• 분석과학
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• 제32권6호
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• pp.233-242
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• 2019

Substance identification is the first step of the REACH registration. It is essential in terms of Classification, Labelling and Packaging (CLP) regulation and because even trace amounts of impurities or additives can affect the classification. In this study, a scheme for the screening, quantification, and interpretation of trace amounts of hazardous inorganic substances is proposed to detect the presence of more than 0.1% hazardous inorganic substances that have been affecting the hazard classification. An exemplary list of hazardous inorganic substances was created from the substances of very high concern (SVHCs) in REACH. Among 201 SVHCs, there were 67 inorganic SVHCs containing at least one or ~2-3 heavy metals, such as As, Cd, Co, Cr, Pb, Sb, and Sn, in their molecular formula. The inorganic SVHCs are listed in excel format with a search function for these heavy metals so that the hazardous inorganic substances, including each heavy metal and the calculated ratio of its atomic weight to molecular weight of the hazardous inorganic substance containing it, can be searched. The case study was conducted to confirm the validity of the established scheme with zinc oxide (ZnO). In a substance that is made of ZnO, Pb was screened by XRF analysis and measured to be 0.04% (w/w) by ICP-OES analysis. After referring to the list, the presence of Pb was interpreted just as an impurity, but not as an impurity relevant for the classification. Future studies are needed to expand on this exemplary list of hazardous inorganic substances using proper regulatory data sources.

• Bulletin of the Korean Chemical Society
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• 제30권2호
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• pp.368-372
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• 2009

The trace polymer and additives in used stripper solutions were analyzed by a combination of Py-GC/MS and ESI-MS. In the comparison of the pyrolysates produced by the pyrolysis of the pure stripper and photoresist at $500{^{\circ}C}$, the presence of novolac polymer in the used stripper was confirmed by the presence of the characteristic peaks of its pyrolysates, such as those of the methylphenol, di-methylphenol and methylenebis(methylphenol) isomers. The intact trace polymer was measured by ESI-MS, which showed the distribution of oligomers at intervals of 120 Da, indicating di-methylphenol to be the repeat unit. Additional MS/MS measurements demonstrated that the end group is methylphenol and the repeat groups are di-methylphenol. Some modified oligomers caused by the methylation or di-methylation of the repeat unit were also identified. Although the polymer is only present at a trace level in the used stripper, these combined analytical methods provided the means to qualify the stripper solution through the identification and structural determination of the polymer.

• 약학회지
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• 제4권1호
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• pp.8-11
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• 1959

The method for the estimation of trace elements in hair is studied on this paper modifying the circular paper chromatography method shown by Giri and Balakrishnan for the estimation of vitamins from the multivitamin preparation. The elements studied are Ni, Al, Mn, Mg, Zn, Ca, Co, Cu, and Fe. The content of the element is estimated quantitatively by comparison the size and the color density of spots of the standard chromatogram prepared by the known amount of each standard substance and the chromatogram prepared from sample solution, after checking those chromatogram qualitatively. The comparative study has been made between the results from this method and the results from the other methods which are applying routinely at this laboratories. The experimental errors at each elements were within 10% limits. There was no interference between each elements. It is recommendable that this method can be applied to treat numerous speciemens saving times within experimental error of 10%.

• Nutritional Sciences
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• 제9권3호
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• pp.190-194
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• 2006

Silajit is a blackish brown pitch-like gummy substance. It is an important Unani and Ayurvedic medicine widely used in the treatment of many diseases and as nutritional supplement It is found in certain mountainous regions of Pakistan, Afghanistan, India, Nepal, Australia and Russia. Silajit samples of Pakistani origin were obtained from different sources and analyzed for their physical characteristics and biochemical & elemental composition. X-ray diffraction studies on Silajit showed that it is an amorphous substance and has no crystalline structure. Also, pH studies of Silajit (2 g/L of water) indicated that it was slightly acidic in nature and ranged from 3.45 to 7.23. Conductivity ranged from 157.7 to 330. Amino acid analysis revealed that Silajit contained lysine and alanine in higher amounts than all other amino acids and ranged from 1456 to 2240 and 68 to $1615{\eta}mole/g$, respectively. Mean concentration of arsenic, mercury, cadmium, lead, copper and zinc was 73.15, 104.92, 0.496, 3.89, 4.04 and 17.23 ppm, respectively. Silajit samples were also analyzed for calcium, potassium and sodium.

