• 제목/요약/키워드: Traditional korean Medicine

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Developing an Intelligent Health Pre-diagnosis System for Korean Traditional Medicine Public User

  • Kim, Kwang Baek
    • Journal of information and communication convergence engineering
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    • 제15권2호
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    • pp.85-90
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    • 2017
  • Expert systems for health diagnosis are only for medical experts who have deep knowledge in the field but we need a self-checking pre-diagnosis system for preventive public health monitoring. Korea Traditional Medicine is popular in use among Korean public but there exist few available health information systems on the internet. A computerized self-checking diagnosis system is proposed to reduce the social cost by monitoring health status with simple symptom checking procedures especially for Korea Traditional Medicine users. Based on the national reports for disease/symptoms of Korea Traditional Medicine, we build a reliable database and devise an intelligent inference engine using fuzzy c-means clustering. The implemented system gives five most probable diseases a user might have with respect to symptoms given by the user. Inference results are verified by Korea Traditional Medicine doctors as sufficiently accurate and easy to use.

부인과 복강경 수술의 합병증에 대한 한의진료 방향에 대한 고찰 -부인과 복강경 수술 후 발생한 좌골신경병증 1례를 중심으로- (Traditional Korean Medicine Management of Complications of Gynecologic Laparoscopy -A Case Report of Sciatic Neuropathy after Gynecologic Laparoscopy-)

  • 최민선;김동일
    • 대한한방부인과학회지
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    • 제23권1호
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    • pp.124-135
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    • 2010
  • Purpose: To report the patient with sciatic neuropathy after gynecologic laparoscopy, who improved by Traditional Korean Medical treatment and to study Traditional Korean Medicine(TKM) management of complications of gynecologic laparoscopy. Methods: A patient with sciatic neuropathy after gynecologic laparoscopy was managed with herbal medicine, acupuncture and moxibustion treatment. Results: After about 2 months treatment, patient's symptoms and signs were improved. TKM management was effective in recovery of neurologic complication after gynecologic laparoscopy. Conclusion: We need to actively participate in management of complications of gynecologic laparoscopy as primary or adjuvant therapy. And more study is needed for developing Traditional Korean Medical indication of complications of Gynecologic Laparoscopy.

퇴행성 슬관절염의 한의학적 치료에 대한 국내 연구 동향 (The Domestic Trends of Traditional Korean Medicine Treatments on Degenerative Knee Arthritis)

  • 김태윤;김정현;박종훈;이제균;한창;금창준;오재우
    • 척추신경추나의학회지
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    • 제9권2호
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    • pp.69-79
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    • 2014
  • Objectives : The purpose of this review is to investigate the trends of Traditional Korean Medicine treatments on degenerative knee arthritis. Methods : We investigated the studies on traditional Traditional Korean Medicine (TKM) treatments for degenerative knee arthritis via searching 5 Korean web databases. Results : 31 research papers were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, the types of treatments. 31 papers were published since 1992. The studies on TKM treatments about degenerative knee arthritis were mainly published in The journal of korean acupuncture & moxibustion medicine. 13 Randomized Controlled Trials, 10 Case series, 4 Reviews, 3 Non RCTs, and 1 Case Report had been under research. In 22 cases of the studies, one method was used to treat the symptoms. Whereas in 5 cases of the studies, various TKM treatments were used to treat the symptoms. Visual analogue score(VAS) and patient's subjective complaints were used as primary assessments. Conclusion : In this study, we analyzed the trends of TKM treatments on degenerative knee arthritis. Reviewing the domestic trends of studies on Traditional Korean Medicine treatments on degenerative knee arthritis and examining the strong and weak points of those treatments are essential for the further studies.

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Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived from 18F-FDG-PET/MRI

  • Jie Ma;Xu-Yun Hua;Mou-Xiong Zheng;Jia-Jia Wu;Bei-Bei Huo;Xiang-Xin Xing;Xin Gao;Han Zhang;Jian-Guang Xu
    • Korean Journal of Radiology
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    • 제23권10호
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    • pp.986-997
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    • 2022
  • Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent 18F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUVmean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10-3 and (0.0967 ± 0.0545) × 10-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUVmean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

알도즈 환원효소 활성억제와 소비톨 축적 억제로 인한 벌개미취 추출물의 당뇨병성 백내장 발병 지연 효능 (Slow Development of Diabetic Cataract in Streptozotocin-induced Diabetic Rats via Inhibition of Aldose Reductase Activity and Sorbitol Accumulation by Use of Aster koraiensis Extract)

