• Molecules and Cells
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• v.23 no.3
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• pp.331-339
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• 2007

It has been suggested that the structure and function of nuclear receptors are evolutionally conserved. Here, we compare the molecular functions of the nile tilapia (Oreochromis niloticus) small heterodimer partner (nSHP/NR0B2) and the Dosage-sensitive sex reversal AHC critical region on X chromosome gene 1 (nDAX-1/NR0B1) with those of human SHP and DAX-1 (hSHP and hDAX-1, respectively). We found that, upon transient cotransfection of human cells, nDAX-1 repressed the activity of tilapia SF-1 (nSF-1) but not that of human SF-1, although the physical interaction with human SF-1 was retained. Similarly, nSHP repressed the activity of nSF-1, whereas hSHP did not, pointing to divergent evolution of SHP/SF-1 in fish and human. We thus propose that the repressive functions of SHP and DAX-1 have been conserved in fish and mammals although with different transcriptional targets and mechanisms. These differences provide new insights into the physiological diversification of atypical orphan nuclear receptors during vertebrate evolution.

• Structural Engineering and Mechanics
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• v.51 no.4
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• pp.685-705
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• 2014

This paper presents a new formulation for forward scalar wave simulations in semi-infinite media. Perfectly-Matched-Layers (PMLs) are used as a wave absorbing boundary layer to surround a finite computational domain truncated from the semi-infinite domain. In this work, a hybrid formulation was developed for the simulation of scalar wave motion in two-dimensional PML-truncated domains. In this formulation, displacements and stresses are considered as unknowns in the PML domain, while only displacements are considered to be unknowns in the interior domain. This formulation reduces computational cost compared to fully-mixed formulations. To obtain governing wave equations in the PML region, complex coordinate stretching transformation was introduced to equilibrium, constitutive, and compatibility equations in the frequency domain. Then, equations were converted back to the time-domain using the inverse Fourier transform. The resulting equations are mixed (contain both displacements and stresses), and are coupled with the displacement-only equation in the regular domain. The Newmark method was used for the time integration of the semi-discrete equations.

• Journal of the Semiconductor & Display Technology
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• v.8 no.3
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• pp.31-37
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• 2009

This paper presents one and two dimensional simulation results with discontinuous features (shocks) of capacitively coupled rf plasmas. The model consists of the first two and three moments of the Boltzmann equation for the ion and electron fluids respectively, coupled to Poisson's equation for the self-consistent electric field. The local field and drift-diffusion approximations are not employed, and as a result the charged species conservation equations are hyperbolic in nature. Hyperbolic equations may develop discontinuous solutions even if their initial conditions are smooth. Indeed, in this work, secondary electron emission is shown to produce transient electron shock waves. These shocks form at the boundary between the cathodic sheath (CS) and the quasi-neutral (QN) bulk region. In the CS, the electrons emitted from the electrode are accelerated to supersonic velocities due to the large electric field. On the other hand, in the QN the electric field is not significant and electrons have small directed velocities. Therefore, at the transition between these regions, the electron fluid decelerates from a supersonic to a subsonic velocity in the direction of flow and a jump in the electron velocity develops. The presented numerical results are consistent with both experimental observations and kinetic simulations.

• Animal cells and systems
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• v.7 no.1
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• pp.63-68
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• 2003

Until recently, interest in human complement receptor type I (CR1) has focused on immune complex processing, which contributed to our understanding of regulatory mechanism of complement activation. However, the promoter structure and transcriptional regulation of human CR1 gene has not been clear. To study the unique regulation of human CR1 gene expression, we assessed promoter activity of the $5^1$-flanking region of human CR1 gene using transient transfection and gel mobility shift assays. In this study we demonstrated that NF-Y binds to the inverted CCAAT element and that the functional interaction with protein(s) which bind to the GC-rich motif may be necessary for optimal transcription of human CR1 gene. We also show that sequence elements which located at-95/58 and +45/+50 are important for optimal transcription of CR1 gene.

• Journal of the Korean Society of Industry Convergence
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• v.22 no.3
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• pp.365-371
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• 2019

Recently, the demonstration and research on the power transmission using high voltage DC such as HVDC(High Voltage DC), Smart Grid, DC transmission and distribution have been actively conducted. In order to control the power converter in high-voltage DC power transmission system, SMPS(Switching Modulation Power Supply) for power converter control using high-voltage DC input is essential. However, the demand for high-pressure SMPS is still low, so the development is not enough. In the low-output SMPS using the high-voltage input, it is difficult to achieve high efficiency due to the switching transient loss especially at light load. In this paper, we propose a new switching scheme for high power SMPS control for low output power. The proposed method can provide better efficiency increase effect in the light load region compared to the existing PWM method. To verify the feasibility of the proposed method, a 40 W SMPS for HVDC MMC(Modulation Multi-level Converter) was designed and verified by simulation.

