• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.825-826
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• 2012

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.1425-1426
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• 2013

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.17 no.1
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• pp.233-248
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• 1987

The author studied the effect of periapical bone loss on radiographic interpretation by using a dry adult human mandible. Artificial bony lesions were created at the apices of two mandibular second molars and four mandibular bicuspids. The jaw was stabilized and various artificial lesions were radiographed under ideal circumstances. Radiographic pictures were recorded and compared with the size of the actual lesions. The obtained results were as follows: 1. The size of actual lesions were always larger than their radiographic pictures. 2. The size of actual lesion had a greater discrepancy in the molar area where the cortical plates were havier, but the lesions in the bicuspid areas were only slightely larger than their radiographic pictures, and in these areas the cortical plates were quite thin. 3 Periapical lesions located in cancellous bone did not appear on a radiograph, regardless of the size of the created lesion, but when the junctional bone was involved or the cortical plate was perforated, the definite bone destructive change was observed on the roentenogram. 4. Removal of the entire buccal or lingual plate did not affect the trabecular pattern of bone on the roentgenogram. 5. When the cancellous bone and junctional bone were removed simultaneously, altered trabecular patterns were observed on the roentgenogram.

• Journal of Biomedical Engineering Research
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• v.33 no.4
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• pp.207-212
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• 2012

It is widely known that sciatic nerve injury (SNI) can negatively affect the biomechanical characteristics of the musculoskeletal system. However, there were no studies that evaluated and compared denervated side with another side limb at the same time. In this study, sixteen male 12-week-old mice were allocated into two groups: HEMI (Right Sciatic nerve denervated) and CON (Control). Both limbs were scanned using micro-CT at 0 week and 4 weeks. There were significant differences in relative variation (RV) of BMD and all structural parameters compared CON and HEMI in right tibia (p < 0.05). Tb.Th and Tb.Sp distributions were differed CON with HEMI in right tibia. In left tibia, there were significant differences in RV of BMD (p < 0.05) and Tb.Sp distribution. These result means that SNI can induce bone loss in the both side tibiae. However, there was a different profile of bone loss between left and right tibiae.

• Nutritional Sciences
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• v.8 no.2
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• pp.89-96
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• 2005

To determine the deleterious effects of chronic alcohol consumption on bone especially in adolescents or young adults, 8 week-old Sprague Dawley male rats were fed with Lieber-Decarli ethanol liquid diet, containing $36\%$ of energy as ethanol, ad libitum (ethanol group) or isocaloric normal liquid diet (control group) for 7 weeks. Body weight was significantly lower in ethanol group than that in control group after 1 week of feeding to the end. liver weight and the ratio of liver or kidney weight to body weight in ethanol group were significantly increased when compared to those in control group. Ethanol group showed significantly lower serum protein and albumin levels (p<0.05), higher total cholesterol and HDL-cholesterol levels (p<0.05), and AST, ALT and BUN activities than control group, but serum triglyceride, Ca and phosphate levels were not different. Ethanol group had significantly lower tibial trabecular bone area and serum osteocalcin level than control group (p<0.05), but urinary Ca and NTx (cross-linked N-telopeptide of type I collagen) concentrations and serum testosterone and parathyroid hormone levels were not different. In conclusion, chronic alcohol consumption in growing young male rats may result in osteopenia through the reduction of bone formation as well as liver malfunction.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.41
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• pp.11.1-11.6
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• 2019

Background: Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. Results: The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group. Conclusion: Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.

• Archives of Pharmacal Research
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• v.28 no.1
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• pp.106-110
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• 2005

The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.

• Journal of Acupuncture Research
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• v.18 no.1
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• pp.61-75
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• 2001

Objectives : This study was designed to evaluate on the effects of the Carthami semen Cervi pomtotrichum cornu Hominis placenta aquacupuncture on the osteoporosis in the rats Materials and Methods : In order to induce estrogen deficient osteoporosis, ovariectomy was done on rats. Then aquacupunctures were injected into the pai shu points corresponding to urinary bladder meridian of human body in experimental groups. And such indexes were measured as the change of body weight, bone mineral density, histological change of tibia, and levels of osteocalcin, bone alkaline phosphatase, calcium, phosphorus in serum. Results : 1. Significant changes of trabecular area % in epiphysis of tibia were shown between control group and experimental group II and between experimental group I and group II. 2. Significant changes of trabecular area % in diaphysis of tibia were shown between control and experimental groups. 3. Significant changes of serum osteocalcin were shown between control group and experimenta group I . 4. Significant changes of levels of serum bone alkaline phosphatase were shown between control group and experimental group I and II. Conclusions : The Carthami semen Cervi pomototrichum cornu Hominis placenta aquacupuncture is effective to estrogen deficient osteoporosis, ovariectomy was done on rats.

• Imaging Science in Dentistry
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• v.36 no.2
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• pp.69-72
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• 2006

Purpose : We evaluated the fractal dimension changes on bovine rib radiographs according to the decalcification degree and the exposure time in the bovine rib. Materials and Methods : Twenty 5 mm thick cross-sectional blocks from bovine rib bone were progressively decalcified in 30 mL 0.1 N hydrochloric acid for 5, 30, and 90 minutes. They were radiographed at three exposure time settings (0.22, 0.36, 0.43 mAs) before and after each decalcification stage. We selected $100{\times}100$ pixel-sized regions of interests (ROIs) on trabecular bone and calculated fractal dimensions by box-counting method. Results : Repeated measures ANOVA showed that fractal dimensions gradually decreased after acid-induced demineralization and with more exposure (P<0.001). Conclusion : The fact that fractal dimensions decrease after decalcification might support the hypothesis that patients with osteoporosis have decreased radiographic fractal dimension in trabecular bone in comparison to normal subjects.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.38 no.2
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• pp.96-100
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• 2012

Objectives: This study sought to evaluate trabecular changes in the mandible using fractal analysis and to explain the transient osteopenia related to rapid orthodontic tooth movement after orthognathic surgery. Materials and Methods: Panoramic radiographs were taken of 26 patients who underwent bilateral sagittal split ramus osteotomy. Radiographs taken before the surgery and 1 month after surgery were overlapped, and $40{\times}40$ pixel square regions of interest were selected near the mandibular canines and 1st molars. After the image processing procedure, the fractal dimension was calculated using the box-counting method. Results: Fractal dimension after orthognathic surgery decreased in a statistically significant manner (P<0.05). The change in fractal dimension on the canine side had greater statistical significance as compared to that seen on the 1st molar side. Conclusion: This study found that bone density decreases after orthognathic surgery due to transient osteopenia related to the regional acceleratory phenomenon. This result can provide a guide to evaluating orthodontic tooth movement after orthognathic surgery.