• 한국환경보건학회지
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• 제48권3호
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• pp.159-166
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• 2022

Background: A quantitative structure-activity relationship (QSAR) model was adopted in the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH, EU) regulations as well as the Act on Registration, Evaluation, etc. of Chemicals (AREC, Republic of Korea). It has been previously used in the registration of chemicals. Objectives: In this study, we investigated the correlation between the predicted data provided by three prediction programs using a QSAR model and actual experimental results (acute fish, daphnia magna toxicity). Through this approach, we aimed to effectively conjecture on the performance and determine the most applicable programs when designating toxic substances through the AREC. Methods: Chemicals that had been registered and evaluated in the Toxic Chemicals Control Act (TCCA, Republic of Korea) were selected for this study. Two prediction programs developed and operated by the U.S. EPA - the Ecological Structure-Activity Relationship (ECOSAR) and Toxicity Estimation Software Tool (T.E.S.T.) models - were utilized along with the TOPKAT (Toxicity Prediction by Komputer Assisted Technology) commercial program. The applicability of these three programs was evaluated according to three parameters: accuracy, sensitivity, and specificity. Results: The prediction analysis on fish and daphnia magna in the three programs showed that the TOPKAT program had better sensitivity than the others. Conclusions: Although the predictive performance of the TOPKAT program when using a single predictive program was found to perform well in toxic substance designation, using a single program involves many restrictions. It is necessary to validate the reliability of predictions by utilizing multiple methods when applying the prediction program to the regulation of chemicals.

• 한국자원리싸이클링학회:학술대회논문집
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• 한국자원리싸이클링학회 2001년도 정기총회 특별강연 및 춘계학술연구발표회(2)
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• pp.109-112
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• 2001

A case study of foodwaste treatment was conducted to compare the impacts of four scenarios: incineration, incineration after biogasification, biogasification followed by composting, and composting. Potential contributions to climate change, acidification, consumption of landfill and human toxicity were assessed. Characterization of human toxicity caused by metals and PCDD/DF was performed by three multimedia fate models. Scenarios with a biogasification process showed lower impact on climate change and human toxicity. The ranking of four scenarios on human toxicity varied depending on the characterization models applied. The steady state models placed high priority on emission of heavy metals to farmland, whereas the dynamic model estimated the emission of PCDD/DF from the incineration process as more significant.

• Carbon letters
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• 제20권
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• pp.10-18
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• 2016

Nanoporous carbon structures were synthesized by pyrolysis of grass as carbon precursor. The synthesized carbon has high surface area and pore volume. The carbon products were acid functionalized and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Brunauer–Emmett–Teller, transmission electron microscopy, and Energy Dispersive X-ray microanalysis. Acid functionalized nanoporous carbon was explored for use in removal of toxic Cr(VI) ions from aqueous media. An adsorption study was done as a function of initial concentration, pH, contact time, temperature, and interfering ions. The experimental equilibrium data fits well to Langmuir isotherm model with maximum monolayer adsorption capacity of 35.335 mg/g. The results indicated that removal obeys a pseudo-second-order kinetic model, and that equilibrium was reached in 10 min. A desorption study was done using NaOH. The results of the present study imply that acid functionalized nanoporous carbon synthesized from grass is an efficient, renewable, cost-effective adsorbent material for removal of hexavalent chromium due to its faster removal rate and reusability.

• Journal of Advanced Marine Engineering and Technology
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• 제36권3호
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• pp.368-377
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• 2012

Most tunnel simulations have been focused on the thermal field and the critical velocity for suppression of hot back-layering flow in case of fire and on the characteristics of a tunnel fire in terms of the flame propagation and the toxic gas generation. In this paper, a comparative study of the flow characteristics of polluted air with no heat source in a tunnel model opened and closed at both end sides is implemented into a recognized CFD simulation code. The model is used to investigate the flow characteristics depending on the three different Reynolds numbers of 640, 1270 and 2120, which have been chosen by the flow velocities of 0.3, 0.6 and 1.0 m/s through the inlet. The results of this study have shown that the CFD predictive and experimental approaches are available in qualitatively studying the correlation of flow behaviors for a better tunnel design.

