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Single Centre Experience on Decision Making for Mechanical Thrombectomy Based on Single-Phase CT Angiography by Including NCCT and Maximum Intensity Projection Images - A Comparison with Magnetic Resonance Imaging after Non-Contrast CT

  • Kim, Myeong Soo;Kim, Gi Sung
    • Journal of Korean Neurosurgical Society
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    • v.63 no.2
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    • pp.188-201
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    • 2020
  • Objective : The purpose of this study was to suggest that computed tomography angiography (CTA) is valuable as the only preliminary examination for mechanical thrombectomy (MT). MT after single examination of CTA including noncontrast computed tomography (NCCT) and maximum intensity projection (MIP) improves door-to-puncture time as well as results in favorable outcomes. Methods : A total of 157 patients who underwent MT at Dong Kang Medical Center from April 2015 to March 2019 were divided into two groups based on the examination performed prior to MT : CTA group who underwent CTA with NCCT and MIP, and NCCT+magnetic resonance image (MRi) group who underwent MRI including perfusion images after NCCT. In the two groups, time to CTA imaging or NCCT+MRi imaging after symptom onset, and time to arterial puncture and reperfusion were characterized as time-related outcomes. The evaluation of vascular recanalization after MT was defined as a modified thrombolysis in cerebral infarction (mTICI) scale. National Institutes of Health Stroke Scale (NIHSS) was assessed at the time of the visit to the emergency room and modified Rankin Scale (mRS) was assessed after 90 days. Results : Typically, there were 34 patients in the CTA group and 33 patients in the NCCT+MRi group. A significantly shorter delay for door-to-puncture time was observed (mean, 86±22.1 vs. 176±47.5 minutes; <0.01). Also, a significantly shorter door-to-imege time in the CTA group was observed (mean, 13±6.8 vs. 93±30.8 minutes; p<0.01). Moreover, a significantly shorter onset-to-puncture time was observed (mean, 195±128.0 vs. 314±157.6 minutes; p<0.01). Reperfusion result of mTICI ≥2b was 100% (34/34) in the CTA group and 94% (31/33) in the NCCT+MRi group, and mTICI 3 in 74% (25/34) in the CTA group and 73% (24/33) in the NCCT+MRi group. Favorable functional outcomes (mRS score ≤2 at 90 days) were 68% (23/34) in the CTA group and 60% (20/33) in the NCCT+MRi group. Conclusion : A single-phase CTA including NCCT and MIP images was performed as a single preliminary examination, which led to a reduction in the time of the procedure and resulted in good results of prognosis. Consequently, it is concluded that this method is of sufficient value as the only preliminary examination for decision making.

A Prioritized Call Admission Control using Prediction-Based Adaptive Bandwidth Reservation in High-Speed Multimedia Wireless Networks (고속 멀티미디어 무선 망에서 예측 기반의 적응적 대역폭 예약을 이용한 우선순위 호수락 제어)

