• Title/Summary/Keyword: Triple-helix

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Backbone assignment of human Hoxc9DBD

  • Ja-Shil Hyun;Sung Jean Park
    • Journal of the Korean Magnetic Resonance Society
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    • v.27 no.4
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    • pp.23-27
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    • 2023
  • Hoxc, or the Homeobox C cluster, is a group of genes that play a crucial role in embryonic development, particularly in patterning the body along the anterior-posterior axis. These genes encode transcription factors, which are proteins that bind to DNA and regulate the expression of other genes. Hoxc9 is specifically involved in the development of the skeletal system, nervous system, and adipose tissue. Hoxc9 overexpression has been linked to the development of various cancers such as leukemia and breast cancer. Here, we assigned the chemical shifts Hoxc9 DNA binding domain (DBD) using heteronuclear NMR techniques. The helical regions of Hoxc9 DBD correspond to the residues T200 - F213 (Helix I), T218 - L229 (Helix II), and T232 - K249 (Helix III). Our result would be helpful for studing the molecular interactions of the Hoxc9 DBD and other proteins.

Joint bibliometric analysis of patents and scholarly publications from cross-disciplinary projects: implications for development of evaluative metrics

  • Gautam, Pitambar;Kodama, Kota;Enomoto, Kengo
    • Journal of Contemporary Eastern Asia
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    • v.13 no.1
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    • pp.19-37
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    • 2014
  • In an attempt to develop comprehensive evidence-based methods for evaluation of the R&D performance of cross-disciplinary projects, a joint bibliometric analysis of patents and publications was performed for two industry-university-government collaborative projects aimed at commercialization: Hokkaido University Research & Business Park Project (2003-2007; 63 inventors; 176 patents; 853 papers), and Matching Program for Innovations in Future Drug Discovery and Medical Care - phase I (2006-2010; 46 inventors; 235 patents; 733 papers). Besides the simple output indicators (for five years period), and citations (from the publication date to the end of 2012), science maps based on the network analysis of words and co-authorship relations were generated to identify the prominent research themes and teams. Our joint analysis of publications and patents yields objective and mutually complementing information, which provides better insights on research and commercialization performance of the large-scale projects. Hence, such analysis has potential for use in the industry-university project's performance evaluation.

Entrepreneurial Universities - Towards a Revised Paradigm

  • Meissner, Dirk
    • STI Policy Review
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    • v.8 no.1
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    • pp.23-40
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    • 2017
  • This article provides a comprehensive review of the entrepreneurial university concept and its place and role in the triple helix of university, industry, and government. This is increasingly important because stake-holders' expectations towards universities are growing; this growth in turn leads to increased pressure on universities to move beyond their traditional roles and models towards taking responsibility for economic development, large scale basic education and targeted further education and the development of value from research. These expectations provide opportunities for universities, but impose threats on the existing models and practices. It further elaborates on implications for university management, departments, faculty members and supporting organizations. Moreover it reflects on the meaning of the entrepreneurial university for stakeholders, i.e., university boards, regional and national policy and administrative bodies, funding agencies, the business community, university ranking institutions and the global university community overall. Recent literature on entrepreneurial universities is incomplete and mostly focused on the commercialization of research, technology transfer and the third mission of universities. The article expands the predominant thinking about entrepreneurial universities and gives a broader structured definition. Eventually the article shows the need for STI policy to intervene and measures for developing entrepreneurial universities further.

A Conceptual Framework for Value Co-creation in an Innovation Ecosystem: The Case of Technology-based Collaboration Network

  • Han, Eunjung;Hong, Soon-Goo
    • Journal of Korea Society of Industrial Information Systems
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    • v.22 no.4
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    • pp.29-43
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    • 2017
  • Innovation Cosystems are Conceptualized as Organizational Networks of Economic Actors, Technologies and Social Contexts that Interact for Knowledge Production, use, and Adaptation. This Paper Proposed a Conceptual Framework to Describe Value Co-creation of Organizational Networks Engaged in Technology Innovation. We Adopted Theory-Based Approach by Integrating the Perspective of Service-Dominant (S-D) Logic Into the Evolutionary Model of the Triple Helix. The Framework Gives a Plausible Explanation on how Actors Collaborate to Create Value in Dynamic Contexts of an Innovation Ecosystem. The Innovation Ecosystem can be Considered as a Composite of Sub-Ecosystems, Including Knowledge, Sectoral, and Business Ecosystems. When these Sub-Ecosystems are Recursively Transformed by Coordination of Functional Mechanisms that Serve Value Co-creation in the Innovation Process, the Innovation Ecosystem will be Re-Organized and Evolve. The case of the Digital Living Network Alliance (DLNA) was Examined to Demonstrate the Fundamental Mechanisms for Value Co-creation that was Described in the Framework. The case Study Indicates Features of Value Co-creation when Implementing Innovation in Organizational Networks.

A IT Support policy for R&D competence : steel industry case (R&D 역량 강화를 위한 IT 지원정책에 관한 연구 : 철강산업 사례)

  • Kim, Sung-Hong;Kim, Jin-Han
    • Journal of Korea Society of Industrial Information Systems
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    • v.14 no.4
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    • pp.143-152
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    • 2009
  • This paper deals with a case which is focused on the policy development connected with IT, and verify its validity to enhance R&D capability for Korean steel industry. Korean steel industry, which is at a turning point from technological catch-up to technological frontier, should go ahead with open R&D system to be able to connect with other steel companies, universities and laboratories for its capability buildup. To meet such a challenge, IT should act a critical part in R&D capability enhancement. In this study we discuss not only IT-related support policies and validity of proposed policies through priority analysis, but also the role of government, company and academia within the framework of Triple Helix.

Structural Assets of Local Broadcasting Networks and Regional Gap: Foucsing on Local MBC stations in South Korea (지역 방송국 네트워크의 구조적 자산(asset)과 지역 간 격차: 지역MBC를 중심으로)

  • Son, Ji-Hoon;Lee, Jung-Min;Kim, Jae-Hun;Park, Han-Woo
    • The Journal of the Korea Contents Association
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    • v.22 no.9
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    • pp.194-204
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    • 2022
  • This study examined the social capital and geographical gaps of local television stations using web data gathered through website crawling. URLs for 16 local MBC websites were collected. MBC is an abbreviation for Munhwa Broadcasting Corporation, one of South Korea's largest television and radio broadcasters. Munhwa is a Sino-Korean term that means "culture." It initially determined which institutions local broadcasting stations were linked to using a Web Impact Report. To investigate the specific connection type, URL information was classified using the n-tuple helix model, followed by 2-mode network analysis. The n-tuple helix model is an analysis method that extends the standard university-business-government triple-helix model by including a new network innovation originator. As a result, local broadcasting stations relied heavily on activities like as festivals, performances, and exhibitions to engage the local community. Local stations in Daegu-Gyeongbuk area and the Busan-Ulsan-Gyeongnam area were identified as having the most diverse connections to the local population among other regions.