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Dietary modification reduces serum angiopoietin-like protein 2 levels and arterial stiffness in overweight and obese men

  • Park, Jiyeon;Choi, Youngju;Mizushima, Ryoko;Yoshikawa, Toru;Myoenzono, Kanae;Tagawa, Kaname;Matsui, Masahiro;Tanaka, Kiyoji;Maeda, Seiji
    • Korean Journal of Exercise Nutrition
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    • v.23 no.3
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    • pp.39-44
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    • 2019

  • [Purpose] Weight loss can reduce obesity-induced arterial stiffening that is attributed to decreased inflammation. Angiopoietin-like protein 2 (ANGPTL2) is a pro-inflammatory adipokine that is upregulated in obesity and is important in the progression of atherosclerosis and cardiovascular disease. The purpose of this study is to investigate the effects of dietary modification on circulating ANGPTL2 levels and arterial stiffness in overweight and obese men. [Methods] Twenty-two overweight and obese men (with mean age of 56 ± 2 years and body mass index of 28.6 ± 2.6 kg/m2) completed a 12-week dietary modification program. We measured the arterial compliance and β-stiffness index (as the indices of arterial stiffness) and serum ANGPTL2 levels before and after the program. [Results] After the 12-week dietary modification, body mass and daily energy intake were significantly reduced. Arterial compliance was significantly increased and β-stiffness index was significantly decreased after the 12-week dietary modification program. Serum ANGPTL2 levels were significantly decreased. Also, the changes in arterial compliance were negatively correlated with the changes in serum ANGPTL2 levels, whereas the changes in β-stiffness index were positively correlated with the changes in serum ANGPTL2 levels. [Conclusion] These results suggest that the decrease in circulating ANGPTL2 levels can be attributed to the dietary modification-induced reduction of arterial stiffness in overweight and obese men.

  • https://doi.org/10.20463/jenb.2019.0021 인용

Palladium Dichloro Complex Catalysed Oxidation of Cyclopentene by Dioxygen in Tetralin$^\dag$

  • Takehira, Katsuomi;Hayakawa, Takashi;Orita, Hideo;Shimizu, Masao;Oh, In-Hwan
    • Bulletin of the Korean Chemical Society
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    • v.8 no.4
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    • pp.254-257
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    • 1987

  • Palladium dichloro complexes catalysed the oxidation of cyclopentene by dioxygen in tetralin solvent at ambient temperature. Cyclopentanone formed mainly together with autoxidation products from both cyclopentene and tetralin. The oxidation seems to proceed by co-oxidation mechanism, where tetralin was first oxidized to its hydroperoxide which then oxidized cyclopentene to cyclopentanone. Mechanism of the other by-products formations has been discussed.

  • https://doi.org/10.5012/bkcs.1987.8.4.254 인용 PDF