• Journal of the Society of Cosmetic Scientists of Korea
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• v.25 no.4 s.34
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• pp.1-5
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• 1999

The purpose of this study was to determine the effect of IPBC(3-lodo-2-propynylbutylcarbamate) on dandruff caused by the anthropophilic fungus Malassezia furfur. The effects of IPBC on dandruff were examined by evaluating (a) the MIC value of IPBC using broth dilution method; (b) the remnant antimicrobial activity of IPBC containing shampoo on skin disc; (c) the antidandruff efficacy of 1.0 % IPBC containing shampoo in double blind clinical trial. To investigate the remnant antimicrobial activity of IPBC against Malassezia furfur, guinea pig-skin disc was washed with antidandruff shampoo and then the diameter of inhibition zone per disc was measured. For clinical trial, thirty healthy volunteers, aged 25-35, participated in 4 week study. At 0, 2, 4 weeks, examinations of scaling, itching on scalp were carried out. The MIC(Minimun Inhibition Concentration) values of IPBC range from 0.10 to 1.00${\mu}g/ml$ and it seems that IPBC is more effective in the MIC values than zinc pyrithione, selenium disulphide, piroctone olamine and comparable to ketoconazole, climbazole. When the remnant antimicrobial activity of IPBC shampoo on skin disc was determined, 0.5% IPBC shampoo and 2.0% Ketoconazole shampoo resulted in similar antimicrobial effect. In addition, 1.0%, 2.0% IPBC shampoo was more effective than 2.0% ketoconazole shampoo. After two and four-weeks of 1.0% IPBC shampoo treatment, there was significant reduction of scaling, itching in test group compared to control group. On the basis of these results, it can be concluded that 1.0% IPBC is more effective than 2.0% Ketoconazole in reducing dandruff. It seems that strong capacity of drug binding to the stratum corneum plays a role in its antidandruff effect since adsorption of active ingredients on scalp is very important factor in reducing dandruff.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.2
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• pp.99-112
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• 2016

Objectives: Gyejibokryeong-hwan (GBH), a traditional Korean herbal medicine, has been widely used for the treatment of the blood stasis syndrome. This study is purposed to analyze the experimental research trend of GBH in Korea for developing further research plan. Methods: A search of Korean research database-Oasis, RISS and KISS- and Pubmed was carried out for publications until 2015, for the words, 'Guizhifulingwan', ‘Gyejibokryeonghwan’, or ‘Keishibukuryogan’. Then study selection is conducted according to PRISMA guidelines, studies not related or using modified formula or administered for human are excluded, 48 studies are included in this review, finally. We analyzed studies by research method, subject, outcome measure, and result of the study. Results: There were 31 in vivo studies about the effect of GBH on platelet aggregation, anti-oxidant, blood viscosity, and hypercholesterolemia, etc. 12 in vitro studies were about the effect of GBH on the cervical carcinoma, chronic kidney disease, uterine myoma, hepatocarcinoma, atherosclerosis, cancer chemo-prevent. 9 ex vivo studies were about the effect of GBH on the platelet aggregation, chronic kidney disease, ovaulatory disorder, and rheumarthritis.Conclusions: We proposed the translational research of GBH involving scientific discoveries and developing practical applications by investigating the concept of blood stasis syndrome in terms of current physiopathological mechanism.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.17 no.2
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• pp.133-137
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• 2006

Objectives : The purpose of this paper is to know the efficacy of voice therapy for vocal fold nodules in children. Materials and Methods : Sixty two patients with vocal nodules(46 boys and 16 girls) were retrospectively reviewed. Age ranged from 4 to 15 years with mean age of 8 years. Questionnaire survey was carried out with voice handicap index, at pretherapy and post-therapy(3 months and 5 years after voice therapy). Results : Sixty two percent of the patients showed improvement by voice therapy. Twenty five patients continued education at home after voice therapy, but only eight childrens were included this group in pre-school aged children. Voice handicap index was improved in 3 months and 5 years after voice therapy. In contrast, pre-school children group showed slight aggravation in 5 years, especially in emotional subdomain. Conclusion : Voice therapy is effective primary treatment in children with vocal fold nodules. Different result between preschool aged children and school aged group shows needs for age specific approach of voice therapy.

