• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1310-1319
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• 2024

The reactor cavity cooling system (RCCS) is a passive reactor safety system commonly present in the designs of High-Temperature Gas-cooled Reactors (HTGR) that removes heat from the reactor pressure vessel by means of natural convection and radiation. It is one of the factors responsible for ensuring that the reactor does not melt down under any plausible accident scenario. For the simulation of accident scenarios, which are transient phenomena unfolding over a span of up to several days, intermediate fidelity methods and system codes must be employed to limit the models' execution time. These models can quantify radiation heat transfer well, but heat transfer caused by natural convection must be quantified with the use of correlations for the heat transfer coefficient. It is difficult to obtain reliable correlations for HTGR RCCS heat transfer coefficients experimentally due to such a system's size. They could, however, be obtained from high-fidelity steady-state simulations of RCCSs. The Rayleigh number in RCCSs is too high for using a Direct Numerical Simulation (DNS) technique; thus, a Reynolds-Averaged Navier-Stokes (RANS) approach must be employed. There are many RANS models, each performing best under different geometry and fluid flow conditions. To find the most suitable one for simulating an RCCS, the RANS models need to be validated. This work benchmarks various RANS models against three experiments performed on the HTTR RCCS Mockup by the Japanese Atomic Energy Agency (JAEA) in 1993. This facility is a 1/6 scale model of a vessel cooling system (VCS) for the High Temperature Engineering Test Reactor (HTTR), which is operated by JAEA. Multiple RANS models were evaluated on a simplified 2d-axisymmetric geometry. They were found to reproduce the experimental temperature profiles with errors of up to 22% for the lowest temperature benchmark and 15% for the higher temperature benchmarks. The results highlight that the pragmatic turbulence models need to be validated for high Rayleigh natural convection-driven flows and improved accordingly, more publicly available experimental data of RCCS resembling experiments is needed and indicate that a 2d-axisymmetric geometry approximation is likely insufficient to capture all the relevant phenomena in RCCS simulations.

• The Korean Journal of Quaternary Research
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• v.33 no.1_2
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• pp.49-58
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• 2021

In the Paleoclimate Modeling Intercomparison Project phase 4 (PMIP4), various experiments for quaternary climatic change are being carried out along with the Coupled Model Intercomparison Project phase 6 (CMIP6). With the CMIP6 preindustrial climate experiment (piControl), the equilibrium climate simulations of 6 ka Holocene experiment (midHolocene), 21 ka Last Glacial Maximum experiment (lgm), and 127 ka Last Interglacial experiment (lig127k) experiment, and transient climate simulations of 850-1849 Common Era Last Millennium experiment (past1000), 21-9 ka last deglaciation, and 140-127 ka penultimate deglaciation experiment have been carried out under PMIP4 protocols by several modeling groups. In this technical note, important physical parameters and boundary conditions of these Tier 1 experiments and a list of additional Tier 2 and 3 experiments are summarized.

• Journal of Korea Water Resources Association
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• v.44 no.7
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• pp.511-522
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• 2011

Two-dimensional shallow water model based on the cut cell and the adaptive mesh refinement techniques is presented in this paper. These two mesh generation methods are combined to facilitate modeling of complex geometries. By using dynamically adaptive mesh, the model can achieve high resolution efficiently at the interface where flow changes rapidly. The HLLC Reimann solver and the MUSCL method are employed to calculate advection fluxes with numerical stability and precision. The model was applied to simulate the extreme urban flooding experiments performed by the IMPACT (Investigation of Extreme Flood Processes and Uncertainty) project. Simulation results were in good agreement with observed data, and transient flows as well as the impact of building structures on flood waves were calculated with accuracy. The cut cell method eased the model sensitivity to refinement. It can be concluded that the model is applicable to the urban flood simulation in case the effects of sewer and stormwater drainage system on flooding are relatively small like the dam brake.

