• Transactions of the Korean Society of Mechanical Engineers
• /
• v.9 no.4
• /
• pp.403-413
• /
• 1985

Hot-wire measurements of second and third-order mean products of velocity fluctuations have been made in the separated, reattached, and redeveloping boundary layer behind a vertical fence. Mean velocity, wall static pressure distributions have also been measured in the whole flow field. Upstream of the reattachment point, the separated shear layer developes as a free mixing layer, but the gradient of the maximum slope thickness, turbulent intensities and the Reynolds shear stress are higher than that of the mixing layer due to initial streamline curvature and the effects of highly turbulent recirculating flow region. In the reattachment region, Reynolds shear stress and triple products near the surface is far more rapid than the decrease of the shear stress; that is the presence of the solid wall has a marked effect on the apparent gradient diffusivity of intensity or shear stress and throws doubts upon the usefulness of the simple gradient diffusivity model in this region.

• Proceedings of the Korean Institute of Surface Engineering Conference
• /
• 2017.05a
• /
• pp.97-97
• /
• 2017

This study investigated the corrosion protection by electrodeposited copper layer on AZ31 Mg alloy with and without additional silver layer by immersion test, salt spray test, OCP transient and potentiodynamic polarization experiment. The single electrodeposited Cu layer on AZ31 Mg alloy showed a nodular structure with many imperfections of crevices between the nodules, which resulted in the fast initiation of pitting corrosion within first few hours of immersion. Double-layer coating of Cu and outer Ag layer slightly increased the initiation time for pitting corrosion. Triple-layer coatings of Cu/Ag/Cu exhibited the most efficient corrosion protection of AZ31 Mg alloy, compared to the single- and double-layer coatings. Surface morphology of the outer Cu layer in the triple-layer was changed from the nodular structure to fine particle structure with no crevices due to the presence of an additional Ag layer. Thus, the improved corrosion resistance of AZ31 Mg alloy by electrodeposited Cu/Ag or Cu/Ag/Cu layers is readily ascribed to the decreased number of imperfections in the electrodeposited layers due to the additional silver layer. It is concluded that the additional silver layer provides many nucleation sites for the second Cu plating, resulting in the formation of finer and denser structure than the first Cu electrodeposit.

• 한국신재생에너지학회:학술대회논문집
• /
• 2009.11a
• /
• pp.581-586
• /
• 2009

Knowledge of ground thermal properties is most important for the proper design of large scale BHE(borehole heat exchanger) systems. The type, pipe size and thermal performance of the BHE is highly dependent on the ground source heatpump system-efficiency and instruction cost. Thermal response tests with mobile measurement devices were developed primarily for insitu determination of design data for large diameter BHE for triple-U spacer apply. The main purpose has been to determine insitu values of effective ground thermal conductivity and thermal resistance, including the effect of ground-water flow and natural convection in the boreholes. The test rig is set up on a some trailer, and contains a circulation pump, a inline heater, temperature sensors, flow meter, power analysis meter and a data logger for recording the temperature, fluid flow data. A constant heat power is injected into the borehole through the tripl-U pipes system of test rig and the resulting temperature change in the borehole is recorded. The recorded temperature data are analysed with a line-source model, which gives the effective insitu values of rock thermal conductivity and borehole thermal resistance of large diameter BHE for spacer apply.

• Biomolecules & Therapeutics
• /
• v.24 no.1
• /
• pp.62-66
• /
• 2016

Amygdalin, D-mandelonitrile-${\beta}$-D-glucoside-6-${\beta}$-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor agent against breast cancer cells is not clear. The present study aimed to investigate the effect of amygdalin on the proliferation of human breast cancer cells. Here, we show that amygdalin exerted cytotoxic activities on estrogen receptors (ER)-positive MCF7 cells, and MDA-MB-231 and Hs578T triple-negative breast cancer (TNBC) cells. Amygdalin induced apoptosis of Hs578T TNBC cells. Amygdalin downregulated B-cell lymphoma 2 (Bcl-2), upregulated Bcl-2-associated X protein (Bax), activated of caspase-3 and cleaved poly ADP-ribose polymerase (PARP). Amygdalin activated a pro-apoptotic signaling molecule p38 mitogen-activated protein kinases (p38 MAPK) in Hs578T cells. Treatment of amygdalin significantly inhibited the adhesion of Hs578T cells, in which integrin ${\alpha}5$ may be involved. Taken together, this study demonstrates that amygdalin induces apoptosis and inhibits adhesion of breast cancer cells. The results suggest a potential application of amygdalin as a chemopreventive agent to prevent or alleviate progression of breast cancer, especially TNBC.

• Journal of the Mineralogical Society of Korea
• /
• v.11 no.2
• /
• pp.106-116
• /
• 1998

The adsorption of Cs-137 and Sr-90 onto kaolinite in prescence of major groundwater cations (Ca2+, K+, Na+) with different concentrations was simulated by using triple-layer surface complexation model (TL-SCM). The site density (8.73 sites/nm2) of kaolinite used for TL-SCM was calculated from it's CEC and specific surface area. TL-SCM modeling results indicate that concentrations dependence on 137Cs and 90Sr adsorption onto kaolinite as a function of pH is best modeled as an outer-sphere surface reaction. This suggests that Cs+ and Sr2+ are adsorbed at the $\beta$-layer in kaolinite-water interface where the electrolytes, Nacl, KCl and CaCl2, bind. However, TL-SCM results on Sr adsorption show a discrepancy between batch data and fitting data in alkaline condition. This may be due to precipitation of SrCO3 and complexation such as SrOH+. Intrinsic reaction constants of ions obtained from model fit are as follows: Kintcs=10-2.10, KintSr=10-2.30, KintK=10-2.80, KintCa=10-3.10 and KintNa=10-3.32. The results are in the agreement with competition order among groundwater ions (K+>Ca2+>Na+) and sorption reference of nuclides (Cs-137>Sr-90) at kaolinite-water interface showed in batch test.

