• 동아시아식생활학회지
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• 제15권1호
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• pp.40-48
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• 2005

This study was carried out to investigate the effect of body weight reduction of patty containing glucomannan in high fat diet-induced obese rats. Male Spraque-Dawley rats were randomly assigned to control and high fat diets groups for 4 weeks. After 4 weeks, the control and high fat diet groups were rearranged into 5 groups by different levels of patty containing glucomannan (60%). After 5 weeks, serum and whole blood levels were analyzed. Obesity index was significantly lower in the group fed patty containing glucomannan than that of high fat diet groups. The status of white blood cells in hematological examination was significantly higher in rats fed high fat diet and not significantly different from those fed patty. Serum albumin levels were not significantly different, while serum glucose levels were significantly different among groups. Serum Triglyceride and total cholesterol levels were the highest in rats fed high fat diets, while the lowest in rats fed patty containing glucomannan.

• 전기학회논문지
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• 제58권4호
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• pp.849-856
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• 2009

Truncal obesity associated with insulin resistance and metabolic syndrome increase the likelihood of hypertension, various cardiovascular diseases, hyperlipidemia and coronary heart diseases. International Diabetes Federation (IDF) experts recognized that it is necessary to develop the simple diagnostic tool which is applicable to diagnose truncal obesity worldwide, and proposed the method using a waist circumference but there is a limit to estimate subcutaneous fat distribution. However, waist line is also influenced by total fat capacity less than the intra abdominal fat. The more having severe obesity, the more correlation coefficient between waist line and intra abdominal fat is low. Therefore, this thesis defines a new abdominal impedance measurement position and impedance-index to analysis central obesity. This proposes the new model to estimate abdominal obesity using the abdominal impedance-index and CT images acquired fro 160 Korean subjects. The proposed model shows that the abdominal fat distribution has a higher correlation than waist line. (Adj R2=0.809, 0.667 and 0.687 with abdominal fat area, visceral fat area and subcutaneous fat area respectively).

• 한방비만학회지
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• 제12권1호
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• pp.20-32
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• 2012

Object The purpose of this study is to evaluate the effect of far-infrared (FIR) therapy on weight loss. Method Thirty five participants (BMI ${\geq}25kg/m^2$) were recruited. Body weight, Waist circumference (WC), Bio Impedance Analysis (BIA), abdominal fat Computer Tomography (CT) scanning were evaluated. Results of 25 women were analyzed. Result After 6 weeks of FIR therapy, there was significant efficacy on obese women in body weight, WC, Body fat mass (BFM), and Visceral fat area (VFA). But there was no efficacy in Total fat area (TFA), and Subcutaneous fat area (SFA). Conclusion This study suggests that FIR therapy might be an effective way to promote weight and abdominal visceral fat loss in Korean obese women.

• 한방비만학회지
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• 제6권2호
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• pp.75-83
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• 2006

Objectives : This study was performed to identify the effects of high frequency therapy on localized obesity. Methods : This trial was carried out in 12 volunteers. Volunteers were divided into 3 groups; upper arm group (n=4), thigh group (n=4) and abdomen group (n=4) according to local obesity type. Body weight and body fat were measured by Inbody 720 and CT (Computed Tomography) immediately before and following high frequency therapy. Diathermy was performed twice a week for 4 weeks for a total of 8 treatments. Results : In the upper arm group, body weight, body fat mass, fat area by CT scan and circumference were increased after treatment but not significantly (p>0.05). In the thigh group, body weight, body fat mass and circumference were decreased and fat area by CT scan was increased but both not significantly (p>0.05). In the abdomen group, significant differences were not found despite decreases in body weight, body fat mass, visceral fat and subcutaneous fat after diathermy (p>0.05). Conclusions : There was no significant effects of high frequency therapy on localized obesity.

• 운동영양학회지
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• 제23권1호
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• pp.28-35
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• 2019

[Purpose] The purpose of this study was to investigate the effects of treadmill exercise on oxidative stress in the hippocampal tissue and mitochondrial dynamic-related proteins in rats fed a long-term high-fat diet (HFD). [Methods] Obesity was induced in experimental animals using high fat feed, and the experimental groups were divided into a normal diet-control (ND-CON; n=12), a high fat diet-control (HFD-CON; n=12) and a high fat diet-treadmill exercise (HFD-TE; n=12) group. The rats were subsequently subjected to treadmill exercise (progressively increasing load intensity) for 8 weeks (5 min at 8 m/min, then 5 min at 11 m/min, and finally 20 min at 14 m/min). We assessed weight, triglyceride (TG) concentration, total cholesterol (TC), area under the curve, homeostatic model assessment of insulin resistance, and AVF/body weight. Western blotting was used to examine expression of proteins related to oxidative stress and mitochondrial dynamics, and immunohistochemistry was performed to examine the immunoreactivity of gp91phox. [Results] Treadmill exercise effectively improved the oxidative stress in the hippocampal tissue, expression of mitochondrial dynamic-related proteins, and activation of NADPH oxidase (gp91phox) and induced weight, blood profile, and abdominal fat loss. [Conclusion] Twenty weeks of high fat diet induced obesity, which was shown to inhibit normal mitochondria fusion and fission functions in hippocampal tissues. However, treadmill exercise was shown to have positive effects on these pathophysiological phenomena. Therefore, treadmill exercise should be considered during prevention and treatment of obesity-induced metabolic diseases.

