• Title/Summary/Keyword: UBC

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Dietary Behaviors, Self Perception of Body Image, Hematological Index and Nutrient Intake of Female Athletes in Incheon

  • Cheong, Sun-Hee;Hyuni Sung;Kim, Soon-Ki;Cho, Mi-Hye;Chang, Kyung-Ja
    • Proceedings of the KSCN Conference
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    • 2003.11a
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    • pp.1048-1048
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    • 2003
  • The purpose of this study was to investigate dietary behaviors, body image, hematological index and nutrient intake of female athletes in Incheon. The subjects were 112 female athletes (field and track: n=32, firing: n=27, fencing: n=29, swimming: n=14, badminton: n=10) from middle and high schools in Incheon. This cross-sectional study was conducted by a self-administered questionnaire. Fasting blood samples were obtained and analyzed for hemoglobin (Hb), hematocrit(Hct), ferritin, serum iron, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), unsaturated iron binding capacity (UBC), total iron binding capacity (TIBC) and transferrin saturation (TS). Nutrient intakes collected from 3 day-recalls were analyzed by the Computer Aided Nutritional Analysis Program. Statistical analysis was conducted using SPSS 10.0 program. The results are summarized as follows: Average age of field and track athletes, firing, fencer and swimmer was 14 years and that of badmintoner was 17 years. Most of female athletes had dietary problems such as unbalanced meals, skipping meals, and preference of processed foods. More than 60% of female athletes skipped breakfast. As for perception of body image, most of female athletes perceived themselves fatter compared to normal body image. Especially, field and track athletes were more significantly experienced weight control compared to the other athletes (p<0.05). As for physical burden during exercise, 56.3% of swimmer and 31.3% of field and track athletes answered “very hard”, which showed a significant difference (p<0.001) More than 80% of female athletes had experienced a vertigo during exercise (p<0.01). Also, more than 50% of female athletes except badmintoner had experienced an irregular menstruation (p<0.05). Average serum iron level (p<0.05) and TS (p<0.05) of field and track athletes were significantly lower compared to the other athletes. Serum ferritin of badmintoner, field and track athletes and fencer was significantly lower compared to firing and swimmer (p<0.05). Nutrient intakes of female athletes except vitamin B6, niacin and phosphorus were lower than the Korean RDA. Especially, calcium and iron intakes of female athletes were under the 50% of the Korean RDA. Therefore, proper nutrition education and supplementation are required for female athletes to encourage desirable food habits as well as to improve their nutritional status and exercise performance.

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Characteristics of Integrated Aging-friendly Technologies into Future Smart Housing (미래주택에 적용될 고령친화기술의 특성연구)

  • Cui, Jing yu;Lee, Yeun sook;Hwang, Ji hye
    • Design Convergence Study
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    • v.15 no.2
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    • pp.1-15
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    • 2016
  • The purpose of this study is to identify the characteristics of aging-friendly technology that can be integrated into future smart homes in an aging society. The literature survey and content analysis method were used to collect and analyze data. Papers of the international journal ICOST (International Conference on Smart Homes and Health Telematics) that professionally deal with converged technologies were analysis units. Sixty-five papers among 215 papers published from 2007 through 2014 were selected on the basis of end-users orientation. Totally, out of 65 papers 76 technology items were extracted. Characteristics of those technologies were analyzed focusing on purpose and application methods. As results, in terms of purpose, the technologies were oriented to provide both of psychological and physiological support to the users, focusing on the safety, convenience, health and entertainment to extend independent life of the elderly. Among the application method such as building structure, furniture, product, wearable device and free movable robot, product were dominant. Through those results, the aging-friendly technology is expected to alleviate a wide range of issues in aging society.

The Role of Ubiquitin-conjugating Enzymes as Therapeutic Targets in Cancer (암 치료 표적으로써 유비퀴틴 접합 효소 UBE2의 기능)

  • Seon Min Woo;Taeg Kyu Kwon
    • Journal of Life Science
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    • v.33 no.6
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    • pp.523-529
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    • 2023
  • Ubiquitination is a post-translational modification that is involved in the quality control of proteins and responsible for modulating a variety of cellular physiological processes. Protein ubiquitination and deubiquitination are reversible processes that regulate the stability of target substrates. The ubiquitin proteasome system (UPS) helps regulate tumor-promoting processes, such as DNA repair, cell cycle, apoptosis, metastasis, and angiogenesis. The UPS comprises a combination of ubiquitin, ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin-ligase enzymes (E3), which complete the degradation of target proteins. Ubiquitin-conjugating enzymes (UBE2s) play an inter-mediate role in the UPS process by moving activated ubiquitin to target proteins through E3 ligases. UBE2s consist of 40 members and are classified according to conserved catalytic ubiquitin-conjugating (UBC) domain-flanking extensions in humans. Since UBE2s have specificity to substrates like E3 ligase, the significance of UBE2 has been accentuated in tumorigenesis. The dysregulation of multiple E2 enzymes and their critical roles in modulating oncogenic signaling pathways have been reported in several types of cancer. The elevation of UBE2 expression is correlated with a worse prognosis in cancer patients. In this review, we summarize the basic functions and regulatory mechanisms of UBE2s and suggest the possibility of their use as therapeutic targets for cancer.

Three Qualities of OTT Services: A Mixed Methods Approach (OTT 서비스의 세 가지 질적 요소: 혼합적 연구방법을 통한 접근)

  • Jae Sun Yoo;Jaecheol Park;Hyun Jun Jeon;Jai-Yeol Son
    • Information Systems Review
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    • v.24 no.1
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    • pp.59-87
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    • 2022
  • Since over-the-top (OTT) service has emerged as a new way of consuming video contents, OTT markets grow exponentially and the competition among the OTT services becomes intense. Only limited systematic research effort has been paid to understand why users subscribe such OTT services among other services. Therefore, we used developmental sequential mixed methods approach to find out the quality factors and their effect on post-subscription experiences and continuance intention. In the qualitative study, we derived six factors which a user considers important to continue the subscription. Based on the explored factors, we hypothesized a research model with modified three qualities from ISSM. The proposed research model was validated through quantitative research, a survey of 226 OTT service users in South Korea, using structural equation modeling. The results indicated that content quality is the key factor affecting both perceived enjoyment and satisfaction whereas system quality affects satisfaction, and service quality only affects enjoyment. Enjoyment affects satisfaction which sequentially affects continuance usage intention. This study contributes to research by modifying ISSM through mixed methods. It also provides OTT service providers with insight to enhance users' post experience and continuance intention to use the service through qualities derived from the interview.