• Environmental Analysis Health and Toxicology
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• 제21권3호
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• pp.239-244
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• 2006

Caenorhabditis elegans(C. elegans) is a free-living soil nematode that commonly used as a biological model and recently, much work has been done using C. elegans as a toxicity model. To evaluate the acute toxicity of phenols to C. elegans, worms were subsequently exposed to nine different xenobiotics. This study described lethal toxicity, reproductive toxicity and movement inhibition using 2-propylphenol, 4-propylphenol, 2-tert-butylphenol, 3-tert-butylphenol, 4-tert-butylphenol, 2-phenylphenol, 4-phenylphenol, nonylphenol and 4-dodecylphenol to C. elegans for 24 hr or 72 hr. We found that phenols used in this study were very toxic to C. elegans. The order of lethal toxicity, reproductive toxicity and movement inhibition is as follows. 4-propylphenol > 2-phenylphenol > 2-tert-butylphenol > 2-propylphenol > nonylphenol > B-tert-butylphenol > 4-dodefylphenol > 4-tert-butylphenol > 4-phenylphenol.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2001년도 Proceedings of the 3rd Annual Meeting of Yellow Sea Environment
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• pp.42-48
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• 2001

A kinetic model was presented to estimate the uptake/release rate constants and thereafter, bioconcentration factor, $k_1$, $k_2$ and BCF (bioconcentration factor), for the uptake of PH by plankton were obtained. Implies that PH(petroleum hydrocarbon) caused no significant influence on the uptake of $N-NO_3$, but significant influence on that of $P-PO_4$. In addition, the application of kinetic model for the bioconcentration of volatile organic toxic compound by organism suggests that the uptake of PH by plankton was an important process for the environmental capacity of PH.

• 터널과지하공간
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• 제6권3호
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• pp.250-259
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• 1996

According to the wide application of diesel equipments in tunneling faces, the air contamination by various toxic gases and carcinogenic diesel particulate matter becomes a serious problem these days. For taking a scientific measures to solve the problem, the way to simulate 3 dimensional flow movement of the working sites is required. In this paper, the newly developed simulation program(3D-FLOW) and the results of a simulation on a model tunneling workings using diesel equipments are introduced. In case of typical model of tunneling face, the gas concentration of human height is about one third of roof concentration and right side half of the tunnel shows better environment than left half. NOx concentration of workings can be estimated about 0.45ppm which is much lower than permissible level(5 ppm).

• Toxicological Research
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• 제25권1호
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• pp.9-15
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• 2009

Historically, research in toxicology has utilized non-human mammalian species, particularly rats and mice, to study in vivo the effects of toxic exposure on physiology and behavior. However, ethical considerations and the overwhelming increase in the number of chemicals to be screened has led to a shift away from in vivo work. The decline in in vivo experimentation has been accompanied by an increase in alternative methods for detecting and predicting detrimental effects: in vitro experimentation and in silico modeling. Yet, these new methodologies can not replace the need for in vivo work on animal physiology and behavior. The development of new, non-mammalian model systems shows great promise in restoring our ability to use behavioral endpoints in toxicological testing. Of these systems, the zebrafish, Danio rerio, is the model organism for which we are accumulating enough knowledge in vivo, in vitro, and in silico to enable us to develop a comprehensive, high-throughput toxicology screening system.

• Preventive Nutrition and Food Science
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• 제6권4호
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• pp.253-256
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• 2001

Irradiation of food is not only used for sanitation purposes but can be used for processing techniques to reduce or eliminate toxic or undesirable compounds on food. Irradiation wag effective to reduce the allergenicity of food by modification of the structure of proteins causing allergy reactions. Volatile N-nitrosmaine was reduced or eliminated by irradiation in the model system study and the breakdown products by irradiation did not recombine under human stomach conditions (pH 2,3, and 4,37$^{\circ}C$). The possibility of residual chlorophyll b reduction by irradiation was also found, and the model study indicated that irradiation be used to destroy chlorophyll b, resulting in protection from photooxidation in oil without acceleration of lipid oxidation during irradiation. In this paper, several on-going research projects for the application of food irradiation as a new processing technique are introduced, including reduction of food allergens, breakdown of volatile N-nitrosamine and residual chlorophyll b.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.2533-2538
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• 2014

본 연구에서는 노래방 화재의 위험성을 예측하기 위하여 2-zone model CFAST소프트웨어를 이용하여 해석을 수행하였다. 모델은 3차원 비정상 상태이다. 또한, CFAST의 해석 결과와 실제 화재 재현 실험결과를 비교 분석하여 CFAST의 정확성이 검증되었다. 해석 결과 화재가 발생된 방에서 화재발생 5분 이내에 산소농도는 10% 까지 감소하며, 이산화탄소 농도는 5%까지 증가하였다. 따라서 노래방과 같은 밀폐된 공간에서는 유독가스에 의한 질식으로 더 위험한 상황이 발생한다는 것을 예측할 수 있다.