• Asian Journal of Atmospheric Environment
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• 제6권2호
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• pp.96-103
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• 2012

Ambient particulate matter (PM) and particle-bound polycyclic aromatic hydrocarbon (PAH) concentrations were measured continuously for 70 days at a Korean elementary school located near a highway. The $PM_{10}$, $PM_{2.5}$, and $PM_1$ values were measured with a light-scattering, multi-channel, aerosol spectrometer (Grimm, Model 1.107). The number concentrations of the particles were measured using a scanning mobility particle sizer and counter (SMPS+C) which counted particles from 11.1 to 1083.3 nm classified in 44 channels. Particle-bound PAHs were measured with a direct reading, photoelectric aerosol sensor. The daily $NO_2$, $SO_2$, and CO concentrations were obtained from a national air-monitoring station located near the school. The average concentrations of $PM_{10}$, $PM_{2.5}$, and $PM_1$ were 75.3, 59.3, and $52.1{\mu}g/m^3$, respectively. The average number concentration of the ultrafine particles (UFPs) was $46,307/cm^3$, and the averaged particle-bound PAHs concentration was $17.9ng/cm^3$ during the study period. The ambient UFP variation was strongly associated with traffic intensity, particularly peak concentrations during the traffic rush hours. Particles <100 nm corresponded to traffic-related pollutants, including PAHs. Additional longterm monitoring of ambient UFPs and high-resolution traffic measurements should be carried out in future studies. In addition, transient variations in the ambient particle concentration should be taken into consideration in epidemiology studies in order to examine the short-term health effects of urban UFPs.

• International Journal of Fluid Machinery and Systems
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• 제6권2호
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• pp.87-93
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• 2013

In order to study the effect of the fluid-structure interaction (FSI) on the simulation results, the external characteristics and internal flow features of a diffuser pump were analyzed with a two-way flow solid coupling method. And the static and dynamic structure analysis of the blade was also caculated with the FEA method. The steady flow field is based on Reynolds Averaged N-S equations with standard $k-{\varepsilon}$ turbulent model, the unsteady flow field is based on the large eddy simulation, and the structure response is based on elastic transient structural dynamic equation. The results showed that the effect of FSI on the head prediction based on CFD really exists. At the same radius, the van mises stress on the nodes closed shroud and hub was larger than other nodes. A large deformation region existed near inlet side at the middle of blades. The strength of impeller satisfied the strength requirement with static stress analysis based on the fourth strength theory. The dynamic stress varied periodically with the impeller rotating. It was also found that the fundamental frequency of the dynamic stress is the rotating frequency and its harmonic frequency. The frequency of maximum stress amplitude at node 1626 was 7 times of the rotating frequency. The frequency of maximum stress amplitude at node 2328 was 14 times of the rotating frequency. No matter strength failure or fatigue failure, the root of blades near shroud is the key region to analyse.

• 한국전산구조공학회논문집
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• 제16권2호
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• pp.207-216
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• 2003

본 논문에서는 균열을 지닌 축대칭 문제를 해석하기 위하여 시간적분형 운동방정식을 바탕으로 한 유한요소 해법을 제시한다. 유한요소메쉬는 8절점 등매개변수 사변형 요소와 균열선단에서의 1/4절점 삼각형 특이요소로 구성되며, 동적 응력확대계수는 균열면상의 1/4절점의 y방향 변위로부터 구한다. 제시된 해법의 정확성과 타당성을 검증하기 위하여 내부에 원환균열을 지닌 무한 탄성체가 균열면상에서 충격하중을 받을 때의 동적 응력확대계수를 계산하고 타 수치결과와 비교 검토하였다. 응용 예제로서 원환균열과 원주균열을 지닌 중실축과 중공축의 동적 응력확대계수를 균열의 길이와 축의 길이에 따른 영향을 자세히 조사하였다. 균열길이가 커지면 동적 응력확대계수가 커지고, 축의 길이가 길어지면 동적 응력확대계수 곡선의 폭도 함께 증가됨을 확인하였다. 그리고 균열의 위치가 안쪽에 포함될 경우보다는 바깥쪽에 포함될 때 더 큰 동적 응력확대계수가 발생됨을 밝힌다.

