• Food Science and Preservation
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• v.22 no.2
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• pp.251-255
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• 2015

To optimize the medium composition of Undaria pinnatifida as a pH modulator the growth of Lactobacillus plantarum industrial scale, we analyzed the pH and growth characteristics of L. plantarum in basal medium. Subsequently, the medium compositions addition of carbon, nitrogen sources and buffering agents were optimized. When 0.5% yeast extract and 2% glucose, L. plantarum grew to maximum cell density in experimental condition. However, the growth of L. plantarum rapidly pH 4.0 in basal medium. A high alkali-ash value and low cost-effective utilization n the waste part as examined. ddition of U. pinnatifida extract alleviated the serious decrease. Among them, juice of U. pinnatifida was most helpful for the growth of L. plantarum ($36.3{\pm}1.810^8CFU/mL$). These results show that U. pinnatifida be large-scale cultivation of L. plantarum. This optimized U. pinnatifida medium can be used for safe and economical production of Lactobacillus.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.193-201
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• 2020

Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.

• Journal of Bio-Environment Control
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• v.30 no.4
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• pp.251-256
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• 2021

This study aimed to compare the growth and production of paprika (Capsicum annuum) planted directly on a coir substrate slab according to the bending methods. The existing root direction was bent to 0° (I-type), 90° (L-type), and 180° (U-type), respectively. The weekly average growth such as stem length, diameter, and leaf area tended to be the highest in the I-type bending, but there was no statistical difference. Root weight at 46 weeks after planting was also about 1.3 to 1.7 times heavier in the I-type than the L- and U-type bending. As the yield produced by 330 plants by bending methods, the initial yield was the highest in the U-bending, but then the highest in the I-bending. Accordingly, the total yield was the highest in I-bending. Consequently, when planting on coir substrates directly in paprika cultivation, the I-type bending should be considered most suitable for securing root and plant vigor in the early stages of planting and for enhancing fruiting stability.

• Advances in nano research
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• v.5 no.3
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• pp.245-251
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• 2017

Multiwalled carbon-nanotubes (MWCNT) and micro-structured carbon, such as biochar or activated carbon (AC), have been seen to significantly increase the growth indices of certain plant species such as maize (Zea mays L.). Seed imbibition is the stage where environmental factors that affect water transport across the seed coat barrier, make a large impact. This work explores the effect on water imbibition by maize seeds when the aqueous environment surrounding the seed is diluted by small concentrations (10 and 20 mg/l) of pristine MWCNT (p-MWCNT), carboxylate functionalized MWCNT (COO-MWCNT) and AC. The degree of sensitivity of the process to (i) large structural changes is seen by utilizing the nano (the MWCNT) and the micro (the AC) allotropic forms of carbon; (ii) to small changes in the purity and morphology of the p-MWCNT by utilizing 95% pure and 99% pure p-MWCNTs of slightly differing morphologies; and (iii) to MWCNT functionalization by using highly pure (97%) COO-MWCNT. Water imbibition was monitored over a 15 hour period by Near Infrared Thermography (NIRT) and also by seed weighing. Seed surface topography was seen by SEM imaging. Analysis of the NIRT images suggests rapid seed surface topological changes with the quantity of water imbibed. While further work is necessary to arrive at a conclusive answer, this work shows that the imbibition phase of the maize seed is sensitive to the presence of MWCNT even to small differences in the purity of the p-MWCNT and to small differences in the physicochemical properties of the medium caused by the hydrophilic COO-MWCNT.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.242-251
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• 2015

This paper is to analyse statutes and execution system on 'plain language policy' of the U.S. in the process of policy was instituted, and to suggest the meaningful implications for Korean easy public language improvement project based on the conclusions drawn. The summarized conclusion is as follows. First, the continuous interests of Presidents and taking the lead of federal agencies played important roles until the U.S. plain language policy has been established as a system. Second, in executing the U.S. plain language policy, laws legislated by period contributed to elicit mandatory compliances from the federal agencies. Third, a propelling agent of plain language policy, PLAIN, is not an administrative department but a community consisted of federal employees and experts. Fourth, plain language policy was unexpectedly given wholehearted support and assistance by Presidents and their administrations from the reform-minded Democratic party. Fifth, during the 2000s most federal departments and agencies held self-managed websites and programs related to plain language. To conclude the current U.S. plain language policy surely performs a mechanism to improve communication and a role as a ladder of trust between the public and government.

• Journal of the Korean Society for Library and Information Science
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• v.47 no.3
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• pp.251-274
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• 2013

This study aims to analyze data management policies offered by 15 government funding agencies in the U.S., UK, Canada, and Australia, and to make recommendations for developing data management policies in Korea. For the analysis of data management policies, five criteria were suggested based on literature review as follows: 1) the definition of research data, 2) principles of data management, 3) data management plan, 4) the implementation of data management, 5) legal and ethical issues. It was found that there was no policy that covers all the criteria for the analysis. Several funding agencies, however, commonly dealt with each criteria in their data management policies. Based on the findings from the analysis, this study made the following suggestions: First, data policies provide definitions and types of research data based on the understanding of data creation in the fields of funding interests. Second, data policies include principles of data management applicable to data practices in Korea. Third, data policies implement data management plans to promote responsibility of researchers for managing data. Fourth, data policies specify data management implementations to facilitate and support data sharing practices. Fifth, data policies should minimize legal and ethical challenges in data sharing through the review of the applicability of related laws and regulations and their improvement.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.251-258
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• 2019

