• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3464-3471
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• 2023

The Uranium/Molybdenum metallic fuel has been proposed as promising advanced fuel concept especially in the dispersed fuel geometry. The fuel is manufactured in the form of small fuel droplets (particles) placed in a fuel pin covered by a matrix. In addition to fuel particles, the pin contains voids necessary to compensate material swelling and release of fission gases from the fuel particles. When investigating this advanced fuel design, two important questions were raised. Can the dispersed fuel performance be analyzed using homogenization without significant inaccuracy and what size of fuel drops should be used for the fuel design to achieve optimal utilization? To answer, 2D burnup calculations of fuel assemblies with different fuel particle sizes were performed. The analysis was supported by an additional 3D fuel pin calculation with the dispersed fuel particle size variations. The results show a significant difference in the multiplication factor between the homogenized calculation and the detailed calculation with precise fuel particle geometry. The recommended fuel particle size depends on the final burnup to be achieved. As shown in the results, for lower burnup levels, larger fuel drops offer better multiplication factor. However, when higher burnup levels are required, then smaller fuel drops perform better.

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4499-4513
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• 2022

Spent fuel behavior of dry storage was simulated in a continuous state from steady-state operation by modifying FRAPCON-4.0 to incorporate spent fuel-specific fuel behavior models. Spent fuel behavior of a typical PWR was compared with that of NuScale Power Module (NPM^TM). Current PWR discharge burnup (60 MWd/kgU) gives a sufficient margin to the hoop stress limit of 90 MPa. Most hydrogen precipitation occurs in the first 50 years of dry storage, thereby no extra phenomenological safety factor is identified for extended dry storage up to 100 years. Regulation for spent fuel management can be significantly alleviated for LWR-based SMRs. Hydride embrittlement safety criterion is irrelevant to NuScale spent fuels; they have sufficiently lower plenum pressure and hydrogen contents compared to those of PWRs. Cladding creep out during dry storage reduces the subchannel area with burnup. The most deformed cladding outer diameter after 100 years of dry storage is found to be 9.64 mm for discharge burnup of 70 MWd/kgU. It may deteriorate heat transfer of dry storage by increasing flow resistance and decreasing the view factor of radiative heat transfer. Self-regulated by decreasing rod internal pressure with opening gap, cladding creep out closely reaches the saturated point after ~50 years of dry storage.

• Journal of Life Science
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• v.17 no.4 s.84
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• pp.552-560
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• 2007

Histone deacetylase (HDAC) is overexpressed in a variety of cancers and is closely correlated with oncogenic factors. HDAC inhibitors such as trichostatin A(TSA) and sodium butyrate (Na-B) have been shown to induce apoptosis in vitro and in vivo in many cancer cells. The anti-apoptotic Bcl-2 protein has the remarkable ability to prevent cell death and Bcl-2 overexpression has been reported to protect against cell death. We previously reported that the apoptotic cell death of human leukemic U937 cells by TSA and Na-B treatment was associated with the down-regulation of Bcl-2 expression and activation of caspases. In the present study, we investigated the effects of Bcl-2 overexpression on the growth inhibition, cell cycle arrest and apoptosis induced by TSA and Na-B in U937 cells. TSA-induced growth inhibition, cell cycle arrest and apoptosis were significantly attenuated in Bcl-2 overexpressing U937/Bcl-2 cells however Na-B did not affected. Induction of apoptosis by TSA was accompanied by down-regulation of Bcl-2 expression, activation of caspase-3, -8 and -9, and degradation of DNA fragmentation factor/inhibitor of caspase-activated DNase, which was blocked by the overexpression of Bcl-2. Collectively, these findings suggest that ectopic expression of Bcl-2 appeared to inhibit TSA-induced apoptosis by interfering with inhibition of Bcl-2 and caspase activation.

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.2
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• pp.233-243
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• 2006

The aim of this study was to investigate the relationship between the C-factor and shrinkage strain values of composite resin and examine the strain values in different incremental filling techniques. Experiment consisted two aims. First, we compared with strain value in two different C-factors(3.7 and 1.0). Second, we examined the strain values in three different filling techniques. The results of the present study can be summarized as follows : 1. High C-factor groups showed higher contraction stress values than low C-factor groups at 900 sec after polymerization. 2. Hybrid resin showed higher contraction stress values than flowable resin in high C-factor cavities. But contraction stress was not revealed significant difference between hybrid resin and flowable resin in low C-factor cavities (P>0.05). 3. Bulk felling with hybrid resin(Group 1) showed high contraction stress and lining with flowable resin followed hybrid resin (Group 5) showed lower contraction stress. 4. Contraction stress were increased during 900 sec after polymerization in high C-factor groups but decreased gradually after 900 sec. 5. Low C-factor groups showed tight marginal seal between resin and cavity wall but high C-factor groups showed gaps formed between resin and cavity wall in part. On the basis above results, layering techniques in high C-factor cavity showed advantages in reducing contraction stress and gap formation between cavity wall and resin restoration.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.11B no.4
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• pp.193-199
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• 2001

