• 구강회복응용과학지
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• 제34권1호
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• pp.17-31
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• 2018

목적: 이 연구의 목적은 다양한 구강 스캐너를 사용하여 협측 악간관계 스캔에 따른 상하악 악궁 관계의 정확성을 비교 평가하는 것이다. 연구 재료 및 방법: 정상 교합을 보이는 상하악 전악 모델을 5종(Cerec Omnicam, CS3500, iTero, Trios, TruDef)의 구강 스캐너로 제조사의 지시대로 스캔하였다. 폴리비닐실록산 교합 재료로 고정시킨 금속 지그를 이용하여 우측 구치부를 1, 2, 3, 4 mm 단계적으로 올린 후 좌측 협측 악간관계 스캔을 채득하였다. 두 데이터를 중첩하여 전체적인 삼차원 변이를 평가하였고, 교합 평면에 수직인 단면을 분석하여 교두간 거리의 양과 방향을 평가하였다. 결과: 중첩연구에서 Cerec Omnicam ($165.5{\mu}m$)이 가장 적은 변이를 보였고, CS3500 ($369.0{\mu}m$)이 가장 큰 변이를 보였으며(P < 0.01), 1 mm 보다 3, 4, 2 mm 이개 그룹에서 변이가 유의미하게 컸다(P < 0.01). 단면 연구에서는 Cerec Omnicam이 교두끼리의 거리가 가장 먼 변이를 보였고($-242.8{\mu}m$), CS3500이 가장 가까워지는 변이를 보였으며($312.5{\mu}m$), 다른 거상 높이 보다 3 mm 이개 그룹에서 유의하게 변이가 컸다(P < 0.01). 결론: 구강 스캐너 마다 협측 악간관계 스캔을 이용해 상하악 교합 관계를 재현하는 정확성이 달랐다.

• 대한치과보철학회지
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• 제59권1호
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• pp.11-17
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• 2021

목적: 본 연구의 목적은 3가지 종류의 CAD 프로그램들에 따라 렌더링 화면 차이가 CAD 프로그램 상의 거리 측정에서의 차이로 나타나는지 알아보고자 함이다. 재료 및 방법: 치과용 스캐너 평가를 위해 제시된 ISO 12836 규격 인레이 모형을 70% 축소한 모델을 제작하였다. 이 모델을 Trios II (3Shape, Denmark)를 사용하여 총 15회 반복하여 연속적으로 스캔을 시행하였다. 출력된 STL 파일을 이용하여 3Shape CAD, inLab 15, ExoCAD 프로그램을 통해 인접한 점각 간 수평 거리(H)와 수직 거리(V)를 각각 측정하는 실험을 수행하였고, 각 실험마다 CAD 프로그램 종류에 따라 3개의 군으로 설정하였다. One-way ANOVA test를 통해 통계 분석하였고, Dunnett T3법으로 사후분석을 시행하였다. 결과: 수평거리와 수직거리 측정에서 모두 CAD 프로그램에 따른 세 군 간의 측정값 평균의 유의한 차이는 없었다 (P > .05). 결론: 치과용 CAD 프로그램상에서 인레이 모형의 수평, 수직 직선거리를 측정할 때, 프로그램 간의 렌더링 화면 차이에 따른 영향은 없다.

• The Journal of Advanced Prosthodontics
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• 제9권3호
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• pp.208-216
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• 2017

PURPOSE. The aim of this study was to compare the precision of optical impression (Trios, 3Shape) versus that of conventional impression (Imprint IV, 3M-ESPE) with three different margins (shoulder, chamfer, and knife-edge) on Frasaco teeth. MATERIALS AND METHODS. The sample comprised of 60 zirconia half-crowns, divided into six groups according to the type of impression and margin. Scanning electron microscopy enabled us to analyze the gap between the zirconia crowns and the Frasaco teeth, using ImageJ software, based on eight reproducible and standardized measuring points. RESULTS. No statistically significant difference was found between conventional impressions and optical impressions, except for two of the eight points. A statistically significant difference was observed between the three margin types; the chamfer and knife-edge finishing lines appeared to offer better adaptation results than the shoulder margin. CONCLUSION. Zirconia crowns created from optical impression and those created from conventional impression present similar adaptation. While offering identical results, the former have many advantages. In view of our findings, we believe the chamfer margin should be favored.

