• 한국식품영양과학회지
• /
• 제41권3호
• /
• pp.345-350
• /
• 2012

본 실험은 CRE 80% 에탄올 추출물을 식이에 0.5%, 1% 혼합하여 5주간 섭취시켰을 때 CRE 추출물이 SHR의 혈압에 미치는 영향을 확인함으로써 CRE 추출물이 고혈압 흰쥐의 지질성분과 혈압에 미치는 영향을 조사함으로써 CRE의 기능성식품으로서의 이용 가능성을 확인하였다. 실험기간 중 실험쥐의 일일평균 체중변화량은 0.5% CRE 보충군(II)은 1.63 g/day로 정상식이 급여군보다 일일평균 체중증가량이 유의적으로 감소하는 결과를 나타내었다. 간, 신장, 비장의 무게 변화를 측정한 결과 유의적인 차이를 나타내지 않았으며, 혈청 내 포도당 농도 또한 정상식이 급여군에 비해서 0.5%, 1% CRE 추가 보충군이 감소하는 경향은 보였으나 유의적인 차이는 나타나지 않았다. 본 실험에서 총 cholesterol 함량은 정상식이 급여군보다 0.5%, 1% CRE 보충 급여군에서 유의적으로 증가하는 경향을 보였지만 HTR을 확인한 결과 정상식이 급여군보다 0.5%, 1% CRE 보충 급여군이 각각 11% 증가한 결과를 나타냈기 때문에 혈중 총 cholesterol 함량의 증가는 HDL-cholesterol의 농도 증가에 의한 것으로 생각된다. HDL-cholesterol 농도는 정상식이 급여군과 0.5%, 1% CRE 보충 급여군 모두에서 유의적으로 증가하는 경향을 나타냈다. LDL-cholesterol 역시 유의적으로 증가하는 경향을 나타냈지만 HDL-cholesterol/LDL-cholesterol의 증가 비율로 봤을 때 HDL-cholesterol이 정상식이 급여군보다 0.5% CRE 보충 급여군이 15%, 1% CRE 보충급여군이 36.5%로 유의적으로 증가하는 결과를 나타냈다. 실험기간 동안 SHR의 혈압 변화는 정상식이 급여군(I)의 경우 거의 일정하게 혈압이 유지되는 경향을 보이다가 5주차에는 다시 증가한 반면 CRE 0.5% 보충군(II)은 초기혈압에서 떨어지는 경향을 보이다가 2주째에 혈압이 다시 상승했다. 하지만 그 후 다시 감소하는 경향을 보였고, CRE 1% 보충군(III)은 일정하게 혈압이 감소하는 경향을 나타냈다. 따라서 CRE 추출물이 SHR의 혈압을 낮추고 지질대사 개선에 영향을 주어 혈관계 장애로 인해 발병되는 고혈압, 당뇨, 뇌혈관질환, 동맥경화증과 같은 질환을 예방하는 기능성식품으로서 이용 가능성이 기대된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3447-3450
• /
• 2014

Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: A total of 72 patients were randomly divided into a combination group (pemetrexed+bevacizumab, n=36) and a pemetrexed group (n=36) and assessed for disease control (CR+PR+SD) after 4-cycles of first-line GP chemotherapy (gemcitabine+cisplatin). Clinical efficacy, progression-free survival time (PFS), overall survival time (OS), overall response rate (ORR), disease control rate (DCR) and rate of adverse responses between two groups were observed and compared. Results: ORR and DCR were 27.8% and 83.4% in combination group, and 16.7% and 69.5% in the pemetrexed group, respectively, but there were no significant differences (P>0.05). PFS in combination group and pemetrexed group were 4.6 months and 3.9 months respectively (P=0.09), whereas OS in the combination group was 14 months, evidently higher than in the pemetrexed group (11 months, P=0.004). Adverse responses in both groups included high blood pressure, bleeding, thrombocytopenia, anemia, elevated transaminase, diarrhea, vomiting and proteinuria, but there were no significant differences (P>0.05). Conclusions: Bevacizumab concomitant with pemetrexed has better clinical efficacy and safety, giving rise to prolonged survival time in patients with advanced NSCLC.

