• Journal of the Korean Magnetic Resonance Society
• /
• v.10 no.2
• /
• pp.175-187
• /
• 2006

Binding interactions between a positively charged porphyrin derivative TMAP(meso-tetra(p-trimethylanilinium-4-yl)porphyrin) and triple helical $(dT)_{12}{\cdot}(dA)_{12}{\cdot}(dT)_{12}$, as well as double helical $(dA)_{12}{\cdot}(dT)_{12}$ have been studied with NMR, UV and CD spectroscopy to obtain the detailed information about the binding mode and binding site. UV melting studies showed both DNA duplex and triple helix represented very similar UV absorption patterns upon binding TMAP, but the presence of third strand of triple helical $(dT)_{12}{\cdot}(dA)_{12}{\cdot}(dT)_{12}$, inhibited improvement in thermal stability in terms of melting temperature, $T_m$. In addition, the TMAP molecule is thought to bind to the major groove, according to CD and NMR data. But absence of the clear isosbestic point in UV absorption spectra represented that binding of TMAP to DNA duplex as well as DNA triplex did not show a single binding mode, rather complex binding modes.

• Journal of KIISE:Computing Practices and Letters
• /
• v.8 no.3
• /
• pp.303-317
• /
• 2002

In this paper, we design and implement E-COIRS enabling users to query with concepts and image features used for further refining the concepts. For example, E-COIRS supports the query "retrieve images containing black home appliance to north of reception set. "The query includes two types of concepts: IS-A and composite. "home appliance"is an IS-A concept, and "reception set" is a composite concept. For evaluating such a query. E-COIRS includes three important components: a visual image indexer, thesauri and a query processor. Each pair of objects in an mage captured by the visual image indexer is converted into a triple. The triple consists of the two object identifiers (oids) and their spatial relationship. All the features of an object is referenced by its old. A composite concept is detected by the triple thesaurus and IS-A concept is recolonized by the fuzzy term thesaurus. The query processor obtains an image set by matching each triple in a user with an inverted file and CS-Tree. To support efficient storage use and fast retrieval on high-dimensional feature vectors, E-COIRS uses Cell-based Signature tree(CS-Tree). E-COIRS is a more advanced content-based image retrieval system than other systems which support only concepts or image features.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2019.05a
• /
• pp.315-315
• /
• 2019

증산과 증발의 합으로 나타내지는 증발산은 지구내에서의 수문 순환에 영향을 미치는 중요한 인자로써, 지표와 대기의 에너지 교환을 담당하고 있다. 정확한 관측을 위해서 오래전부터 증발산에 대해서 관측하기 위하여 직접관측 방법들인 증발산계를 이용한 관측방법, 에디 공분산 방법을 이용한 플럭스타워 관측 방법 등을 사용하였으며, 물리 및 경험적인 방법인 Penman (1948), Monteith (1965) 방법, PT (Priestley and Taylor, 1972) 방법 등을 이용함으로써 증발산과 관계를 가진 수문기상인자를 이용함으로써 증발산에 대해서 추정하여 왔다. 대부분 지상 관측에 의존하기 때문에 시공간적인 값의 표현이 어렵다는 문제를 가지고 있으며, 관측 장비의 관리 및 유지비용이 증대로 인하여 조밀한 관측망을 구축하기 어렵다. 이러한 단점을 개선하고자 인공위성 및 재분석 자료를 활용하여 여러 경험식을 통해서 증발산 자료가 제공되고 있다. 그러나 이러한 자료들의 문제점은 각기 다른 경험식 및 다른 입력자료를 제공하고 있을 뿐만 아니라, 자료별 지역별 정확성이 차이가 발생한다. 따라서, 최근 연구에서는 지점자료와 인공위성 자료 및 재분석 자료를 모두 사용함으로써 수문기상인자를 개선하고자 하는 연구가 진행되어왔으며, 정확성 또한 개선된 것을 확인 할 수 있다. 그러나, 이러한 방법들의 가장 큰 문제점은 관측 자료가 필수적으로 필요하다는 것에 있다. 대부분의 나라나 지역에서는 조밀한 구축망을 구축하기 어렵기 때문에 실질적으로 적용하기가 어렵다는데 있다. 따라서 본 연구에서는 이러한 문제를 해결하기 위하여 지점자료가 필요없는 융합방법을 triple collocation 방법을 이용함으로써 제안하고자 한다.

