• Journal of Ginseng Research
• /
• v.42 no.1
• /
• pp.98-106
• /
• 2018

Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases.

• The Journal of Korean Medical History
• /
• v.19 no.1
• /
• pp.77-97
• /
• 2006

Korean traditional Oriental medicine is a medical system that has been developed based on the locality and history of Korea as well as the blood and constitution of Korean people. It is closely connected to Korean history and culture, and is in close internal linkage with oral and written legends, traditions and folktales. Referring to previous researches on these legends, the present study extracted medicine related legends from various legend collections, classified them by subject, analyzed representative cases, and examined their meanings and values in terms of medical culture.

• Korean Journal of Oriental Medicine
• /
• v.14 no.2
• /
• pp.121-129
• /
• 2008

The fusion research subjects of Oriental medicine and Information-Technology are actively advanced. These researches provide Oriental medicine the objectivity and support the infra to all study area of Oriental medicine. This paper considers the inside and outside of the country technical development trend of ontology research by analyzing papers and going through case study. It executed information analysis about changes to number of research papers, present state and star higher officer of research facility from the dissertation which it sees. It is known that our country research result is slight so far in quantity and quality as result of analysis. But hereafter it contains many developmental possibilities. Also it reflects the appearance and a growth of new field like bio-informatics biology. In the area of medicine, ontology used to define the terminology for information documentation and the medical terms linked up by high correlation. Also medical information system developed briskly using ontology technology. The ontology of traditional korean medicine play an important role in base infra of traditional korean medicine EHR(Electronic health record).

• The Journal of Korean Medicine
• /
• v.27 no.3 s.67
• /
• pp.132-144
• /
• 2006

Objectives: In order to improve our understanding of the meridian, it is necessary to analyze how meridian theory formed. In this regard, the primitive form of meridians requires further study. Methods: Data from the pre-Han and Han dynasties were used, as such data document primitive forms of the meridian. Results: 1. Some of the terminology of the primitive meridians did not include symmetrical terms such as hand, foot, yin and yang; instead, terms of travel area were used. 2. In the primitive meridians, most travel from the bottom to the top. 3. The twelve meridian system had not yet been introduced into the primitive system. 4. In the primitive meridians, only a few had branches. 5. In the primitive meridians, they did not have obvious connections with the five vital organs and the six viscera. Conclusions: Although the primitive meridian system differs from the modem, studying the primitive meridians may improve our understanding of the modem meridians.

• Journal of Society of Preventive Korean Medicine
• /
• v.16 no.1
• /
• pp.1-13
• /
• 2012

The objective of this study is to discuss the role of integrative medicine (IM) in contemporary health care settings, and how and which factors affect and facilitate the success of IM in terms of the integration of complementary and alternative medicine (CAM) and conventional medicine in primary health care (PHC). IM is meant to provide the best possible health care, for both patient and physician. The way of IM use in the developed countries presents various ways that IM can be provided, and it appears that strategies have been successfully developed to facilitate integration. Although few of the barriers to the integration of CAM and conventional medicine have been resolved, concerns over the legitimacy of CAM in health care (e.g., safety, biomedical evidence, and efficacy) are being overcome by the use of evidence-based practice in IM delivery. There are dominant models of IM that have been developed. The model types signify different levels of equity between CAM and conventional medicine in regard to the power, autonomy, and control held by each. However, the factors common to all IM models, whether describing CAM as supplementary or complementary to conventional medicine, is the concept of a health care model that aspires to be client-centred and holistic, with focus on health rather than disease as well as mutual respect among peer practitioners. Finally, this study concluded that the growth and viability of traditional Korean medicine(TKM) depend on evidence-based practices and identifying the successful influences on the integration of TKM and conventional medicine for recognition of its inherent value in PHC. Some recommendations for the integration of TKM and conventional medicine were suggested.

• Journal of Ginseng Research
• /
• v.38 no.4
• /
• pp.227-232
• /
• 2014

Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use are from Jilin Province. The province has established 36 good agricultural practice bases for 22 typical TCMs. The overall situation, in terms of collection, processing, and preparation, and the implementation of good agricultural practice of TCM materials in Jilin Province are summarized.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.5
• /
• pp.765-772
• /
• 2011