• Environmental Analysis Health and Toxicology
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• 제21권2호
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• pp.173-184
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• 2006

From the harmfulness expectation test conducted through a toxicity anticipation program, methylcyclohexane turned out to be harmful and simulative, but no carcinogenicity was anticipated. In a four-hour acute inhalation toxicity test, the result showed that lethal concentration ($LC_{50}$) was 3,750 ppm (15,054 mg/L), which was identified as a harmful substance on the basis of the harmful substance classification standard $2 of the Industrial safety and health law. methylcyclohexane fell under the category $4(2,500 substance from the GHS standard acute toxicity harmfulness classification. Also, from subchronic inhalation toxicity test that included 6 hours a day, five days a week, and for 13 weeks, we could observe weight, activity, long term weight, blood and blood biochemical influence from the exposure of test substance. No-observed effect level (NOEL) was determined below $100{\sim}400ppm$ inboth male and female. This material falls under the Category 2 ($50{\sim}250ppm/6hours/90days$) in the GHS (Globally Harmonized System) standard trace long-term whole body toxicity repeated exposure, and can be classified as a harmful substance in accordance with the Industrial Safety and Health Law harmful substance standard $NOEL{\leq}0.5mg/L/6hr/90day$ (rat).

• 공업화학
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• 제17권2호
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• pp.119-124
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• 2006

물 속에 존재하는 자연 유기물의 성분은 계절과 장소에 따라 다양하게 변하므로 이들 성분에 대한 고찰과 이들이 환경에 미치는 영향을 고찰할 필요가 있다. 본 총설에서는 물 속에 존재하는 휴믹 물질, 탄수화물, 단백질(아미노산), hexosamine, 유지, 오일, 그리스 및 미량 유기물질(내분비교란화학물질과 의약품) 등의 자연 유기물의 특성을 정리하였다.

• 한국물환경학회지
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• 제21권5호
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• pp.431-441
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• 2005

The study was carried out to improve and regulate the drinking water quality standard and drinking water quality monitoring substances. For the reliability and safety of finished water, It has been monitored for trace organic and inorganic compounds of 333 in finished water of water treatment plants during 1989 to 2003. As a result of monitoring, 51 compounds were detected from 333 compounds, and it has been regulated the drinking water quality standard of 26 substances and 20 mitoring substance. Improvement and regulation method of the drinking water quality standard was performed by comparing and analyzing with detection concentration, detection frequency, risk assessment and foreign drinking water quality standard.

• 지질공학
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• 제16권4호
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• pp.351-357
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• 2006

상수원으로 사용하고 있는 주요 하천으로의 위해물질의 유입은 정수장에서의 고도기술을 요구하게 된다. 그러므로 산업폐수로부터 방류되는 이들 미량유해화학물질의 모니터링을 적절하게 하는 것은 위해도 저감 뿐 만 아니라 하천관리의 경제성도 증가시킬 수 있다. 본 연구를 통해 모니터링 한 여러 미량 유해화학물질 중에서 산업폐수의 방류수에서 검출된 오염물질 중 가장 주요한 항목은 Hexachlorobutadiene 였다. 그러나 반도체, 전기/전자 및 금속조립 산업폐수로 구성된 Group II에서는 모든 항목이 불검출로 나타났다. 따라서 향후 상수원 수질개선 및 보호를 하기 위해 모니터링 항목을 선정하는데 있어서는 해당 수계로 부하되는 물질들의 특성과 거동을 제대로 파악하기 위한 사전모니터링을 실시하여 시간, 노력 및 경제적인 손실을 최소화하여 효율적인 상수원관리를 해야 한다.

• Journal of Animal Science and Technology
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• 제63권1호
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• pp.160-169
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• 2021

Boiled feed is obtained by mixing and boiling agricultural by-products such as rice straw, rice bran, and bean curd with grains. The study explored the change in fatty acid, free amino acid, nucleotide, mineral, cholesterol, myoglobin and collagen of longissimus dorsi muscle in Hanwoo steers fed with boiled feed. Forty steers, 20 heads per group, were divided into two groups: a control group and a boiled feed group. The steers were raised for 10 months. The boiled feed group was enriched with palmitoleic acid, oleic acid, arachidonic acid and unsaturated fatty acids compared with the control group. There were no significant differences in amino acid and nucleic acid composition between the two groups. The boiled feed group contained higher levels of iron and manganese in the boiled feed group compared with the control group. The total cholesterol level was significantly increased, whereas calorie levels, myoglobin and collagen composition showed no differences. As the supply of boiled feed increases the content of fatty acids, unsaturated fatty acids and minerals related to flavor, it should be a feed that leads to the production of high-quality beef.

• Preventive Nutrition and Food Science
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• 제4권2호
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• pp.152-158
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• 1999

Polystyrene is frequently used for food packaging because of its eaxy processing rigidity , and low cost. Styrene, which is present in detectable amouts in the polymer, is usually considered to be the substance responsible for the possible tainting of a polystyrene-packed food by migration. The contamination of foods and beverages by trace amounts of materials which have migrated from plastics use din packaging is a concern both on the grounds of adversely affecting product quality and of food safety. These lead to increasing attention to the potentional hazards of a large variety of plastic materials and foods. In this paper we reviewed the history of Styrene and various analytical methods of sample preparation and detection to assess the extent to which styrene is present in food-grade polystrene materials and to what extent it leaked into foods and food stimulants.