• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.555-561
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• 2020

TWIK-related two-pore domain K⁺ channel-2 (TREK-2) has voltage-independent activity and shows additional activation by acidic intracellular pH (pH_i) via neutralizing the E³³² in the cytoplasmic C terminal (Ct). We reported opposite regulations of TREK-2 by phosphatidylinositol 4,5-bisphosphate (PIP₂) via the alkaline K³³⁰ and triple Arg residues (R^355-357); inhibition and activation, respectively. The G³³⁴ between them appeared critical because its mutation (G³³⁴A) endowed hTREK-2 with tonic activity, similar to the mutation of the inhibitory K³³⁰ (K³³⁰A). To further elucidate the role of putative bent conformation at G³³⁴, we compared the dual mutation forms, K³³⁰A/G³³⁴A and G³³⁴A/R^355-7A, showing higher and lower basal activity, respectively. The results suggested that the tonic activity of G³³⁴A owes to a dominant influence from R^355-7. Since there are additional triple Arg residues (R^377-9) distal to R^355-7, we also examined the triple mutant (G³³⁴A/R^355-7A/R^377-9A) that showed tonic inhibition same with G³³⁴A/R^355-7A. Despite the state of tonic inhibition, the activation by acidic pH_i was preserved in both G³³⁴A/R^355-7A and G³³⁴A/R^355-7A/R^377-9A, similar to the R^355-7A. Also, the inhibitory effect of ATP could be commonly demonstrated under the activation by acidic pH_i in R^355-7A, G³³⁴A/R^355-7A, and G³³⁴A/R^355-7A/R^377-9A. These results suggest that the putative bent conformation at G³³⁴ is important to set the tug-of-war between K³³⁰ and R^355-7 in the PIP₂-dependent regulation of TREK-2.

• Korean Institute of Interior Design Journal
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• v.21 no.4
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• pp.114-120
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• 2012

There are lots of buildings which were built before the Legislation on building energy rating system. Remodeling of the buildings would be required for an improvement of the building energy rating system was enforced by the government. In the Passive Building Design, Elements which will be used for the remodeling are Insulation, Window, External venetian blind, Heat exchanger. The Purpose of this study is to indicate a Method for the improvement of Energy saving by an analysis of Construction Cost, Cost Evaluation, Energy performance Efficiency in applied design elements. In this study, the remodeling of existing public buildings to improve energy efficiency rating was applied to extract the elements of design-specific energy performance, efficiency, and the application of the designs that has been analyzed. The results were as follows: applying the design-specific cost-effective investment that represents the economy (investment efficiency/%) surveyed the average insulation(7.0%), triple glazed windows(10.1%), double glazed windows(12.1%), external shading(24.5%), and Heat(77.2%) were analyzed in order to be more efficient. Analysis of the basis of information on the existing public buildings to improve energy efficiency rating for the remodeling depending on driving conditions at a degree of individual difference. The main effect, however, depending on economic investment, design elements, heat exchangers, external awning, double glazed windows, triple glazed windows, insulation, is recommended as review of the order shall be determined.

• Journal of Chest Surgery
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• v.18 no.3
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• pp.446-455
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• 1985

A total and consecutive 156 patients have undergone cardiac valve surgery including 13 closed mitral commissurotomy, 13 open mitral commissurotomy, one mitral annuloplasty, 75 mitral valve replacement, one aortic annuloplasty, 24 aortic valve replacement, 3 tricuspid valve replacement, 25 double valve replacement and one triple valve replacement. 155 prosthetic valves were replaced in a period between September 1976 and August 1985. There were 68 males and 88 females with age range from 8 to 69 yrs [mean 36.5 yr]. Out of replaced valves, 61 was tissue valve including 54 Carpentier-Edwards, and 4 was mechanical valves including 74 St. Jude Medical, and the position replaced was 101 valves for mitral, 46 for aortic and 8 for tricuspid. Single valve replacement in 102 cases, double valve replacement in 25 cases [17 for AVR+MVR, and 8 for MVR+TVR], and only one case was noted in the triple valve replacement. Early mortality within 30 days after operation was noted in 11 cases [7%]; 7 after MVR, 2 after DVR, and each one after open mitral commissurotomy and mitral annuloplasty. Cause of death was valve thrombus, cerebral air embolism, low output syndrome, uncontrollable arrhythmia, parapneumonic sepsis, acute cardiac tamponade and left atrial rupture. 7 late deaths were noted during the follow-up period from 1 to 104 months [average 48 month]; three due to valve and left atrial thrombus formation, two due to CVA from overdose of warfarin, and each one due to congestive heart failure and chronic constrictive pericarditis, Anticoagulants after prosthetic valve replacement were maintained with warfarin, dipyridamole and aspirin to the level of around 50% of normal prothrombin time in 79 cases, and Ticlopidine with aspirin in 47 cases to compare the result of each group. There were 11 major thromboembolic episodes including 3 deaths in the warfarin group. Two cases of CVA due to overdose of warfarin was noted in the warfarin group. In the ticlopidine group, there was only one left atrial thrombus confirmed at the time of autopsy. Among the survived 138 cases, nearly all cases[136 cases] were included in NYHA functional class I and II during the follow-up period. In conclusion, surgical treatment of the cardiac valve disease in 156 clinical cases revealed excellent result with acceptable operative risk and late mortality. Prevention of thrombus formation with anti-platelet aggregator Ticlopidine has better result than warfarin group presently with no specific side effect such as bleeding or gastrointestinal trouble.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9627-9630
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• 2014

