• Journal of Korean Medicine Rehabilitation
• /
• v.32 no.4
• /
• pp.83-88
• /
• 2022

This case report introduced the use of herbal medicine to treat a sternum fracture. A 46-year-old female patient with a sternum fracture from a traffic accident suffered from anterior chest wall pain. She was treated with herbal medicine. The patient's progress was evaluated using a numerical rating scale (NRS), and the frequency of tingling in the chest wall was also tracked. After treatment, both the NRS of chest pain and frequency of tingling decreased. The results of this study suggest that herbal medicine can effectively decrease pain and discomfort in patients suffering from a sternum fracture. However, further studies are needed to obtain stronger evidence for its efficacy.

• Natural Product Sciences
• /
• v.28 no.4
• /
• pp.161-167
• /
• 2022

Obesity is a complex metabolic disorder that increases the risk for type 2 diabetes, hyperlipidemia, hypertension, and atherosclerosis. In this study, we evaluated the anti-obesity effects of Nelumbo nucifera leaf (NL) extract in 3T3-L1 adipocytes and obese db/db mice. NL extract among various parts (leaf, seed, and root) of N. nucifera most effectively reduced adipogenesis via inhibiting CCAAT enhancer binding protein α (C/EBPα) and peroxisome proliferator activated receptor γ (PPARγ) expression in 3T3-L1 adipocytes. The addition of NL extract enhanced the protein expression of uncoupling protein 2 (UCP2) as compared to untreated 3T3-L1 adipocytes. The oral administration of NL extract (100 mg/kg BW) significantly reduced food efficacy ratio, body weight, and face or total cholesterol level in obese db /db mice. Also, administration of NL extract significantly decreased adipocyte size and C/EBPα or PPARγ expression in the adipose tissues as compared with control (obese db/db mice). Therefore, our results suggest that NL extract among various parts of N. nucifera could be used as a functional food ingredient for the prevention and treatment of metabolic diseases including obesity and diabetes.

• Korean Journal of Artificial Intelligence
• /
• v.11 no.3
• /
• pp.29-34
• /
• 2023

Recently, the rapid development of artificial intelligence technology, many studies are being conducted to predict the risk of heart disease in order to lower the mortality rate of cardiovascular diseases worldwide. This study presents exercise or dietary improvement contents in the form of a software app or web to patients with cardiovascular disease, and cardiovascular disease through digital devices such as mobile phones and PCs. LR, LDA, SVM, XGBoost for the purpose of developing "Life style Improvement Contents (Digital Therapy)" for cardiovascular disease care to help with management or treatment We compared and analyzed cardiovascular disease prediction models using machine learning algorithms. Research Results XGBoost. The algorithm model showed the best predictive model performance with overall accuracy of 80% before and after. Overall, accuracy was 80.0%, F1 Score was 0.77~0.79, and ROC-AUC was 80%~84%, resulting in predictive model performance. Therefore, it was found that the algorithm used in this study can be used as a reference model necessary to verify the validity and accuracy of cardiovascular disease prediction. A cardiovascular disease prediction analysis algorithm that can enter accurate biometric data collected in future clinical trials, add lifestyle management (exercise, eating habits, etc.) elements, and verify the effect and efficacy on cardiovascular-related bio-signals and disease risk. development, ultimately suggesting that it is possible to develop lifestyle improvement contents (Digital Therapy).

• The Korea Journal of Herbology
• /
• v.24 no.1
• /
• pp.41-47
• /
• 2009

Objectives : The objective of this study was to examine the effects of P. oleracea into the HCl-ethanol induced gastritis in rats, and to isolate and determine the chemical compounds from P. oleracea. Methods : The rats were orally administered with crude extract or fractions or isolated compounds of P. oleracea 30 mins before the induction of gastric lesion by oral administration of HCl-ethanol. The gastric lesional area was measured using pixel counting software. Then the chemical compounds from P. oleracea was isolated and determined by LC-MS and NMR. Results : The inhibition effect of oral administration of crude extract of P. oleracea at a dose of 500 mg/kg in HCl-ethanol induced gastritis was similar to cimetidine. Then, aqueous fraction at a dose of 240 mg/kg exhibited the effects similar to cimetidine. Then, the aqueous fraction was further separated by MPLC and yielded four sub fractions. Among those sub fractions, agent II at a dose of 40 mg/kg possessed the strongest effect in the HCl-ethanol induced gastritis. The water fraction yielded-Uridine, Adenosine, Guanosine, which were characterized by Mass, 1H-NMR, 13C-NMR. Conclusions : This study suggest that a P. oleracea and its compounds showed potent efficacy on the development of HCl-ethanol induced gastritis. Thus, P. olaracea can be a potential natural resource for the management of gastritis although the mechanism of action involved in the treatment remains to be explored.

