• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2004.07a
• /
• pp.24-24
• /
• 2004

• Proceedings of the KSAR Conference
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• 2004.06a
• /
• pp.189-189
• /
• 2004

Histone acetylation as epigenetic marker plays a critical role in gene expression through the interaction of nucleosomes with DNA, modulating the efficiency which RNA-polymerase can interact with promotors to initiate transcription. After fertilization, highly acetylated chromatin takes place and maintain during 1cell stages. The hyperacetylation may lead minor genome activation for survival and cleavage, and then may affect embryonic genome activation and development to balstocyst. (omitted)