• Title/Summary/Keyword: Treatment Exposure

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Post-exposure Treatment and Seroconversion to Blood-borne Viruses after Needlestick Injuries among Healthcare Personnel (의료종사자의 주사침 손상 사고 후 감염예방처치와 혈액매개바이러스 혈청양성전환)

  • Jeong, Jae Sim
    • Journal of Korean Biological Nursing Science
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    • v.16 no.1
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    • pp.26-32
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    • 2014
  • Purpose: Needlestick injuries (NSI) is the most frequent occupational hazard for healthcare personnel (HCP), and immediate report and adequate post-exposure prophylaxis (PEP) is essential in preventing occupational transmission of blood-borne pathogens. Methods: From June 2010 to October 2010, 544 NSI were reported through websites from 21 general hospitals in Korea. Among those, 499 cases of NSI were analyzed to identify the rate of follow-up treatment completion and for seroconversion. Results: 88.2% of the cases were completed with follow-up treatment, 8.8% of the NSI were not completed with follow-up treatment, and 5 cases were unavailable to trace. 4.2% cases of NSI required a hepatitis B vaccination concurrent with hepatitis B immunoglobulin. 41.1% of the cases and 31.1% of the cases needed to be tested for anti HCV and anti HIV, respectively. Prophylaxis medication for HIV was prescribed in 3 cases, and all cases completed required 1 month of medication. There was 1 case (0.2%) of seroconversion to HCV. Conclusion: The PEP completion rate was not satisfactory, and the importance of completion of PEP treatment should be emphasized through education and counseling. Also, a careful risk assessment is needed for HCP who are exposed to HCV or HIV.

Radiological safety assessment of lead shielded spent resin treatment facility with the treatment capacity of 1 ton/day

  • Byun, Jaehoon;Choi, Woo Nyun;Kim, Hee Reyoung
    • Nuclear Engineering and Technology
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    • v.53 no.1
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    • pp.273-281
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    • 2021
  • The radiological safety of the spent resin treatment facility with a14C treatment capacity of 1 ton/day was evaluated in terms of the external and internal exposure of worker according to operation scenario. In terms of external dose, the annual dose for close work for 1 h/day at a distance of more than 1 m (19.8 mSv) satisfied the annual dose limit. For 8 h of close work per day, the annual dose exceeded the dose limit. For remote work of 2000 h/year, the annual dose was 14.4 mSv. Lead shielding was considered to reduce exposure dose, and the highest annual dose during close work for 1 h/day corresponded to 6.75 mSv. For close work of 2000 h/year and lead thickness exceeding 1.5 cm, the highest value of annual dose was derived as 13.2 mSv. In terms of internal exposure, the initial year dose was estimated to be 1.14E+03 mSv when conservatively 100% of the nuclides were assumed to leak. The allowable outflow rate was derived as 7.77E-02% and 2.00E-01% for the average limit of 20 mSv and the maximum limit of 50 mSv, respectively, where the annual replacement of the worker was required for 50 mSv.

Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead

  • Lee, Hwayoung;Lee, Minyoung;Kim, Hyung-Ki;Kim, Young Ock;Kwon, Jun-Tack;Kim, Hak-Jae
    • The Korean Journal of Physiology and Pharmacology
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    • v.23 no.6
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    • pp.467-474
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    • 2019
  • Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead acetate (0.2%) in drinking water during pregnancy and lactation causes behavioral impairment and affects the expression of proteins associated with neurodevelopment. Lead exposure altered several parameters in rat offspring compared with those unexposed in open-field, social interaction, and pre-pulse inhibition tests. These parameters were restored to normal levels after clozapine treatment. Western blot and immunohistochemical analyses of the hippocampus revealed that several neurodevelopmental proteins were downregulated in lead-exposed rats. The expression was normalized after clozapine treatment (5 mg/kg/day, postnatal day 35-56). These findings demonstrate that downregulation of several proteins in lead-exposed rats affected subsequent behavioral changes. Our results suggest that lead exposure in early life may induce psychiatric disorders and treatment with antipsychotics such as clozapine may reduce their incidence.