• The Korean Journal of Pain
• /
• v.27 no.2
• /
• pp.103-111
• /
• 2014

Nefopam (NFP) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the nonsedative benzoxazocine, developed and known in 1960s as fenazocine. Although the mechanisms of analgesic action of NFP are not well understood, they are similar to those of triple neurotransmitter (serotonin, norepinephrine, and dopamine) reuptake inhibitors and anticonvulsants. It has been used mainly as an analgesic drug for nociceptive pain, as well as a treatment for the prevention of postoperative shivering and hiccups. Based on NFP's mechanisms of analgesic action, it is more suitable for the treatment of neuropathic pain. Intravenous administration of NFP should be given in single doses of 20 mg slowly over 15-20 min or with continuous infusion of 60-120 mg/d to minimize adverse effects, such as nausea, cold sweating, dizziness, tachycardia, or drowsiness. The usual dose of oral administration is three to six times per day totaling 90-180 mg. The ceiling effect of its analgesia is uncertain depending on the mechanism of pain relief. In conclusion, the recently discovered dual analgesic mechanisms of action, namely, a) descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and b) inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.13 no.4
• /
• pp.699-707
• /
• 2010

Electric-field-induced electron emission from the three kinds of $Pb(Zr_{0.56}Ti_{0.44})O_3$ ferroelectric cathodes with different electrode structure has been investigated. Regardless of the electrode structures, a threshold field of the each cathode was 2.5-2.6kV/mm, which is 3 times higher than the coercive field of $Pb(Zr_{0.56}Ti_{0.44})O_3$ material. Although the waveform of the electron currents was affected by the structure of the electrode, no significant difference for the emission properties such as the peak current and the pulse width was observed from the three kinds of the cathodes. However, the current density of the cathode was dependent on the electrode structure. From the simulation of electric field distribution, the surface flashover, and the injury region of the cathode surface, it was proved that the prime electrons were initiated at the electrode-ceramic-vacuum triple point by field emission and the emission currents were strongly enhanced by the surface plasma.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.22 no.4
• /
• pp.509-516
• /
• 2019

It is well known that nitroglycerin(NG) may evaporate and migrate from the triple base propellant grains in storage. This physical process makes it double base environment to the CCC(combustible cartridge case) which is based on nitrocellulose(NC) without NG. Meanwhile, it is not appropriate to use diphenylamine(DPA) as a stabilizer for CCC in this double base environment because of incompatibility between DPA and NG. So we estimated the shelf life to study the effect of NG migration from propellant to CCC by following the procedures in the STANAG 4257. And we found out that CCC with ethylcentralite(ECL) has 7.5 years longer shelf life than with DPA, when NG migrates to CCC from triple base propellant grains.

• Journal of Korean Port Research
• /
• v.8 no.2
• /
• pp.37-56
• /
• 1994

The effects of wave energy focusing by a submerged berm type of structure is examined. The fundamental idea is based on the phenomenon of refraction by a lens-shaped crescent structure which results in the focusing of wave energy on the center line of the structure. The shape of the submerged structure is a complex curve combining circular with elliptical elements. Based on the design procedure, a special configuration of structure(termed herein as a triple crescent structure) is introduced. Next, some hydraulic model tests are performed to confirm the wave focusing effect in laboratory. In addition, in order to interpret the wave focusing performance behind the structure, a numerical procedure by the hybrid element method is used on the basis of the conventional mild slope equation but modified and extended to allow for steeper bottom slopes and higher curvature. The modified refraction and diffraction provide additional mechanism for wave height amplification and the maximum amplification for triple crescent structure is presented. It also allows for the possibility of wave energy scattering with the change of the incident wave direction. Comparisons with previous theoretical results involving a submerged crescent shape structure are described.

• Nuclear Engineering and Technology
• /
• v.55 no.4
• /
• pp.1342-1349
• /
• 2023

The planning accuracy of charged particle therapy (CPT) is subject to the accuracy of stopping power (SP) estimation. In this study, we propose a method of deriving a pseudo-triple-energy CT (pTECT) that can be achievable in the existing dual-energy CT (DECT) systems for better SP estimation. In order to remove the direct effect of errors in CT values, relative CT values according to three scanning voltage settings were used. CT values of each tissue substitute phantom were measured to show the non-linearity of the values thereby suggesting the absolute difference and ratio of CT values as parameters for SP estimation. Electron density, effective atomic number (EAN), mean excitation energy and SP were calculated based on these parameters. Two of conventional methods were implemented and compared to the proposed pTECT method in terms of residuals, absolute error and root-mean-square-error (RMSE). The proposed method outperformed the comparison methods in every evaluation metrics. Especially, the estimation error for EAN and mean excitation using pTECT were converging to zero. In this proof-of-concept study, we showed the feasibility of using three CT values for accurate SP estimation. Our suggested pTECT method indicates potential clinical utility of spectral CT imaging for CPT planning.