• Agribusiness and Information Management
• /
• 제8권1호
• /
• pp.1-10
• /
• 2016

Information and communication technologies (ICTs) have always mattered in agriculture too. In day-to-day practices of agriculture and allied sectors, the farmers often share their information. Changing weather patterns, soil conditions, pests and diseases always throw challenges to small and marginal farmers. So, the farmer needs up-dated information to cope with and even benefit from these changes. In the developing countries like India, where agriculture still plays a crucial role (over 58% of the rural households depend on agriculture as their livelihood) and the rising population from 1027 million to 1419 million during 2001-16 (a total rise of 38 percent or 1.3 percent per year) pose a lot of pressure on land and other resources to meet the food security needs on one hand and to meet the challenges of globalization on the other. Understanding and addressing these challenges are very crucial, in which ICT can play a major role. With the booming mobile, wireless, and Internet industries, ICT has found a foothold even in poor marginal and smallholder farms and in their activities. The survey conducted among the 120 farmers in Srikakulam district in India revealed that, ICT has revolutionized the agriculture in the modern days. Production and marketing information is accessed by 91% of the sample farmers through mobile in 2015, where it was only 5% in 2005. The extent of use of mobile phones by the farmers varied with the decision to be taken by them like Harvesting, packing, and storing (94%), Selling Decision (91%), Seed purchase (89%), Application of fertilizers and pesticides (88%) and Land preparation and planting (84%), other package of practices (77%). The farmers further opined that, 'Voice' was the dominating source of communication (96%) compared to Short Message Service (SMS) (only 27%) and Internet access (10%), as majority are illiterate. The use of camera (71%), Bluetooth (33%), Radio (61%) TV (41%) are the other means of sharing the information. In this context of importance of ICTs in Indian agriculture, greater attention justifies about the applications of ICT's to alleviate poverty and promote economic growth of the farming population.

• 대한조선학회논문집
• /
• 제53권1호
• /
• pp.62-68
• /
• 2016

A simple calculation tool for added resistance in waves is developed to utilize for initial design or embedded module for navigation support system. In order to select an appropriate calculation method for added resistance in waves, three methods (drift method, integrated pressure method, radiated energy method) based on strip method are applied to Wigley I and KVLCC2. The methods for added resistance in waves give the underestimated results because it is difficult to consider nonlinear effects due to reflected wave. We apply asymptotic (Faltinsen's method) and empirical formula (NMRI's method) to improve the accuracy for short wave length region. In comparison with experimental results, the combination of radiated energy method and short wave correction method of NMRI is the most reasonable. However, a simple sum of results calculated by two methods gives rise to the overestimation of added resistance for short wave length region because added resistance of radiated energy method exits in total reflection region. To overcome this problem, modified radiated energy method is proposed using correction coefficient defined by reflection coefficient of NMRI's method. Finally, added resistance in regular waves is composed of added resistance of modified radiated energy method and that of short wave correction method of NMRI. Estimated added resistance in regular waves is validated by comparison with experimental results of other research groups.

• 한국유체기계학회 논문집
• /
• 제12권2호
• /
• pp.8-16
• /
• 2009

The objective of this study is to investigate the three-dimensional turbulence flow characteristics of a rotor passage of an one-stage axial flow gas turbine and to investigate the effects of a boundary layer fence installed on the hub endwall of the rotor passage. Secondary flows occurring within the rotor passage (e.g. horseshoe vortex, passage vortex, and cross flow) cause secondary loss and reduce turbine efficiency. To control these secondary flows, a boundary layer fence measuring half the height of the thickness of the inlet boundary layer was installed on the hub endwall of the rotor passage. This study was performed numerically. The results show that the wake and secondary flows generated by the stator reduced the rotor load to constrain the development of cross flow and secondary flow reinforced by the rotor passage. In addition, the secondary vortices occurring within the rotor passage were reduced by the rotation of the rotor. Although, the boundary layer fence induced additional vortices, giving rise to an additional loss of turbine, its presence was shown to reduce the total pressure loss when compared to effects of the case without fence regardless of the relative position of blades by enervating secondary vortices occurred within the rotor passage.