Background: Although efficacy of aprepitant for suppressing emesis associated with single-dose cisplatin has been demonstrated, there are limited data on the antiemetic effect of this oral neurokinin-1 receptor antagonist during daily administration of cisplatin. Accordingly, we investigated the efficacy and safety of aprepitant in patients with head and neck cancer (HNC) receiving combination therapy with cisplatin and 5-FU (FP therapy). Materials and Methods: Twenty patients with HNC were prospectively studied who received a triple antiemetic regimen comprising granisetron ($40{\mu}g/kg$ on Days 1-4), dexamethasone (8 mg on Days 1-4), and aprepitant (125 mg on day 1 and 80mg on days 2-5) with FP therapy (cisplatin $20mg/m^2$ on days 1-4; 5-FU $400mg/m^2$ on days 1-5) (aprepitant group). We also retrospectively studied another 20 HNC patients who received the same regimen except for aprepitant (control group). Results: For efficacy endpoints based on nausea, the aprepitant group showed significantly better results, including a higher rate of complete response (no vomiting and no salvage therapy) for the acute phase (p=0.0342), although there was no marked difference between the two groups with regard to percentage of patients in whom vomiting was suppressed. There were no clinically relevant adverse reactions to aprepitant. Conclusions: This study suggested that a triple antiemetic regimen containing aprepitant is safe and effective for HNC patients receiving daily cisplatin therapy.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.1
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• pp.133-143
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• 2001

This paper describes the correlation of the transient impedance and its parameters with the stationary resistance of a grounding system to a square pulse current and a lightning impulse current. In the experiment, the grounding system consists of a single grounding rod$(\Psi10[mm], 1[m])$and/or a triple-grounding rods of equilateral triangles with 5[m] spacing for operation. To analyze the transient impedance characteristics of the grounding system, a pulse generator which can produce square wave of a 30[ns] rise-time and a $20[\mus] $pulse duration is designed and fabricated. The injected content in the grounding system and the developed potential were recorded, and the time variation of the transient impedance were calculated as the ratio of the potential rising to the injected current at each time. The transient impedance and the effective surge impedance Z3 which defines economic protection level in power system were quite higher than the stationary resistance. The grounding impedance is decreased by the application of the triple-rods grounding system, and its effect is decreased as the frequency of the current is increased due to the inductance of the grounding leads.

• Korean Journal of Materials Research
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• v.29 no.12
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• pp.741-746
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• 2019

New triple tungstate phosphors NaPbLa(WO₄)₃:Yb³⁺/Ho³⁺ (x = Yb³⁺/Ho³⁺ = 7, 8, 9, 10) are successfully fabricated by microwave assisted sol-gel synthesis and their structural and frequency upconversion (UC) characteristics are investigated. The compounds crystallized in the tetragonal space group I4₁/a and the NaPbLa(WO₄)₃ host have unit cell parameters a = 5.3927(1) and c = 11.7961(3) Å, V = 343.05(2) ų, Z = 4. Under excitation at 980 nm, the phosphors have yellowish green emissions, which are derived from the intense ⁵S₂/⁵F₄→⁵I₈ transitions of Ho³⁺ ions in the green spectral range and strong ⁵F₅→⁵I₈ transitions in the red spectral range. The optimal Yb³⁺:Ho³⁺ ratio is revealed to be x = 9, which is attributed to the quenching effect of Ho³⁺ ions, as indicated by the composition dependence. The UC characteristics are evaluated in detail under consideration of the pump power dependence and Commission Internationale de L'Eclairage chromaticity. The spectroscopic features of Raman spectra are discussed in terms of the superposition of Ho³⁺ luminescence and vibrational lines. The possibility of controlling the spectral distribution of UC luminescence by the chemical content of tungstate hosts is demonstrated.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.497-500
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• 2008

