• 제목/요약/키워드: UL54

검색결과 24건 처리시간 0.019초

Inhibition Effect of Human Cytomegalovirus Replication by Peptide nucleic acids (PNA)

  • Park, Young-Doo;Eum, Jin-Seong;Paik, Soon-Young;Hong, Seong-Karp
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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    • pp.971-975
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    • 2008
  • Human cytomegalovirus (HCMV) provokes fatal infections in AIDS patients that have deficient immune functions and patients that have cellular immune responses repressed after bone marrow transplantation. A new candidate for therapeutic against HCMV is needed because conventional treatments as ganciclovir, acyclovir, cidofovir, and foscarnet cytosine used currently are improper due to their side effects and advent of resistant HCMV. In this study, peptide nucleic acids (PNAs) against UL54 (DNA polymerase) and UL97 (phosphotransferase) that were essential in replication of HCMV were applied in inhibition of replication of HCMV. From the results of this study, 4 PNAs $_{PNA}UL97-1$, $_{PNA}UL97-2$, $_{PNA}UL54-3$, and $_{PNA}UL54-4$ showed 3.7, 3.1, 1.7, and 1.6 folds of inhibition effect against replication of HCMV in the human fibroblast cells. These PNA suggest a novel possibility as therapeutic against HCMV.

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환경기술정책 발전방향

  • 이규용
    • 한국환경독성학회:학술대회논문집
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    • 한국환경독성학회 2001년도 춘계심포지움 및 학술발표회
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    • pp.7-25
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    • 2001
  • $\square$ 범부처적 $\boxDr$환경산업 발전전략$\boxUl$ 추진 o 소관부처별로 $\boxDr$환경산업 발전전략$\boxUl$(5개 중점분야 54개과제) 세부실천계획을 수립, 중점 추진(4월) - 정부ㆍ민간 합동으로 21세기형 환경기술을 중점 개발 - 환경친화적 생산ㆍ건설ㆍ소비문화 확산 등을 통한 국내 환경시장 수요 창출 (중략)

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UL 268 시험화원에 따른 CO센서의 화재감지센서로서의 적용성에 관한 연구 (A Study on the Adaptability of the CO Sensor as A Fire Detection Sensor According to the Test Fire Source of UL 268)

  • 이춘하;성완기;이종화;김형권;지승욱;김시국
    • 한국화재소방학회논문지
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    • 제28권2호
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    • pp.54-63
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    • 2014
  • 본 논문은 CO센서의 화재에 대한 감지특성을 분석 후 화재감지기로서의 적용성 판단을 하기 위한 논문이다. CO센서의 화재감지기로의 적용성을 판단하기 위해 UL 268에서 규정하고 있는 화재시험실과 유사한 규모의 화재실험장을 설계 제작하고, UL 268에서 제시된 화재시험기준에 준한 실화재실험을 실시하여 화원 종류에 따른 CO센서와 광전식연기감지기의 다양한 화원의 화재에서 발생하는 일산화탄소와 연기에 대한 감지특성을 측정하여 비교 분석하였다. 실험결과 종이화원 및 목재화원과 같이 불완전연소로 진행되는 초기화재에서 CO센서가 광전식연기감지기보다 약 2~3배 빠른 감지특성이 나타났다. 특히, 목재훈소화재에서 CO센서의 감지특성이 매우 우수한 것으로 나타났다.

Propagation of radiation source uncertainties in spent fuel cask shielding calculations

  • Ebiwonjumi, Bamidele;Mai, Nhan Nguyen Trong;Lee, Hyun Chul;Lee, Deokjung
    • Nuclear Engineering and Technology
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    • 제54권8호
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    • pp.3073-3084
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    • 2022
  • The propagation of radiation source uncertainties in spent nuclear fuel (SNF) cask shielding calculations is presented in this paper. The uncertainty propagation employs the depletion and source term outputs of the deterministic code STREAM as input to the transport simulation of the Monte Carlo (MC) codes MCS and MCNP6. The uncertainties of dose rate coming from two sources: nuclear data and modeling parameters, are quantified. The nuclear data uncertainties are obtained from the stochastic sampling of the cross-section covariance and perturbed fission product yields. Uncertainties induced by perturbed modeling parameters consider the design parameters and operating conditions. Uncertainties coming from the two sources result in perturbed depleted nuclide inventories and radiation source terms which are then propagated to the dose rate on the cask surface. The uncertainty analysis results show that the neutron and secondary photon dose have uncertainties which are dominated by the cross section and modeling parameters, while the fission yields have relatively insignificant effect. Besides, the primary photon dose is mostly influenced by the fission yield and modeling parameters, while the cross-section data have a relatively negligible effect. Moreover, the neutron, secondary photon, and primary photon dose can have uncertainties up to about 13%, 14%, and 6%, respectively.

