• Pediatric Infection and Vaccine
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• 제28권2호
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• pp.110-117
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• 2021

독성거대결장은 염증성 장질환, 감염성 대장염 등에 의해 발생하는 치명적인 합병증이다. 중증도에 따라 장절제부터 사망까지 예후가 나빠 조기 진단과 적절한 치료가 매우 중요한 질환이다. 하지만, 소아에서 그 유병률은 매우 낮으며 염증성 장질환과 같은 기저질환이 없이 발생할 경우 조기진단이 늦어질 수 있다. 기저질환이 없는 12세 남자가 하복부 통증과 발열, 그리고 혈변을 주소로 병원을 방문했다. 항생제 치료에도 불구하고 환자의 증상은 악화되었다. 3병일째 복부 컴퓨터단층촬영에서 횡행결장의 심각한 팽창이 관찰되었고 이를 통해 독성거대결장으로 진단할 수 있었다. 광범위항생제와 함께 정맥 스테로이드 치료를 시행하였으며, 환자의 증상은 호전되었다. 이후 대변 배양 검사에서 Salmonella enteritidis group D가 배양되었으며, 직장 내시경 검사를 통해 염증성 장질환을 배제할 수 있었다. 저자는 독성거대결장을 적절한 영상 검사를 통해 조기 진단하였고, 내과적으로 성공적인 치료를 하여 이에 대한 경험을 공유하고자 한다.

• 한국운동역학회지
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• 제32권1호
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• pp.17-23
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• 2022

Objective: The aim of this study was to investigate the effect Tiger-step walking on the movement of the lower extremities during walking. Method: Twenty healthy male adults who had no experience of musculoskeletal injuries on lower extremities in the last six months (age: 26.85 ± 3.28 yrs, height: 174.6 ± 3.72 cm, weight: 73.65 ± 7.48 kg) participated in this study. In this study, 7-segments whole-body model (pelvis, both side of thigh, shank and foot) was used and 29 reflective markers and cluster were attached to the body to identify the segments during the gait. A 3-dimensional motion analysis with 8 infrared cameras and 7 channeled EMG was performed to find the effect of tigerstep on uphill walking. To verify the tigerstep effect, a one-way ANOVA with a repeated measure was used and the statistical significance level was set at α=.05. Results: Firstly, Both Tiger-steps showed a significant increase in stance time and stride length compared with normal walking (p<.05), while both Tiger-steps shown significantly reduced cadence compared to normal walking (p<.05). Secondly, both Tiger-steps revealed significantly increased in hip and ankle joint range of motion compared with normal walking at all planes (p<.05). On the other hand, both Tiger-steps showed significantly increased knee joint range of motion compared with normal walking at the frontal and transverse planes (p<.05). Lastly, Gluteus maximus, biceps femoris, medial gastrocnemius, tibialis anterior of both tiger-step revealed significantly increased muscle activation compared with normal walking in gait cycle and stance phase (p<.05). On the other hand, in swing phase, the muscle activity of the vastus medialis, biceps femoris, tibialis anterior of both tiger-step significantly increased compared with those of normal walking (p <.05). Conclusion: As a result of this study, Tiger step revealed increased in 3d range of motion of lower extremity joints as well as the muscle activities associated with range of motion. These findings were evaluated as an increase in stride length, which is essential for efficient walking. Therefore, the finding of this study prove the effectiveness of the tiger step when walking uphill, and it is thought that it will help develop a more efficient tiger step in the future, which has not been scientifically proven.

• Journal of Ginseng Research
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• 제46권2호
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• pp.235-247
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• 2022

Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.

• 대한통합의학회지
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• 제10권4호
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• pp.175-185
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• 2022

Purpose : This study was conducted to determine the effect of Kegel exercise using a pressure biofeedback unit (PBU) for 2 weeks on maximum voluntary ventilation (MVV) and abdominal muscle thickness based on previous studies. Methods : The subjects of this study were 20 healthy female students in their 20s. Subjects were randomly assigned to two groups. Eleven subjects were assigned to the experimental group (EG) and 9 subjects were assigned to the control group (CG). Subjects measured MVV with a spirometer. In hooklying position, transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) of the dominant side were measured using ultrasound. For the measurement value, the average value of three times was adopted. After 2 weeks of intervention, the measurements were measured in the same way. In the EG, pelvic setting training using PBU was performed before Kegel exercise. The PBU was first placed at the waist in the Kegel exercise position and the starting pressure was set at 40 mmHg and adjusted to 60 mmHg through pelvic floor muscle contraction. After performing pelvic control using PBU, Kegel exercise was performed with 8 seconds of contraction, 8 seconds of relaxation, and 3 sets of 10 reps per set. A significance level of 𝛼=.05 was used to verify statistical significance. Results : In the variable of MVV, a significant increase was confirmed in the EG (p<.05). In the abdominal muscle thickness variable, significant increases were confirmed in IO and TrA in the EG (p<.05). In addition, a significant increase in IO was confirmed in the CG (p<.05). Significant increases in IO and TrA were confirmed between groups (p<.05). Conclusion : Based on the previous study, this study confirmed that Kegel exercise using a PBU had a positive effect on MVV and abdominal muscle thickness based on a 2-week intervention.