• 한국음향학회지
• /
• 제29권8호
• /
• pp.476-482
• /
• 2010

전체 192개의 압전소자 중 64개를 동시 구동하여 빔을 형성하는 중심주파수 3.5 MHz인 선형배열 의료용 초음파프로브를 대상으로 일부의 압전소자가 결함으로 인해 동작하지 않을 때의 과도음장 및 점 표적에 대한 초음파 B-모드 영상을 시뮬레이션하여 정상 초음파프로브의 것과 비교 분석하였다. 그 결과, 결함소자의 수가 한 개에서 네 개로 증가함에 따라 주엽이 만드는 음장의 최대음압준위 및 그 -3 dB 폭은 정상일 때에 비해 선형적으로 감소하나, 초점심도는 거의 변화가 없고, 부엽에 의한 음장의 음압준위 상승으로 인해 주엽과 부엽과의 음압 차이는 감소하는 경향을 보였다. 이와 같은 음압준위의 변화는 점 표적에 대한 B-모드 영상에 영향을 주어 표적의 좌우에 허상을 만들며, 축 방향의 공간분해능은 거의 일정하나 측 방향으로는 다소 감소하는 경향을 나타내었다.

• 한국전문물리치료학회지
• /
• 제15권1호
• /
• pp.38-45
• /
• 2008

This study investigated gait characteristics, kinematics, and kinetics in the lower extremities between two different shoe conditions (high heeled shoes (7 cm), and high heeled shoes with a total contact insert (TCI)) after lower extremity muscle fatigue. Although TCI shave been applied in high heeled shoes to increase comfort and to decrease foot pressure, no study has attempted to identify the effects of TCI in fatigue conditions. The purpose of this study was to determine the effects of walking in high heeled shoes with TCI after lower extremity muscle fatigue was induced. This study was carried out in a motion analysis laboratory at Hanseo University. A volunteer sample of 14 healthy female subjects participated. All in fatigue conditions, the subjects were divided into two groups. The muscle fatigue was induced by 40 voluntary dorsi- and plantar-flexion exercises and 40 heel-rise exercises of the dominant foot. Surface electromyography was used to confirm the localized muscle fatigue using power spectral analysis of three muscles (tibialis anterior, gastrocnemius medialis and lateralis). The results were as follows: (1) In muscle fatigue conditions, the use of TCI decreased the peak flexion angle of the hip joint significantly in the early stance phase (p<.05) and increased the peak hip flexion moment in the terminal stance phase (p<.05). (2) In muscle fatigue conditions, the application of TCI also increased peak hip power generation in the early stance phase and peak hip power absorption in the terminal stance phase (p<.05). (3) In muscle fatigue conditions, the use of TCI reduced the impact force significantly and increased the secondary peak vertical GRF. These findings suggest that the TCI may provide beneficial effects when muscle fatigue occurs for a high heeled shoe gait. Future research employing the patient population and various types of TCI materials are required to clarify the effects of TCI.

• 한국지반환경공학회 논문집
• /
• 제12권10호
• /
• pp.63-72
• /
• 2011

초고층 건축물 기초의 고용량 하중 지지능력을 확인할 수 있는 가장 현실적인 방안인 고유압방식의 고용량 양방향 말뚝재하시험을 2개 현장에서 실시하였다. 고유압 복동식 양방향 말뚝재하시험은 정재하시험 시 재하용량 한계와 현장조건의 제약을 극복 할 수 있는 가장 현실적인 방안으로 볼 수 있었으며 고용량이 필요한 시험말뚝에 대한 재하시험에 매우 유용한 시험방법으로 판단되었다. 2개의 사례에서 계산된 설계하중 충족비는 각각 3.3, 2.1이었으므로 사례(P-2)에서 1방향 재하하중을 다소 작게 재하하였더라면 말뚝기초의 안정성을 실증적으로 확인하지 못하였을 것으로 판단되었다. 초고용량의 양방향 말뚝재하시험에서 설정한 최대하중까지 재하하더라도 말뚝 및 지반의 극한상태를 확인하는 것은 쉽지 않았으므로 대구경 현장타설말뚝의 극한지지력을 추정하기 위하여 2개의 고용량 대구경 현장타설말뚝에 대한 수치해석을 실시하였다.