An External Dose Assessment of Worker during RadWaste Treatment Facility Decommissioning

  • Chae, San;Park, Seungkook;Park, Jinho;Min, Sujung;Kim, Jongjin;Lee, Jinwoo
    • Journal of Radiation Protection and Research
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    • v.45 no.2
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    • pp.81-87
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    • 2020
  • Background: Kori unit #1 is permanently shut down after a 40-year lifetime. The Nuclear Safety and Security Commission recommends establishing initial decommissioning plans for all nuclear and radwaste treatment facilities. Therefore, the Korea Atomic Energy Research Institute (KAERI) must establish an initial and final decommissioning plan for radwaste-treatment facilities. Radiation safety assessment, which constitutes one chapter of the decommissioning plan, is important for establishing a decommissioning schedule, a strategy, and cost. It is also a critical issue for the government and public to understand. Materials and Methods: This study provides a method for assessing external radiation dose to workers during decommissioning. An external dose is calculated following each exposure scenario, decommissioning strategy, and working schedule. In this study, exposure dose is evaluated using the deterministic method. Physical characterization of the facility is obtained by both direct measurement and analysis of the drawings, and radiological characterization is analyzed using the annual report of KAERI, which measures the ambient dose every month. Results and Discussion: External doses are calculated at each stage of a decommissioning strategy and found to increase with each successive stage. The maximum external dose was evaluated to be 397.06 man-mSv when working in liquid-waste storage. To satisfy the regulations, working period and manpower must be managed. In this study, average and cumulative exposure doses were calculated for three cases, and the average exposure dose was found to be about 17 mSv/yr in all the cases. Conclusion: For the three cases presented, the average exposure dose is well below the annual maximum effective dose restriction imposed by the international and domestic regulations. Working period and manpower greatly affect the cost and entire decommissioning plan; hence, the chosen option must take account of these factors with due consideration of worker safety.

A Study on the Neutron Dose Distribution in Case of 10 MV X-rays Radiotherapy (10MV X선 방사선 치료 시 중성자 선량 분포에 관한 연구)

  • Park, Cheol-Soo;Lim, Cheong-Hwan;Jung, Hong-Ryang;Shin, Seong-Soo
    • Journal of radiological science and technology
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    • v.31 no.4
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    • pp.415-417
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    • 2008
  • This study is to measure the radiation dose of neutrons generated by the particle accelerator during X-ray (photon) treatment with a neutron detection method by using CR-39, and to research how the generation of neutrons may incur problems associated with radiation doses for patient treatment when using high energy photons for cancer treatment as a clinical application. The findings are summarized as follows : The results showed that average 0.35mSv was measured with exposure of 1Gy photon in case of fast neutron, 0.65mSv with exposure of 2Gy photon, 1.82mSv exposure of 5Gy, 0.26mSv with exposure of 1Gy photon in case of thermal neutron, 0.56mSv with exposure of 2Gy photon, and 1.23mSv with exposure of 5Gy of photon. By measuring the occurrence of neutron by using Wedge Filter, it has been confirmed that the occurrence of neutrons increased when using Wedge Filter. The results also showed that more neutrons were detected over the existing experiments when using an SRS Cone requiring high doses of radiation. Total 2.85mSv neutrons were found on the average with exposure of 5Gy photon in case of fast neutron and 1.37mSv neutrons were found on the average with exposure of 5Gy photon in case of thermal neutron. During the general treatment, about 1.6 times more neutrons over 5Gy photon were found in case of fast neutron and about 1.12 time more neutrons over 5Gy photon were found in case of thermal neutron.

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Effects of Germinating Types of Water-soaking & Air-exposure and Chitosan Treatment on Brown Rice Germination (침수 및 대기 발아방식과 키토산 처리가 현미발아에 미치는 영향)

  • Lee J.;Lim K.T.;Hong J.H.;Rhee C.O.;Choi Y.S.;Lee Y.B.;Choi S.M.;Chung J.H.
    • Journal of Biosystems Engineering
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    • v.31 no.4 s.117
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    • pp.363-368
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    • 2006
  • The effects of germinating types and treatments of acetic acid, water-soluble and water-insoluble chitosan on the germination ratio and sprout length of brown rice were investigated in this study. The treatment of 0.001% acetic acid improved the germination ratio and sprout growth of brown rice in the germinating types of a air-exposure method after water-soaking (Type II) and a repetitive method of water-soaking & air-exposure (Type III), not water-soaking method (Type I). The treatment of water-soluble chitosan with higher concentration caused higher germination ratio and faster sprout growth. The treatment of water-insoluble chitosan repressed the germination and the sprout growth of brown rice. The germination ratios of brown rice germinated by the Type III were higher than those by Type I and Type II for all the treatments of acetic acid and water-soluble & water-insoluble chitosan as more than 97% germination ratio. Also, the Type III method accelerated the sprout growth of brown rice compared with Type I and Type II.