• Journal of Korean Medical classics
• /
• v.35 no.2
• /
• pp.121-141
• /
• 2022

Objectives : This paper aims to examine the Yin-Yang characteristics of bland taste. Methods : Medicinals including bland taste were searched in herbology textbooks and mainly in the Bencaogangmu, of which major discourses were analyzed to examine the Yin-Yang characteristics of bland taste. Results & Conclusions : Most medicinals with bland taste were sweet-bland-cold, holding properties of cooling heat, stimulating urination and detoxification. These properties could be explained in relation to the Triple Burner's metabolism of Qi and fluids, as they stimulate perspiration and urination, improving the flow of fluids which in turn supports production of Original Qi, by working on the TB's Qi circulation system. In the bland taste discourse, it was understood that bland taste moves the Qi system and produces fluids, by first ascending then descending. Zhudanxi and the Neijing have opposing views on whether bland taste is Yin or Yang, but both saw blandness to have both Yin and Yang qualities. Characteristics of the bland taste could be better understood in relation to the Triple Burner. The phrase 'bland is attached to sweet taste[淡附于甘]' refers to the likeliness between the two tastes in that bland taste has the Central Earth qualities, integrating others and concealing itself in its blandness, its taste unspecific, mild and unstimulating thus communicating the Qi within the entire Triple Burner from Upper to Middle to Lower, as does sweet taste.

• Biomolecules & Therapeutics
• /
• v.30 no.6
• /
• pp.585-592
• /
• 2022

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist in human triple-negative breast cancer BT-20 and HCC-70 cells. Hydroxyzine inhibited the growth of cells in dose- and time-dependent manners. The annexin V/propidium iodide double staining assay showed that hydroxyzine induced apoptosis. The hydroxyzine-induced apoptosis was accompanied down-regulation of cyclins and CDKs, as well as the generation of reactive oxygen species (ROS) without cell cycle arrest. The effect of hydroxyzine on the induction of ROS and apoptosis on TNBC cells was prevented by pre-treatment with ROS scavengers, N-acetyl cysteine or Mito-TEMPO, a mitochondria-targeted antioxidant, indicating that an increase in the generation of ROS mediated the apoptosis induced by hydroxyzine. Western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of JAK2 and STAT3 by hydroxyzine treatment. In addition, hydroxyzine induced the phosphorylation of JNK and p38 MAPK. Our results indicate that hydroxyzine induced apoptosis via mitochondrial superoxide generation and the suppression of JAK2/STAT3 signaling.

• Journal of Appropriate Technology
• /
• v.5 no.1
• /
• pp.38-45
• /
• 2019

In 2017, aiming at developing, educating, and commercializing innovative appropriate technologies that are suitable for Tanzanian environment, the Ministry of Science and ICT in Korea established an innovative technology and energy center in a Tanzanian university. Using the qualitative methodologies such as an ethnography of a research project, document analyses of memoranda of understandings, journal articles, reports, announcements, and newspaper articles, participant observation of formal and informal meetings, and semi-structured interviews with participants engaging in an appropriate technology center, this study examines how triple helix model in S&T innovation has been applied to the development of the Korea-Tanzania appropriate technology center. Despite growing importance in national S&T policies, only few studies have discussed office development aid (ODA) in association with innovation. The analysis of the appropriate technology center with the framework of the triple-helix model shows the close tie between official development aid (ODA) and the cross national innovation promoted in Korea. This study also contributes to understanding embedded organizational structure, conflicts, and barriers of an ODA project in Korea.

