• BMB Reports
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• v.57 no.6
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• pp.273-280
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• 2024

Cancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different morphological states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a theory derived from tissue biopsy, which explains the acquisition of EMT transcription factors (TFs) that convey mesenchymal features during cancer migration and invasion. On the other hand, adherent-to-suspension transition (AST) is an emerging theory derived from liquid biopsy, which describes the acquisition of hematopoietic features by AST-TFs that reprograms anchorage dependency during the dissemination of circulating tumor cells (CTCs). The induction and plasticity of EMT and AST dynamically reprogram cell-cell interaction and cell-matrix interaction during cancer dissemination and colonization. Here, we review the mechanisms governing cellular plasticity of AST and EMT during the metastatic cascade and discuss therapeutic challenges posed by these two morphological adaptations to provide insights for establishing new therapeutic interventions.

• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.1
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• pp.21-39
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• 2016

Although the demand for IT outsourcing (ITO) has increased recently because of the recent recession, concerns about business discontinuity in the transition phase cause companies to hesitate to adopt ITO. Therefore, a guideline to improve the prospects is needed. However, studies on the success factors of the transition phase in ITO are lacking. In this study, we develop an expert hierarchical value map (HVM) of the success of the transition phase in ITO by using cognition scientific methodologies. We empirically verify how success factors affect the success of the transition phase. Specifically, we derive an HVM of main stakeholders by using in-depth interviews and approaches, such as repertory grid technique (RGT) and laddering, based on means-end chain theory. We validate the success factors empirically through a bipolar analysis of RGT. Finally, we determine the most important cluster of success factors through cluster analysis.

• Journal of Family Resource Management and Policy Review
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• v.19 no.1
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• pp.111-138
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• 2015

The purpose of this study was to understand the lived experiences of grandmothers and family in transition. Grandmothers in transition means grandmothers who had married children at least one even if there are no grandchildren yet. The data for this study came from 20 grandmothers in transition of 5 focus group(each 4 persons) interview. 9 of them was pre-grandmother without grandchildren yet, 11 was grandmother who had grandchildren. The result of this study revealed that the meaning of grandmotherhood. Dynamics of family in transition around supporting child care represent change of family relations. It didn't means 'empty-nest' model of foreign theory. The Absolute quantity of intergeneral exchange and conflict extended as three generational families.

• Journal of Families and Better Life
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• v.17 no.3
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• pp.1-16
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• 1999

This study focuses on the beginning of transition to parenthood expectation and applies the exchange theory in order to examine reward and cost of transition to parenthood expectation and picks up the main cause effecting it. This study conducted structured questionnaires to total 330 first pregnant women and examined descriptive statistics and t-test F-test analysis by using collected data. And here are the result of research. First the transition to parenthood expectation expected rewards much more than costs and had much importance on individual aspects in parenthood. The more were they aged hardly educated and housewives the higher did they showed expectation of reward. The less did they have high education the more did they expect costs of the transition to parenthood expectation. Second to examined the reward/cost of transition to parenthood expectation according to martial satisfaction the more did they have martial satisfaction the more did they expectation of the rewa ds on transition to parenthood expectation. On the contrary the more did they respect from husbands the less did they cost of transition to parenthood expectation. This study would be helpful to lead family life having childbirth to the positive way be examining the process from childbirth plan to delivery. Also it will be applicable to seek for the methods to help would-be parents as basic data on material on education about transition to parenthood.

• Bulletin of the Korean Chemical Society
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• v.23 no.2
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• pp.337-345
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• 2002