Performance Enhancement due to Oxygen Plasma Treatment on the Gate Dielectrics of OTFTs (게이트 절연막의 $O_2$플라즈마 처리에 의한 펜타센 OTFT의 성능 개선)

  • 이명원;김광현;허영헌;안정근
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.40 no.7
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    • pp.494-498
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    • 2003
  • In this paper, the plasma treatment on gate surface has been applied prior to deposition of pentacene and the effects on performance were investigated. The Plasma treatment produced the mobility of 0.05$\textrm{cm}^2$/V.sec which is 10 times larger than the non-treated. The resistance was also reduced from 400K$\Omega$ to 50K$\Omega$. In addition, the standard deviation of performance parameters variation was reduced with the plasma exposure time, which implies that plasma treatment makes the gate surface states be uniform across the whole wafer area. The performance parameters were increased with the exposure time up to 5min, after which they degraded again. Therefore, the optimal exposure time was found to be 5min.

Effects of Ar-Plasma Treatment in Alkali-Decomposition of Poly(ethylene terephthalate)

  • Seo, Eun-Deock
    • Macromolecular Research
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    • v.11 no.5
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    • pp.387-392
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    • 2003
  • The ablation effects of Ar-plasma treatment and alkali-decomposition behavior in NaOH solution of polyethylene terephthalate (PET) film were investigated. The modifications were evaluated by analysis of atomic force microscopy topographical changes, and by the measurement of decomposition yield in conjunction with heats of formation and electron densities of acyl carbon calculated by Parameterization Method 3 method. It has shown that the alkali-decomposition is hampered by plasma treatment and its decomposition yield is closely related with plasma treatment conditions such as exposure time to plasma. Plasma-treated PET films exhibited lower decomposition yield, compared to that of virgin PET. Increasing plasma exposure time contributes positively to decrease the decomposition yield. It has also shown that the topography of PET surface was affected by the base-promoted hydrolysis as well as Ar-plasma treatments. These behaviors are attributed to the decreased nucleophilicity of acyl carbon damaged by the ablation of Ar-plasma.

Effects of Vacuum Heat Treatment and Salt bath Heat Treatment Conditions on Mechanical Properties of High Speed tool Steel (금속도 공구강의 기계적 성질에 미치는 진공열처리와 염욕열처리 조건의 영향)

  • Kim, Je-Don;Kim, Kyung-Sik
    • Journal of the Korean Society for Heat Treatment
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    • v.26 no.1
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    • pp.7-13
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    • 2013
  • Vacuum heat treatment(indirect heating method) has long exposure time at high temperature and low quenching rate. Contrarily salt bath heat treatment (direct heating method) has short exposure time at high temperature and fast cooling rate. With these different features of processes, mechanical properties such as hardness, tensile strength and impact strength of products show very different results. In this study, Salt bath heat treated products showed higher tensile strength and impact strength than vacuum heat treated products but hardness was not much different. These lower mechanical properties of vacuum heat treated products are due to differences in heat process and secondary hardening with high temperature tempering process. Consequently, It indicates that salt bath heat treatment is better way than vacuum heat treatment for product to have high mechanical properties.

The Relationship between the Media Exposure of Hospital Physicians and Patient Volume - a University Hospital Case - (병원의료진의 언론노출과 진료실적간의 관계 - 일개 대학병원 사례를 기준으로 -)

  • Kim, Sung Cheol;Kim, Tae Kyung;Kim, Tae Hyun;Park, So Hee;Lee, Sang Gyu
    • Korea Journal of Hospital Management
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    • v.21 no.1
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    • pp.51-61
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    • 2016
  • This study attempted to investigate how mass media marketing of a hospital influences patient volume. Additionally, the association of patient volume with exposure time and the type of mass media was examined. Data from a university hospital in Bundang (from January 2014 to November 2014) were used. Degree of physicians' mass media marketing was measured by the number of media exposure. Linear mixed model for repeated measures data was run to identify the associations between the number of media exposure and patient volume. First, the number of hospital physician's mass media exposure and new patients and the first visit patients were positively associated. Second, broadcasting media which has relatively significant in patient volume is TV programs such as cultural programs and news. Third, hospital physicians with higher ranks who were exposed to press media receive more patient appointment. Also, nonsurgical hospital physicians who were exposed to press media receive more patients. Fourth, medical treatment activities for hospital staff who hold the rank of Professor in case of making an appearance at press media have relatively increased. Hospital physician's media exposure, particularly TV programs, was significantly related to patient volume for outpatients.