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Preparation and Evaluation of Bupivacaine Microspheres by a Solvent Evaporation Method (II) (용매증발법에 의한 부피바카인 마이크로스피어의 제조 및 평가 (II))

  • 곽손혁;이시범;이종수;이병철;황성주
    • YAKHAK HOEJI
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    • v.45 no.6
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    • pp.623-633
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    • 2001
  • Various bupivacaine-loaded microspheres were prepared using poly(d,1-lactide) (PLA) and poly(d,1-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency and yield of PLGA micro- spheres were higher than those of PLA microspheres. The prepared microspheres had an average particle size below 5${\mu}{\textrm}{m}$. The particle size range of microspheres was 1.65~2.24${\mu}{\textrm}{m}$. As a result of SEM, the particle size of PLA microspheres was smaller than that of PLGA microspheres. In morphology studies, microspheres showed a spherical shape and smooth surface in all process conditions. In thermal analysis, bupivacaine-loaded microspheres showed no peaks originating from bupivacaine. This suggested that bupivacaine base was molecular-dispersed in the polymer matrix of microspheres. The release pattern of the drug from microspheres was evaluated for 96 hours. The initial burst release of bupivacaine base decreased with increasing the molecular weight of PLGA, and the drug from microspheres released slowly. In conclusion, bupivacaine-loaded microspheres were successfully prepared from poly(d,1-lactide) and poly (d,1- lactic-co-glycolide) polymers with different molecular weights allowing control of the release rate.

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Flow visualizations and analysis on characteristics of bubbly flows exhausted from a venturi-type bubble generator with an air vent (공기유입구를 가진 벤츄리 형상의 기포발생기에서 토출되는 기포 유동 특성의 가시화 측정 분석)

  • Bae, Hyunwoo;Lee, Seungmin;Song, Moonsoo;Sung, Jaeyong
    • Journal of the Korean Society of Visualization
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    • v.17 no.1
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    • pp.60-68
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    • 2019
  • Flow visualizations have been carried out to analyze the characteristics of bubby flows exhausted from a venturi-type bubble generator with an air vent. For various design parameters and operating conditions of the bubble generator, the images of bubbly flows was recorded using a high-speed camera and a microscope. Then the amount and size distribution of bubble was evaluated by an image processing technique. The results show that for increasing the amount of bubble, it is more effective to reduce the venturi throat than to enlarge the air vent diameter. If the water flow rate increases, the bubble generation rate increases but reaches a status of saturation, whose condition depends on Reynolds number at a given air vent diameter. The bubble size increases as the diameter of venturi throat decreases and Reynolds number increases. However, the air vent diameter is not a significant factor on bubble size.

Analysis on Measurements and Shapes of Adult Male Hands for Functional Product Design (기능성 제품 설계를 위한 성인 남성의 손 관련 치수 및 형상 분석)

  • Jeon, Eunkyung
    • Journal of the Korean Society of Clothing and Textiles
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    • v.45 no.5
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    • pp.758-769
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    • 2021
  • Today, functional gloves must allow the wearer to perform many kinds of delicate work while protecting the hands from hazardous materials. In this study, multiple analyses of 3D hand measurements were performed to provide information on the hand size and shape required for the design of functional gloves for adult men. Size and shape characteristics were identified from 19 different hand measurements, and three factors were collected through factor analysis. The aggregated factor score was used to classify men's hand shapes into three types. These types showed different distribution patterns according to age, indicating a significant distribution difference between hand type and age group. Discriminant analysis extracted nine items that highly contributed to determining hand type. However, since the data provided by Size Korea have some limitations in fully representing hand shape, sampling additional types of hand measurements and using consistent conditions and methods are required for more accurate analysis.

The Characteristics of Decrepit Migration Village and Living Space and it's Transformation of the Elderly People in Yeongdo's Sunrise Village (영도 해돋이마을의 이주주택 지속현황과 공간변용 특성)

  • Kim, Dae-Hwan;Oh, Kwang-Suek;Yoo, Jae-Woo
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.34 no.7
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    • pp.13-20
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    • 2018
  • In this study, it was started with the research for improving the housing plan of the elderly and the aged housing environment. The spatial extent of the study is in Haedoji Village, Yeongdo, Busan, and the time ranged from the mid-1950s, when the Korean war broke out and the refugees started to settle, to the present as of August 2017. As Result, the size of the residential space per capita was overcrowded at $9.2m^2$ in the 1970s and 1980s, when the number of families was high, but since 2010, the size of the residential space currently living alone with only one elderly or couple was $29.2m^2$. In the future, it can be judged that the size of elderly housing can be expected to be envisioned within about $35{\sim}40m^2$ in consideration of the diversity of housing including table space in the 2LDK type.

Stretchable Electrode Properties Study According to Particle Size of Flake-type Ag Powders (Flake-type Ag분말의 입자크기에 따른 신축성 전극 특성 연구)

  • Nam, Hyun Min;Sea, Min Ho;Nam, Su Yong
    • Journal of the Microelectronics and Packaging Society
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    • v.29 no.4
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    • pp.35-40
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    • 2022
  • In this study, the average particle size of silver powder was 2㎛, 7㎛, and a mixture of these (50:50wt%), three kinds of silver pastes were prepared. In addition, as a result of examining the viscosity and viscoelasticity of the three silver pastes, TGA measurement, resistance change according to strain, and change in surface structure of the electrode, the following conclusions were obtained. Summarizing these results, it was found that it is most desirable to have a particle size of about 2㎛ in order to minimize the change in resistance due to strain.

