• Title/Summary/Keyword: Transient effects

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Protective Effects of Folium Artemisiae Argyi Herbal Acupuncture on Transient Forebrain Ischemic Injury in Rats (흰쥐의 일과성 전뇌 허혈 손상에 대한 애엽 약침의 신경보호 작용)

  • 김재효;장진요;박병림;김경식;손인철
    • The Journal of Korean Medicine
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    • v.24 no.2
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    • pp.81-93
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    • 2003
  • Objectives : Recently, the new therapeutic tool, that is herbal acupuncture, has been developed and applied to various diseases including the cerebrovascular accident. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics. The objective was to determine the effect of folium artemisiae argyi (艾葉) herbal acupuncture on the trasient forebrain ischemic injured rat. Methods : In this study, the effects of folium artemisiae argyi (艾葉) herbal acupuncture on the $LR_3$ named Taechung, on neuroprotection after the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohistochemistry and ELISA technique. Results : Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium artemisiae argyi' herbal acupuncture on $LR_3$ significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group. These features were observed in the retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium artemisiae argyi' herbal acupuncture on $LR_3$ significantly increased the expression of BDNF protein in the hippocampus ($263.26{\pm}44.56{\;}pg/ml$ extracted by water, $275.35{\pm}51.47{\;}pg/ml$ extracted by moxa tar)and the cortex ($102.33{\pm}13.65{\;}pg/ml$ extracted by water, $109.54{\pm}9.37{\;}pg/ml$ extracted by moxa tar) compared to the hippocampus ($134.07{\pm}2.96{\;}pg/ml$) and the cortex ($61.16{\pm}4.11{\;}pg/ml$) in control group at 48 hrs after transient forebrain ischemia. Conclusions : These results suggest that pretreatment with folium artemisiae argyi' herbal acupuncture on $LR_3$ has neuroprotective effect on transient forebrain ischemia and the herbal acupunture on $LR_3$ may be related to antioxidative function of folium artemisiae argyi.

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Effects of Folium Artemisiae Argyi and Moxa Tar' Herbal Acupuncture on Transient Forebrain Ischemic Injury in Rats (애엽(艾葉) 및 구진(灸津) 약침(藥鍼)이 일과성(一過性) 전뇌(前腦) 허혈(虛血) 손상(損傷)에 미치는 효과(效果))

  • Kim Jae-Hyo;Lee Kwan-Hyung;An Young-Nam;Kim Yong-Deuk;Kim Kyung-Sik;Sohn In-Chul
    • Korean Journal of Acupuncture
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    • v.20 no.3
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    • pp.61-80
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    • 2003
  • Objectives : Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. Recently, the new therapeutic tool, that is herbal acupuncture, has been developed since the 1950' and applied to various diseases including the cerebrovascular accident. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics. Methods : In this study, effects of folium Artemisiae Argyi and moxa tar' herbal acupuncture on the $GV_{20}$, named Baek-Hue, on neuroprotection after the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohis- tochemistry and ELISA technique. Results : Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium Artemisiae Argyi or moxa tar' herbal acupuncture on $GV_{20}$ significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group, respectively. These features were observed in the motor cortex and retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium Artemisiae Argyi and moxa tar' herbal acupuncture on$GV_{20}$ significantly increased the expression of BDNF protein in the hippocampus and the cortex compared to control group at 48 hrs after transient forebrain ischemia, respectively. Conclusions : These results suggest that pretreatment with folium Artemisiae Argyi or moxa tar' herbal acupuncture on $GV_{20}$ has neuroprotective effect on transient forebrain ischemia and theherbal acupuncture on $GV_{20}$ may be related to antioxidative function.

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Effects of Folium Artemisiae Argyi' Herbal Acupuncture of $LR_3$ on Transient Forebrain Ischemic Injury in Rats (태충(太衝) 애엽(艾葉) 약침(藥鍼)이 일과성(一過性) 전뇌(前腦) 허혈(虛血) 손상(損傷)에 미치는 효과(效果))