  • Kim, Mi-Hui;Chae, Gi-Jun
    • Journal of KIISE:Computer Systems and Theory
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    • v.26 no.8
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    • pp.984-998
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    • 1999
  • 최근 개인 휴대 통신에 대한 관심도가 증가하면서 B-ISDN (Broadband Integrated Services Digital Network)과 같은 기존의 유선 망에서 제공하던 다양한 멀티미디어 응용 지원을 무선 망으로 확장시키기 위한 연구가 활발히 진행되고 있다. 그러나 기존의 유선 망에서는 멀티미디어 응용 지원을 위해 QoS (Quality of Service) Provisioning에 관한 많은 연구가 되어 있으나 무선 망에서는 이동성과 무선 전파의 열악한 전송으로 인해 새로운 QoS Provisioning 방법에 관한 연구가 필수적이다. 본 논문에서는 이러한 무선 망의 특수성으로 인해 발생할 수 있는 서비스의 질 저하와 강제 종료를 줄임으로써 지속적인 QoS를 보장해 주고 한정된 무선 자원을 효율적으로 사용하며 처리에 의한 오버헤드를 줄이기 위하여 다음과 같은 세 가지 방법을 제안하였다. 첫째, 핸드오프 강제 종료율을 줄이기 위하여 대역폭 예약 방법을 사용하되 특정 셀의 트래픽 특성에 맞게 또한 시간대에 따른 트래픽 특성에 따라 예약 대역폭의 양을 조절하는 적응적 대역폭 예약 방법이다. 둘째, 많은 경우 각 셀의 트랙픽 변화는 일정한 주기로 변화한다는 특성에 따라 과거의 트래픽 정보를 이용하는 예측 기반의 대역폭 예약 방법이다. 마지막으로 호의 종류, 트래픽 특성, 단말기의 이동 속도에 따라 다른 우선 순위에 의해 호 수락 제어를 수행하는 우선 순위 기반의 호 수락 제어를 제안하였다. 시뮬레이션을 통하여 기존에 제안된 방법과 성능 비교하여, 요구되는 수준의 QoS 보장과 효율적인 자원의 사용, 요구되는 처리비용의 최소화를 통해 전체 시스템의 성능 향상을 입증하였다.Abstract As interest in wireless hand-held terminals and in personal communications services increases recently, there have been broad studies on the ways to support multimedia applications provided in wired networks such as B-ISDN (Broadband Integrated Services Digital Network) in wireless networks. However, since many studies have focused on Quality of Service (QoS) Provisioning in wired networks to provide multimedia applications, new methods of QoS Provisioning are needed in wireless networks to resolve the problem of wireless channel fading and the difficulty of mobility occurred in wireless networks. This paper proposes three schemes of QoS Provisioning in wireless networks which will make continuous QoS guarantee and efficient use of limited wireless resources possible. The first scheme reserves bandwidth in proportion to the amount of real-time traffic in the neighbor cells to decrease the handoff dropping rate of delay sensitive real-time connections, adapting reserved bandwidth for efficient resource utilization. The second scheme is predictive bandwidth reservation scheme that utilizes the past handoff information. It can decrease overheads required to adapt bandwidth reservation. The last scheme is priority-based call admission control prioritizing traffic type (real-time traffic/ non-real-time traffic), connection type (new connection /handoff connection), and mobile terminal speed (fast mobile/slow mobile). Simulation results show that the proposed QoS Provisioning schemes improve the total system performance by achieving three goals - required QoS guarantee, higher bandwidth utilization and less overhead.

A Study on the Performance and Combustion Characteristics with CNG Substitution Rate in a Diesel Engine (CNG 혼소율 변화에 따른 디젤엔진의 성능 및 연소 특성에 관한 연구)

  • Jang, Hyeong-Jun;Lee, Sun-Youp;Kim, Chang-Gi;Cho, Jeong-Kwon;Lim, Jong-Han;Yoon, Jun-Kyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.5
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    • pp.700-707
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    • 2017
  • In the international natural gas market, natural gas has markedly low calories. The domestic calories standard of natural gas was changed and the performance and efficiency of many industrial machines using natural gas were affected because of low caloric natural gas. Therefore, in this study, a dual fuel engine fueled with natural gas and diesel was tested to examine the effects of the CNG substitution rate on the combustion characteristics, such as thermal efficiency, COVimep and heat release rate. The CNG substitution rate was defined as the ratio of CNG instead of diesel, which was calculated as the total energy. The conditions of the tested engine were fixed $1800rpm/500N{\cdot}m$. In addition, diesel fuel was injected at $16^{\circ}CA$ BTDC and the fuel pressure was fixed at 85 MPa; the lower heating value of CNG was $10,400kcal/Nm^3$. The results of the engine test showed that the amount of diesel fuel was changed according to the CNG substitution rate. Therefore, when the substitution rate was increased, the amount of diesel fuel was decreased, which affected the energy for ignition. In addition, the ignition delay duration was increased, which affected the thermal efficiency and torque. On the other hand, the COVimep was less than 5% and a stable combustion state of the engine was shown.