• Nutritional Sciences
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• 제9권3호
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• pp.179-189
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• 2006

Objective: We investigated the efficacy of a 12-week supplementation of soy isoflavone with L-carnitine on the development of obesity in high fat-induced obese C57BL/6J mice, which are known as a good model of diet-induced obesity. Methods: We measured body weights, adipose tissue mass, serum/liver lipid profiles and fat cell size/number in C57BL/6J mice fed diets containing either low fat (4%) or high fat (35%), or high fat supplemented with soy isoflavone powder containing 10% isoflavone and L-camitine for 12 weeks. Results: Body weight gain, abdominal adipose tissue and liver weight were lower by 31% 78% and 31.4% respectively, in mice on high fat diet containing soy isoflavone+L-carnitine (SC mixture) compared with high fat diet group. Also, SC mixture improved serum lipid profiles such as total cholesterol (TC), triglycerides (TG), and liver lipid profiles such as total lipids and TG. As subsequent results, this SC mixture prevented high-fat diet from accumulating TG in the liver. The size of fat cell was also significantly decreased in SC mixture fed mice. At the end point of this experiment, our results showed that feeding with soy isoflavone for 12 weeks finally increased camitine palmitoyltransferase 1 (CPT 1) activity through elevating the level of CPT1 expression. Conclusions: This study suggests that long-tenn supplementation with dietary soy isoflavone and L-carnitine is more synergistically beneficial for the suppression of high-fat diet induced obesity by inhibiting liver TG accumulation and the gain in abdominal adipose tissue weight than that with soy isoflavone. The antiobesity effects of SC mixture might be attributed, at least in part, to the induction of fatty acid catabolism by soy isoflavone, genistein.

• 한국식품영양과학회지
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• 제31권4호
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• pp.664-671
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• 2002

완전 단식군의 흰쥐(FO)와 단식중에 소기름(FT), 옥수수기름(FC), 들깨기름(FP)만을 각각 투여하고 비교하니 FO군은 대부분 6일까지 생존하고 FT, FC, FP군은 대부분 16일까지 생존하였다. 폐사 직전의 모든 흰쥐 체중은 -24.5~-25%로 감소되었다. 단식중 유지 섭취는 다소 생명을 연장하나 식이 유지 종류에 따른 생존기간과 체중 변화에 미치는 영향에는 괄목할 차이가 없었다. 간장과 신장 무게 변화도 체중변화와 유사한 양상을 보였다. FO군의 혈중 총 cholesterol 농도, 중성지방 농도, 혈당은 대폭 감소되고 GPT 활성값과 BUN 농도는 상당 수준으로 증가되었다. FC군과 FP군에서 유지의 n-6/n-3비율 혹은 불포화도 특성 차이가 총 cholesterol농도, 중성지방농도, 혈당농도, BUN농도, 단식 초기의 GPT활성도에 영향을 주지 못했다. 그러나 기아사 직전의 FP군에서 GPT활성도가 FT, FC군보다 높았다. 본 연구에서 결론은 기아 상태의 흰쥐에 유지 단독섭취는 유지 종류에 관계없이 생존일수를 다소 비슷하게 연장하였고 n-6/n-3비율, 불포화도 특성차이가 전반적으로 단식중의 대사에 미치는 영향에서 별다른 차이가 없었음을 알 수 있었다.

• 한국식품영양과학회지
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• 제30권5호
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• pp.858-864
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• 2001

젖산나트륨과 복합지방대체제가 저지방 볼로나의 품질과 냉장 중 저장안정성에 미치는 영향에 관하여 조사하였다. 유화형 볼로나를 대조구로 하여 일반성분을 분석한 결과 수분 600%, 지방 22% 및 단백질 함량이 12.4%를 함유하는, 반면 저지방 볼로나는 수분 73~76%, 지방 ~2% 및 단백질함량이 14~15%로 기존의 유화형 볼로나에 비하여 고단백, 저지방 소시지이었다. 저장 중 유화형 및 저지방(<3%) 볼로나의 유리수분량과 진공감량이 증가함에 따라 조직의 경도가 감소하였고(p<0.05), 총균수는 증가하였으나, 냉장 8주에 모두 가식 부위에 있었다. 젖산나트륨과 지방대체제를 첨가한 저지방 볼로나가 기존의 유화형 볼로나에 비해 가열 감량이 낮았으며(p<0.05) 경도를 비롯한 조직감은 높았다. 저지방 볼로나는 젖산나트륨의 첨가량이 증가할수록 유리수분량과 경도가 증가하였고, TBA값은 오히려 낮은 결과를 보여주었다. 냉장저장 중 젖산나트륨의 첨가에 따른 총균수에 영향이 나타났으며, 3.3% 젖산나트륨을 첨가한 처리구는 처리하지 않은 처리구보다 미생물의 성장억제 작용이 현저했다. 결론적으로 복합 지방대체제를 첨가한 저지방 볼로나의 젖산나트륨의 첨가량에 딸라 품질에 영향을 미쳤으며, 총균수와 TBA값을 낮출 수 있었다. 차후의 연구로 저지방 소시지에서 오염될 수 있는 Listeria monocytogenes 등과 같은 특정균을 일정균수($10^3$CFU/g) 접종함으로써 젖산나트륨의 특정미생물억제 효과에 관한 연구가 필요하다고 사료된다.