• The Journal of Advanced Prosthodontics
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• 제10권1호
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• pp.58-64
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• 2018

PURPOSE. The aim of this study was to design an intraoral environment simulator and to assess the accuracy of two intraoral scanners using the simulator. MATERIALS AND METHODS. A box-shaped intraoral environment simulator was designed to simulate two specific intraoral environments. The cast was scanned 10 times by Identica Blue (MEDIT, Seoul, South Korea), TRIOS (3Shape, Copenhagen, Denmark), and CS3500 (Carestream Dental, Georgia, USA) scanners in the two simulated groups. The distances between the left and right canines (D3), first molars (D6), second molars (D7), and the left canine and left second molar (D37) were measured. The distance data were analyzed by the Kruskal-Wallis test. RESULTS. The differences in intraoral environments were not statistically significant (P>.05). Between intraoral scanners, statistically significant differences (P<.05) were revealed by the Kruskal-Wallis test with regard to D3 and D6. CONCLUSION. No difference due to the intraoral environment was revealed. The simulator will contribute to the higher accuracy of intraoral scanners in the future.

• Journal of Ginseng Research
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• 제9권1호
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• pp.86-94
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• 1985

Attempts were made if diol and triol fractions of ginseng saponin affect on glutamine transport into rat renal cortical mitochondria, swelling, phosphate dependent glutaminase activity, and consumption of oxygen. The following results were obtained. When mitochondrial preparation from rat renal cortex was incubated in medium containing 14C-glutamine and either triol or diol fractions, radioactivity was shown to increase at both 10-6% and 10-5% triol fractions of ginseng saponin, but reduce in case of diol fraction. The remarkable acceleration of the rate of swelling of renal cortical mitochondria was observed in the presence of 10-1% trios and diol fractions but no accerelation at lower concentrations. The activity of phosphate dependent glutaminase from renal cortical mitochondria was slightly activated at 10-2% of triol fraction. However, there was no effect in case of diol fraction. Oxygen consumption by mitochondria from renal cortex was remarkably increased at concentrations of 10-5% and 10-6% triol fractions, but reduced in the case of diol fractions. On the basis of these observations it was concluded that triol fraction of ginseng saponin might increase the transport of glutamine into mitochondria by accelerating the respiratory chain and supplying additional energy to mitochondria, and physiological role of triol fraction was entirely different from that of diol fraction of ginseng saponin.

• BMB Reports
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• 제46권8호
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• pp.416-421
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• 2013

Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diversity is valuable for the investigation of possible population specific and independent effects of variants. EvoSNP-DB aims to provide information regarding genetic diversity among East Asian populations, including Chinese, Japanese, and Korean. Non-redundant SNPs (1.6 million) were genotyped in 54 Korean trios (162 samples) and were compared with 4 million SNPs from HapMap phase II populations. EvoSNP-DB provides two user interfaces for data query and visualization, and integrates scores of genetic diversity (Fst and VarLD) at the level of SNPs, genes, and chromosome regions. EvoSNP-DB is a web-based application that allows users to navigate and visualize measurements of population genetic differences in an interactive manner, and is available online at [http://biomi.cdc.go.kr/EvoSNP/].

• 생물정신의학
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• 제16권2호
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• pp.121-126
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• 2009

Objectives : The serotonin transporter gene(SLC6A4) is one of the most widely studied candidate genes in autism spectrum disorder(ASD), but there have been conflicting results from studies into the association between SLC6A4 and ASD. The aim of this study was to evaluate the association between single nucleotide polymorphisms(SNPs) in the SLC6A4 gene and ASD in the Korean population. Methods : We selected 12 SNPs in SLC6A4 and observed the genotype of 151 Korean ASD trios. We tested the family-based association for each individual polymorphism and haplotype by using the standard TDT method in Haploview(http://www.broad.mit.edu/mpg/haploview/). Results : Through transmission-disequilibrium testing and haplotype analysis, we could not find any statistically significant transmitted allele or haplotype. In addition, a case-control association test with Korean HapMap data did not reveal any statistical significance. Conclusion : Although serotonin-related genes must be considered candidate genes for ASD, we suggest that common SNPs of SLC6A4 are not important markers for associations with Korean ASD.