• Korean Journal of Pharmacognosy
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• v.8 no.1
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• pp.1-15
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• 1977

In an attempt to deduce which plants might have been used for their anticancer activities in traditional oriental herb medicine, 127 prescriptions were selected from 'Dong-Eui-Bo-Gam', the Classic Handbook of Korean Traditional Medicine, written by $H_{UH}$ Jun and published in 1613. These are the prescriptions indicated for the systemic treatment of various tumors and some conditions resembling tumors, e.g. inflammatory masses and indurations, and they include 150 natural products of plant origin. The frequency of appearance of each medicinal plant in these selected prescriptions was compared with the frequency of its appearance in all prescriptions listed in 'Bang-Yak-Hap-Pyon', another popular Oriental Medicine Formulary in Korea, written by $H_{WANG}\;Pil-Su$ in 1885. From the latter book, $H_{ONG}$ has recently enumerated frequencies of 235 medicinal plants included in a total of 467 prescriptions. Chi-square tests revealed that 11 plant remedies appear with significantly higher frequency in the prescriptions for "tumors", and 10 for "inflammations". The plants with potential antitumor activities, in decreasing order of statistical significance, are Scirpus maritimus, Curcuma zedoaria, Prunus persica, Rheum coreanum, Foeniculum vulgare, Rhus vernifera, Daphne pseudogenkwa, Galarhaeus sieboldiana, Croton tiglium, Raphanus sativus and Galarhaeus pekinensis. The drugs for potential antibacterial or anti-inflammatory activities are Olibanum(Frankincense), Forsythia coreana, Lonicera japonica, Gleditchia officinalis, $M_{YRRH}$, Trichosanhes kirilowii, Astragalus membranaceus, Rheum coreanum, Platycodon grandiflorum and Fritillaria verticillata. Despite the uncertainties involved in the terminology of various diseases used in pre-modern medicine, and the reservations about the efficacy of remedies used for those diseases, it would be worthwhile to investigate these few selected plants for anticancer, antibacterial, anti-inflammatory or antifungal effects, employing modern scientific methodology.

• The Plant Pathology Journal
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• v.21 no.1
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• pp.64-67
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• 2005

The biocontrol agent Serratia plymuthica A21-4 readily colonized on the root of pepper plant and the bacterium moves to newly emerging roots continuously. The colonization of A21-4 on the pepper root was influenced by the presence ofPhytophthora capsici in the soil. When P. capsici was introduced in advance, the population density of A21-4 on the root of pepper plant was sustained more than $10^6$ cfu/g root until 3 weeks after transplanting. On the other hand, in the absence of P. capsici, the population density of A21-4 was reduced continuously and less than $10^5$ cfu/g root at 21 days after transplanting. S. plymuthica A21-4 inhibited successfully the P. capsici population in pepper root and rhizosphere soil. In the rhizosphere soil, the population density of P. capsici was not increased more than original inoculum density when A21-4 was treated, but it increased rapidly in non-treated control. Similarly, the population density of P. capsici sharply increased in the non-treated control, however the population of P. capsici in A21-4 treated plant was not increased in pepper roots. The incidence of Phytophthora blight on pepper treated with A21-4 was 12.6%, while that of non-treated pepper was 74.5% in GSNU experimental farm experiment. And in farmer's vinyl house experiment, the incidence of the disease treated with the fungicide was 27.3%, but treatment of A21-4 resulted in only 4.7% of the disease incidence, showing above 80% disease control efficacy.

• The Plant Pathology Journal
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• v.21 no.1
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• pp.68-72
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• 2005

The production of antibiotic substances by Serratia plymuthica A21-4 was greatly enhanced by modifying components of a growth medium. When the minimal medium containing $K_2HPO_4$ 0.7%, $KH_2PO_4$ 0.2%, $(NH_4)_2SO_4$ 0.1%, $MgSO_4$ 0.01% was used as basal medium, the best carbon source for antibiotic production was glycerol and the most favorable nitrogen source was ammonium sulfate. The modified medium for antibiotic production also increased colonization ability of A21-4 on pepper root and in the rhizosphere soil. When the cells of A21-4 were suspended in modified medium, the population density of A21-4 on pepper root was 10-100 times higher than that suspended in 0.1 M $MgSO_4$. The population density of A21-4 on root did not decrease under $10^6$ cfu/groot up to 21 days after treatment although the inoculum of A21-4 was reduced to $10^7$ cell/ml. Similar tendency was also observed in the rhizosphere soil. Consequently, Phytophthora blight of pepper was successfully controlled by A21-4 with $10^7$ cell/ml suspended in the modified buffer solution instead of $10^9$ cfu/ml suspended in 0.1 M $MgSO_4$.

