• Title/Summary/Keyword: U251

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Synthesis and in vitro/vivo Evaluation of Iodine-123/124 Labelled Hypericin Derivatives

  • Kim, Sang-Wook;Park, Jeong-Hoon;Yang, Seung-Dae;Hur, Min-Goo;Choi, Chang-Woon;Yu, Kook-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.29 no.10
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    • pp.2023-2025
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    • 2008
  • To evaluate the potential of radioiodine labelled hypericin as a malignant glioma imaging agent, U-251 MG, U-373 MG, C6 glioma and fibroblast were treated with a I-123 labelled hypericin derivative and C6 glioma transplanted nude mouse were injected with a I-124 labelled hypericin derivative for a micro PET imaging. 2- Iodohypericin was prepared as a reference compound. In this paper, we describe the syntheses of 2- iodohypericin and 2-[$^{123}I/^{124}I$]iodohypericin and the results of a corresponding biological evaluation. In all glioma cell lines, 2-[$^{123}I$]iodohypericin uptake was increased in a time dependant manner and an accumulation of 2-[$^{124}I$]iodohypericin was observed in C6 glioma bearing nude mouse. These results suggest that radioiodine labelled hypericin can visualize a PKC overexpressed malignant glioma.

A Study on the Operation and Services of Public Libraries in the U.K. (영국 공공도서관의 운영 및 서비스에 관한 연구)

  • Kim, Young-Seok
    • Journal of the Korean Society for Library and Information Science
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    • v.43 no.2
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    • pp.233-251
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    • 2009
  • Following the Industrial Revolution, the United Kingdom achieved political, economic and social development earlier than other countries. The British people, who gained free time, wanted to have library services. Thus, the central government established the Public Libraries and Museums Act in 1850, which was the first in the world. The local government began to establish public libraries using tax income and provided free library services. At present, the operation and services of British public libraries have been developed and are exemplary, compared to South Korea and other developing countries. Thus, this study examined how the central and local governments in the U.K. developed their public library operations and services, and how they operate public libraries.

Clinical Specimen Printing System using RFID (RFID를 이용한 검체 프린팅 시스템)

  • Kim, Yong-Phil;Choi, Kwang-Il;Jung, Hoe-Kyung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.18 no.2
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    • pp.351-356
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    • 2014
  • Although the demand for histopathological examinations has been increasing, medical accidents in management of specimens also have been increasing because most of the examinations are processed manually which can cause careless handing, confusing information and mismatching during the procedure. In the future, histopatological examination will be used frequently for handing incurable diseases and verification of new drug. Thus, efficient and error-free management system for handling personalized medical history and test results is infallibly necessary. In this paper, I have proposed an integrated printing system for informatization of histopathological examination that support the u-Healthcare environment based on RFID in near future. The proposed system supports systematization of whole examination process and information of pathological samples. This system will contribute to reduction of costs, improvement of operational efficiency, and mostly fundamental prevention of medical accidents.

Biological control of Botrytis cinerea on tomato using antagonistic bacteria

  • Hong, Sung-Jun;Kim, Yong-Ki;Jee, Hyeong-Jin;Park, Jong-Ho;Han, Eun-Jung;An, Nan-Hee;Kim, Jung-Hyun;Goo, Hyung-Jin
    • Korean Journal of Organic Agriculture
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    • v.19 no.spc
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    • pp.251-254
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    • 2011
  • Botrytis cinerea infects stems and leaves of greenhouse tomatoes and can cause serious economic losses. This study was conducted to develop environment-friendly control method against tomato gray mold. Antagonistic microorganisms (bacteria) were screened for control activity against Botrytis cinerea, both in vitro and in vivo, using stem sections. One hundred bacterial strains were isolated from the rhizospheric soil of various plants including tomato. These strains were screened for growth inhibition of Botrytis cinerea on agar plate by the dual culture and thirty strains showing strongly inhibitory effect against the pathogen were selected first. Among thirty strains, JB 5-12, JB 22-2, JB 22-3, U 4-8 and U46-6 reduced significantly disease incidence, when applied simultaneously with the pathogen. These results suggested that five antagonistic bacteria strains selected have the potential to control tomato gray mold in organic farming.

Studies on the Utilization of Korean Citrus Peel Waste -II. Contents of Pectin, Hesperidin and Naringin- (한국산(韓國産) 감귤과피(柑橘果皮)의 효율적(效率的) 이용(利用)에 관(關)한 연구(硏究) -II. 펙틴, 헤스페리딘, 나린진의 함량(含量)에 관(關)하여-)

  • Chang, Ho-Nam;Nam, Kyung-Eun;Hur, Jong-Wha
    • Korean Journal of Food Science and Technology
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    • v.9 no.4
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    • pp.251-254
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    • 1977
  • Pectin, hesperidin and naringin were extracted from hot air-dried peel ($60^{\circ}C$, 1 hr and air velocity 160 fpm) of citrus produced in Korea in order to see the amount of each component contained in the peel. Pectin was extracted by three different methods and the quality and contents of the pectins were determined respectively. 1. The pectin yield by the total pectic substance method was the highest (26.0% for unshiu (U) and 28.5% for natsudaidai (N) expectedly and the soluble pectic substance method the least (13.5%(U) and 15.6% (N)) The yield by method III (extraction by water at pH 1.5 followed by isopropanol precipitation) was intermediate (18.1% (U) and 20.8%(N)). Anhydrouronic acid (AUA) content was the highest (92.0% (U) and 90.3%(N)) in those by method III. The AUA contents of the other pectins were 80.0% for soluble pectin (for both U and N), 71.6% for the commercial pectin (Sunkist Groups Inc., U.S.A.), 58.0%(N) and 63.4%(U) for total pectic substance. 2. The methoxyl content of total pectic substance was the lowest (4.81%(U) and 4.88%(N)). However, there was no significant difference in methoxyl content among the rest which were found to have low levels(5.27-7.20%). 3. The pectin by method III gave the highest jelly strength. The commercial pectin, soluble pectice substance and total pectic substance were next in order. 4. The hesperidin content of unshiu was 5.07% (dry basis) and the naringin content of natsudaidai 3.03% (dry basis).

