• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7431-7434
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• 2015

As an important component of innate immune system, neutrophil has been involved in many other physiological processes, including tumor-related diseases. In 2004, the phenomenon of NETs was reported for the first time. Extracellular decondensed chromatin, released from activated neutrophils, forms a network structure, which is NETs. This review focuses on the function of NETs in tumor cell proliferation, metastasis, and tumor-associated thrombosis; it also explores the application of NETs specific markers in the diagnosis of pre-thrombotic state and tumor associated diseases; it also explores NETs inhibitor for the treatment of tumor-related diseases. In view of the rapid development of NETs, it may provide new therapeutic targets for tumor-associated thrombosis, and even tumor itself.

• 대한두경부종양학회지
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• 제22권2호
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• pp.188-191
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• 2006

Papillary thyroid carcinoma is rarely associated with macroscopic vascular invasion or tumor thrombosis. Especially, superior vena cava syndrome(SVCS) resulted from tumor thrombosis of papillary thyroid carcinoma is extremely rare. We present herein a case of SVCS caused by tumor thrombosis from papillary thyroid carcinoma which was successfully solved by intravascular placement of self-expandable stent in 74-year-old woman.

• 대한골관절종양학회지
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• 제12권1호
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• pp.83-88
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• 2006

골연골종은 가장 흔한 양성 골 종양으로, 주변 골단판 연골의 골막하 전위에 의한 과증식성 골 병변이며, 대개 골단판이 닫히면서 성장이 끝나는 것으로 알려져 있다. 이러한 골연골종이 혈관계 합병증을 유발하는 경우는 드물지만, 종괴 효과로 주변의 동맥이나 정맥을 눌러 허혈이나 정맥염이 생기거나, 연골모가 골화되면서 생기는 날카로운 말단에 의해 동맥벽의 천공이 생길 수 있다. 이러한 혈관계 합병증은 대부분 젊은 남자의 동맥에서 발생하며, 정맥에 생기는 경우는 드문 것으로 알려져 있다. 저자들은 원위 대퇴골 골연골종으로 인해 심부 정맥 혈전증이 발생한 21세 남자 환자에서 골연골종의 제거 후 정맥 절제술 및 복재 정맥 이식술로 치료한 경험을 보고하고자 한다.

• Investigative Magnetic Resonance Imaging
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• 제23권4호
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• pp.361-366
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• 2019

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy common in young male patient. Typical imaging features of DSRCT include multiple soft tissue masses in the peritoneal cavity, omentum, or mesentery without an organ of origin. This report presents a rare manifestation of DSRCT revealing a solitary large retroperitoneal mass with hepatic metastasis and malignant portal vein thrombosis in 70-year-old women together with the review of literature. The tumor showed a hemorrhagic and necrotic mass with peripheral portion of T2 hypo-intensity and delayed enhancement that indicated desmoplastic stroma with dense cellularity.

• 대한두경부종양학회지
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• 제22권1호
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• pp.58-61
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• 2006

Differentiated thyroid carcinomas are rarely associated with macroscopic vascular invasion and intraluminal tumor thrombus in great cervical veins. The best treatment for such cases appears to be a total thyroidectomy with en-block resection of the involved vessels, followed by postoperative radioiodine therapy(RI). We report two cases of follicular thyroid carcinoma with vascular invasion and intraluminal tumor thrombosis in great cervical veins that were successfully treated using complete surgical resection and postoperative RI.

• Journal of Chest Surgery
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• 제49권1호
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• pp.42-45
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• 2016

Thrombosis at the left ventricular outflow tract occurs without any detectable heart disease or predisposing factors only extremely rarely. A 48-year-old male visited Konkuk University Medical Center with loss of consciousness one month prior to presentation. Before he visited our hospital, he had been diagnosed with a cardiac tumor, which was located between the left atrium and posterior aortic root, and which was adjacent to both the aortic and mitral valves. Cardiac transplantation was recommended at the other hospital because of the high risk of cardiac dysfunction induced by both aortic and mitral valvular dysfunction after surgical resection. Based on preoperative transthoracic echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging, and intraoperative transesophageal echocardiography, we considered it to be a benign tumor. Complete resection was achieved and the pathology confirmed organizing thrombus. We report a case of organizing thrombus mimicking a cardiac tumor, which was located at the mitral-aortic intervalvular fibrosa of the left ventricular outflow tract without any heart disease.

• 대한영상의학회지
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• 제83권5호
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• pp.1147-1152
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• 2022

특발 두개내압상승은 특별한 기질적 원인 없이 두개 내압의 증가가 생기는 증후군으로 이 질환의 약 10%에서 두개내 정맥동의 혈전 형성이 생길 수 있다고 알려져 있다. 체중이 정상 범위이며 응고 장애가 없는 특발 두개내압상승 환자에게서 정맥동의 혈전 형성은 간과될 수 있다. 본 증례 보고에서는 특별한 위험인자가 없던 환자에게서 설하신경관의 신경 원성 종양으로 오인되었던 정맥동 혈전의 케이스를 소개하고, 두개 내압상승의 다양한 영상 소견에 대해 고찰하고자 한다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 1996년도 추계학술대회 초록집
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• pp.75-75
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• 1996

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3509-3514
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• 2013

The prognostic value of the fibroblast growth factor-inducible 14 (Fn14) expression in hepatocellular carcinoma (HCC) is unknown. Real-time PCR (RT-PCR), western blot assays and immunohistochemistry analysis were here performed in order to compare Fn14 expressios in paired liver samples of HCC and normal liver tissue. Most of the tumor tissues expressed significantly higher levels of Fn14 compared to adjacent non-tumor tissues, with Fn14High accounting for 54.6% (142/260) of all patients. The Pearson ${\chi}^2$ test indicated that Fn14 expression was closely associated with serum alpha fetal protein (AFP) (P=0.002) and tumor number (p=0.019). Univariate and multivariate analyses revealed that along with tumor diameter and portal vein tumor thrombosis (PVTT ) type, Fn14 was an independent prognostic factor for both overall survival (OS) (HR=1.398, p=0.008) and recurrence (HR=1.541, p=0.001) rates. Fn14 overexpression HCC correlated with poor surgical outcome, and this molecule may be a candidate biomarker for prognosis as well as a target for therapy.

• 대한영상의학회지
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• 제81권3호
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• pp.707-713
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• 2020

간문맥 종양혈전이 있으면서 간 실질에 이상 소견이 없는 것은 매우 드문 일이다. 간에서 종양 혈전이 있는 경우 간세포암이 가장 발생률이 높으며 림프종은 감별질환으로 잘 생각되지 않는다. 림프종의 종양혈전이 간문맥을 침범한 것은 이제까지 총 네 가지 경우에서만 보고되어 있고, 모든 경우에서 종양이 혈관으로 직접 전파되거나 또는 그 외의 림프종을 시사하는 다른 병변들이 있었다. 혈관 내 대세포 림프종이 간문맥을 함께 침범한 경우, 본 케이스와 영상학적으로 비슷하게 보일 수 있으나 본 증례 보고는 혈관 내 대세포 림프종이 아니므로 제외하여 생각하였다. 미만성 거대 B세포 림프종이 간문맥에서만 발견된 무증상의 면역력이 정상인 67세 여자 환자에 대한 증례를 소개한다. 이전에 발표된 증례에서 이와 비슷한 경우는 보고된 바가 없다.