• Animal cells and systems
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• v.1 no.4
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• pp.647-651
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• 1997

We have used a transient expression assay employing Drosophila S2 cells to study the transcriptional repression activity of a 27 amino acid residue-long repression domain FS1 which was generated by a frame-shift in a pair-rule gene, even-skipped of Drosophila melanogaster. In an attempt to define a minimal requirement for the repression activity, we constructed a series of truncation mutant forms of the FS1, fused to a heterologous GAL4 DNA-binding domain, and measured their activities. All of the mutant forms, including the GAL4-FS1 (5-23) which retains the smallest number (19) of amino acid residues of FS1, were found to repress an initiator, a minimal TATA-lacking promoter, in a GAL4-binding-site-dependent manner. These findings suggest that a 19 amino acid residue-long region, rich in proline and leucine residues, is a transcriptional repression domain and may interact with the general transcription machinery.

• Journal of Astronomy and Space Sciences
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• v.14 no.1
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• pp.80-86
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• 1997

High energy particles in the earth's radiation belts cause transient and long term effects on electronic materials, devices, and integrated circuits on board the satellites. Hence, it is very important to have the information on the space radiation environment and the damage on the electronics caused by the se high energy particles. One of the radiation monitor devices frequently used in space is RADFET, a specially designed MOSFET with a thick gate oxide region. The present study focuses on the calibration of RADFET TOT500 using the $Co^{60}{\gamma}-ray$ source. The result shows that the response of RADFET is very sensitive to the change of temperature. The peculiar behavior observed in the TDE (Total Dose Experiment) on board the KITSAT-1 is identified as the thermal effect due to the change in the eclipse rate of the satellite.

• Korean Journal of Biological Psychiatry
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• v.3 no.1
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• pp.115-120
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• 1996

To investigate characteristic drug effects on the genetic basis, the authors administered haloperidol- the $D_2$ antagonist- and clozapine -the atypical antipsychotics with few extra- pyramidal side effects- to the rats. Then, we edobtain brain specimen from the striatum, prefrontal cortex, and cortical region and compared the degree of c-fos expression. The results are 1) haloperidol was found to produce a rapid and transient induction of dos mRNA expression in striatum as compared with cortex and prefrontal area. 2) clozapine was found to produce rapid induction of c-fos mRNA in striatum and prefrontal area. From these data, we can concluded that the mechanism of action of haloperidol is different from the mechanism of clozapine in gene expression.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1370-1375
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• 2004

This article investigates the heat transfer characteristics in a RTA system for LCD manufacturing and suggests a way to evaluate the quality of a poly-Si film from the thin film optics analysis. The transient and one-dimensional conductive/radiative heat transfer equation considering wave interference effect is solved to predict surface temperatures of thin films. In dealing with radiative heat transfer, a one-dimensional two-flux method is used and the ray tracing method is also utilized to account for the wave interference effects. It is assumed that each interface is assumed diffusive but the spectral radiative properties are included. It is found that the selective heating region exists for various wavelengths and consequently may contribute to heat the poly-Si film. Using the formalism of the characteristic transmission matrix, the lumped structure reflectance, transmittance, and absorptance are calculated and they are compared with experimental data of the poly-Si film during the SPC process via the FE-RTA (Field-Enhanced RTA) technology.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.499-505
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• 2004

A Propulsion System of the CRW(Canard Rotor Wing) type UAV(Unmanned Aerial Vehicle) was composed of the turbojet engine to generate the propulsive exhaust gas, and the duct system including straight bent ducts, tip-jet nozzles, a master valve and a variable main nozzle for three flight modes such as lift/landing mode, low speed transition flight mode and high speed forward flight mode. In this study, in order to operate safely the propulsion system, the dynamic Performance behavior of the system was modeled and simulated using the SIMULIN $K^{ }$, which is the user-friendly GUI type dynamic analysis tool provided by MATLA $B^{ }$. In the transient performance model, the inter-component volume model was used. The performance analysis using the developed models was performed at various flight condition, valve angle positions and fuel flow schedules, and these results could set the safe flight mode transition region to satisfy the inlet temperature overshoot limitation as well as the compressor surge margin. Performance analysis results using the SIMULIN $K^{ }$ performance program were compared with them using the commercial program GSP.m GSP.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.186-191
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• 2004