• 동아시아식생활학회지
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• 제20권1호
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• pp.37-45
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• 2010

오가피 추출물이 고지방 식이를 급여한 흰쥐의 체내 지질대사, 심혈관계질환지수 항산화능 및 항산화 효소계에 어떤 영향을 미치는지 알아보고자 하였다. 연구 결과를 요약하면 아래와 같다. 1. 식이 섭취량은 고지방 식이군이 정상 식이군에 비해 유의적 (p<0.05)으로 감소하였으며, 식이 효율은 유의적 (p<0.05)으로 높았다. 최종 체중과 체중 증가량은 고지방 식이군과 정상 식이군 간에 유의적인 차이가 없었다. 2. 혈장의 HDL-콜레스테롤은 고지방 식이군에서 오가피 추출물의 첨가로 증가하였으며 LDL-콜레스테롤은 감소하였다(p<0.05). 중성지방은 고지방 식이군이 정상 식이군에 비해 증가하였으며, 오가피 추출물 섭취로 감소하였다(p<0.05). 간의 총 지질은 군 간에 차이가 없었고, 총콜레스테롤은 정상 식이군에 비해 고지방 식이군에서 유의하게 증가하였으나(p<0.05) 오가피 추출물의 첨가로 유의하게 감소하였으며(p<0.05), 중성지방 농도는 정상 식이군에 비하여 고지방 식이군에서 유의적으로 증가하였다(p<0.05). 3. 심혈관위험지수와 동맥경화지수는 고지방 식이군에 비하여 고지방 식이 오가피 추출물군에서 유의적으로 감소하였다(p<0.05). 4. 혈장과 간의 지질 과산화물 농도는 정상 식이군에서 오가피 추출물 섭취로 유의하게 감소하였다(p<0.05). 혈장의 TAS 값은 고지방 섭취로 감소되었으나, 오가피 추출물 섭취로 유의하게(p<0.05) 증가되었다. 5. 간의 SOD, catalase 및 GST 활성도는 정상 식이군과 고지방 식이군에서 오가피 추출물 첨가군이 오가피 추출물 무첨가군에 비해 유의적으로 증가하였고(p<0.05), glutathione peroxidase 활성도와 glutathione 함량은 고지방 식이군에서 오가피 추출물 첨가로 유의하게(p<0.05) 증가하였다. 이상의 결과에서 고지방 식이를 공급하였을 때 오가피 추출물 섭취는 혈장의 HDL-콜레스테롤 농도는 높이고, 혈장과 간의 총콜레스테롤과 중성지방의 농도는 낮추어 심혈관 위험지수와 동맥경화지수를 효과적으로 감소시키므로 지질 개선 및 고지혈증에 대한 개선 효과가 있을 것으로 보인다. 또한 항산화 효소 활성을 증가시켜 혈장과 간의 지질 과산화물 생성을 억제시키므로 항산화제로서 작용할 수 있음을 시사해 주고 있다. 그러나 지질 개선 및 천연 항산화제로서 작용할 수 있는 오가피의 용량에 대해서는 좀 더 많은 연구가 필요한 것으로 사료된다.

• 동아시아식생활학회지
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• 제8권2호
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• pp.93-106
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• 1998

This study was designed to find out the effects on the lipid metabolism of two herbs used in folk treatment in Korea The two herbs were A: Equisetum arvense L. (Seddugi), B: Eunymus alatus Siebold (Hwasalnamoo). The experiment was performed with the male rats of Sprague-Dawley which fed on high calorie and animal fat supplemented diets from which 30% of the total calories can from lard. Experimental groups were divided into standard (ST) and two other(A, B) groups for the each herb. Each of the two experimental groups consisted of three subgroups (I, II, III) according to the three different doses of the folk remedy used, which were five times and ten times the dose commonly used in a folk remedy. During the experimental period, total food intake and body weight gains were measured, and FER, CER, PER were calculated at the same times. Serum levels of triglyceride, total lipid, ttal cholesterol, HDL-cholesterol, and total lipid as well as cholesterol contents of the liver were measured at the time of sacrifice. Epididymal fat pads were weighted and an indes was calculated. The results of the effects on the lipid metabolism were as follows : 1.Total food intake and body weight gains increased in group A & B. 2. The serum levels of the total lipid and triglyceride decreased in AIII, BI and BIII.3. The serum level of cholesterol decreased in group B, while level of HDL-Cholesterol were increased in all groups and most effectively in group B. 4. The contents of total liver lipid increased in groups A&B. cholesterol decreased in groups A&B. In conclusion, effects on the lipid metabolism associated with the kinds of herbs a diet were the increase of body weighta and the decrease of total lipid and cholesterol levels in serum and liver.