Le Fort I 골절단술을 통한 상악의 후상방 회전에 따른 상순과 비부의 연조직 변화 (Soft tissue changes of upper lip and nose following posterosuperior rotation of the maxilla by Le Fort I osteotomy)

  • 권영욱;표성운;이원;박재억
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제37권6호
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    • pp.457-463
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    • 2011
  • Introduction: This study evaluate the soft tissue changes to the upper lip and nose after Le Fort I maxillary posterosuperior rotational movement. Materials and Methods: Twenty Skeletal class III patients, who had undergone bimaxillary surgery with a maxillary Le Fort I osteotomy and bilateral sagittal split ramus osteotomy, were included in the study. The surgical plan for maxilla was posterosuperior rotational movement, with the rotation center in the anterior nasal spine (ANS) of maxilla. Soft and hard tissue changes were measured by evaluating the lateral cephalograms obtained prior to surgery and at least 6 months after surgery. For cephalometric analysis, four hard tissue landmarks ANS, posterior nasal spine [PNS], A point, U1 tip), and five soft tissue landmarks (pronasale [Pn], subnasale [Sn], A' Point, upper lip [UL], stomion superius [StmS]) were marked. A paired t test, Pearson's correlation analysis and linear regression analysis were used to evaluate the soft and hard tissue changes and assess the correlation. A P value <0.05 was considered significant. Results: The U1 tip moved $2.52{\pm}1.54$ mm posteriorly in the horizontal plane (P<0.05). Among the soft tissue landmarks, Pn moved $0.97{\pm}1.1$ mm downward (P<0.05), UL moved $1.98{\pm}1.58$ mm posteriorly (P<0.05) and $1.18{\pm}1.85$ mm inferiorly (P<0.05), and StmS moved $1.68{\pm}1.48$ mm posteriorly (P<0.05) and $1.06{\pm}1.29$ mm inferiorly (P<0.05). The ratios of horizontal soft tissue movement to the hard tissue were 1:0.47 for the A point and A' point, and 1:0.74 for the U1 tip and UL. Vertically, the movement ratio between the A point and A' point was 1:0.38, between U1 tip and UL was 1:0.83, and between U1 tip and StmS was 1:0.79. Conclusion: Posterosuperior rotational movement of the maxilla in Le Fort I osteotomy results in posterior and inferior movement of UL. In addition, nasolabial angle was increased. Nasal tip and base of the nose showed a tendency to move downward and showed significant horizontal movement. The soft tissue changes in the upper lip and nasal area are believed to be induced by posterior movement at the UL area.

온도가 스쿠티카충 Miamiensis avidus의 증식과 넙치에 감염시 폐사에 미치는 영향 (The effect of temperature to scuticociliatida Miamiensis avidus proliferation, and to mortality of infected olive flounder Paralichthys olivaceus)

  • 배민지;임은영;김흥윤;정성주
    • 한국어병학회지
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    • 제22권2호
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    • pp.97-105
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    • 2009
  • 본 연구는 양식넙치에 높은 폐사율과 성장저하를 일으키는 스쿠티카섬모충 Miamiensis avidus (syn. Philasterides dicentrarchi)의 성장과 병원성에 미치는 온도의 영향을 알아보았다. in vitro 배양조건에서 이분열에 걸리는 시간은 $5{^{\circ}C}$에서 61.82시간, $10{^{\circ}C}$에서 26.32시간, $15{^{\circ}C}$에서 21.14시간, $20{^{\circ}C}$에서 16.86시간 그리고 25℃에서 는 16.21시간이었다. 최고로 배양 가능한 충수는 $1.54-1.75{\times}10^{5}$/ ml의 범위로 $10{^{\circ}C}$이상의 모든 온도범위에서 유사했다. 넙치(평균 8.34 cm, 4.33g)마리당 $1{\times}10^{2}$/ ul, $1{\times}10^{6}$/ ul, $1{\times}10^{4}$/ ul 과 $1{\times}10^{5}$/ ul 으로 스쿠티카충을 복강에 감염시킨 후 $10{^{\circ}C}$, $15{^{\circ}C}$$20{^{\circ}C}$에서 사육하면서 폐사를 관찰하는 실험을 2회 실시한 결과, 수온 $10{^{\circ}C}$에서는 폐사가 현저히 낮았고 온도가 높아질수록 폐사가 증가하였다. 또한 감염농도가 높아질수록 폐사는 증가하였다. 그러므로 스쿠티카섬모충 M. avidus는 온도가 높을수록 증식이 잘 되며 또한 수온이 높아질수록 온도의존적으로 폐사가 증가하므로 폐사를 경감시키기 위해서는 고수온기의 수온관리가 중요한 것으로 사료된다.

구형 LNG운반선의 탱크지지 구조인 스커트의 좌굴강도에 대한 연구 (A Study on the Buckling Strength of the Skirt Structure in the Spherical LNG Carriers)

  • 김을년
    • 대한조선학회논문집
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    • 제54권5호
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    • pp.393-405
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    • 2017
  • This paper deals with the buckling strength of the skirt structure in the spherical LNG carriers. The spherical cargo tank systems consist of spherical tank, skirt, tank cover, pump tower, etc. The skirt supports the spherical cargo tank and is connected with ship hull structure. It is designed to act as a thermal brake between the tank and the hull structure by reducing the thermal conduction from the tank to the supporting structure. It is built up of three parts, upper aluminum part, middle stainless steel part and lower carbon steel part. The 150K spherical LNG carrier was designed and carried out the strength verification under Classification Societies Rule. The design loads due to acceleration, thermal distribution, self-weight and cargo weight were estimated considering requirements of the Class Rule and numerical simulation analyses. Based on the obtained design loads and experienced project data, the initial structure scantling was carried out. To verify the structural integrity, theoretical and numerical analyses were carried out and strength was evaluated aspect of buckling capacity. The results by LR and DNV design code are shown and discussed.