• Title/Summary/Keyword: Triterpene acid

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A new triterpene acid from phytolacca esculenta possessing anti-inflammatory action (상륙의 항염증성분 triterpene acid에 관한 연구)

  • 우원식
    • YAKHAK HOEJI
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    • v.15 no.3_4
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    • pp.99-102
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    • 1971
  • 상륙(Phytolacca esculenta)에서 새로운 물질 trihydroxyolean-12-ene dicarboxylic acid, $C_{30}H_{46}O_{7}$, m.p.318-$320^{\circ}$, [$\alpha$]$_D$$^{6}$ = +113.$7^{\circ}$를 분리하고 jaligonic acid라고 명명하였다. 본물질은 carrageenin으로 유발시킨 edema형성을 강력하게 억제하였다.

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A new Cytotoxic Triterpene Hydroperoxide from the Aerial Part of Youngia japonica (뽀리뱅이의 세포독성 트라이테르펜 하이드로퍼옥사이드 성분)

  • 이강노;이원빈;권학철;이재훈;최상운
    • YAKHAK HOEJI
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    • v.46 no.1
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    • pp.1-5
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    • 2002
  • A new cytotoxic triterpene hydroperoxide (3) was isolated from the methylene chloride extract of the aerial part of Youngia japonica together with four known triterpenes (1, 2, 4 and 5). Their structures were identified by means of physico-chemical and spectral data to be $\beta$-amyrin acetate (1), taraxasterol (2), 2l$\alpha$-hydroperoxy-taraxasterol (3), oleanolic acid (4) and ursolic acid (5). Compounds 3 and 5 showed moderate cytotoxicity against five tumor cell lines.

Quantitative Analysis of ${\gamma}-oryzanol$ in Rice Bran (미강의 약리성분 감마-오리자놀의 정량)

  • Kwak, Tae-Soon;Park, Hee-Juhn
    • Korean Journal of Medicinal Crop Science
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    • v.5 no.2
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    • pp.113-118
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    • 1997
  • Phytochemical analysis on rice bran and its pitch was performed by the tool of TLC, UV- and IR-spetroscopy, so that it was found that they contained ${\gamma}-oryzanol$ and free sterol. GC-MS analysis of free sterol revealed that it was composed of ${\beta}-sitosterol$, campesterol and stigmasterol. Successive phytochemical analysis of ${\gamma}-oryzanol$ revealed that it was composed of ferulic acid ester of triterpene and sterol, respectively. Triterpene moieties of ${\gamma}-oryzanol$ were identified as follows: cycloartanol, cycloartenol, 24-methylenecycloartanol and unknown triterpene; And sterol moieties were found to be identical with free sterols. In addition, characteristic absorption band in UV spectrum (220-340 nm) was exclusively due to ${\gamma}-oryzanol$. Thus, it was suggested that rice brans of nearly all species of Oryza sativa can be quantitatively analyzed by UV absorption spectrometry, even when water soluble pigments was contained in the rice bran.

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A Triterpene Glycoside in Berries of Rubus coreanus (복분자(覆盆子)의 Triterpene 배당체)

  • Kim, Eun;Kim, Young-Choong
    • Korean Journal of Pharmacognosy
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    • v.18 no.3
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    • pp.188-190
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    • 1987
  • A triterpene glycoside was first isolated from berries of Rubus coreanus Miquel in the family of Rosaceae, which have been used as a tonic in chinese drug. The compound was identified as $28-{\beta}-D-glycopyranosyl$ ester of $2{\alpha},3{\beta},19{\alpha},23-tetrahydroxyurs-12-en-28-oic$ acid by IR, MS, $^{1}H-NMR$, $^{13}C-NMR$ spectra.

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Structure Determination of a New Lupane-type Triterpene, Tiarellic Acid, Isolated from Tiarella polyphylla

  • Lee, Hyeong-Kyu;Park, Si-Hyung;Oh, Sei-Ryang;Ahn, Kyung-Seop;Kim, Jae-Gil
    • Archives of Pharmacal Research
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    • v.25 no.1
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    • pp.57-60
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    • 2002
  • A new 27-carboxylic lupane-type triterpene, tiarellic acid (1), was isolated from Tiarella polyphylla together with corosolic acid (2) and tormentic acid (3). Tiarellic acid was characterized as 3,23-dihydroxy-20(29)-lupen-27-oic acid and its NMR data were unambiguously assigned using 2-D NMR techniques.

A New Lupane-Triterpene Glycoside from the Leaves of Acanthopanax gracilistylus

  • Liu, Xiang-Qian;Chang, Seung-Yeup;Park, Sang-Yong;Nohara, Toshihiro;Yook, Chang-Soo
    • Archives of Pharmacal Research
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    • v.25 no.6
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    • pp.831-836
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    • 2002
  • A new and two known lupane-triterpene glycosides were isolated from the hot MeOH fraction of the leaves of Acanthopanax gracilistylus W. W. Smith. Based on the physical properties and spectroscopic data, their chemical structures were determined as acankoreoside A (1), acankoreoside D (2), and $3{\alpha}-hydroxy-lup-23-al-20(29)-en-28-oic$ acid $28-O-{\alpha}-L-rhamnopyranosyl-(1{\rightarrow}4)-{$beta}-D-glucopyranosyl-(1{\rightarrow}6)-{\beta}-D-glucopyranosyl$ ester (3), respectively. To our best knowledge, compand 3 appears to be novel, which was named as wujiapioside A.

Analysis of Triterpene Glycoside Levels and Antioxidant Activity in the Different Shoot Tissues of Centella asiatica (L.) Urban (병풀 지상부 조직에서 시기별 triterpene glycoside 함량 및 항산화활성 분석)

  • Kil, Young Sook;Sin, Seung Mi;Lee, Dong Yeol;Jeong, Won Min;Yang, Ki jeung;Lee, Shin-Woo;Kim, Yun-Hee;Goo, Young-Min
    • Journal of Life Science
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    • v.28 no.8
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    • pp.917-922
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    • 2018
  • Centella asiatica is one of the local herbs that is claimed to possess various physiological effects. C. asiatica also accumulates large amounts of pentacyclic triterpenoid saponins known as centelloids. These terpenoids usually include asiatic acid, asiaticoside, madecassoside, and madecassic acids. In the present study, to understand the changes of triterpene glycoside levels in the different shoot tissues of C. asiatica during seasonal cultivation, we investigated the High-Performance Liquid Chromatography (HPLC) analysis via different extraction methods, such as water, 20% ethanol and methanol extracts. Significant increases were observed in the levels of madecassoside and asiaticoside in the leaf extracts by methanol compare with extracts using water or 20% ethanol. Additionally, we also analyzed the various antioxidant activity in the different shoot tissues of C. asiatica using different extracts, such as leaves, petioles and both materials. Among these petiole extracts showed high 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTs) scavenging activity in all extracts, whereas 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity exhibited high activity levels in the leaf part using methanol and ethanol extracts. Levels of total phenolics and flavonoid also showed the highest levels in the leaf tissues using all extracts such as methanol, ethanol and water. Our results indicated that the increased levels of triterpene glycoside and antioxidant activity in the leaf parts of the C. asiatica were indicating that useful metabolites were mainly maintained through seasonal cultivation such as madecassoside, asiaticoside.