• Nuclear Engineering and Technology
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• v.50 no.7
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• pp.1173-1183
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• 2018

Transient fluid velocity and pressure fields in a pressurized water reactor (PWR) steam generator (SG) secondary side during the blowdown period of a feedwater line break (FWLB) accident were numerically simulated employing the saturated water flashing model. This model is based on the assumption that compressed water in the SG is saturated at the beginning and decompresses into the two-phase region where saturated vapor forms, creating a mixture of steam bubbles in water by bulk boiling. The numerical calculations were performed for two cases of which the outflow boundary conditions are different from each other; one is specified as the direct blowdown discharge to the atmosphere and the other is specified as the blowdown discharge to an extended calculation domain with atmospheric pressure on its boundary. The present simulation results obtained using the two different outflow boundary conditions were discussed through a comparison with the predictions using a simple non-flashing model neglecting the effects of phase change. In addition, the applicability of each of the non-flashing water discharge and saturated water flashing models for the confirmatory assessments of new SG designs was examined.

• Wind and Structures
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• v.32 no.5
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• pp.453-469
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• 2021

Snow accumulation on the road frequently induces a big traffic problem in the cold snowy region. Accurate prediction on snow distribution is fundamental for solving drifting snow disasters on roads. The present study adopts the transient method to simulate the wind-induced snow distribution on embankment based on the mixture multiphase model and dynamic mesh technique. The simulation and field measurement are compared to confirm the applicability of the simulation. Furthermore, the process of snow accumulation is revealed. The effects of friction velocity and snow concentration on snow accumulation are analyzed to clarify its mechanism. The results show that the simulation agrees well with the field measurement in trends. Moreover, the snow accumulation on the embankment can be approximately divided into three stages with time, the snow firstly deposited on the windward side, then, accumulation occurs on the leeward side which induced by the wake vortex, finally, the snow distribution reaches an equilibrium state with the slope of approximately 7°. The friction velocity and duration have a significant influence on the snow accumulation, and the vortex scale directly affected the snow deposition range on the embankment leeward side.

• Journal of Audiology & Otology
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• v.23 no.2
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• pp.89-95
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• 2019

Background and Objectives: Knowing the ototoxic potential of the agents used in medical treatments is important for the protection of hearing. Although we have knowledge regarding some effects of dexmedetomidine, which is an anesthetic-sparing drug, its influence over the hearing system has never been studied and is obscure yet. The aim of this study is to determine the effects of intravenous dexmedetomidine application during sevoflurane anesthesia on otoacoustic emissions (OAEs). Subjects and Methods: This prospective randomized study was performed on 60 patients (34 male, 26 female, mean age: 30.6±9.2 years) who were scheduled for an elective surgery under general anesthesia and the patients were enrolled and randomly divided into 2 groups. They received dexmedetomidine (Group D) or Saline (Group S) infusion during a standardized Sevoflurane anesthesia. Transient and distortion product OAEs were measured preoperatively and postoperatively (24th hour). OAE results were compared within and between groups. Results: In group D postoperative OAEs were lower than preoperative OAEs and postoperative levels of group S, especially at low frequencies (p<0.05). Conclusions: Dexmedetomidine infusion affects the micromechanical function of cochlea especially in the low-frequency region. Dexmedetomidine should be carefully used during general anesthesia to avoid its probable harmful effects on cochlear micromechanics.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.2
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• pp.48-58
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• 1995

A micro positioning system using piezoelectric actuators have very wide application region such as ultra-precision machine tool, optical device, measurement systen. In order ro keep a high precision displacement resolution, they use a position sensor and feedback the error. From the practical point of view, a high-resolution displacement sensor system are very expensive and difficult to guarantee such sensitive sensors work properly in the hard opera- tion environment of industry. In this study, a micro-positioning grinding table which does not require position sensor but uses piezoelectric voltage feedback, has been developed. It is driven by hystersis-considering reference input voltage which calculated from computer and then uses actuator/sensor characteristics of piezoelectric materials. From the result of experiments we proved a fast and stable response of micro-positioning system and suggested efficient technique to control the piezoelectric actuator. And through grinding experiments, it is revealed that a characteristics of ground surfaces transient to plastic deformation as extremely small depth of grinding.

• Korean Journal of Audiology
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• v.23 no.2
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• pp.89-95
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• 2019

Background and Objectives: Knowing the ototoxic potential of the agents used in medical treatments is important for the protection of hearing. Although we have knowledge regarding some effects of dexmedetomidine, which is an anesthetic-sparing drug, its influence over the hearing system has never been studied and is obscure yet. The aim of this study is to determine the effects of intravenous dexmedetomidine application during sevoflurane anesthesia on otoacoustic emissions (OAEs). Subjects and Methods: This prospective randomized study was performed on 60 patients (34 male, 26 female, mean age: 30.6±9.2 years) who were scheduled for an elective surgery under general anesthesia and the patients were enrolled and randomly divided into 2 groups. They received dexmedetomidine (Group D) or Saline (Group S) infusion during a standardized Sevoflurane anesthesia. Transient and distortion product OAEs were measured preoperatively and postoperatively (24th hour). OAE results were compared within and between groups. Results: In group D postoperative OAEs were lower than preoperative OAEs and postoperative levels of group S, especially at low frequencies (p<0.05). Conclusions: Dexmedetomidine infusion affects the micromechanical function of cochlea especially in the low-frequency region. Dexmedetomidine should be carefully used during general anesthesia to avoid its probable harmful effects on cochlear micromechanics.