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.10
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• pp.251-275
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• 2004

In diesem Aufsatz geht es um die Frage. womit Leo Weisgerber seine Sprachtheorie entwickelt hat. Er wurde von mehreren Theoretikern und Wissenschaftlern $beeinflu{\ss}t$, wie z. B. Wilhelm von Humboldt, Ernst Cassirer, Wilhelm Wundt, Ferdinand de Saussure usw. Aber in einigen besonderen Bereichen seiner Sprachtheorie wurde or besonders von F. de Saussure stark $beeinflu{\ss}t$. Leo Weisgerber hat sehr viele $Aufs\"{a}tze$ und $B\"{u}cher$ geschrieben. Aber darunter gibt es einige Werke, die seine Sprachtheorie zusarnmenfassend darstellen. Sie sind die folgenden: seine Habillitationsschrift(1925), Muttersprache und Geistesbildung(1929), Grundzuge der inhaltbezogenen Grammatik(1962). Wir haben daher versucht, zu erfurschen, welchen Einfluss Saussure auf diese Werke Weisgerbers ausgeubt hat. In der Habilitationsschrift konnten wir herausfinden, $da{\ss}$ Weisgerber die $Ans\"{a}tze$ Sausssures kritisierend aufgenommen hat. Wahrend Saussure Sprache nicht als einen Organismus betrachtet $h\"{a}lt$ Weisgerber Sprache $f\"{u}r$ einen lebendigen Organismus. $Dar\"{u}her$ hinaus ist nach Weisgerber die Unterscheidung, zwischen langue und parole $unn\"{o}tig$. Leo Weisgerber hat in dem Buch 'Muttersprache und Geistesbildung' seine Zeichen-Theorie zusammenfasst. Da war or damit einverstanden, $da{\ss}$ ein Zeichen aus signifiant und signifie besteht. $Au{\ss}erdem$unterscheidet or Sprache, $\"{a}hnlich$ wie Saussure, wie folgt : das Sprechen, der Sprachbesitz des einzelnen, Sprache als Kulturbesitz einer Gemeinschaft, das allgemein menschliche Prinzip Sprache im Sinne der fuel die Menscheit kennzeichnenden Sprachtaetigkeit. In 'Grundzugo der inhaltbezogenen Grammatik' stellt or dar, wie die Untersuchung der Sprachinhalte $durchgef\"{u}hrt$ werden soll. Nach ihm ist ein Wortinhalt immer $erkl\"{a}rbar$, durch ein Wert in einem Wortfeld. Dieser Begriff 'Wert' entstammt vom 'valour', den Saussure gemacht hat. Aber die Zeichentheorie Weisgerbers ist ein $bi{\ss}chen$ anders geworden. $W\"{a}hrend$ Saussure ein zweidimensionales Zeichenmodel (signifiant und signifie) aufstellt, stellt Weisgerber ein dreidimensionales Zeichenmodell dar, das aus drei Elemente (Lautform - geistige Zwischenwelt - $Au{\ss}enwelt$) besteht. Aus diesen Ergebnissen der Untersuchung konnen wir $schlie{\ss}en$, $da{\ss}$ Weisgerber mehr oder weniger von F. do Saussure beeinflusst wurde.

• Bioinformatics and Biosystems
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• v.1 no.2
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• pp.115-122
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• 2006

A three-dimensional pharmacophore model was developed based on 24 currently available inhibitors, which were rationally selected from 472 compounds with diverse molecular structure and bioactivity, for generating pharmacophore of uPA (Urokinase Plasminogen Activator) inhibitors. The best hypothesis (Hypo1) comprised of five features, namely, one positive ionizable group, one hydrogen-bond acceptor group and three hydrophobic aromatic groups. The correlation coefficient, root mean square deviation and cost difference were 0.973, 0.695, and 94.291 respectively, suggesting that a highly predictive pharmacophore model was successfully obtained. The application of the model showed great success in predicting the activities of 251 known uPA inhibitors (test set) with a correlation coefficient of 0.837, and there was also none of the outcome hypotheses that had similar cost difference and RMS deviation (RMSD) with that of the initial hypothesis generated by Cat-Scramble validation test with 95% confidence level. Accordingly, our model should be reliable in identifying structurally diverse compounds with desired biological activity.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.10
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• pp.1780-1785
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• 2016

This paper presents few case studies of state diagnosis of XLPE cables using very low frequency techniques. The power cables of 22.9kV which have installation fault were assessed using VLF technique in addition to other techniques like insulation resistance and DC voltage withstand test. From the experimental results, The dielectric loss($tan{\delta}$) values of degradation of the cable(joint, knife, needle) at $U_0$ were 5.839, 5.526 and 6.251, respectively and all values were "further study advised". VLF PD measurement was also found defective portion. These method was effective in defect to fault in the degradation of the cable. However, the breakdown did not occur in the degradation of the cable because of properties of XLPE insulation. Few case studies of using VLF $tan{\delta}$ diagnosis for fault are measured and analyzed. The $tan{\delta}$ values at $U_0$ were "further study advised" or "action required".