• The Journal of Advanced Prosthodontics
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• 제11권5호
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• pp.271-279
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• 2019

PURPOSE. The newest technologies for digital implant impression (DII) taking are developing rapidly and showing acceptable clinical results. However, scientific literature is lacking data from clinical studies about the accuracy of DII. The aim of this study was to compare digital and conventional dental implant impressions (CII) in a clinical environment. MATERIALS AND METHODS. Twenty-four fixed zirconia restorations supported by 2 implants were fabricated using conventional open-tray impression technique with splinted transfers (CII group) and scan with Trios 3 IOS (3Shape) (DII group). After multiple verification procedures, master models were scanned using laboratory scanner D800 (3Shape). 3D models from conventional and digital workflow were imported to reverse engineering software and superimposed with high resolution 3D CAD models of scan bodies. Distance between center points, angulation, rotation, vertical shift, and surface mismatch of the scan bodies were measured and compared between conventional and digital impressions. RESULTS. Statistically significant differences were found for: a) inter-implant distance, b) rotation, c) vertical shift, and d) surface mismatch differences, comparing DII and CII groups for mesial and distal implant scan bodies ($P{\leq}.05$). CONCLUSION. Recorded linear differences between digital and conventional impressions were of limited clinical significance with two implant-supported restorations.

• The Journal of Advanced Prosthodontics
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• 제13권4호
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• pp.205-215
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• 2021

PURPOSE. The purpose of this study was to compare the accuracy of three intraoral scanner (IOS) systems with three different dental arch widths. MATERIALS AND METHODS. Three dental models with different intermolar widths (small, medium, and large) were attached to metal bars of different lengths (30, 40, and 50 mm). The bars were measured with a coordinate measuring machine and used as references. Three IOSs were compared: TRIOS 3 (TRI), True Definition (TD), and Dental Wings (DW). The relative length and angular deviation of both ends of the metal bars from the scan data set (n = 15) were calculated and analyzed. RESULTS. Comparing among scanners in terms of trueness, the relative length deviation of DW in the small (1.28%) and medium (1.08%) arches were significantly higher than TRI (0.46% and 0.48%) and TD (0.33% and 0.18%). The angular deviation of DW in the small (1.75°) and medium (1.83°) arches were also significantly greater than TRI (0.63° and 0.40°) and TD (0.55° and 0.89°). Comparing within scanner, the large arch of DW showed better accuracy than other arch sizes (P < .05). On the other hand, the larger arch of TD presented a greater tendency of angular deviation in terms of trueness. No significant differences were found in terms of trueness between the arch widths of TRI group. CONCLUSION. The different widths of the dental arches can affect the accuracy of some intraoral scanners in full arch scan.

• The Journal of Advanced Prosthodontics
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• 제14권4호
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• pp.236-249
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• 2022

PURPOSE. The present study compared the accuracy between digital and conventional implant impressions. MATERIALS AND METHODS. The experimental models were divided into six groups depending on the implant location and the scanning span. Digital impressions were captured using the intraoral optical scanner TRIOS (3Shape, Copenhagen, Denmark). Conventional impressions were taken with the monophase impression material based on addition-cured silicones, Honigum-Mono (DMG, Hamburg, Germany). A high-precision laboratory scanner D900 (3Shape, Copenhagen, Denmark) was used to obtain digital data of resin models and stone casts. Surface tessellation language (STL) datasets from scanner were imported into the analysis software Geomagic Qualify 14 (3D Systems, Rock Hill, SC, USA), and scan body deviations were determined through two-dimensional and three-dimensional analyses. Each scan body was measured five times. The Sidak t test was used to analyze the experimental data. RESULTS. Implant position and scanning distance affected the impression accuracy. For a unilateral arch implant and the mandible models with two implants, no significant difference was observed in the accuracy between the digital and conventional implant impressions on scan bodies; however, the corresponding differences for trans-arch implants and mandible with six implants were extremely significant (P<.001). CONCLUSION. For short-span scanning, the accuracy of digital and conventional implant impressions did not differ significantly. For long-span scanning, the precision of digital impressions was significantly inferior to that of the traditional impressions.