• Journal of Ginseng Research
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• v.42 no.1
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• pp.35-41
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• 2018

Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces $[Ca^{2+}]i$ transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin exhibits anti-Alzheimer disease effects in model mice. However, little is known about the intestinal absorption of gintonin. The aim of this study was to investigate gintonin absorption using two model systems. Methods: Gintonin membrane permeation was examined using a parallel artificial membrane permeation assay, and gintonin absorption was evaluated in a mouse everted intestinal sac model. Results: The parallel artificial membrane permeation assay showed that gintonin could permeate an artificial membrane in a dose-dependent manner. In the everted sac model, gintonin absorption increased with incubation time (from 0 min to 60 min), followed by a decrease in absorption. Gintonin absorption into everted sacs was also dose dependent, with a nonlinear correlation between gintonin absorption and concentration at 0.1-3 mg/mL and saturation at 3-5 mg/mL. Gintonin absorption was inhibited by the Rho kinase inhibitor Y-27632 and the sodiumeglucose transporter inhibitor phloridzin. Moreover, lipid extraction with methanol also attenuated gintonin absorption, suggesting the importance of the lipid portion of gintonin in absorption. This result shows that gintonin might be absorbed through passive diffusion, paracellular, and active transport pathways. Conclusion: The present study shows that gintonin could be absorbed in the intestine through transcellular and paracellular diffusion, and active transport. In addition, the lipid component of gintonin might play a key role in its intestinal absorption.

• The Journal of Engineering Geology
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• v.32 no.1
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• pp.27-40
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• 2022

Every year landslides cause serious casualties and property damages around the world. As the accurate prediction of landslides is important to reduce the fatalities and economic losses, various approaches have been developed to predict them. Prediction methods can be divided into landslide susceptibility analysis, landslide hazard analysis and landslide risk analysis according to the type of the conditioning factors, the predicted level of the landslide dangers, and whether the expected consequence cased by landslides were considered. Landslide susceptibility analyses are mainly based on the available landslide data and consequently, they predict the likelihood of landslide occurrence by considering factors that can induce landslides and analyzing the spatial distribution of these factors. Various qualitative and quantitative analysis techniques have been applied to landslide susceptibility analysis. Recently, quantitative susceptibility analyses have predominantly employed the physically based model due to high predictive capacity. This is because the physically based approaches use physical slope model to analyze slope stability regardless of prior landslide occurrence. This approach can also reproduce the physical processes governing landslide occurrence. This review examines physically based landslide susceptibility analysis approaches.

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.5
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• pp.81-92
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• 2013

The satellite includes many release mechanisms such as solar array deployment, antenna deployment, cover to protect contamination in scientific equipment, pyro value of the propulsion subsytem, and bypass device in Li-Ion cell module. A drive the initiators is a critical to the successful mission because the initiators of release mechanism driving by the pyrotechnic circuit is operated in single short. The pyrotechnic circuit has to provide switching network for safety. A typical switching network has defect consisting of high current rating fire switch to handle switching transient current during fire the initiator. The pyrotechnic circuit is required some form of power conditioning to reduce the peak power demanded from the bus if the initiators are to be fired from the main bus. This paper design a pyrotechnic circuit synchronized to the fire-command to activate the fire switch to overcome use high current rating fire switch to handle switching transient current during fire the initiator. The pyrotechnic circuit provides a current limited widow pulse for fire current synchronized to the fire-command to insure that fire switch will only carry the current but never switch it. The current limited widow pulse for fire current can be possible to use low current rating and light mass switch in switching network. The current limit function in the pyrotechnic circuit reduces supply voltage to initiator and provides the effect of power conditioning function to reduce peak bus power. The pyrotechnic circuit to apply satellite development on geostationary orbit is verified the function by test in development model.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.10
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• pp.895-906
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• 2015

This paper presents a methodology and a model that can analyze the high frequency transfer characteristics from socket in the AC power port to the 5 V DC output port in the mobile charging circuit. This is to predict the output signals coming from the IEC(International Electrotechnical Commission) Standard(IEC 61000-4-4), EFT/B(Electric Fast Transient and Burst) immunity test for mobile charging circuit. Since the mobile charging circuit is energized from the AC power socket from the power line, it is necessary to know the high frequency transfer characteristics with activated AC power line. A simple CDN(Coupling-Decoupling Network) is designed and manufactured for measuring S-parameters of mobile charging circuit with and without AC power line activated. The result shows that the S-parameters of the specific mobile charging circuits are almost the same, independent of AC power line activation. Consequently, the S-parameters without AC line could be used to predict the output response to the EFT/B signals, and it was shown that the proposed methodology predicts the output responses quite accurately, which proves the validness of the methodology presented in this paper.

