• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.269-271
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• 2002

It is reported that exposure for the patient and the medical staff from IVR is large. Direct measurement of patient exposure is difficult, since the measurement disturbs reading of images. The fluorescence glass-dosimeter system consisting of small-size glass chips is developed in recent years. Owing to its small size and physical characteristics, direct monitoring of surface dose may be feasible. The dose measurement for patient and medical staff during head interventional radiology (IVR) examinations was tried by using the fluorescence glass-dosimeter system. A dose response of the glass dosimeter is almost linear in large dose range but its energy dependency is high. About 20% variation of sensitivity was observed in the effective energy of 45-60keV which was used in IVR. In spite of this shortcoming, the fluorescence glass-dosimeter system is a convenient means for a dose monitoring during IVR performance.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.361-366
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• 2005

Opium poppy (Papaver somniferum L.) is one of the most important medicinal plants, which is used as a sole commercial source of narcotic analgesic, morphine. The transformant of opium poppy we have established by infection of Rhizobium rhizogenes (formerly Agrobacterium rhizogenes) strain MAFF03-01724 showed aberrant morphology and altered opium alkaloid composition. The major alkaloid produced by this transformant was thebaine (16.3%, opium dry weight) instead of morphine. It is likely that this 'thebaine poppy' phenotype was caused by the integration of T-DNA(s) into the poppy genome DNA, and their inserted loci are of great interest. To gain an insight into the mechanism of nonnarcotic thebaine accumulation for the further approach toward the creation of 'codeine poppy' which produces codeine as a major alkaloid, the genetical and morphological analyses on the transformant was carried out. Here we report the results of the detailed analysis on the T-DNA inserted loci of T0 transfromant and the correlation between opium alkaloid composition and segregated T-DNA integration pattern in the self-pollinated T1 transformants.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권4호
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• pp.219-226
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• 2000

The application of recombinant DNA technology to restructure metabolic net-work can change metabolite and protein products by altering the biosynthetic pathways in an organism. Although some success has been achieved, a more detailed and thorough investigation of this approach is certainly warranted since it is clear that such methods hold great potential based on the encouraging results obtained so far. In last decade, there have been tremendous advances in the field of glycobiology and the stage has been set for the biotechnological production of glycoproteins for therapeutic use. Today glycoproteins are one of the most important groups of pharmaceutical products. In this study the attempt was made to focus on identifying technologies that may have general application for modifying glycosylation pathway of the yeast cells in order to produce glycoproteins of therapeutic use. The carbohydrates of therapeutic recombinant glycoproteins play very important roles in determining their pharmacokinetic properties. A number of biological interactions and biological functions mediated by glycans are also being targeted for therapeutic manipulation in vivo. For a commercially viable production of therapeutic glycoproteins a metabolic engineering of a host cell is yet to be established.

• Journal of Plant Biotechnology
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• 제7권3호
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• pp.195-202
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• 2005

The effects of constituent amino acids of glutathione (GSH), glutamate (Glu), cysteine (Cys) and glycine (Gly), on GSH synthesis in lettuce seedlings were examined in this study. The GSH concentration of the seedlings was increased to 5.1-fold and 1.6-fold the concentration of the control in the first leaves and roots, respectively, by simultaneous application of these constituent amino acids (Glu+Cys+Gly) at 100 mg/l to the culture solution for two days. In the first leaves and roots of these seedlings, the concentration of GSH was 180.4 and 14.6 nmole/gFW, and non-essential amino acids including Glu, Cys and Gly occupied 93.2% and 84.0% of the total free amino acids, respectively. Application of Cys greatly increased the concentration of GSH in the roots, and application of 50 mg/l Cys increased it to 26.1-fold the concentration in the control. The activity of GSH synthetase was higher in the leaves than in the roots, whereas the activity of ${\gamma}$-glutamylcysteine synthetase was higher in the roots than in the leaves.

• 감성과학
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• 제24권3호
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• pp.115-124
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• 2021

Non-verbal communication is important in human interaction. It provides a layer of information that complements the message being transmitted. This type of information is not limited to human speakers. In human-robot communication, increasing the animacy of the robotic agent-by using non-verbal cues-can aid the expression of abstract concepts such as emotions. Considering the physical limitations of artificial agents, robots can use light and movement to express equivalent emotional feedback. This study analyzes the effects of LED and motion animation of a spherical robot on the emotion being expressed by the robot. A within-subjects experiment was conducted at the University of Tsukuba where participants were asked to rate 28 video samples of a robot interacting with a person. The robot displayed different motions with and without light animations. The results indicated that adding LED animations changes the emotional impression of the robot for valence, arousal, and dominance dimensions. Furthermore, people associated various situations according to the robot's behavior. These stimuli can be used to modulate the intensity of the emotion being expressed and enhance the interaction experience. This paper facilitates the possibility of designing more affective robots in the future, using simple feedback.

