한 연관성이 추정됨에 따라 도시지역 초미세입자에 대한 다각적인 연구의 필요성이 증대하고 있다. 초미세입자들은 전체 질량농토에 대한 그 기여도가 매우 낮아 수 농도와 크기분포에 의하여 보다 잘 표현되지만 도시지역 초미세입자의 수 농도 크기분포에 대한 자료는 아직 부족한 실정이다. (중략)

• Journal of Oral Medicine and Pain
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• 제48권4호
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• pp.137-143
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• 2023

Purpose: To assess Google Trends (GT) search behavior regarding orofacial pain (OFP) and headaches. Methods: GT scores for OFP and headache specialists between February 2013 and December 2022 were analyzed. Statistical tests such as Poisson regression analyses, mean differences, and Cohen's D were used to assess the score change over time. Results: The top three search words for OFP specialists were "temporomandibular joint (TMJ) specialist," "TMJ doctor," and "TMJ dentist," whereas the top three search words for headache specialists were "Headache specialist," "Headache doctor," and "Migraine specialist." Here, TMJ is temporomandibular joint. The GT scores for OFP specialists increased significantly (p<0.05) for all years except 2017, with the highest mean difference in 2020. The scores for headache specialists showed similar trends but gradually. Conclusions: The interest in OFP and headache specialists expressed by Google searches has increased over the years. More awareness is needed regarding the OFP scope of practice, and the use of GT may serve as an indicator.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권5호
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• pp.413-429
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• 2021

Background: Migraine headaches are the second leading cause of disability worldwide and are responsible for significant morbidity, reduction in the quality of life, and loss of productivity on a global scale. The purpose of this systematic review and meta-analysis was to evaluate the efficacy of ketamine on migraines and other primary headache disorders compared to placebo and other active interventions, such as midazolam, metoclopramide/diphenhydramine, and prochlorperazine/diphenhydramine. Methods: An electronic search of databases published up to February 2021, including Medline via PubMed, EMBASE, Web of Science, and Cochrane Library, a hand search of the bibliographies of the included studies, as well as literature and systematic reviews found through the search was conducted to identify randomized controlled trials (RCTs) investigating ketamine in the treatment of migraine/headache disorders compared to the placebo. The authors assessed the risk of bias according to the Cochrane Handbook guidelines. Results: The initial search strategy yielded 398 unduplicated references, which were independently assessed by three review authors. After evaluation, this number was reduced to five RCTs (two unclear risk of bias and three high risk of bias). The total number of patients in all the studies was 193. Due to the high risk of bias, small sample size, heterogeneity of the outcomes reported, and heterogeneity of the comparison groups, the quality of the evidence was very low. One RCT reported that intranasal ketamine was superior to intranasal midazolam in improving the aura attack severity, but not duration, while another reported that intranasal ketamine was not superior to metoclopramide and diphenhydramine in reducing the headache severity. In one trial, subcutaneous ketamine was superior to saline in migraine severity reduction; however, intravenous (I.V.) ketamine was inferior to I.V. prochlorperazine and diphenhydramine in another study. Conclusion: Further double-blind controlled studies are needed to assess the efficacy of ketamine in treating acute and chronic refractory migraines and other primary headaches using intranasal and subcutaneous routes. These studies should include a long-term follow-up and different ketamine dosages in diagnosed patients following international standards for diagnosing headache/migraine.

• BMB Reports
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• 제48권12호
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• pp.668-676
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• 2015

Pluripotent stem cells only exist in a narrow window during early embryonic development, whereas multipotent stem cells are abundant throughout embryonic development and are retainedin various adult tissues and organs. While pluripotent stem cell lines have been established from several species, including mouse, rat, and human, it is still challenging to establish stable multipotent stem cell lines from embryonic or adult tissues. Based on current knowledge, we anticipate that by manipulating extrinsic and intrinsic signaling pathways, most if not all types of stem cells can be maintained in a long-term culture. In this article, we summarize current culture conditions established for the long-term maintenance of authentic pluripotent and multipotent stem cells and the signaling pathways involved. We also discuss the general principles of stem cell maintenance and propose several strategies on the establishment of novel stem cell lines through manipulation of signaling pathways.