• International Journal of Computer Science & Network Security
• /
• v.23 no.1
• /
• pp.53-63
• /
• 2023

Many researchers are trying hard to minimize the incidence of cancers, mainly Gastric Cancer (GC). For GC, the five-year survival rate is generally 5-25%, but for Early Gastric Cancer (EGC), it is almost 90%. Predicting the onset of stomach cancer based on risk factors will allow for an early diagnosis and more effective treatment. Although there are several models for predicting stomach cancer, most of these models are based on unbalanced datasets, which favours the majority class. However, it is imperative to correctly identify cancer patients who are in the minority class. This research aims to apply three class-balancing approaches to the NHS dataset before developing supervised learning strategies: Oversampling (Synthetic Minority Oversampling Technique or SMOTE), Undersampling (SpreadSubsample), and Hybrid System (SMOTE + SpreadSubsample). This study uses Naive Bayes, Bayesian Network, Random Forest, and Decision Tree (C4.5) methods. We measured these classifiers' efficacy using their Receiver Operating Characteristics (ROC) curves, sensitivity, and specificity. The validation data was used to test several ways of balancing the classifiers. The final prediction model was built on the one that did the best overall.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.22 no.1
• /
• pp.182-190
• /
• 2009

Purpose: The pilot study was done for checking the efficacy of using functional soap, containing medicinal herbs on acne skin. Methods: 30 participants with acne skin was recruited. They used functional soap during 8 weeks. Before and after the study, we checked the KAGS(Korean Acne Grading System) grade, and compared those score. For examining the clinical effect, global evaluation was done by both investigator and participants. Results: KAGS grade decreased from 1.6316 to 1.4211(p value = 0.042). And the clinical global evaluation was improved. Conclusion: This pilot test showed that using functional soap, containing medicinal herbs would be one of treatment on acne skin.

• CELLMED
• /
• v.12 no.1
• /
• pp.5.1-5.8
• /
• 2022

Ābzan(sitz bath or hydration therapy) is one of the important and widely practised methods of regimenal therapy used for local evacuation or diversion of morbid humours described for various diseases in Unani system of medicine. Itis a type of bath in which hips and buttocks are immersed in water, either plain or medicated for therapeutic effects. Thus, it serves as an important and effective external mode of treatment. It has been successfully practised by Greeko-Arab physicians in the management of almost all types of gynaecological disorders like genital prolapse, leucorrhoea, pruritus vulvae, menstrual disorders, infertility, pelvic inflammatory diseases etc, but its efficacy has been proved in very few gynaecological diseases only. Hence, there is a need for systemic review to investigate the effectiveness of sitz bath in gynaecological disorders to generate scientific based evidence for the clinician as well as for common public. Based on the available literature, this review article suggests that the sitz bath has a scientific evidence-based effect in treating gynaecological diseases.

• Journal of Korean Neurosurgical Society
• /
• v.66 no.4
• /
• pp.356-381
• /
• 2023

Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the blood-brain-barrier, antigenic heterogeneity, and the highly immunosuppressive microenvironment of glioblastomas. The antitumor efficacy of endogenously activated effector cells induced by peptide or dendritic cell vaccines in particular has been insufficient to control tumors. Effector cells, such as T cells and natural killer (NK) cells can be expanded rapidly ex vivo and transferred to patients. The identification of neoantigens derived from tumor-specific mutations is expanding the list of tumor-specific antigens for glioblastoma. Moreover, recent advances in gene-editing technologies enable the effector cells to not only have multiple biological functionalities, such as cytokine production, multiple antigen recognition, and increased cell trafficking, but also relieve the immunosuppressive nature of the glioblastoma microenvironment by blocking immune inhibitory molecules, which together improve their cytotoxicity, persistence, and safety. Allogeneic chimeric antigen receptor (CAR) T cells edited to reduce graft-versus-host disease and allorejection, or induced pluripotent stem cell-derived NK cells expressing CARs that use NK-specific signaling domain can be a good candidate for off-the-shelf products of glioblastoma immunotherapy. We here discuss current progress and future directions for T cell and NK cell therapy in glioblastoma.

• Journal of Microbiology and Biotechnology
• /
• v.33 no.6
• /
• pp.823-830
• /
• 2023

Lactococcus lactis is a lactic acid bacterium and used in the dairy food industry. The ameliorating effects of Lactobacillus species on atopic dermatitis (AD) have been extensively studied, but the specific effect of L. lactis strains has not yet been investigated. In this study, the efficacy of L. lactis LB 1022, isolated from natural cheese, was evaluated using RAW 264.7, HMC-1 and HaCaT cell lines and an ovalbumin-sensitized AD mouse model. L. lactis LB 1022 exhibited nitric oxide suppression and anti-allergy and anti-inflammatory activity in vitro. Oral administration of L. lactis LB 1022 to AD mice significantly reduced the levels of IgE, mast cells, and eosinophils, and a range of T cell-mediated T helper Th1, Th2, and Th17-type cytokines under interleukin (IL)-10, transforming growth factor-β (TGF-β), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP). In addition, L. lactis LB 1022 treatment increased the concentration of short-chain fatty acids. Overall, L. lactis LB 1022 significantly modulated AD-like symptoms by altering metabolites and the immune response, illustrating its potential as candidate for use in functional food supplements to alleviate AD.

• Proceedings of the Korean Environmental Sciences Society Conference
• /
• 2020.10a
• /
• pp.221-221
• /
• 2020

Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases. In the present study, we found the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) during the wound closure. We found that the efficacy of hUCB-MSCs migration induced by CN was 1000-fold higher than that of curcumin powder. CN significantly increased the motility of hUCB-MSCs by activating c-Src, which is responsible for the phosphorylation of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). CN induced the expression levels of α-actinin-1, profilin-1 and filamentous-actin, as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In a mouse skin excisional wound model, we found that transplantation of UCB-MSCs pre-treated with CN enhances wound closure, granulation, and re-epithelialization at mouse skin wound sites. These results indicate that CN is a functional agent that promotes the mobilization of UCB-MSCs for cutaneous wound repair.