• 대한정형도수물리치료학회지
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• 제29권1호
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• pp.1-9
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• 2023

BACKGROUND: The purpose of this study was to find out which exercise is more effective for the activation of the trunk, when the suspension plank and modified bridge exercise are performed. Weakening of the trunk muscles can lead to secondary injuries such as back injuries. In order to prevent injury, trunk muscles must be strengthened, and representative trunk strengthening exercises include planks and bridges. Each has been developed with a modified method, but since there is no paper comparing which exercise is more effective for trunk muscle strength, it was written to compare the two exercises. METHODS: The subjects were a random sample of 30 healthy men who agreed to participate in the study. The subjects were divided into two groups of 15 people each, and the suspension plank and the modified bridge exercise were performed for six weeks. The thickness of the transverse abdominis (TrA), internal abdominal oblique (IO), external abdominal oblique (EO), rectus abdominis (RA), multifidus (MF) was measured before and after the exercise. The two groups were analyzed using an independent t-test and paired t-test to compare the muscle thickness and the difference before and after exercise. RESULTS: The trunk muscle thickness was increased in both groups with suspension plank and modified bridge exercise, and there was a statistically significant difference. When comparing the two groups, the suspension plank group also showed a significant difference in RA (p<.05). CONCLUSION: As a result of this study, suspension plank exercise can have a positive effect on activating the trunk muscles and strengthening the strength of RA. Therefore, it is considered that suspension plank exercise is a more effective intervention to strengthen trunk muscle than modified bridge exercise.

• 터널과지하공간
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• 제33권3호
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• pp.150-168
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• 2023

암석의 이방성 거동은 조암광물들의 방향성 배열과 미세균열의 분포 특성이 주된 원인이다. 특히, 퇴적암과 변성암은 횡등방성 강도 및 변형 특성을 또렷이 나타내는 경우가 많다. 그러므로 암석역학적 설계과정에서는 횡등방성 암석의 변형 및 파괴 특성을 정확하게 이해하는 것이 중요하다. 횡등방성 암석의 변형은 실내시험을 통해 측정할 수 있는 5개의 독립된 탄성정수를 이용하여 기술된다. 이 연구에서는 문헌에 보고된 실험자료를 이용하여 횡등방성 암석의 겉보기 탄성정수의 방향성 변화 특성을 분석하였다. 임의 방향으로 회전된 직각좌표계에서 겉보기 탄성정수 값을 효율적이고 체계적으로 계산하기 위해 Mehrabadi & Cowin의 구성방정식을 도입하였다. 문헌에 보고된 4개 횡등방성 암석을 선택하여 연약면의 방향 변화가 겉보기 탄성계수, 겉보기 전단 탄성계수, 겉보기 포아송비의 변화에 미치는 영향을 분석하였다. 이러한 분석 결과를 바탕으로 새로운 탄성정수 제약 조건식을 제안하였다. 제안한 제약 조건식을 만족하면 횡등방성 암석에서 겉보기 탄성정수의 방향성 변화는 직관적으로 예측되는 경향과 일치하게 된다.

• 대한토목학회논문집
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• 제30권3A호
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• pp.329-336
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• 2010

이 논문에서는 경간장이 30 m인 표준 PSC I 거더의 정착부 거동을 평가하기 위한 실험적 연구를 수행하였다. 현재 사용되고 있는 표준 PSC I 거더의 정착부 파열보강철근은 텐던 긴장으로 인한 단부 콘크리트의 응력흐름을 정확히 반영하지 못 한 채 설계되었고, 과대보강으로 인해 콘크리트 타설 시 작업성이 크게 떨어지고 있는 실정이다. 따라서 이 논문에서는 표준 PSC I 거더와 동일한 단면을 갖는 실험체 3개를 제작하여 인장실험을 수행하였다. 각 실험체의 파열보강철근은 100 mm, 200 mm, 300 mm 간격의 격자형으로 배근되었다. 실험결과, 파열균열 긴장력은 모든 실험체에서 설계 긴장력의 1.6배 내외로 나타났고, 파열균열은 정착단부 내부에서 수직방향으로 발생하였다. 또한 설계 긴장력의 2.7배까지 긴장력을 도입한 결과, 파열보강철근 간격이 300 mm인 실험체의 일부 수평방향 파열보강철근만 항복되었다. 따라서 표준 PSC I 거더의 정착부 파열보강철근은 도로교설계기준에서 제한하고 있는 최대 간격 300 mm를 만족시키는 것만으로도 파열력에 대한 안전성을 충분히 확보할 수 있음을 확인하였다.

