• 제목/요약/키워드: Trichstatin A

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Regulation of Histone Acetylation during First Mitosis in Bovine Clone Embryos

  • Gabbine Wee;Koo, Deog-Bon;Kang, Man-Jong;Moon, Seung-Ju;Lee, Kyung-Kwang;Han, Yong-Mahn
    • 한국동물번식학회:학술대회논문집
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    • 한국동물번식학회 2004년도 춘계학술발표대회
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    • pp.189-189
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    • 2004
  • Histone acetylation as epigenetic marker plays a critical role in gene expression through the interaction of nucleosomes with DNA, modulating the efficiency which RNA-polymerase can interact with promotors to initiate transcription. After fertilization, highly acetylated chromatin takes place and maintain during 1cell stages. The hyperacetylation may lead minor genome activation for survival and cleavage, and then may affect embryonic genome activation and development to balstocyst. (omitted)

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