  • Jang, Jin-Yo;Kim, Jae-Hyo;Park, Sung-Seup;Park, Gyi-Jong;Kim, Kyung-Sik;Sohn, In-Chul
    • Korean Journal of Acupuncture
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    • v.22 no.3
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    • pp.63-81
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    • 2005
  • Herbal acupuncture has been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics. In this study, neuroprotective effects of folium artemisiae argyi (艾葉)' herbal acupuncture on the $LR_3$ (Taechung) on the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohistochemistry and ELISA technique. Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium artemisiae argyi' herbal acupuncture on $LR_3$ significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group. These features were observed in the motor cortex and retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium artemisiae argyi' herbal acupuncture on $LR_3$ significantly increased the expression of BDNF protein in the hippocampus ($263.26{\pm}44.56pg/ml$ extracted by water, $275.35{\pm}51.47pg/ml$ extracted by moxa tar)and the cortex ($102.33{\pm}13.65pg/ml$ extracted by water, $109.54{\pm}9.37pg/ml$ extracted by moxa tar) compared to the hippocampus $(134.07{\pm}2.96pg/ml)$ and the cortex $(61.16{\pm}4.11pg/ml)$ in control group at 48 hrs after transient forebrain ischemia. These results suggest that pretreatment with folium artemisiae argyi'herbal acupuncture on $LR_3$ has neuroprotective effect on transient forebrain ischemia and the herbal acupunture on $LR_3$ may be related to antioxidative function of folium artemisiae argyi.

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Effects of Initial Conditions on Transient Responses in Dynamic Simulation of FOWT (초기 조건이 부유식 풍력터빈 동역학 해석의 과도응답에 미치는 영향)

  • Song, Jin-Seop;Rim, Chae-Whan;Moon, Seok-Jun;Nam, Yong-Yun
    • Journal of Ocean Engineering and Technology
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    • v.28 no.4
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    • pp.288-293
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    • 2014
  • The IEC standard for onshore or offshore wind turbines requires additional dummy simulations (at least 5 s) for the transient responses due to initial conditions. An increase in the dummy time causes a considerable increase in the computational cost considering multiple design spirals with several thousand design load analysis cases. A time of 30 s is typically used in practical simulations for a wind turbine design with a fixed platform. However, 30 s may be insufficient for floating offshore wind turbines (FOWT) because the platforms have lower natural frequencies, and the transient responses will last much longer. In this paper, an initial condition application algorithm is implemented for WindHydro, and the appropriate dummy simulation time is investigated based on a series of dynamic simulations of a FOWT. As a result, it is found that more than 300 s is required for the platform to have stationary motion after the initial transient responses for the FOWT under the conditions considered.

Effects of Thermal Contact Resistance on Transient Thermoelastic Contacts for an Elastic Foundation (시간에 따른 탄성지지 열탄성 접촉에 대한 열접촉저항의 영향)

  • Jang, Yong-Hoon
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2005.05a
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    • pp.330-333
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    • 2005
  • The paper presents a numerical solution to the problem of a hot rigid indenter siding over a thermoelastic Winkler foundation with a thermal contact resistance at constant speed. It is shown analytically that no steady-state solution can exist for sufficiently high temperature or sufficiently small normal load or speed regardless of the thermal contact resistance. However, the steady state solution may exist in the same situation if the thermal contact resistance is considered. This means that the effect of the large values of temperature difference and small value of force or velocity which occur at no steady state can be lessened due to the thermal contact resistance. When there is no steady-state the predicted transient behavior involves regions of transient stationary contact interspersed with regions of separation regardless of the thermal contact resistance. Initially, the system typically exhibits a small number of relatively large contact and separation regions, but after the initial transient the trailing edge of the contact area is only established and the leading edge loses contact, reducing the total extent of contact considerably. As time progresses, larger and larger number of small contact areas are established, until eventually the accuracy of the algorithm is limited by the discretization used.

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A Study on the Analysis of Transient Overvoltages and Harmonics due to Utility STATCON Switching (전력회사의 스타콘 투입시 과도 전압 상승과 고조파 분석에 관한 연구)

  • 김경철;서범관;송영주;이일무
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.17 no.5
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    • pp.51-59
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    • 2003
  • The utility and many customers employ capacitor banks(STATCON so called at the utility) to help control the power factor(customers) or voltage(the utility) by supplying reactive power to inductive loads. This paper presents analysis of transient overvoltages and harmonics due to utility STATCON switching. One simple and inexpensive means of limiting the voltage magnification transient and reducing harmonics is to switch the capacitor banks on a few minutes after the STATCON has been switched. Simulation results used the EDSA software package show the effects of decreased the transient voltage and harmonic reduction at the customer. And also harmonic limits based on the well-known international harmonic standards IEEE 519 and IEC 1000 are evaluated for the customer.