• Archives of Plastic Surgery
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• v.40 no.6
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• pp.666-675
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• 2013

Background Stem cells are a unique cell population characterized by self-renewal and cellular differentiation capabilities. These characteristics, among other traits, make them an attractive option for regenerative treatments of tissues defects and for aesthetic procedures in plastic surgery. As research regarding the isolation, culture and behavior of stem cells has progressed, stem cells, particularly adult stem cells, have shown promising results in both translational and clinical applications. Methods The purpose of this review is to evaluate the applications of stem cells in the plastic surgery literature, with particular focus on the advances and limitations of current stem cell therapies. Different key areas amenable to stem cell therapy are addressed in the literature review; these include regeneration of soft tissue, bone, cartilage, and peripheral nerves, as well as wound healing and skin aging. Results The reviewed studies demonstrate promising results, with favorable outcomes and minimal complications in the cited cases. In particular, adipose tissue derived stem cell (ADSC) transplants appear to provide effective treatment options for bony and soft tissue defects, and non-healing wounds. ADSCs have also been shown to be useful in aesthetic surgery. Conclusions Further studies involving both the basic and clinical science aspects of stem cell therapies are warranted. In particular, the mechanism of action of stem cells, their interactions with the surrounding microenvironment and their long-term fate require further elucidation. Larger randomized trials are also necessary to demonstrate the continued safety of transplanted stem cells as well as the efficacy of cellular therapies in comparison to the current standards of care.

• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.671-676
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• 2000

Pleural effusion is a state, retention of a mount of liquid in pleural cavity. Main causes of pleural effusion is Congestive Heart Failure that is caused by left ventricular heart failure. And that of Congestive heart failure is caused by increase of pleural capillary pressure or remain of effusion in pleural cavity. Bilateral venous pressure of pleura make worse pleural effusion and one way of venous pressure of that bring out pleural effusion. The purpose of this study is to examine the efficacy of oriental treatment for pleural effusion is caused by heart failure. One woman of 86 years old complained the symptom of general weakness, dyspnea, flank pain, anorexia, insomnia, coughing, secretion mixed blood. The symptom is caused by effusion that is brought out acute pneumonia, heart failure. At the time of Admission, in the diagnosis of Admission, in the diagnosis of Hyuneum(懸飮) she had taken Kungha-tang hap pleurisy-bang,(芎夏湯合助膜炎方), so improved dyspnea, flank pain, insomnia, coughing. In views of examination, decrease of heart failure' s symptom and pleural effusion. After 13days of admission, she had taken palmul-tang.(八物湯). As a conseguence of that, the symptom of general weakness. anorexia is improved and she was discharged.

• The Journal of Internal Korean Medicine
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• v.31 no.1
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• pp.66-78
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• 2010

Objective : This study was designed to investigate the possibility of AR for chronic renal injury. Methods : The author first investigated the expression levels of DNA by inducing of chronic renal injury. Then, the author investigated the effects of AR on chronic renal injury induced by combination treatment with Adriamycin and cisplatin in terms of changes in body weights and renal tissues, urine volume, BUN and creatinine levels, creatinine clearance and histopathological changes in renal tissues. Total expression levels of 546 genes were elevated or lowered by induction of chronic renal injury. Genes of which whose expression levels were elevated by induction of chronic renal injury were related to the PPAR signaling pathway and fatty acid mechanism, etc. Genes of which expression levels were lowered by induction of chronic renal injury were related to the neuroactive ligand-receptor signaling pathway. Results : Oral administration of AR restored renal mass which was reduced by induction of chronic renal injury. AR also restored creatinine clearance and lowered serum BUN level. In histopathological observation, the AR group has a tendency to prevent tissue damages as shown in the chronic renal injury group. Conclusions : AR can be used to treat patients with chronic renal injury although further study will be needed to elucidate the exact mechanisms in the efficacy of AR on chronic renal injury.

• The Journal of Internal Korean Medicine
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• v.34 no.2
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• pp.122-133
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• 2013

Objectives : Burning mouth syndrome (BMS) is characterized by chronic pain or a burning sensation in the mouth. There is limited evidence available to provide clear guidelines for treating BMS patients and a variety of different treatments have been used. This study was designed to investigate the Effects of Korean medicine therapies on oral pain in patients with BMS. Methods : We surveyed 30 BMS patients who newly visited the Oral Diseases Clinic in the Kyung Hee University Korean Medicine Hospital from February 2012 to March 2013. When the patients visited the clinic for the first time, they were evaluated on sociodemographic characteristics, BMS questionnaire, severity of pain using visual analogue scale (VAS) and pressure pain threshold (PPT) of the acupuncture point CV17. After 3 weeks of Korean medicine therapies (acupuncture, electroacupuncture, pharmacopuncture and herbal medicine), they were re-evaluated with the VAS and the PPT. Results : After 3 weeks of Korean medicine therapies, 30 patients' oral pain improved and the PPT score on CV17 rose, which means decrease of qi-stagnation score. Conclusions : Korean medicine therapies were effective on oral pain in patients with BMS. To confirm the additional curative effect and evaluate the efficacy of each treatment, well-designed randomized controlled trials will be needed in the future.