  • 김찬식;김정현;정일하;김영숙;이준;장대식;김진숙
    • 생약학회지
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    • 제40권4호
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    • pp.339-344
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    • 2009
  • Diabetic cataract is a major complication of diabetes mellitus. Excess accumulation of sorbitol plays an important role in the pathogenesis of diabetic complications such as cataract formation. In this study, we investigated the inhibitory effect of the extract of the aerial parts of Aster koraiensis (AK) on diabetic cataractogenesis. To examine this further, we evaluated sorbitol accumulation during cataract development using streptozotocin-induced diabetic rat, an animal model of type 1 diabetes. Diabetic rats were treated orally with AK (100 mg/kg and 200 mg/kg body weight) once a day orally for 9 weeks. In vehicle-treated diabetic rats, lens opacity was increased, and lens fiber swelling and membrane rupture were observed. In addition, sorbitol accumulation in diabetic lens was markedly enhanced. However, AK treatment delayed the progression of diabetic cataract through the inhibition of sorbitol accumulation, and prevented lens fiber degeneration in a dose-dependent manner. These observations suggest that AK treatment can delay the progression of lens opacification in the diabetic rats during the early diabetic cataractogenesis.

Betulin Targets Lipin1/2-Meidated P2X7 Receptor as a Therapeutic Approach to Attenuate Lipid Accumulation and Metaflammation

  • Dou, Jia-Yi;Jiang, Yu-Chen;Hu, Zhong-He;Yao, Kun-Chen;Yuan, Ming-Hui;Bao, Xiao-Xue;Zhou, Mei-Jie;Liu, Yue;Li, Zhao-Xu;Lian, Li-Hua;Nan, Ji-Xing;Wu, Yan-Ling
    • Biomolecules & Therapeutics
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    • 제30권3호
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    • pp.246-256
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    • 2022
  • The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation. AML-12 and RAW 264.7 cells were administered ethanol (EtOH), lipopolysaccharide (LPS) or BT. Male C57BL/6 mice were fed Lieber-DeCarli liquid diets containing 5% EtOH for 4 weeks, followed by single EtOH gavage on the last day and simultaneous treatment with BT (20 or 50 mg/kg) by oral gavage once per day. In vitro, MTT showed that 0-25 mM EtOH and 0-25 µM BT had no toxic effect on AML-12 cells. BT could regulate sterolregulatory-element-binding protein 1 (SREBP1), lipin1/2, P2X7 receptor (P2X7r) and NOD-like receptor family, pyrin domains-containing protein 3 (NLRP3) expressions again EtOH-stimulation. Oil Red O staining also indicated that BT significantly reduced lipid accumulation in EtOH-stimulated AML-12 cells. Lipin1/2 deficiency indicated that BT might mediate lipin1/2 to regulate SREBP1 and P2X7r expression and further alleviate lipid accumulation and inflammation. In vivo, BT significantly alleviated histopathological changes, reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and triglyceride (TG) levels, and regulated lipin1/2, SREBP1, peroxisome proliferator activated receptor α/γ (PPARα/γ) and PGC-1α expression compared with the EtOH group. BT reduced the secretion of inflammatory factors and blocked the P2X7r-NLRP3 signaling pathway. Collectively, BT attenuated lipid accumulation and metaflammation by regulating the lipin1/2-mediated P2X7r signaling pathway.

한의학 미래예측(2000년~2010년) 문헌 분야 실현 최종 평가 (Final Assessment Year of Realized on Forecasting Studies of the Literature Sector on Traditional Korean Medicine (2000-2010))

  • 신현규;김용진
    • 대한한의학원전학회지
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    • 제26권1호
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    • pp.85-98
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    • 2013
  • Objectives : Final assessment of realized on forecasting studies of the literature sector on traditional Korean medicine (2000-2010) revealed results as follows. Methods : We investigated the related peer-reviewed papers and research project reports through Oriental Medicine Advanced Searching Integrated System(OASIS) of Korea Institute of Oriental Medicine(KIOM) and several publishers. Results : Of total five projects, two were realized and three were partially done. The projects 'It wil be standardized by establishing the concept of traditional Korean medical terms' and 'CDs containing traditional medicine books from China, Japan and Korea wiil be released' were decided to be realized. In addition to those, the projects 'Systematic database will be build up for TKM books', 'translation and annotation versions on TKM old books will be completed', and 'A wide range of literature related to traditional medicine of each Asian countries' were concluded to be partially realized. Five projects on predicting TKM in the year 2006-2007 analyzed in 1996 were evaluated as realized or partially realized. Likewise, the five predictions should be reviewed whether it will be necessary in the future after assessment on their realization. Conclusion : Furthermore, it should be studies if the new projects are needed for the future in addition to the existing challenges.