$N_2$-Laser Flash Photolysis study of Photosensitizing Properties of Benoxaprofen ($N_2$-레이저 플래쉬 광분해 방법에 의한 Benoxaprofen의 광증감 작용에 관한 연구)

  • Lee, Gi Hwan;Yang, Jun Muk;Yun, Min Jung
    • Journal of the Korean Chemical Society
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    • v.34 no.3
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    • pp.255-259
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    • 1990
  • The nitrogen-laser flash photolysis apparatus has been set up to detect directly the transient produced from the excited Benoxaprofen (BXP). The function of the instrument has been tested by using anthracene as a standard sample. The laser photoexcitation of BXP in ethanol has been carried out under a constant stream of $N_2$ gas and a transient absorption spectrurn has been recorded over the 400-600 nm. The effects of oxygen and ${\beta}-carotene$ on the transient spectrum reveal that thee maximum transient absorption at 415 nm is attributed to the triplet state of BXP and the triplet energy of BXP is above 22 Kcal/mole. In addition to the triplet state, another transient species has been observed to be produced, which is probably a radical form of BXP. The photosensitization mechanism of BXP is discussed based on these results.

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A Clinical Comparative Study of Transient Tic Disorder, Chronic Motor Tic Disorder, and Tourette's Disorder (DSM-Ⅳ에 의해 진단된 일과성 틱 장애, 만성 운동성 틱 장애, 뚜렛 장애 환아의 증례 비교 보고)

  • Yu, Hyeon-Yeong;Kim, Ki-Bong;Min, Sang-Yeon;Kim, Jang-Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • v.21 no.3
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    • pp.71-84
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    • 2007
  • Objectives The purpose of this study is to report a case of transient tic disorder, chronic motor tic disorder, and Tourette's disorder of the children who treated by herbal medicine. Methods We treated the tic-disorder children with herbal medicine (Samchulgeonbitang, Oyaksun- gisankamibang, Cheonggan-soyosan), and we evaluated tic disorder cases by Yale Global Tic Severity Scale (YGTSS). Results We treated a tic-disorder patients with herbal medicine and we had some good effects on a patients who had transient tic disorder, chronic motor tic disorder, and Tourette's disorder. The patients' symptomswere improved and the YGTSS also decreased. Conclusions Herbal medicine works well especially for tic-disorder, and active medical treatments are the most important thing for Transient tic disorder.

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HEPATOTOXICITY OF PHOTOTOXIC DRUGS USED IN SYSTEMIC PHOTOCHEMOTHERAPY

  • Hann, Seung-Kyung;Choi, Gwang-Seong;Park, Yoon-Kee
    • Journal of Photoscience
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    • v.3 no.1
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    • pp.29-31
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    • 1996
  • Psoralens are metabolized in the liver and thus can produce liver damage in laboratory animals when given in excessive doses. However, in humans, reports of the effects of psoralens on liver functions during photochemotherapy have been contradictory. We studied 311 patients t o observe the effects of various phototoxic drugs: 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), 4,5,8-trimethylpsoralen (TMP)-on liver function during photochemotherapy. Of the 311 patients, only seven had transient elevations of transaminases. Incidence of hepatotoxicity of 8-MOP, TMP and 5-MOP showed 0.6%, 6% and 3%, respectively. Although the effects of psoralens on liver functions during photochemotherapy have been contradictory in humans and there have been few cases showing transient elevated values of liver transaminases during photochemotherapy, it is advisable to obtain serial liver function tests before and during photochemotherapy.

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Improved Evaluation Method of Flicker considering Disturbances of Power System

  • Kim, Jae-Chul;Moon, Jong-Fil;Jung, Seung-Bock;Choe, Kyu-Ha
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.22 no.3
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    • pp.8-14
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    • 2008
  • This paper studies a more exact flicker evaluation method by detecting power quality disturbances and excluding the effects of power quality disturbances. Up to the present, power quality disturbances affect flicker evaluation index because power quality problems do not have been considered. However, flick index should represent only flicker without power quality disturbances. Thus, in this paper, we present the improved flicker evaluation method which removing the effects of power quality disturbances such as voltage sag and transient caused by fault and inverter/breaker switching. We detect voltage sag and transient using wavelet transform and remove the effects of power quality disturbances from flicker index.