• 한국환경보건학회지
• /
• 제50권2호
• /
• pp.102-112
• /
• 2024

Background: Despite the rise in the number of domestic indoor climbing gyms, there is a lack of specific hygiene standards and research on the holds installed in them. Holds can act as vectors for microbial transmission through the hands, posing a risk of infectious diseases, especially with damaged skin. Objectives: The aim of this study is to investigate the contamination level and species of microorganisms on holds according to the management methods practiced in indoor climbing gyms and identify effective strategies for reducing microbial contamination. Methods: We investigated factors that may influence microbial contamination of holds, including hold management methods, user information, and hygiene management at three climbing gyms in Seoul. A total of 72 holds were sampled, 18 for each management method of brushing, high-pressure washing, and ethanol disinfection. Samples were cultured on LB and blood agar at 37℃ for 48 hours to calculate CFUs. PCR assay targeting 16S rRNA was carried out to identify microorganisms. Dunn-Bonferroni was employed to see the microbial reduction effect of the management method and the difference in microbial contamination by management method and climbing gym. Results: As a result of microbial identification, microorganisms such as Bacillus, Staphylococcus, and Micrococcus, which were derived from various environments such as skin and soil, were discovered on the surface of the climbing hold. Among the discovered microorganisms, some species had potential pathogenic properties that could cause food poisoning, gastrointestinal disease, bacteremia, and sepsis. All hold management methods were effective in reducing microorganisms (p<0.05), with ethanol disinfection being the most effective (p<0.001). Conclusions: Our results indicate that there are potential pathogens on holds that demand thorough management for microbial prevention. Proposed methods include regular brushing and ethanol disinfection in addition to high-pressure washing with long cycles, which are the existing forms of hold management. Further studies on shoe management are advised to curb soil-derived microorganisms.

• 한국응급구조학회지
• /
• 제11권2호
• /
• pp.51-66
• /
• 2007

Purpose: With a view to providing basic data to develop cardiopulmonary resuscitation education suitable for elementary students, the cardiopulmonary resuscitation education was conducted to grasp students' knowledge, skills accuracy and the attitude change before and after the education. Methods: Convenience sampling was made on fourth and fifth graders(total-35 students) of S elementary school located in K city, Chungcheongnam-do, and this was a pre-experiment research designed before and after choosing a single group. In terms of methods, specifically we, researchers ; 1) Handed out questionnaires to students directly to make them fill in firsthand and collected the questionnaires. 2) Utilized PPT materials based on 2005 AHA guideline and DVD materials of AHA, to give students theoretical education of cardiopulmonary resuscitation. We used Anne/SkillReporter$^{(R)}$ torso produced by Leardal Inc, and Little Anne to conduct practical education individually. 3) Asked students to give Anne/SkillReporter$^{(R)}$ torso cardiopulmonary resuscitation five times with the ratio of 30 : 2, and then one of researchers filled in the evaluation sheet individually. 4) Evaluated the accuracy of students' ability to perform the resuscitation based on the record of Anne/SkillReporter$^{(R)}$ integrated printer(which was the objective tool to grasp students' skills accuracy). 5) Gave out questionnaires to make students fill them in and then collected them. after completing the practical evaluation. Results: 1) In case of the attitude about cardiopulmonary resuscitation, Students' confidency rose from 19.28%(before the education) to 93.57(after the education)- which is a positive change. 2) As the result of the education, some elementary students scored 11 points (full score-16 points), up from 5 points before the education, in terms of the knowledge about cardiopulmonary resuscitation. The average point also reached 13.14 points(after the education), jump from 8.37(before the education), which was the rise of 29.8%. 3) When it comes to the practical performance, the skills accuracy was 80.93% on average, and the calculation method was as follows: total items were 16, and each item was marked form 0 to 2 points, meaning the full score was 32 points. The minimum score was 19 points and the maximum was 32($M{\pm}SD=25.90{\pm}2.88$), which was calculated based on percentage. 4) Regarding skills accuracy, respiration accuracy(%)($M{\pm}SD=30.20{\pm}27.16$) was higher than pressure accuracy(%) ($M{\pm}SD=15.34{\pm}25.27$). Conclusion: The result showed that students' attitude on cardiopulmonary resuscitation changed positively. and meaningful difference(p = .00) existed in the change of students' knowledge. In terms of skills accuracy. chest compression and airway control showed high accuracy, but the result of Anne/SkillReporter$^{(R)}$ performance showed that the accuracy of chest compression was lower than that of mouth-to-mouth resuscitation.