• Korean Journal of Environment and Ecology
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• v.18 no.4
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• pp.437-445
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• 2004

The purpose of this study was to provide basic visitor and trail use data for developing trail management strategies in Korean national park system. To accomplish the purpose of the study, a questionnaire survey was carried on at two different national parks(Bukhansan and Chiaksan National Park). As for the results, root and rock exposure on the trails and trail width expansion were perceived as major types of trail impact. In addition, majority of respondents pointed to construct or maintain facilities on steep paths and repair trail surface as for the priority of trail maintenance. In conclusion, the priority of trail management and maintenance has to be differently determined based on each trail conditions because visitor impacts on the trails vary along with site-specific and activity-specific differences. Findings of the study expect to be used as fundamentals in trail management strategy making for Korean national parks.

• Journal of Wetlands Research
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• v.17 no.2
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• pp.176-183
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• 2015

This study is aimed at deducting the evaluation standard of the walking tour trail and evaluating the real condition of trail facilities and operation & management. On the basis of the research on the walking tour, this study deducted the evaluation index of the trail facilities and administrative control, and divided it into visit resources, visit facilities and trail operation-management. This study selected the course of high use satisfaction among the Ganghwa Nadeul-gil section, and evaluated the real condition of Ganghwa Nadeul-gil trail by classifying the route as nature-oriented trail and culture-oriented trail. In case of nature-oriented trail, it's necessary to discover living culture resources of the village linked with the trail, and to develop amenities using bus stations and supermarket. In case of culture-oriented trail, it's required that economic regeneration plan should be arranged using the declining facilities.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.62-67
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• 2012

TNF-related apoptosis-inducing ligand (TRAIL) is a promising agent for management of cancer because of its selective cytotoxicity to cancer cells. However, some cancer cells have resistance to TRAIL. Accordingly, novel treatment strategies are required to overcome TRAIL resistance. Here, we examined the synergistic apoptotic effect of apigenin in combination with TRAIL in Huh-7 cells. We found that combined treatment of TRAIL and apigenin markedly inhibited Huh-7 cell growth compared to either agent alone by inducing apoptosis. Combined treatment with apigenin and TRAIL induced chromatin condensation and the cleavage of poly (ADP-ribose) polymerase (PARP). In addition, enhanced apoptosis by TRAIL/apigenin combination was quantified by annexin V/PI flow cytometry analysis. Western blot analysis suggested that apigenin sensitizes cells to TRAIL-induced apoptosis by activating both intrinsic and extrinsic apoptotic pathway-related caspases. The augmented apoptotic effect by TRAIL/apigenin combination was accompanied by triggering mitochondria-dependent signaling pathway, as indicated by Bax/Bcl-2 ratio up-regulation. Our results demonstrate that combination of TRAIL and apigenin facilitates apoptosis in Huh-7 cells.

• Journal of Agricultural Extension & Community Development
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• v.17 no.3
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• pp.587-606
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• 2010

Theme trail construction should be changed from existing form which connects line to line, or point to line. It should be developed into area form. The project of Trail construction must be converted in area form. The aggregate of the points which is a base element of walk is a line, and the harmonious connection of various line is the area. The close relationship with points and lines is important to operate the project of trail construction in area form effectively. Subject of the project of Theme trail construction of area form must become the village residents which are being contiguous in trail. They must operate management and about trail. The project of Trail construction of area form the plan making is established and if the subjects which, will operate and manage that place are decided upon according to theme must construct the trail of the wide area concept which connects the trail of that trail and neighborhood. If becomes like that local resident and the citizen will be able to coexist with mediation of Trail. If the project of Trail construction of village resident leading is propelled applying rural amenity resources in a way, the trail model which one phases advances could be presented for ecological, economical and cultural.

• Journal of Korean Society of Forest Science
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• v.100 no.2
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• pp.273-282
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• 2011

This study was aimed to identify determinants of users' satisfaction and behavioral intention in Jirisan trail of Korea and provide effective trail building and management strategy. The result of survey by 645 trail users showed that four dimensions were derived from 14 satisfaction items, which were experiential resources, cost resources, information, amenities. Of these dimensions, experiential resources along trails including natural environment, the level of trail development, trail condition, cultural & tourist resources, kindness of residents had the greatest effect on overall satisfaction and behavioral intention, which included revisit intention, recommendation intention and continuance intention. According to analysis by detailed variables, natural environment, road signs, kindness of residents and related information significantly affected overall satisfaction and behavioral intention.

• Korean Journal of Environment and Ecology
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• v.11 no.4
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• pp.469-479
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• 1998

This study was aimed to predicting the exercise load in mountain climbing related physical condition of trail, and to propose a capability of user management. It appeared that exercise load in mountain climbing was mainly influenced by the slope of trail and weight of load. It thought that the trails of steep area could be controled the use of person who have a low athletic power as a propose the exercise load index by age.