Knowledge which is represented by formal logic are widely used in many domains such like artificial intelligence, information retrieval, e-commerce and so on. And for medical field, medical documentary records retrieval, information systems in hospitals, medical data sharing, remote treatment and expert systems need knowledge representation technology. To retrieve information intellectually and provide advanced information services, systematically controlled mechanism is needed to represent and share knowledge. Importantly, medical expert's knowledge should be represented in a form that is understandable to computers and also to humans to be applied to the medical information system supporting decision making. And it should have a suitable and efficient structure for its own purposes including reasoning, extendability of knowledge, management of data, accuracy of expressions, diversity, and so on. we call it ontology which can be processed with machines. We can use the ontology to represent traditional medicine knowledge in structured and systematic way with visualization, then also it can also be used education materials. Hence, the authors developed an Shanghanlun ontology by way of showing an example, so that we suggested a methodology for ontology development and also a model to structure the traditional medical knowledge. And this result can be used for student to learn Shanghanlun by graphical representation of it's knowledge. We analyzed the text of Shanghanlun to construct relational database including it's original text, symptoms and herb formulars. And then we classified the terms following some criterion, confirmed the structure of the ontology to describe semantic relations between the terms, especially we developed the ontology considering visual representation. The ontology developed in this study provides database showing fomulas, herbs, symptoms, the name of diseases and the text written in Shanghanlun. It's easy to retrieve contents by their semantic relations so that it is convenient to search knowledge of Shanghanlun and to learn it. It can display the related concepts by searching terms and provides expanded information with a simple click. It has some limitations such as standardization problems, short coverage of pattern(證), and error in chinese characters input. But we believe this research can be used for basic foundation to make traditional medicine more structural and systematic, to develop application softwares, and also to applied it in Shanghanlun educations.

• Herbal Formula Science
• /
• v.21 no.2
• /
• pp.13-28
• /
• 2013

Objectives : Term standardization is the most important for knowledge information in every study. There are several tries to make terminology standards in Korean Traditional Medicine(KTM). We, authors took a review on romanized prescription nomenclature of main titles in Herbal Formula Science to criticize the ways of romanized prescription nomenclature. Methods : We extract romanized prescription name from Vol. 11, No. 1 to latest Issue Vol. 21, No. 1, Herbal Formula Science. Results : The Korean Academy of Oriental Medicine Prescription has guideline for romanized prescription nomenclature. However, only 6 out of 147 romanized prescription name are confirmed with guideline. In addition, 58 out of 142 names are italicized without guideline. Also there are several ways of marking for prescription names. Conclusions : For making knowledge information and easy searching for terms, we need normative regulations for romanized prescription nomenclature by the Society of Korean Medicine level.

• The Journal of Pediatrics of Korean Medicine
• /
• v.30 no.3
• /
• pp.52-60
• /
• 2016

Objectives The purpose of this study is to analyze studies about the effects of topical application of Chinese herbal medicine for allergic rhinitis within randomized controlled trials (RCT). Methods The search database includes KJTK (Korean Traditional Knowledge Portal), OASIS (Oriental Medicine Advanced Searching Integrated system), CNKI (China National Knowledge Infrastructure), PubMed, and EMBASE. We used the following key search terms: "allergic rhinitis", "traditional Chinese medicine", "traditional Korean medicine", "Chinese herbal medicine", "randomized controlled trial", "clinical study", "nasal spray", and "nasal drop" Results Five studies were selected for analysis. Three studies used nasal spray of Chinese herbal medicine and two studies used nasal drops of Chinese herbal medicine for the intervention. Frequently used herbs were Magnoliae Flos (辛夷), Scutellariae Radix (黃芩), Coptidis Rhizoma (黃連), and Astragali Radix (黃芪). For the outcome measures, studies used symptom score, questionnaire of Quality of Life, nasal airway resistance, or laboratory studies. From all 5 studies, it has been shown that topical application of Chinese herbal medicine was effective for improving symptoms of allergic rhinitis. Two out of five studies showed statistical difference between study group and control group. Conclusions This study shows that topical application of Chinese herbal medicine can improve symptoms of allergic rhinitis. Well-designed RCT studies with low risk of bias and studies with outcome measures for assessing the immunomodulatory effects are necessary to confirm these findings.

• Korean Journal of Oriental Medicine
• /
• v.14 no.2
• /
• pp.81-86
• /
• 2008

Objective: This study was aimed to review the recent trends of complementary medicine research in ICCMR 2008. Methods: Analyzed data include all researches of both oral and poster presentations in ICCMR. We classified presented researches according to their treatment method, nations, and targeted diseases. Results: In total, 338 researches were presented. In terms of methods, 68 basic researches, 98 clinical trials, 55 commentaries, 46 reviews, 71 trend analysis papers were classified. Herbal medicine was the most common treatment for research in ICCMR. And in terms of nation. Australia's announcement was the most in ICCMR. Lastly, cancer was the most focused theme in the conference. Conclusion: In the recent CAM research, cancer, depression and stress are the most targeted diseases since they are difficult to cure in modern medicine and since patients have high hopes to overcome their state by CAM. This review will help Korean doctors or scientists to systematically understand traditional medicine and to develop their researches.