A Study on Construction of Express Lane Applied by Bus Only Lane as Seperation Facility: Focused on Pangyo-Hannam Section of Gyeongbu Expressway (버스전용차로를 분리시설로 활용한 Express Lane 구축에 관한 연구: 경부고속도로 판교-한남 구간을 중심으로)

  • Kim, Min Kyoung;Kim, Ju Hyun;Shin, Eon Kyo
    • Journal of Korean Society of Transportation
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    • v.31 no.4
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    • pp.32-46
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    • 2013
  • Because of short length between interchanges, traffic congestion has been caused by a lot of short trip traffic in the urban section of interregional expressway. Also, in case of expressway with Bus Only Lane, bus causes dangerous situation by conflicting between vehicles and buses in order to access from Bus Only Lane to IC. Therefore, this study aims to propose Express Lane applied by Bus Only Lane as a new lane operation in order to efficiently operate and to analyze the effectiveness on constructing Express Lane to the Pangyo-Hannam section in Gyeongbu Expressway. The study analyzes effectiveness by scenario using the micro traffic simulation tool, VISSIM 5.4. For this, the indicators which evaluate construction effect of Express Lane, are used by average delay time, average speed and total travel time. The results of the study showed the best effectiveness when Express Lane installed one, and it represented an ideal traffic condition when long distance trip traffic of the whole traffic is 25% in the study section. Therefore, the construction of Express Lane using Bus Only Lane achieves positive effectiveness on safety and expense aspect as well as uncongested flow.

Application of Multi-Server Queuing Theory to Estimate Vehicle Travel Times at Freeway Electronic Toll-Collection Systems (고속도로 자동요금징수시스템의 차량 통행시간 산정을 위한 다중서비스 대기행렬이론 연구)

  • Sung, Hyun-Jin;Choi, Jai-Sung;Kim, Sang-Youp
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.10 no.2
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    • pp.22-34
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    • 2011
  • This paper presents the investigation results of a research on how engineers can analyze the economic effect of the ETCS(Electronic Toll Collection System) installed to minimize the vehicle delays on freeway tollgates during toll payments. This research considered this economic effect to occur in the form of vehicle passing time reductions at the ETCS, and the multi-service queuing theory was applied to estimate these values. This research found: 1) When vehicles approaching tollgates show Poisson distribution and the service time of the ETCS shows Exponential distribution, the multi-service queuing theory would be applicable for estimating vehicle passing times at toll-gates, 2) Despite the ETCS placement, exit sections of tollgates give a greater reduction of vehicle passing times than entering sections due to more delays at conventional toll payments, and 3)The ETCS would not guarantee vehicle passing time reductions all the time, because in such a case as many vehicles were queuing at the ETCS, the total delay level for a toll gate would increase greatly. In addition, in order to examine the accuracy of the estimated vehicle passing values, this research compared the values from the multi-service queuing theory with the observed values from a set of field survey values at freeway toll-gates, and found that the two values were in a good agreement with a very low error range of 1-3 seconds per vehicle. Based on this result, the multi-service queuing theory was recommended for practice.

A study on the Factors Affected on the P- and S-wave Velocity Measurement of the Acrylic and Stainless Steel Core (아크릴 및 스테인리스강 시험편의 P-, S-파 속도 산출에 미친 영향 요인 고찰)

  • Lee, Sang-Kyu;Lee, Tae-Jong
    • Geophysics and Geophysical Exploration
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    • v.14 no.4
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    • pp.305-315
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    • 2011
  • A total of 864 measurements for P- and S- wave velocity of acrylic and stainless steel core samples have been performed with respect to their lengths and axial load applied. S-wave velocity measurement was much harder than P-wave velocity, so that it showed higher deviation in measured S-wave velocity with respect to repeated measurement, length of the cores, and the axial load applied. Velocity measurements for acrylic cores showed more stable and less than half of the variation between the measurements than the stainless steel cores. This seems to be come from better coupling between the transducers and acrylic cores than stainless cores, and from larger value of the first arrival time in a similar system noise environments. From the analysis of the 864 measurements, it is recommended that the length of the core be 60 ~ 90 mm, axial load between 20 kg (27.7 $N/cm^2$) and 30 kg (41.6 $N/cm^2$) for measurement of wave velocity of the acrylic and stainless steel cores. Especially for measuring S-wave velocity of stainless steel core, core length should be less than 50 mm, otherwise it will be affected by mode conversion or others. These results can be used in measurement and correction for system delay in wave velocity measurement for rock cores.