• 한국해양환경ㆍ에너지학회지
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• 제19권1호
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• pp.52-61
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• 2016

대용량의 $CO_2$를 지중에 저장하기 위한 CCS(Carbon Capture and Storage)는 고압의 파이프라인 수송공정을 수반한다. 또한, 사고 및 유지보수와 같은 비정상상태가 발생할 경우 고압의 $CO_2$를 대기 중으로 방출시키는 감압공정이 필요하다. 본 연구에서는 고압 $CO_2$ 파이프라인에서의 감압현상을 수치해석적 방법을 이용하여 분석하였다. 수치계산 결과를 실험데이터와 비교분석함으로써 수치해석의 예측 능력을 검증하였다. 수치모델이 기체-액체 혼합 구간에서의 2상 감압현상을 잘 예측하였다. 그러나 초임계 액체 단상 감압과 기체 단상 감압현상에 대해서는 온도변화 등을 예측하는데 한계가 있음을 밝혔다.

• 대한기계학회논문집 C: 기술과 교육
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• 제4권1호
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• pp.35-41
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• 2016

지열 히트펌프 시스템에서 히트펌프 등 시스템 구성 요소의 에너지 소비량을 효율적으로 관리하면, 냉난방 성능을 더 높일 수 있다. 본 논문은 외기온도 제어 방식이 지열 시스템의 성능에 미치는 영향을 분석하였다. 또한 분석 결과를 현재 국내에서 주로 적용하는 제어 방식(Control-A)과 비교하였다. 이를 위해 상용 소프트웨어(TRNSYS 17)를 이용하여 가상 지열 시스템의 모델을 구축한 후, 시뮬레이션을 수행하였다. 외기 온도 제어 방식(Control-B)은 버퍼 탱크의 온도를 외기 온도에 따라 제어하기 때문에, 간절기 때 효과적이었다. 기존 제어 방식과 비교했을 때, 외기 온도 제어 방식은 히트펌프 전력 소비량을 7.7%(147 kWh 절감) 그리고 순환펌프 전력 소비량을 7.5%(28.1 kWh 절감) 줄일 수 있었다.

• Nuclear Engineering and Technology
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• 제52권9호
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• pp.1955-1962
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• 2020

In a sudden shutdown of primary pump or coolant loss accident in a marine nuclear power plant, the primary flow decreases rapidly in a transition process from forced circulation (FC) to natural circulation (NC), and the lower flow enters the steam generator (SG) causing reverse flow in the U-tube. This can significantly compromise the safety of nuclear power plants. Based on the marine natural circulation steam generator (NCSG), an experimental loop is constructed to study the characteristics of reverse flow under middle-temperature and middle-pressure conditions. The transition from FC to NC is simulated experimentally, and the characteristics of SG reverse flow are studied. On this basis, the experimental loop is numerically modeled using RELAP5/MOD3.3 code for system analysis, and the accuracy of the model is verified according to the experimental data. The influence of the flow variation rate on the reverse flow phenomenon and flow distribution is investigated. The experimental and numerical results show that in comparison with the case of adjusting the mass flow discontinuously, the number of reverse flow tubes increases significantly during the transition from FC to NC, and the reverse flow has a more severe impact on the operating characteristics of the SG. With the increase of flow variation rate, the reverse flow is less likely to occur. The mass flow in the reverse flow U-tubes increases at first and then decreases. When the system is approximately stable, the reverse flow is slightly lower than obverse flow in the same U-tube, while the flow in the obverse flow U-tube increases.

• Journal of Microbiology and Biotechnology
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• 제30권3호
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• pp.427-438
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• 2020

Middle East respiratory syndrome coronavirus (MERS-CoV) infects the lower respiratory airway of humans, leading to severe acute respiratory failure. Unlike human dipeptidyl peptidase 4 (hDPP4), a receptor for MERS-CoV, mouse DPP4 (mDPP4) failed to support MERS-CoV infection. Consequently, diverse transgenic mouse models expressing hDPP4 have been developed using diverse methods, although some models show no mortality and/or only transient and mild-to-moderate clinical signs following MERS-CoV infection. Additionally, overexpressed hDPP4 is associated with neurological complications and breeding difficulties in some transgenic mice, resulting in impeding further studies. Here, we generated stable hDPP4-transgenic mice that were sufficiently susceptible to MERS-CoV infection. The transgenic mice showed weight loss, decreased pulmonary function, and increased mortality with minimal perturbation of overexpressed hDPP4 after MERS-CoV infection. In addition, we observed histopathological signs indicative of progressive pulmonary fibrosis, including thickened alveolar septa, infiltration of inflammatory monocytes, and macrophage polarization as well as elevated expression of profibrotic molecules and acute inflammatory response in the lung of MERS-CoV-infected hDPP4-transgenic mice. Collectively, we suggest that this hDPP4-transgenic mouse is useful in understanding the pathogenesis of MERS-CoV infection and for antiviral research and vaccine development against the virus.

