• Journal of Plant Biotechnology
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• v.42 no.4
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• pp.277-283
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• 2015

Plant genome analyses, including Arabidopsis thaliana showed a large gene family of plant receptor kinases with various extracellular ligand-binding domain. Now intensively studies to understand physiological and cellular functions for higher plant receptor kinases in diverse and complex biological processes including plant growth, development, ligands perception including steroid hormone and plant-microbe interactions. Brassinosteroids (BRs) as a one of well know steroid hormone are plant growth hormones that control biomass accumulation and also tolerance to many biotic and abiotic stress conditions and hence are of relevance to agriculture. BRI1 receptor kinase, which is localized in plasma membrane in the cell sense BRs and it bind to a receptor protein known as BRASSINOSTEROID INSENSITIVE 1 (BRI1). Recently, we reported that BRI1 and its co-receptor, BRI1-ASSOCIATED KINASE (BAK1) autophosphorylated on tyrosine residue (s) in vitro and in vivo and thus are dual-specificity kinases. Other plant receptor kinases are also phosphorylated on tyrosine residue (s). Post-translational modifications (PTMs) can be studied by altering the residue modified by directed mutagenesis to mimic the modified state or to prevent the modification. These approaches are useful to not only characterize the regulatory role of a given modification, but may also provide opportunities for plant improvement.

• BMB Reports
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• v.47 no.11
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• pp.599-608
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• 2014

As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome proliferator-activated receptors (PPARs) are involved fundamentally in regulating energy homeostasis; thus, they have been considered attractive drug targets for addressing metabolic disorders. Among the PPARs, $PPAR{\gamma}$ is a master regulator of gene expression for metabolism, inflammation, and other pathways in many cell types, especially adipocytes. It is a physiological receptor of the potent anti-diabetic drugs of the thiazolidinediones (TZDs) class, including rosiglitazone (Avandia). However, TZDs have undesirable and severe side effects, such as weight gain, fluid retention, and cardiovascular dysfunction. Recently, many reports have suggested that $PPAR{\gamma}$ could be modulated by post-translational modifications (PTMs), and modulation of PTM has been considered as novel approaches for treating metabolic disorders with fewer side effects than the TZDs. In this review, we discuss how PTM of $PPAR{\gamma}$ may be regulated and issues to be considered in making novel anti-diabetic drugs that can modulate the PTM of $PPAR{\gamma}$.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.3
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• pp.176-184
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• 1998

We present a sequential factorization method using singular value decomposition (SVD) for recovering both the three-dimensional shape of an object and the motion of camera from a sequence of images. We employ paraperpective projection [6] for camera model to handle significant translational motion toward the camera or across the image. The proposed mthod not only quickly gives robust and accurate results, but also provides results at each frame becauseit is a sequential method. These properties make our method practically applicable to real time applications. Considerable research has been devoted to the problem of recovering motion and shape of object from image [2] [3] [4] [5] [6] [7] [8] [9]. Among many different approaches, we adopt a factorization method using SVD because of its robustness and computational efficiency. The factorization method based on batch-type computation, originally proposed by Tomasi and Kanade [1] proposed the feature trajectory information using singular value decomposition (SVD). Morita and Kanade [10] have extenened [1] to asequential type solution. However, Both methods used an orthographic projection and they cannot be applied to image sequences containing significant translational motion toward the camera or across the image. Poleman and Kanade [11] have developed a batch-type factorization method using paraperspective camera model is a sueful technique, the method cannot be employed for real-time applications because it is based on batch-type computation. This work presents a sequential factorization methodusing SVD for paraperspective projection. Initial experimental results show that the performance of our method is almost equivalent to that of [11] although it is sequential.

• Journal of the Korean Society of Safety
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• v.22 no.1 s.79
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• pp.1-6
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• 2007

In the field of the system dynamics related to the vibration characteristics, there are lots of examples introduced for the translational system, however the analysis of the torsional systems such as driveline in the automobile is rare compared with the translational system. The purpose of this study is to show the simple concepts for the torsional system analysis and explain how to adjust the mathematical methods for the geared motions, which can be applied to the driveline of the automobile. In order to do it, there are several systematical approaches described about how the sub-system motions can be understood with the mathematical descriptions. Based upon this fundamental study, several torsional system modeling methods will be suggested. Therefore, the characteristics of the torsional system and the gear motions will be explained, which can be adjusted in a further study as a next step.

• Journal of Korean Academy of Nursing Administration
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• v.23 no.2
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• pp.111-117
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• 2017

Getting evidence in to practice tends to focus on strategies, theories and studies that aim to close the gap between research knowledge and clinical practice. The evidence to practice gap is more about systems than individual clinician decision making. The absence of evidence for administration and management in the organization of healthcare is persistent. Teaching nurses and providing evidence as the solution to evidence-based healthcare is no longer axiomatic. Previous studies have concluded that unit level strategies integrate multi-professional teams with organizational needs and priorities. This 'best fit' approach that characterizes how healthcare is structured and delivered. The published literature shows that increased readiness for change is aligned with integrated approaches informed by conceptual models. The Joanna Briggs Collaboration is the largest global collaboration to integrate evidence within a theory informed model that brings together academic centres, hospitals and health systems for evidence synthesis, transfer and implementation. The best approaches to implementation are tailored to local culture and context, benchmark against international evidence, combine a theory informed model and stakeholder perspectives to improve the structure and processes of health care policy and practice.

• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.1
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• pp.13-16
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• 2016

Mucolipidosis (ML) II/III are autosomal recessive diseases caused by deficiency of post-translational modification of lysosomal enzymes. The mannose-6-phosphate (M6P) residue in lysosomal enzymes synthesized by N-acetylglucosamine 1-phosphotransferase (GlcNAc-phosphotransferase) serves as recognition marker for trafficking in lysosomes. GlcNAc-phosphotransferase is encoded by GNPTAB and GNPTG. Mutations in GNPTAB cause severe ML II alpha/beta and the attenuated ML III alpha/beta. Whereas mutations in GNPTG cause the ML III gamma, the attenuated type of ML III variant. For the diagnostic approaches, increased urinary oligosaccharides excretion could be a screening test in clinically suspicious patients. To confirm the diagnosis, instead of measuring the activity of GlcNAc phosphotransferase, measuring the enzymatic activities of different lysosomal hydrolases are useful for diagnosis. The activities of several lysosomal hydrolases are decreased in fibroblasts but increased in serum of the patients. In addition, the sequence analysis of causative gene is warranted. Therefore, the confirmatory diagnosis requires a combination of clinical evaluation, biochemical and molecular genetic testing. ML II/III show complex disease manifestations with lysosomal storage as the prime cellular defect that initiates consequential organic dysfunctions. As there are no specific therapy for ML to date, understanding the molecular pathogenesis can contribute to develop new therapeutic approaches ultimately.

• Structural Engineering and Mechanics
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• v.3 no.2
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• pp.121-133
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• 1995

It is well known that two-dimensional simplified third-order theories satisfy the layer interface continuity of transverse shear strains, thus these theories violate the continuity of transverse shear stresses when two consecutive layers differ either in fibre orientation or material. The third-order theories considered herein involve four/or five dependent unknowns in the displacement field and satisfy the condition of vanishing of transverse shear stresses at the bounding planes of the plate. The objective of this investigation is to examine (i) the flexural response prediction accuracy of these third-order theories compared to exact elasticity solution (ii) the effect of layer interface continuity conditions on the flexural response. To investigate the effect of layer interface continuity conditions, three-dimensional elasticity solutions are developed by enforcing the continuity of different combinations of transverse stresses and/or strains at the layer interfaces. Three dimensional twenty node solid finite element (having three translational displacements as degrees of freedom) without the imposition of any of the conditions on the transverse stresses and strains is also employed for the flexural analysis of the laminated plates for the purposes of comparison with the above theories. These shear deformation theories and elasticity approaches in terms of accuracy, adequacy and applicability are examined through extensive numerical examples.

• International Journal of Aeronautical and Space Sciences
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• v.14 no.1
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• pp.11-18
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• 2013

Human spaceflight experience in extra-vehicular activity (EVA) is limited to two regimes: the micro-gravity environment of Earth orbit, and the lunar surface environment at one-sixth of Earth's gravity. Future human missions to low-gravity bodies, including asteroids, comets, and the moons of Mars, will require EVA techniques that are beyond the current experience base. In order to develop robust approaches for exploring these small bodies, the dynamics associated with human exploration on low-gravity surface must be characterized. This paper examines the translational and rotational motion of an astronaut on the surface of a small body, and it is shown that the low-gravity environment will pose challenges to the surface mobility of an astronaut, unless new tools and EVA techniques are developed. Possibilities for addressing these challenges are explored, and utilization of the International Space Station to test operational concepts and hardware in preparation for a low-gravity surface EVA is discussed.

• Journal of Korean Neurosurgical Society
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• v.57 no.6
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• pp.428-431
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• 2015

Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain insights regarding moyamoya disease pathogenesis. We briefly present the recent accomplishments in regard to the studies of vascular progenitor cells in moyamoya disease.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.822-826
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• 2008

A linkage mechanism is a device to convert an input motion into a desired output motion. Traditional linkage mechanism designs are based on trial and error approaches so that size or shape changes of an original mechanism often result in improper results. In order to resolve these problems, an improved automatic mechanism synthesis method that determines the linkage type and dimensions by using an optimization method during the synthesis process has been proposed. For the synthesis, a planar linkage is modeled as a set of rigid blocks connected by zero-length translational springs with variable stiffness. In this study, the sizes of rigid blocks were also treated as design variables for more general linkage synthesis. The values of spring stiffness and the size of rigid block yielding a desired output motion at the end-effecter are found by using an optimization method.