A Cost-Benefit Analysis of Neonatal Screening Tests for Maple Syrup Urine Disease, Homocystinuria, Galactosemia, and Congenital Adrenal Hyperplasia (한국에서의 단풍당뇨증, 호모시스틴뇨증, 갈락토스혈증, 선천성 부신과형성증에 대한 신생아 선별검사의 경제성 분석)

  • Park, Shin-Young;Kim, Dong-Il;Lee, Dong-Hwan
    • Journal of Genetic Medicine
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    • v.5 no.2
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    • pp.111-118
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    • 2008
  • Purpose: Neonatal screening tests are increasingly being used forearly diagnosis of inborn errors of metabolism (IEM) in the hope of avoiding the severe developmental delay, acute illness, and death that may result from these diseases. In this study, a cost-benefit analysis was performed on the neonatal screening of maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia in Korea. Materials and Methods: This study included 1,259,220 Korean newborns born between January 2005 to December 2007, who were screened for maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia. We calculated and compared the total costs in cases where these four screening tests were implemented, and those where they were not. Results: There were no benefits to screening for maple syrup urine disease or homocystinuria due to their low prevalence for these two tests, the costs exceeded the benefits at benefit:cost ratios of 0.5:1 and 0.6:1, respectively. In contrast, benefits far exceed costs at a ratio of 4.1:1 for galactosemia and 2.9:1 for congenital adrenal hyperplasia. The average benefit:cost ratio for all four tests was 2.0:1. Conclusion: Neonatal screening tests for maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia are financially viable.

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Effect of Refrigerated Sea Water on Keeping Freshness of Sardine (냉각해수저장법에 의한 정어리의 선도유지)

  • CHO Young-Je;KIM Chung-Gon;LEE Kang-Ho
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.21 no.3
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    • pp.177-183
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    • 1988
  • The Present study has been carried out to investigate the effect of refrigerated seawater (RSW) at $-1^{\circ}C$ in order to delay spoilage and extend the shelf-life in Sardine(Sardinops melanosticta). The result obtained are summarized as follows : In case of freshness, K-value was shown above $30\%$ at 1 day of storage by icing, but in RSW system was shown $20\%$ until 2 days by storage. VBN and TMA were also shown the similar tendency when compared to K-value. The lipids extracted from sardine muscle held in ice was oxidized much more than those in RSW system by way of chemical test such as TBA and POV. The myofibrillar protein extracted from sardine stored in RSW system was denaturized more slowly compared with those by ice. $Ca^{2+}-ATPase$ activity indicated that myofibrillar protein held in RSW system was more stable than those held in ice. Total viable counts for sardine in RSW system showed an overall lower values. By TPA(Textural Porfile Analysis) , sardine meat pastes held in RSW system have a higher value than those held in ice.

