• Title/Summary/Keyword: Tsukuba

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Preparation and Properties of Palladium (II) Complexes with Ethylenebis (isonitrosoethylacetoacetate imine) and Its Analogue (Ethylenebis (isonitrosoethylacetoacetate imine) 과 유사화합물을 리간드로 하는 팔라듐 (II) 착물의 합성 및 성질)

  • Kim, Soon-Han;Ken-ichi Okamoto;Hisahiko Einaga;Jinsai Hidaka
    • Journal of the Korean Chemical Society
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    • v.29 no.5
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    • pp.490-495
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    • 1985

  • Novel palladium (II) complexes, $[Pd((ieaa)_2-en)]$ and [PdCl((ieaa)-l-pn)] ($(ieaa)_2-en)]$ and (ieaa)-l-pn denote N,N'-ethylenebis(isonitrosoethylacetoacetate imine) and l-N-(2-aminopropyl)-isonitrosoethylacetoacetate imine, respectively), have been prepared. The palladium (II) complexes were characterized on the bases of the electronic absorption, circular dichroism (CD), $^{13}C$ NMR, infrared, and Raman spectra. The reaction of palladium(II) cliloride and isonitrosoethylacetoacetate (ieaa) with methylenediamine gives an $(ieaa)_2-en)]$ type Schiff base, while similar reaction using l-propylenediamine instead of ethylenediamine gives an (ieaa)-l-pn type Schiff base. The difference in formation is discussed from the stereochemical viewpoint of the diamine employed.

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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

  • Fujita, Masahide;Fukuda, Taeko;Sato, Yasuhiro;Takasusuki, Toshifumi;Tanaka, Makoto
    • The Korean Journal of Pain
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    • v.31 no.1
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    • pp.10-15
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    • 2018

  • Background: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the dorsal horn. Methods: In experiment 1, 45 rats were assigned to Control, Allo small-dose (0.16 mg/kg), and Allo large-dose (1.6 mg/kg) groups (n = 15 in each). The weight bearing and mechanical withdrawal thresholds of the hind limb were measured before and at 2, 24, 48, and 168 h after Brennan's surgery. In experiment 2, 16 rats were assigned to Control and Allo (0.16 mg/kg) groups (n = 8 in each). The degree of spontaneous pain was measured using the grimace scale after the surgery. Activities of the primary afferent fibers in the spinal cord (L6) were evaluated using immunohistochemical staining. Results: In experiment 1, the withdrawal threshold of the Allo small-dose group was significantly higher than that of the Control group at 2 h after surgery. Intergroup differences in weight bearing were not significant. In experiment 2, intergroup differences in the grimace scale scores were not significant. Substance P release in the Allo (0.16 mg/kg) group was significantly lower than that in the Control group. Conclusions: Systemic administration of Allo inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allo was proposed as a candidate for postoperative pain management.

  • https://doi.org/10.3344/kjp.2018.31.1.10 인용 PDF KSCI