Suture anchor selection

  • Lee, Gwang-Won
    • The Academic Congress of Korean Shoulder and Elbow Society
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    • 2005.11a
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    • pp.198-205
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    • 2005
  • 1. Many design features including suture type, anchor size and geometry, and anchor material, play a role in the overall strength of the anchor. In addition, technical considerations such as implant orientation, pattern, and location may affect the ultimate success of the repair. 2. Multiple fixation points provide a biomechanically sounder construct in Bankart repair. The size of the glenoid and its rim make anchor size a critical consideration in implant selection and implementation.

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The effect of the structure of each component on the o/w microemulsion droplet size and stability

  • Changgui Han;You
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.22 no.2
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    • pp.20-40
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    • 1996
  • The oil in water type ME of 4 component system was composed with POE monoalkyl ether and POE sorbitan monoalkyl ester as surfactant, saturated hydrocarbon, side chain structure and aromatic structure as oil, and glycerine as cosurfactant using high pressure homogenizer. The objective of this study was to examine the role of surfactant and oil structure on droplet size and stability. The experimental results showed that the droplet size was smaller with bigger polarity of oil, less hydrocarbon, longer hydrophilic chain of surfactant and higher concentration of glycerine. SQ and LP systems showed very stable but AB and ISB system unstable microemulsion.

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Size Refinement of Empirical Likelihood Tests in Time Series Models using Sieve Bootstraps

  • Lee, Jin
    • Communications for Statistical Applications and Methods
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    • v.20 no.3
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    • pp.199-205
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    • 2013
  • We employ sieve bootstraps for empirical likelihood tests in time series models because their null distributions are often vulnerable to the presence of serial dependence. We found a significant size refinement of the bootstrapped versions of a Lagrangian Multiplier type test statistic regardless of the bandwidth choice required by long-run variance estimations.

A Study on the School Uniform Pants Sizing System depending on Lower Body Type for Highschool Girls (여고생 하반신 체형특성에 따른 교복바지 치수설정에 관한 연구)

  • Choi, Eun-Hee;Do, Wol-Hee
    • Fashion & Textile Research Journal
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    • v.14 no.5
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    • pp.834-845
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    • 2012
  • This study was conducted to provide basic information on developing highschool-uniform pants with more suitable fit and to suggest a sizing system for highschool girls' uniform pants that adequately reflects their body figures. To understand the features of high school girls' lower body type, the body measurement values of 833 girls from 16~18 years of age based on Size Korea(2010) were analyzed statistically. For the classification of lower body type for high school girls, a factor analysis and cluster analysis were conducted. The collected data were processed with the programs SPSS 18.0 for windows. The results in this study are follows: The lower body types for high school girls were divided into 3 groups. Body Type A is average stature but the biggest circumference, Type B is the biggest stature and the medium body type, Type C is the smallest stature and skeleton structure. KS size intervals were used for frequency distribution of height and waist for the lower body. Sizing system of the uniform company and frequency distribution of sizes were compared. Using the two-way distribution of highschool girls' waist circumference and hip circumference, sizing system considering body type distribution and high frequency distribution section of sizes was suggested. This study established new sizing system depending on lower body fixed as 26 number of sizes. The most suitable standard is fixed as 12 number of sizes ; 64-88, 64-91, 67-88, 67-91, 67-94, 70-91, 70-94, 70-97, 73-94, 73-97, 76-97, 76-100. The coverage is also calculated. And the coverage of new standard was 63.5%. The continuous study on the uniform pants sizing system of the obesity types is required.

Frontal Body Shapes of Males in Their 20s for the Development of Educational Dress Forms (Part 1) (교육용(敎育用) 인대(dress form) 개발(開發)을 위한 20대(代) 남성(男性)의 정면체형(正面體型) 연구(硏究) 제1보(第1報))

  • Yoo, Hyun;Shim, Boo-Ja
    • Journal of Fashion Business
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    • v.9 no.2
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    • pp.113-130
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    • 2005
  • With a view to developing male dress forms for educational purposes, human body measurement was made for male adults in their twenties residing in Busan, Korea. Based on the results, the following conclusion was obtained: 1. Comparison d the measurement in Busan and the data of the 5th Korean physical dimensions(Size Korea) In the comparison of the Busan male adults in their 20s with national physical dimensions(Size Korea) by way of the Mollison relational deviation line, all the 28 items revealed differences less than 0.7. As the Busan sample reflects the body type d the average Korean men in their 20s, Busan's measurement results can be safely used as the data for dress form development. 2. Results of front body type classification According to the factor analysis, seven factors of the front body type were produced to explain 77.25%. The factors were shoulder angles, waist height, hip shapes, chest shapes, proportion of body(chest, waist, hip)width to shoulder width and so on. Cluster analysis brought about three somatotype groups. First, the body type with the least differences in hip-waist width, shoulder-waist with, and hip angles (24,23% in appearance) was named Type H. Second, the body type with the most chest-waist width and hip angles (38.66% in appearance) was called Type Sam X Third, the body type with the greatest shoulder-chest width, shoulder-hip width, and shoulder angles (37.11% in appearance) was termed Type Y.