• 운동영양학회지
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• 제24권4호
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• pp.24-27
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• 2020

[Purpose] Dehydroepiandrosterone (DHEA) administration reportedly recovers osteoporosis, a bone disorder associated with bone deficiency in postmenopausal women. However, the physiological mechanism of DHEA in osteoporosis remains elusive, especially in terms of intestinal calcium absorption. Therefore, we investigated the effect of DHEA administration on calcium absorption in ovariectomized (OVX) female rats using an estrogen receptor antagonist. [Methods] Female Sprague-Dawley rats (n=23, 6 weeks old) were randomized into three groups: OVX control group (OC, n=7), OVX with DHEA treatment group (OD, n=8), and OVX with DHEA inhibitor group (ODI, n=8) for 8 weeks. [Results] Intestinal calcium accumulation, as well as the rate of absorption, demonstrated no significant differences during the experimental period among investigated groups. The bone mineral density (BMD) of the tibia at the proximal metaphysis was higher in the OD group than that in the OC group (p<0.05); however, BMD of the ODI group showed no significant difference from investigated groups. Furthermore, the BMD of the tibia at the diaphysis did not significantly differ among these groups. [Conclusion] We revealed that DHEA administration does not involve intestinal Ca absorption, although this treatment improves BMD levels in OVX rats. These observations indicate that the effect of DHEA on the bone in postmenopausal women is solely due to its influence on bone metabolism and not intestinal calcium absorption.

• 운동영양학회지
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• 제23권2호
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• pp.7-12
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• 2019

[Purpose] Eccentric exercise induces a decrease in vascular endothelial function. Curcumin, a major component of turmeric, has potent antioxidant and anti-inflammatory properties that are associated with vascular protective effects. The present study examined the effect of acute supplementation of curcumin on eccentric exercise-induced endothelial dysfunction in healthy young men. [Methods] Fourteen healthy sedentary young men (range, 21-29 years) were assigned to either the curcumin (n = 6) or placebo (n = 8) group. All subjects consumed either curcumin or placebo before exercise, and eccentric exercise of the elbow flexors was performed with their nondominant arm. Before and 60 min after exercise, brachial artery flow-mediated dilation (FMD), as an indicator of endothelial function, was measured in the non-exercised arm. [Results] Brachial artery FMD significantly decreased following eccentric exercise (p < 0.05) in the placebo group, but acute supplementation with curcumin before exercise nullified this change. The change in FMD before and after eccentric exercise between the placebo and curcumin groups was significantly different (p < 0.05). [Conclusion] The present study found that acute curcumin supplementation could attenuate the decrease in endothelial function, as measured by FMD, following eccentric exercise in healthy young men.

• 한국산림과학회지
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• 제102권1호
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• pp.7-14
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• 2013

본 연구는 효율적인 박피 밤 생산을 위한 마찰식 박피기의 최적조건과 품종별 밤 과실의 내피박피성을 구명하고자 실시하였다. 마찰식 박피기의 최적조건은 박피시간 50분, 드럼 회전속도 27 rpm이었으며, 내피박피율도 89.3%로 가장 우수하였다. 최적의 박피조건(27 rpm/50분) 하에서 '축파' 등 8품종에 대한 내피박피율을 조사한 결과, '축파'가 89.3%로 가장 우수하였으며, '단택(72.2%)', '석추(70.9%)' 등의 순인 것으로 나타났다. I등급 밤의 비율은 '축파'가 77.2%로 가장 월등하였으며, '석추(46.7%)', '단택(45.0%)' 등의 순으로 높았다. 상품화 비율도 '축파'가 90.5%로 가장 우수하였으며, '단택(74.8%)', '석추(74.3%)' 등의 순으로 나타났다. 박피 시 과육 파손 및 흠집 발생 비율은 '미풍'이 37.2%로 가장 많은 반면, '축파'는 5.9%로 가장 적어 '축파' 품종이 마찰식 박피기를 활용한 고부가가치 가공 밤 생산을 위한 적합한 품종임을 알 수 있었다.

• Journal of Contemporary Eastern Asia
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• 제12권2호
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• pp.1-4
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• 2013

• Kyungpook Mathematical Journal
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• 제27권2호
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• pp.99-107
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• 1987