• 대한토목학회논문집
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• 제28권6A호
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• pp.861-872
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• 2008

콘크리트충전 유리섬유 복합소재 튜브는 좋은 내구성과 심한 부식환경에서 견딜 수 있는 높은 화학적인 저항성으로 인해서 해양구조물에서 종종 사용된다. 이 연구는 원형 콘크리트충전 유리섬유 복합소재 튜브에 대한 다양한 실험을 수행하고 결과를 분석한다. 유리섬유 직포 수적층, 필라멘트 와인딩 적층을 압축을 받는 관의 바깥 튜브로 사용하는 경우에 고려해야 하는 몇 가지 측면을 실험 분석한다. 이 연구의 목적은 다음과 같다: (1) 유리섬유 층의 필라멘트 와인딩 각도의 효율성 검증 (2) GFRP 적층수가 강도 및 최고 변형률에 미치는 영향 평가 (3) 단부 재하조건이 구속효과 및 파괴양상에 미치는 영향 파악, 그리고 (4) 구속 상태에서 콘크리트의 응력-변형률 거동을 모사하는 해석적인 모델 제시이다. 세 가지 서로 다른 종류의 섬유 구성이 사용되었다: 직포층, ${\pm}45^{\circ}$ 필라멘트 와인딩 층, 그리고 ${\pm}85^{\circ}$ 필라멘트 와인딩 층. 각 층은 독립적으로 혹은 복합적으로 함께 사용되었다. 시편의 비 및 지름이 서로 다른 경우도 실험하였다. 총 27개의 GFRP 튜브 시편을 이용해서 인장 실험을 수행하였고, 66개의 콘크리트충전 GFRP튜브 시편을 이용해서 압축 실험을 수행하고 결과를 분석하였다. 구속상태의 콘크리트 응력-변형률 거동을 모사하는 해석적인 모델 및 영향계수를 제시하였다.

• Steel and Composite Structures
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• 제48권2호
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• pp.207-233
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• 2023

Steel-concrete composite box girder bridges are widely used in the construction of highway and railway bridges both domestically and abroad due to their advantages of being light weight and having a large spanning ability and very large torsional rigidity. Composite box girder bridges exhibit the effects of shear lag, restrained torsion, distortion and interface bidirectional slip under various loads during operation. As one of the most commonly used calculation tools in bridge engineering analysis, one-dimensional models offer the advantages of high calculation efficiency and strong stability. Currently, research on the one-dimensional model of composite beams mainly focuses on simulating interface longitudinal slip and the shear lag effect. There are relatively few studies on the one-dimensional model which can consider the effects of restrained torsion, distortion and interface transverse slip. Additionally, there are few studies on vehicle-bridge integrated systems where a one-dimensional model is used as a tool that only considers the calculations of natural frequency, mode and moving load conditions to study the dynamic response of composite beams. Some scholars have established a dynamic analysis model of a coupled composite beam bridge-train system, but where the composite beam is only simulated using a Euler beam or Timoshenko beam. As a result, it is impossible to comprehensively consider multiple complex force effects, such as shear lag, restrained torsion, distortion and interface bidirectional slip of composite beams. In this paper, a 27 DOF vehicle rigid body model is used to simulate train operation. A two-node 26 DOF finite beam element with composed box beams considering the effects of shear lag, restrained torsion, distortion and interface bidirectional slip is proposed. The dynamic analysis model of the coupled composite box girder bridge-train system is constructed based on the wheel-rail contact relationship of vertical close-fitting and lateral linear creeping slip. Furthermore, the accuracy of the dynamic analysis model is verified via the measured dynamic response data of a practical composite box girder bridge. Finally, the dynamic analysis model is applied in order to study the influence of various mechanical effects on the dynamic performance of the vehicle-bridge system.

• 대한토목학회논문집
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• 제26권5B호
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• pp.447-457
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• 2006

본 연구에서는 2차원 수심 적분된 흐름을 모의하기 위한 수치모델을 개발하였다. 유한요소법의 일종인 Characteristic Dissipative Galerkin(CDG) 기법을 적용시켜 천수방정식의 수치해를 구한다. 모델 검증을 위해서 1차원 도수문제에 적용하였고, 계산결과와 해석해를 비교할 때 만족스러운 결과를 얻었다. 정상파를 보이는 단면축소 수로에서의 흐름을 모의한 결과, 실험결과와 유사한 수면분포를 얻었다. 이러한 검증 과정을 통해서 본 수치모델을 이용하여 흐름영역이 갑작스럽게 변화하는 경우에도 모의 가능함을 알았다. 또한 $180^{\circ}$ 만곡수로에 적용한 결과, 만곡부 내측의 유속이 외측에 비해서 크며, 만곡부 내측의 수심은 외측에 비해서 작은 만곡부 흐름특성을 잘 나타내고 있다. 그러나 만곡수로에서 이차류에 의한 운동량의 횡방향 이송을 고려하지 않는 지배방정식의 한계점으로 인해서, 만곡부 끝단을 제외한 만곡부 전체에 걸쳐서 단면상의 종방향 유속이 일정한 분포를 보이고 있다.