The equilibrium structures for the ground and transition states of $C_7H_7^+$ isomers have been investigated using sophisticated ab initio quantum mechanical techniques with various basis sets. The structures of tropyrium and benzyl cations have been fully optimized at the DZP CCSD(T) levels of theory. And the structures of o-, m-and p-tolyl cations are optimized fully up to the DZ CCSD(T) levels of theory. The geometries for the transition states between three isomers of tolyl cations have been optimized up to DZP CISD level of theory. The SCF harmonic vibrational frequencies for tropylium, benzyl, and three isomers of tolyl cations are all real numbers, which confirm the potential minima and each unique imaginary vibrational frequencies for TS1 and TS2 confirm the true transition states. The relative energy of the benzyl cation with respect to the tropyrium cation is predicted to be 28.5 kJ/mol and is in good agreement with the previous theoretical predictions. The 0 K heats of formation, ${\Delta}H^{\circ}_{f0}$, have been predicted to be 890, 1095, 1101, and 1110 kJ/mol for tropylium, ortho-, meta-, and para-tolyl cations by taking the experimental value of 919 kJ/mol for the benzyl cation as the base level. The relative stability between tolyl cations is in the order of ortho

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.5
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• pp.407-419
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• 2008

In this study, the transition Reynolds number of compressible axi-symmetric sharp cone boundary layer is predicted by using a linear stability theory and the -method. The compressible linear stability equation for sharp cone boundary layer was derived from the governing equations on the body-intrinsic axi-symmetric coordinate system. The numerical analysis code for the stability equation was developed based on a second-order accurate finite-difference method. Stability characteristics and amplification rate of two-dimensional second mode disturbance for the sharp cone boundary layer were calculated from the analysis code and the numerical code was validated by comparing the results with experimental data. Transition prediction was performed by application of the -method with N=10. From comparison with wind tunnel experiments and flight tests data, capability of the transition prediction of this study is confirmed for the sharp cone boundary layers which have an edge Mach number between 4 and 8. In addition, effect of wall cooling on the stability of disturbance in the boundary layer and transition position is investigated.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07a
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• pp.486-489
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• 2002

Temperature(T) dependence of the sheet resistance( $R_{$\square$}$) has been investigated on the c-axis oriented thin films of the (Bi2212/Bi2201) mixed crystal with different molar fractions. The $R_{$\square$}$-T superconducting characteristic deteriorated with reduction of the Bi2212 fraction, and almost disappears at 48 mol% where a superconductor-to-insulator transition took place, with the resistance on the normal state, RN, reaching 4.l㏀ at 80 K. This $R_{N}$ value is close to the universal quantum number, h/(2e)$^2$≡6.5㏀ predicted by the Kosterlitz-Thouless(KT) transition theory. The $R_{$\square$}$-T characteristics of the 48 mol% thin film can be elucidated as a competitive process of KT transition brought about by charge or vortex in the two-dimensional layer structure.e.

• Transactions on Electrical and Electronic Materials
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• v.3 no.2
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• pp.20-23
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• 2002

Temperature (T) dependence of the sheet resistance (R$\_$$\square$/) has been investigated an the c-axis oriented thin films of the (Bi2212/Bi2201) mixed crystal with different molar fractions. The R$\_$$\square$/-T superconducting characteristic deteriorated with reduction of the Bi2212 fraction, and almost disappears at 48 mol% where a superconductor-to-insulator transition too k place, with the resistance on the normal state, R$\_$N/, reaching 4.1 kΩka at 80 K. This R$\_$$\square$/ value is close to the universal quantum number, h/(2e)$_2$≡ 6.5 kΩ predicted by the Kosterlitz-Thouless (KT) transition theory. The R$\_$$\square$/-T characteristics of the 48 mol% thin film can be elucidated as a competitive process of KT transition brought about by charge or vortex in the two-dimensional layer structure.

• Industrial Engineering and Management Systems
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• v.10 no.4
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• pp.238-246
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• 2011

Given a directed graph, we can determine how the user's preference moves from one product item to another. In this graph called "preference transition network", each node represents the product item while its edge pointing to the other nodes represents the transition of user's preference. However, with the large number of items make the network become more complex, unclear and difficult to be interpreted. In order to address this problem, this paper proposes a visualization technique in preference transition analysis based on recency and frequency. By adapting these two elements, the semantic meaning of each item and its transition can be clearly identified by its different types of node size, color and edge style. The experiment in a sales data has shown the results of the proposed approach.

• The Journal of Art Theory & Practice
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• no.7
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• pp.65-87
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• 2009