This paper suggests a novel single-stage drive for a switched reluctance motor (SRM) to achieve sinusoidal, near unity power factor input currents. The proposed drive is very simple without additional active switch. As a single-stage approach, which combines a DC link capacitor used as dc source and a drive used for driving the motor into one power stage, a simple structure and low cost drive in implemented. A prototype drive for an 8/6 pole SRM equipping a suitable encoder is designed to evaluate the proposed topology. Also subscription control algorithm is presented. The characteristics and validity of the proposed circuit will be discussed in depth through the experimental results.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2437-2444
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• 2012

Tumor metastasis remains the principal cause of treatment failure and poor prognosis in patients with colorectal cancer. It is a multistage process which includes proteolysis, motility and migration of cells, proliferation in a new site, and neoangiogenesis. A crucial step in the process of intra- and extra-vasation is the activation of proteolytic enzymes capable of degrading the extracellular matrix (ECM). In this stage, urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinases (MMPs) are necessary. Micrometastases need the presence of growth factor and vascular growth factor so that they can form macrometastasis. In addition, cell adhesion molecules (CAMs) and guanine nucleotide exchange factors (GEFs) play important roles in the progression of colorectal cancer and metastatic migration. Further elucidation of the mechanisms of how these molecules contribute will aid in the identification of diagnostic and prognostic markers as well as therapeutic targets for patients with colorectal metastasis.

• Proceedings of the KIEE Conference
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• 1993.11a
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• pp.126-128
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• 1993

Rectifiers of power conversion system are widely used condenser at input to be cheap and to be simple construction. But this method is produced harmonics of pulse at peak value of input AC voltage. The main circuit which make input current of a sinusoidal wave and improve power-factor is almost taken step-up converter. This paper is able to obtain high power-factor and efficiency because the input current is made sinusoidal wave in single phase alternating current(AC) source. Also the proposed converter is able to minimize switching loss by ZVCS(zero voltage switching and zero current switching).

• Proceedings of the KIEE Conference
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• 1995.11a
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• pp.255-257
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• 1995

Many new electronic products are required to have a unity power factor and a distortion free input current waveform. In this parer, a high performance single phase AC/DC converter with input power factor correction is proposed. And each parameters are determined. Proposed control strategy has many advantages which include two Quadrants operation, simplified control circuit, high performance features and continuous Input current. The experimental results are included to verify the validity of this approach.

• The KSFM Journal of Fluid Machinery
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• v.15 no.6
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• pp.31-38
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• 2012

Rotor of rotating machinery is the highly damaged part. Fault of 7 different types was confirmed as the main causes of rotor damage from the pump failure history data in domestic and U.S. nuclear. For each fault types, simulation testing was performed and fault signals were collected form the sensors. To calculate the statistical parameters of time-domain & frequency-domain, measured signals were analyzed by using the discrete wavelet transform, fast fourier transform, statistical analysis. Total 84 parameters were obtained. And Effectiveness factor were used to evaluate the discrimination capacity of each parameter. From the effectiveness factor, RAW-P4/RAW-P7/WT2-NNL/WT2-EE/WT1-P1 showed high ranking. Finally, these parameters were selected as the feature parameters of intelligent fault diagnostics for rotor.

• Journal of Welding and Joining
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• v.18 no.5
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• pp.33-40
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• 2000

Fatigue crack propagation life of weld toe crack through residual stress field was estimated with Elber's crack concept. Propagation of weld toe crack is heavily influenced by residual stress caused by welding process, so it is essential to take into account the effect of residual stress on the propagation life of weld toe crack. Fatigue crack at transverse and longitudinal weld toe was studied respectively, which represent typical weld joint in ship structure. Numerical and experimental studies are performed for both cases. Residual stress near weldment was estimated through nonlinear thermo-elasto-plastic finite element method, and residual stress intensity factor with Glinka's weight function method. Effective stress intensity factor was calculated with Newman-Forman-de Koning-Henriksen equation which is based on Dugdale strip yield model in estimating crack closure level U at different stress ratio. Calculated crack propagation life coincided well with experimental results.