• Journal of the Korean Society of Industry Convergence
• /
• v.26 no.6_2
• /
• pp.1163-1169
• /
• 2023

In this study, the flow characteristics of the filter system were analyzed due to the effect of the density of the filter in the triple filter system. Flow analysis was performed as a flow passing through a porous medium. The flow characteristics of each filter system were analyzed by arranging filters with different densities in the forward flow flow and the reverse flow. The arrangement order of the triple filters was excellent in the case of forward fluid flow and in the case of higher density from the inside to the outside filter. In the reverse flow filter system, the performance of the system was the best in the case of reverse order filter arrangement. As a result of the analysis, Case II, which showed a pressure drop rate of 5.65% for forward flow, was the best in the reverse direction with a pressure drop rate of 14.25%. Considering reverse and forward flows, it was found that the optimal filter arrangement was most effective when the intermediate filter was the densest, and the inner or outer filter was less dense.

• Journal of IKEEE
• /
• v.28 no.1
• /
• pp.72-77
• /
• 2024

In this paper, a triple-mode frequency-tunable filter is proposed to meet the recent demands of various frequency bands of mobile communication services. This filter has a tunable structure that can adjust the resonance frequency using a variable capacitor. To improve the quality factor, a SIW(Substrate Integrated Waveguide) structure was introduced and a structure that induces three resonance modes was implemented through a circular hole located in the center. The change in electric field distribution and resonance frequency by the variable capacitor was simulated using HFSS, and the change in electric field distribution and resonance frequency of Triple Mode mode was confirmed.

• The Journal of the Korea Contents Association
• /
• v.12 no.8
• /
• pp.146-156
• /
• 2012

Film was invented by human's desire to copy the real world, starting in the late 19th century. Since the birth of cinema, It was given mission to replay of the real world. On the other hand, cinema was regarded as a fictitious art form. Although the invention of film brought about experience of replaying of the real world it has been reproduced reality with creative story. And it also has been represent reality with sense of reality. Cinema's way of reproduction implied conflicting concept of mimesis. Triple Mimesis of Paul Ricoeur was an idea expanded into an analytical concept from that simple concept of mimesis. The purpose of this study was to examine the prefiguration of shown behavior in Columbine High School massacre based on Triple Mimesis of Paul Ricoeur. It also was to examine a form of representation on cinema which is 'Elephant' and studied how the form of representation on Elephant could interpret by audience. It could be define the relationship between reality and reproduction through this esthetic study. This paper attempted to build the method communication between the originator and audience with a whole analytic process of time and story on the cinematic representation.

• Korean Journal of Applied Biomechanics
• /
• v.25 no.1
• /
• pp.39-47
• /
• 2015

Objective : The purpose of this study was to investigate the velocity conversion coefficient and invariance for the optimal phase ratio on the performance of the women's triple jump. Methods : Three-dimensional kinematic data were obtained from the three finalists of the women's triple jumper competition at the 2011 Daegu IAAF World Championships. Computer simulations were performed using the biomechanical model of the triple jump to optimize the phase ratio for the longest actual distance for all athletes with altered velocity conversion coefficients. Results : Top elite triple jumpers showed better technical consistency at the phase ratio. Also, no consistent relationship was observed between the loss in horizontal velocity and the gain in vertical velocity across supporting the three phase. In addition, regardless of the magnitude A1, all athletes were optimized with jump-dominated technique. Finally, as the magnitude of A1 increased, the athletes showed better performance. The obtained overall distance jumped showed the longest actual distance when the optimal phase ratio was transferred from hop-dominated to jump-dominated(the step ratio was 30%~31%), and when the optimal phase ratio was transferred from balanced to jump-dominated(the step ratio was 27%~29%). Conclusion : Future studies need to be conducted in order to explore the active landing motion and the inclination angle of the body with the velocity conversion coefficient simultaneously at each supporting phase.