• Computers and Concrete
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• 제16권6호
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• pp.933-961
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• 2015

Damage by high-speed impact fracture is a dominant mode of failure in several applications of concrete structures. Numerical modelling can play a crucial role in understanding and predicting complex fracture processes. The commonly used mesh-based Finite Element Method has difficulties in accurately modelling the high deformation and disintegration associated with fracture, as this often distorts the mesh. Even with careful re-meshing FEM often fails to handle extreme deformations and results in poor accuracy. Moreover, simulating the mechanism of fragmentation requires detachment of elements along their boundaries, and this needs a fine mesh to allow the natural propagation of damage/cracks. Smoothed Particle Hydrodynamics (SPH) is an alternative particle based (mesh-less) Lagrangian method that is particularly suitable for analysing fracture because of its capability to model large deformation and to track free surfaces generated due to fracturing. Here we demonstrate the capabilities of SPH for predicting brittle fracture by studying a slender concrete structure (column) under the impact of a high-speed projectile. To explore the effect of the projectile material behaviour on the fracture process, the projectile is assumed to be either perfectly-elastic or elastoplastic in two separate cases. The transient stress field and the resulting evolution of damage under impact are investigated. The nature of the collision and the constitutive behaviour are found to considerably affect the fracture process for the structure including the crack propagation rates, and the size and motion of the fragments. The progress of fracture is tracked by measuring the average damage level of the structure and the extent of energy dissipation, which depend strongly on the type of collision. The effect of fracture property (failure strain) of the concrete due to its various compositions is found to have a profound effect on the damage and fragmentation pattern of the structure.

• 한국약용작물학회지
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• 제17권5호
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• pp.341-345
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• 2009

Cerebral ischemia results from a transient or permanent reduction in cerebral blood flow that decreases oxygen and glucose supply. When the cellular oxygen supply is reduced to critical level, damage to cells and induction of cell death are occurred by excitotoxicity, oxidative stress and inflammation. Ischemia remains one of the leading causes of death, but there is no effective treatment that might protect neurons gainst ischemia by interrupting the cascade of cell death. In this study, human neuroblastoma SH-SY5Y cells are exposed to oxygen and glucose deprivation (OGD) followed by reoxgenation. OGD can mimic the acute restriction of metabolite and oxygen supply caused by ischemia and is widely used as a model of ischemic conditions. SH-SY5Y cells are treated samples at the commencement of OGD to achieve different final concentrations, and cell viabilities were quantified using the measurement of flow cytometry analysis. Of those tested, the extracts of Polygala tenuifolia (roots), Dictamnus dasycarpus (barks), Polygala tenuifolia (roots), Eucommia ulmoides (branches), Eucommia ulmoides (barks), Poria cocos (whole), Sophora flavescens (roots) showed neuroprotective effects, with $EC_{50}$ values of $4.5{\pm}0.6$, $7.9{\pm}1.5$, $10.5{\pm}0.7$, $18.4{\pm}1.9$, $19.6{\pm}0.3$, $21.6{\pm}1.9$, and $30.7{\pm}3.9{\mu}g/m{\ell}$, respectively.

• 대한한의학회지
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• 제30권2호
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• pp.1-16
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• 2009

Objectives: This study investigated the effect of Yukmijihwangtang on cerebral ischemia-induced learning and memory impairment by middle cerebral artery (MCA) occlusion in rats. Methods: The ability of learning and memory of rats was measured using the eight-arm radial maze and the passive avoidance test, and profile of cholinergic neuron was assessed in the medial septum and hippocampus region by immuno-histochemistry. Results: 1. No differences were found between groups in the number of correct choices in acquisition performance during the eight-arm radial maze task. 2. No differences were found between groups on day 1 in the error rate in acquisition performance, which is defined as the number of enters into the same arm more than once within five minutes. After 5 to 6 days of test, the number of errors was significantly reduced in the Yukmijihwangtang group (forebrain ischemia group with Yukmijihwangtang treatment), compared with the ischemia group. 3. The memory processes significantly improved in the Yukmijihwangtang group according to results of the passive avoidance test. 4. The appearance of AchE (acetylcholinesterase) in the CA1 region of hippocampus significantly decreased in the ischemia group, compared with the sham group (untreated group). The appearance of AchE in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group. 5. The appearance of ChAT (choline acetyltransferase) in the CA1 region of the hippocampus and medial septum decreased in the ischemia group, compared with the sham group. The appearance of ChAT in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group Conclusions: This study provides evidence that Yukmijihwangtang is effective for reviving the ability of learning and memory and damaged neurons in rats with experimental cerebral ischemia.