• Journal of Korean Neurosurgical Society
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• v.58 no.3
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• pp.167-174
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• 2015

Objective : This study investigates the role of a burr hole and calvarial bone marrow-derived stem cells (BMSCs) in a transient ischemic brain injury model in the rat and postulates a possible mechanism for the efficacy of multiple cranial burr hole (MCBH) surgery in moyamoya disease (MMD). Methods : Twenty Sprague-Dawley rats (250 g, male) were divided into four groups : normal control group (n=5), burr hole group (n=5), ischemia group (n=5), and ischemia+burr hole group (n=5). Focal ischemia was induced by the transient middle cerebral artery occlusion (MCAO). At one week after the ischemic injury, a 2 mm-sized cranial burr hole with small cortical incision was made on the ipsilateral (left) parietal area. Bromodeoxyuridine (BrdU, 50 mg/kg) was injected intraperitoneally, 2 times a day for 6 days after the burr hole trephination. At one week after the burr hole trephination, brains were harvested. Immunohistochemical stainings for BrdU, CD34, VEGF, and Doublecortin and Nestin were done. Results : In the ischemia+burr hole group, BrdU (+), CD34 (+), and Doublecortin (+) cells were found in the cortical incision site below the burr hole. A number of cells with Nestin (+) or VEGF (+) were found in the cerebral parenchyma around the cortical incision site. In the other groups, BrdU (+), CD34 (+), Doublecortin (+), and Nestin (+) cells were not detected in the corresponding area. These findings suggest that BrdU (+) and CD34 (+) cells are bone marrow-derived stem cells, which may be derived from the calvarial bone marrow through the burr hole. The existence of CD34 (+) and VEGF (+) cells indicates increased angiogenesis, while the existence of Doublecortin (+), Nestin (+) cells indicates increased neurogenesis. Conclusion : Based on these findings, the BMSCs through burr holes seem to play an important role for the therapeutic effect of the MCBH surgery in MMD.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.5
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• pp.553-562
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• 2012

Computational Fluid Dynamics (CFD) analysis has been performed to estimate the air temperature inside an Auxiliary Feed Water (AFW) Motor-Driven (MD) pump room for the case where there is loss of Heating, Ventilation, and Air-Conditioning (HVAC). A transient calculation for the closed pump room without cooling by any HVAC system shows that the volume-averaged air temperature reaches around $60^{\circ}C$ for a transient period of 8.0 h. From previous studies, the external air and surface boundary temperatures are assumed to increase slowly starting from an initial temperature of $35^{\circ}C$. For the cases where the door is opened at 2, 4, and 6 h after the initiation of HVAC failure, the average air temperature promptly drops by about $4^{\circ}C$ when the door is opened and then slowly increases. The current calculations based on the CFD technique predict the rate of increase of air temperature to be lower than that determined by previous conservative calculations on the basis of a lumped model.

• The Plant Pathology Journal
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• v.24 no.3
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• pp.296-304
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• 2008

The transient and rapid expression system of a foreign protein in planta is a very useful technique in biotechnology application. We have investigated optimum condition of Agrobacterium-infiltration technique in which expression level of foreign proteins were maximized without detrimental effects on plants using GFP and Cucumber mosaic virus 2b protein, which is known as an enhancer of gene expression and a suppressor of post-transcriptional gene silencing(PTGS). The optimum expression level of both RNA and protein of GFP with minimum leaf impairment was obtained at $OD_{600}$=0.2 of Agrobactrium inocula. The steady-state levels of GFP RNA and protein generally peaked at 3 and 7 days post-infiltration(dpi), respectively. In the presence of 2b, both the magnitude and duration of GFP expression was highly increased and we could detect GFP level until 17 dpi. On the other hands, the 2b-mediated higher accumulation of foreign proteins resulted in the repression of normal leaf growth, possibly due to the limitation of supply of energy or materials required for growth maintenance. Using this Agrobacterium-infiltration system with 2b and GFP, we tested a hypothesis for the threshold model of PTGS initiation. Four GFP transgenic lines of N. benthamiana, which shows different expression level of GFP were tested to determine the threshold level for PTGS initiation. Agrobacterium-infiltration of GFP into those GFP-transgenic plants resulted in the co-silencing of the transgenic GFP. It was found that very low concentration of Agrobacterium with GFP and GFP+2b($OD_{600}$=0.002-0.02) which could not phenotypically induce an additive GFP expression, was enough to trigger PTGS pathway in all GFP transgenic plants. This strongly indicates that each GFP-transgenic plant should be expressing the transgenic GFP at its own pre-determined level and there was no buffer zone of additive GFP-expression to the threshold. In other words, the PTGS seems to be immediately activated as a self-defensive mechanism if an internal balance of gene expression is broken.