The reactive flowfield of the transverse injecting combustor has been studied using Euler-Lagrange method in order to develop an efficient solution procedure for the understanding of liquid spray combustion in the transverse injecting combustor which has been widely used in ramjets and turbojet afterburners. The unsteady two-dimensional gas-phase equations have been represented in Eulerian coordinates and the liquid-phase equations have been formulated in Lagrangian coordinates. The gas-phase equations based on the conservation of mass, momentum, and energy have been supplemented by combustion. The vaporization model takes into account the transient effects associated with the droplet heating and the liquid-phase internal circulation. The droplet trajectories have been determined by the integration of the Lagrangian equation in the flow field obtained from the separate calculation without considering the iterative effect between liquid and gas phases. The reported droplet trajectories had been found to deviate from the initial conical path toward the flow direction in the very end of its lifetime when the droplet size had become small due to evaporation. The integration scheme has been based on the TEACH algorithm for gas-phase equation, the second order Runge-Kutta method for liquid-phase equations and the linear interpolation between the two coordinate systems. The calculation results has shown that the characteristics of the droplet penetration and recirculation have been strongly influenced by the interaction between gas and liquid phases in such a way that most of the vaporization process has been confined to the wake region of the injector, thereby improving the flame stabilization properties of the flowfield.

• KIEE International Transactions on Electrophysics and Applications
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• v.5C no.6
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• pp.233-241
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• 2005

The present model of a SF6 arc accounts for the copper vapour contamination from the electrodes inside a Laval nozzle of a circuit breaker. Steady state simulations have been done for the arc with electrode gap of 60mm and DC electric current of 500A, 1000A and 1500A for both cases with and without copper contamination. The effects of electrode polarity are considered for the arc current of 1000A. It was found out that evaporation of copper from the anode results in a cooling of the arc in a region close to the electrodes. The electrical potential across the electrodes is not sensitive to the presence of copper vapour, typically less than $4\%$ difference. Transient analysis has been done in order to obtain the arc properties at current zero. The arc current is increased linearly from -1000 to 0A when the upstream electrode is cathode with constant dI/dt of $27.0A/{\mu}s$ (or decreased linearly from 1000 to 0A when upstream electrode is anode). It has been predicted that the presence of copper vapour reduces the interruption capability of the breaker.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.05c
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• pp.213-216
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• 2003

Recently a new high power device GCT (Gate Commutated Turn-off) thyristor has been successfully introduced to high power converting application areas. GCT thyristor has a quite different turn-off mechanism to the GTO thyristor. All main current during turn-off operation is commutated to the gate. Therefore, IGCT thyristor has many superior characteristics compared with GTO thyristor; especially, snubberless tum-off capacibility and higher turn-on capacibility. The basic structure of the GeT thyristor is same as that of the GTO thyristor. This makes the blocking voltage higher and controllable on-state current higher. The turn-off characteristic of the GCT thyristor is influenced by the minority carrier lifetime and the performance of the gate drive unit. In this paper, we present turn-off characteristics of the 2.5kV PT(Punch-Through) type GCT as a function of the minority carrier lifetime and variation of the doping profile shape of p-base region.

• International Journal of Automotive Technology
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• v.6 no.2
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• pp.133-139
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• 2005

In this study, a three-dimensional transient simulation with a knock model was performed to predict knock occurrence and autoignition site in a heavy-duty LPG engine. A FAE (Flame Area Evolutoin) premixed combustion model was applied to simulate flame propagation. The coefficient of the reduced kinetic model was adjusted to LPG fuel and used to simulate autoignition in the unburned gas region. Engine experiments using a single-cylinder research engine were performed to calibrate the reduced kinetic model and to verify the results of the modeling. A pressure transducer and a head-gasket type ion-probe circuit board were installed in order to detect knock occurrences, flame arrival angles, and autoignition sites. Knock occurrence and position were compared for different piston bowl shapes. The simulation concurred with engine experimental data regarding the cylinder pressure, flame arrival angle, knock occurrence, and autoignition site. Furthermore, it provided much information about in-cylinder phenomena and solutions that might help reducing the knocking tendency. The knock simulation model presented in this paper can be used for a development tool of engine design.

• Journal of Photoscience
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• v.9 no.3
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• pp.41-43
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• 2002

PDT-mediated cyototoxicity basically depends on the penetrated light-dose into the tumor tissue. This limits the efficiency of PDT to the superficial tumor region typically less than 1 cm. The localized photochemical generation of reactive oxygen species, including singlet oxygen is known to increase expression of assortment of early response genes including heat shock protein. In order to increase PDT cytotoxicity in the treatment of solid tumor, it is desirable to combine PDT with other therapeutic effects. In this preliminary study we evaluated enhanced cytotoxicity from the PDT-mediated expression of thymidine kinase in a transfected tumor cell line. Two types of photo sensitizers, a hematoporphyrin derivative(Photogem, Russia) and aluminium sulphonated phthalocyanine(Photosense, Russia) were used to evaluate the overexpression of hsp-70 in PDT-treated cell. Transient increase of hsp-70 was observed at 6-8 hrs later following irradiation in the photosense-treated cell whereas it was not observed in Photogem-treated cell. In the presence of ganciclovia, transfected cell showed a 17％ increase in the cytotoxicity compared to the PDT only cell.