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The Result and Attentiveness of Reconstructive Surgery by Anterolateral Thigh Perforator Free Flap (전외측 대퇴부 천공지 유리피판술의 실패 원인과 합병증)

  • Kang, Kyung-Dong;Lee, Jae-Woo;Kim, Kyoung-Hoon;Oh, Heung-Chan;Choi, Chi-Won;Choi, Soo-Jong;Bae, Yong-Chan;Nam, Su-Bong;Kim, Jung-Il;Chu, Gi-Seok
    • Archives of Plastic Surgery
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    • v.38 no.1
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    • pp.27-34
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    • 2011
  • Purpose: Anterolateral thigh (ALT) perforator free flap is commonly used because of its various benefits. The author reports important factors of preoperative and perioperative ALT perforator free flap and causes of failure. Methods: 84 patients who were treated with ALT perforator free flap from December 2004 to 2008, and February 2010 to April 2010 were studied. 61 patients were male and 23 were female. The mean age of patients was 51.1. The main cause was neoplasm and the main reconstructive areas were head and neck area. The size of flap was various from $3{\times}4$ to $12{\times}18$ cm. 6 patients received split thickness skin graft at donor site. Preoperative angiography was checked to all patients. Results: Among the 84 patients, partial necrosis of flaps occurred in 4 patients because of atherosclerosis, varicose vein, or inattention of patient, etc. And total flap necrosis in 5 patients because of abnormal vessels of recipient area or delay of operation, etc. One case of serous cyst was found as the complication of donor area. Two cases of skin graft on donor site were done because of suspected muscle compartment syndrome, 4 cases of that because of large flap. Septocutaneous perforators were found in 7 cases. The author couldn't find reliable perforator in 3 cases, ipsilateral anteromedial thigh perforator and contralateral ALT perforator and latissimus dorsi musculocutaneous free flap were done instead of ALT. There was no case which needed reoperation because of the impairment of blood supply, and 3 cases were revised by leech because of the burn injury by a lamp or venous congestion. Conclusion: Although ALT perforator free flap is widely used with its various merits, many factors such as preoperative condition of donor or recipient area, morphology of defect and operating time need to consider to prevent flap necrosis. And operators should need careful technique because septocutaneous perforator is uncommon, and musculocutaneous perforator is common but difficult to dissect.

Efficacy and Safety of Raltitrexed Combinations with Uracil-Tegafur or Mitomycin C as Salvage Treatment in Advanced Colorectal Cancer Patients: A Multicenter Study of Anatolian Society of Medical Oncology (ASMO)

  • Bozkurt, Oktay;Karaca, Halit;Ciltas, Aydin;Kaplan, M. Ali;Benekli, Mustafa;Sevinc, Alper;Demirci, Umut;Eren, Tulay;Kodaz, Hilmi;Isikdogan, Abdurrahman;Ozkan, Metin;Buyukberber, Suleyman
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.4
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    • pp.1845-1849
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    • 2014
  • Background: There is no standard treatment for patients with colorectal cancer (CRC) progressing after irinotecan and oxaliplatin treatment. Here we aimed to retrospectively evaluate the efficacy and tolerability of raltitrexed in combination with oral 5-fluoropyrimidine (uracil tegafur-UFT) or mitomycin C as salvage therapy in mCRC patients. Materials and Methods: A total of 62 patients who had received raltitrexed combined with UFT or mitomycin C were identified between December 2008 and June 2013. They were given raltitrexed 2.6 $mg/m^2$ (max 5 mg) i.v. on day 1 in combination with either oral UFT 500 mg/day on days 1-14 every 3 weeks (group A) or mitomycin C 6 $mg/m^2$ i.v. on day every 3 weeks (group B). Results: Forty-two patients (67.7%) were in group A and 20 (32.2%) in group B. In 15 patients (24%) grade 3/4 toxicity was observed, resulting in dose reduction, and in 13 patients (20.9%) dose delay was necessary. The median progression free survival (PFS) was 3 months (95%CI 2.65-3.34) and median overall survival (OS) was 6 months (95%CI 2.09-9.90) in the whole group. Median PFS was 3 months (95%CI 2.60-3.39) in group A vs 3 months (95%CI 1.64-4.35) in group B (p=0.90). Median OS was 6 months (95%CI 2.47-9.53) in group A vs 12 months (95%CI 2.83-21.1) in group B (p=0.46). Conclusions: The combination of raltitrexed with UFT or mitomycin C seem to be a salvage therapy option due to safety profile and moderate clinical activity in heavily-pretreated mCRC patients.