This research carries out experiments for hydration exothermic rate and adiabatic temperature rise of concrete to examine the characteristics of the hydration heat of high flowing self-compacting concrete with a normal strength. As a result of the hydration exothermic rate experiment, the high flowing self-compacting concrete that used Lime stone powder and fly ash as polymers shows that its hydration heat amount reduces due to the reduction of unit cement. The result measured the adiabatic temperature rise of concrete presents that high flowing self-compacting concrete having lots of binder contents has a good performance in temperature reduction due to the effect of polymer and that triple adding high flowing self-compacting concrete has a similar temperature rise speed with conventional concrete. As a result of the research, high flowing self-compacting concrete shows a better temperature reduction performance for the binder content per unit than conventional concrete. In addition, it is judged that triple adding high flowing self-compacting concrete with a specified concrete strength 30 MPa is more beneficial in temperature reduction and early hydration heat than double adding high flowing self-compacting concrete.

• Journal of Ginseng Research
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• v.30 no.3
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• pp.132-136
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• 2006

This study was carried out to study the effect of emergence type of multiple stem and main bud on the quality of fresh and red ginseng in Korean ginseng. To achieve the aim of this study, characteristics of roots and quality factors were investigated. Single stem plants were 62.9% of the total samples, and the remainder(37.1%) were multiple stem plants. The number of stems affected considerably on root weight. Root weight of triple stem type with triple main bud was the largest among the types. As the number of stem per plant increased, the root quality became worse. In both single and multiple stem, the more the number of main buds was, the lower the quality grade was. Yield of the red ginseng was about 30%, showing little difference between single stem and multiple stem plant. As the number of stem increased, yield of Bonsam decreased. The quality grade of red ginseng of single stem was better than that of multiple stem. Multiple stem plant produced relatively more Yangsam and Japsam. As the number of main bud increased, the quality grade of ginseng decreased.

• Current Photovoltaic Research
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• v.2 no.3
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• pp.95-102
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• 2014

Light trapping techniques can change the propagation direction of incident light and keep the light longer in the absorption layers of solar cells to enhance the power conversion efficiency. In thin film silicon (Si) solar cells, the thickness of absorption layer is generally not enough to absorb entire available photons because of short carrier life time, and light induced degradation effect, which can be compensated by the light trapping techniques. These techniques have been adopted as textured transparent conduction oxide (TCO) layers randomly or periodically textured, intermediate reflection layers of tandem and triple junction, and glass substrates etched by various patterning methods. We reviewed the light trapping techniques for thin film Si solar cells and mainly focused on the commercially available techniques applicable to textured TCO on patterned glass substrates. We described the characterization methods representing the light trapping effects, texturing of TCO and showed the results of multi-scale textured TCO on etched glass substrates. These methods can be used tandem and triple thin film Si solar cells to enhance photo-current and power conversion efficiency of long term stability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.2
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• pp.268-275
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• 2014

In this paper, a dual-band circular ring monopole antenna with stub and ground slot for WLAN(Wireless Local Area Networks)/WiMAX(World interoperability for Microwave Access) applications. The proposed antenna is based on a planar monopole design, and composed of one circular ring of radiating patch, cross strip in circular ring, modified feed line, and two rectangular slot in the ground plane for triple-band operation. To obtain the optimized parameters, we used the simulator, Ansoft's High Frequency Structure Simulator(HFSS) and found the parameters that greatly effect antenna characteristics. Using the obtained parameters, the antenna is fabricated. The numerical and experiment results demonstrated that the proposed antenna satisfied the -10 dB impedance bandwidth requirement while simultaneously covering the WLAN and WiMAX bands. And characteristics of gain and radiation patterns are determined for WLAN/WiMAX application.