• YAKHAK HOEJI
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• v.55 no.1
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• pp.49-55
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• 2011

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is one of the promising anti-cancer agent because of its ability to selectively induce apoptosis in tumor cell lines but not in normal cells. However, TRAIL resistance has been reported in some cancer cells including hepatocarcinoma cells. Therefore, studies of agents that sensitize TRAIL-resistant cancer cells could be a effective therapeutic approach in cancer management. In our study, we examined the effect of combination of TRAIL with apigenin in human hepatocellular carcinoma cells. As a result, the combined use of TRAIL and apigenin significantly enhanced the cytotoxicity in PLC-PRF5 cells. Flow cytometry analysis after annexin V-FITC/PI dual staining showed that this increase of cell cytotoxicity was related to enhanced apoptosis in combined treatment of TRAIL with apigenin. Furthermore, synergistic induction of apoptosis was also confirmed by observation of morphological changes and annexin V-FITC/PI fluorescence. Our findings suggests that apigenin has the potential to improve the efficiency of TRAIL-based therapies in human hepatocellular carcinoma cells. Further study is needed to reveal the molecular mechanisms of this combined therapy.

• Journal of Life Science
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• v.24 no.9
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• pp.927-934
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• 2014

Sanguinarine, a benzophenanthridine alkaloid originally derived from the root of Sanguinaria canadensis, has been shown to possess antimicrobial, antioxidant, and anti-cancer properties. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells, but not most normal cells and has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. Our previous study indicated that treatment with TRAIL in combination with subtoxic concentrations of sanguinarine sensitized TRAIL-mediated apoptosis in TRAIL-resistant human gastric carcinoma AGS cells; however, the detailed mechanisms are not fully understood. In this study, we show that sanguinarine sensitizes AGS cells to TRAIL-mediated apoptosis as detected by MTT assay, agarose gel electrophoresis, chromatin condensation and flow cytometry analysis. Combined treatment with sanguinarine and TRAIL effectively induced expression of death receptor (DR) 5 but did not affect expression of DR4 and mitogen activated protein kinases signaling molecules. Moreover, the combined treatment with sanguinarine and TRAIL increased the generation of reactive oxygen species (ROS); however, N-acetylcysteine, ROS scavenger, significantly recovered growth inhibition induced by the combined treatment. Taken together, our results indicate that sanguinarine can potentiate TRAIL-mediated apoptosis through upregulation of DR5 expression and ROS generation.

• Journal of Korean Society of Forest Science
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• v.90 no.5
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• pp.585-592
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• 2001

Interest in the development of urban trails is growing in South Korea. River front trails have been developed in Seoul, Daegu and other major cities. Such trails, and the corridors in which they are developed, often provide a myriad of benefits to the community, including open space, exercise, and stress release. This trend mirrors development patterns found in the United States and European nations. This study examined differences in trail users perceptions of trail attributes, activity participation, willingness to pay for trail access, and perceptions of trail benefits between trail users in the United States and those in South Korea. Perceptions of trail users at three trail sites in the metropolitan area of Daegu were examined, and then were compared to results reported in several studies conducted in the U. S. While this research was exploratory, it did uncover many interesting differences in perceptions of trail attributes between trail users in the two countries. This information may provide insight into the development of greenway systems in South Korea.

• Journal of Korean Society of Rural Planning
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• v.22 no.3
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• pp.21-31
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• 2016

This is a comparative study focused on the scenic landscape preferences derived from visitors's perceptions at the Dulle-gil and the uphill trail in Bukhansan National Park. Unlike previous landscape assessment methods, this study contains more direct and on-site analysis with methods of understanding the visitors' perceptions by using 'visitor employed photography(VEP)' which requires each visitor to take preferable scenic landscape with one's own smart phone camera. The scenic landscape types at two different trails were categorized and then the types favoring most of participants were verified. There are total number of 16 visual landscape types preferred by participants at both the Dulle-gil and the uphill trail in Bukhansan National Park. As in terms of consensus photography(CP) on the Dulle-gil was found to have more diverse elements including both natural and artificial elements compare to the uphill trail. Furthermore, the perceptually excited node(PEN) at the Dulle-gill were found to be more scattered evenly whereas PEN at the uphill trail were concentrated on the entrance and the top of the mountain. It is necessary to consider that the scenic landscape management at the Dulle-gil and the uphill trail require different approaches. Facilities were set based on careful consideration of distinctive geographical features and vegetation in the Dulle-gil. And the management need to be focus on the 'forested area' maintaining natural state in the uphill trail. Futhermore, the result of the CP and PEN in the trails would be helpful to proceed the next step of landscape perception study depending on characteristics of groups.