전통의료 서비스 시장의 현황 및 전망에 대한 조사연구 -한의원을 중심으로- (Survey for Current Status and Prospect of Traditional Medical Market)

  • 유종향;이준혁;박기현;진희정;장은수
    • Korean Journal of Acupuncture
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    • 제27권1호
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    • pp.143-150
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    • 2010
  • Objectives: This research aims to know the current status and prospect of traditional medical market to provide sources in setting a development strategy and making a policy on the traditional medicine Methods: This research categorized 11,611 clinics registered in telephone directory as of 2008 by region and some clinics were extracted with simple random method. The inquiry was made with questionnaires and analyzed on the base of frequency. Results: 1. The number of the employee in a clinic were slightly decreased from 2.9 in 2005 and 2006 to 2.8 in 2007. That of the patients also showed a downward tendency from 11,811 in 2005 through 11,716 in 2006 to 11,344 in 2007. 2. An annual turnover in a clinic amounted to 257 million won in 2007 from 232 million won in 2005 through 245 million won in 2006. 3. Approximately 92% of the responses made a negative diagnosis on the traditional medical market and 21% of responses indicated the overall economic recession as a primary reason in their opinions. 4. About 29% of responses presented the extension of medical insurance on traditional medicine as a prior policy. Conclusions: Based on the survey, the prospect of traditional medical market is positive, but the effort of the people in traditional medical system and the systematic support from government are required to activate the stagnated traditional medical market.

전통한의학 연구방법론의 현대화에 대한 소고(小考) - 역사적 근거중심의학에 대한 제언 - (A Proposal for Use in Research Methodology of Traditional Medicine in East Asia - Historical Evidence-Based Medicine -)

  • 엄석기;김세현;최원철
    • 대한한의학원전학회지
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    • 제23권2호
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    • pp.89-105
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    • 2010
  • Research methodology on Traditional Medicine in East Asia refers to logical thinking system, empirical positivism system and methodology of developing these knowledge systems. Logical thinking system of abstract concepts such as analogy or abduction and positivism system of reasonable explanation such as the five elements and their characteristic theory have been used in various ways empirically or in the form of humanities and knowledge system was developed through parallel structure of empirical positivism and exegetical studies. After the 16th century, evidence was required along with the tradition of putting emphasis on rationality, logicality and empirical positivism and characteristics of medical humanities can be found in emphasizing on medical ethics. Data that can be considered as structural review paper or meta analysis from original data of research on Traditional East Asian Medicine should be evaluated as historical evidence which is equivalent to specialist opinion, descriptive disease research, single case report or case series. Historical evidence based medicine is a research method using Historical evidence to selectively support data that are faithful to traditional theory with higher possibility to be used in future traditional east Asian medicine that links between traditional knowledge and scientific research methodology. Moreover, historical evidence based medicine tries to re-evaluate the value of traditional knowledge and ultimately, guides the direction of development of traditional medicine through scientific rationality based on history and culture.

Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn's disease

  • Chenyang Fang;Yanni Pei;Yunhua Peng;Hong Lu;Yin Qu;Chunsheng Luo;Yafeng Lu;Wei Yang
    • The Korean Journal of Physiology and Pharmacology
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    • 제27권4호
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    • pp.365-374
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    • 2023
  • Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications available for individuals with CD. Therefore, novel therapeutic strategies are urgently needed. The bioactive compounds and targets associated with compounds of Qinghua Xiaoyong Formula (QHXYF) were examined using The Traditional Chinese Medicine Systems Pharmacology database, and 5 disease target databases were also used to identify CD-related disease targets. A total of 166 overlapping targets were identified from QHXYF-related and CD-related disease targets and they were found to be enriched in oxidative stress-related pathways and the PI3K/AKT signaling pathway. Molecular docking was then used to predict how the bioactive compounds would bind to the hub targets. It was found that quercetin could be the core bioactive compound and had good binding affinity to the top 5 hub targets. Finally, animal experiments were performed to further validate the findings, and the results revealed that QHXYF or quercetin inhibited 2,4,6-trinitrobenzenesulfonic acid-induced inflammation and oxidative stress processes by inhibiting the PI3K/AKT pathway, thereby improving CD symptoms. These findings suggest that QHXYF and quercetin may be potential novel treatments for CD.