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Modeling of Switching Surge using EMTP-RV (EMTP-RV를 이용한 개폐서지 모델링)

  • Seo, Hun-Chul;Han, Hoo-Suk;Han, Seung-U
    • Proceedings of the KIEE Conference
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    • 2006.11a
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    • pp.249-251
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    • 2006
  • 현재 전력계통해석은 단인 주파수의 정상 및 과도상태 해석용 페이서 개념의 해석 툴을 사용하고 있다. 이는 뇌서지, 개폐서지, TRV, 병렬회선 공진 등 비선형적 계통현상분석 시 한계를 보이게 된다. 더욱이 계통이 거대화, 복잡화 됨에 따라 비선형적 과도현상 발생 빈도가 더욱 증가하여 과도현상 해석의 필요성이 점점 증가하고 있는 실정이다. 전력계통 해석 소프트웨어 중 EMTP는 비선형적 요인에 의한 고장발생 시 원인분석 해석 기술을 제공하고 있다. EMTP-RV는 EMTP를 GUI 방식으로 재구성한 툴로서 더욱 사용하기 편한 장점을 지니고 있다. 따라서, 본 논문에서는 여러 과도현상 중 개폐서지에 대하여 EMTP-RV를 이용한 분석 기법을 나타내었다. 여러 개폐서지 발생 원인을 EMTP-RV를 이용하여 모델링 하였으며, 모의 결과를 분석하였다.

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A Study on the Evaluation of JIT Operational Techniques in the Domestic Industries -Using Compatibility in the AHP- (국내기업에서의 JIT 운용기법 중요성 평가에 관한 연구 -Compatibility를 이용한 AHP를 중심으로-)

  • 구일섭;임익성;김태성
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.21 no.48
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    • pp.241-251
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    • 1998
  • The purpose of this study is to evaluate the relative importance of seven JIT operational techniques in Domestic industries. These techniques are used to improve manufacturing effectiveness and efficiency such as : Setup time reduction, Kanban, Multi-functional worker, U type layout, Andon(line stop), Atonomation, and Smoothing production. The new analytic hierarchy process(AHP) model is used in order to evaluate the relative importance of the seven JIT operational techniques which are used to increase the manufacturing effectiveness and efficiency. To aggregate the multi-divisions priorities, in this paper, we suggest a way which decision maker can exclude outlier matrix from group by using the concept of the compatibility in AHP.

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Fundamental Frequencies of Normal Children's Voice in mutational Period (변성기 일반 아동 음성의 기본주파수 연구)

  • Kim, Sun-Hai
    • Speech Sciences
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    • v.14 no.4
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    • pp.251-260
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    • 2007
  • The structure changes of the vocal folds are related to the fundamental frequencies (F0). In other words, the increasing in vocal fold length and thickness makes the result of dropping in the F0 during the mutational period. The purpose of this study was to investigate F0 of normal children's voice in mutational period. 360 children (180 boys and 180 girls) were participated in this experiment. The age was ranged from 11 to 16 years. The subjects were asked to produce sustained comer vowels (/a/ /i/ /u/) five times each and the data were analyzed using the MDVP of CSL. The result shows that the F0 are considerably decreased with age and reach to adults' F0 by 16 years in most cases. In particular, the F0 of male subjects were rapidly decreased between the ages from 12 ($226.98\;{\pm}\;19\;Hz$) to 13 years ($169.3\;{\pm}\;25\;Hz$), while the F0 of female subjects were slowly changed from the later period of 12 to 16 years old. This result may be used by the meaning of guideline and lead the basic data to differentiate between normal voice and voice disorder.

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UX Design of Next Generation Web Platform (차세대 웹 플랫폼의 UX설계)

  • Kim, Seon-U;Cho, Young-Ju;Kim, Jin-Hyuk
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2017.01a
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    • pp.251-254
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    • 2017
  • 최근 현대인들은 웹 환경에 대해 높은 관심을 보이고 있다. 또한 웹 환경에서 HTML5의 표준화에 따라 사용자의 경험, 즉 'UX(User Experience)' 설계에 대한 관심 또한 높아지고 있다. 이러한 환경을 차세대 웹 플랫폼이라 한다. 차세대 웹 플랫폼이라 함은 HTML5라는 웹 표준 규약에 따라 설계한 것을 뜻한다. 따라서 본 논문에서는 이러한 차세대 웹 플랫폼의 UX 설계에 대한 최신 트렌드와 콘텐츠 UX에 대해서 설명하고 반응형 디자인에 따른 웹사이트 수익과의 관계까지 실험결과를 토대로 제시하고자 한다.

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