• 한국자동차공학회논문집
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• 제23권2호
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• pp.208-213
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• 2015

In this study, two models due to the configuration of caliper cylinder among the parts of automotive brake system are studied by structural and fatigue analysis. As the maximum equivalent stress at model 2 becomes 1.5 times lower than model 1, model 2 can endure load higher than model 1. In case of fatigue damage analysis on model 1 and 2, model 1 has the damage area more than model 2. Fatigue damage at model 1 happen more than model 2. These study results can be effectively utilized with the design on caliper cylinder by anticipating prevention against its damage and investigating durability.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2016년도 춘계 학술논문 발표대회
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• pp.128-129
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• 2016

This paper evaluates experimentally the explosion proof of fiber reinforced cement composite(FRCC) panels with various fibers of 2 % volume fraction subjected to contact explosions using an emulsion explosive. As a results, the proportion of the total damage in FRCC panels is not biased scabbing on the rear side with contrast to plain panels, which means that the local damage of FRCC panels was significantly controlled. The experimental results presented useful information for prediction of limited thickness on the local damage subjected to contact explosions through comparison with existing damage evaluation prediction equations.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 가을 학술발표회 논문집
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• pp.249-256
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• 1999

This study is intended to propose a systematic procedure for the development of the reliability-based seismic safety and cost-effective Performance criteria for design and upgrading of long span PC bridges. In the paper, a set of cost function models for life cycle cost analysis of bridges is proposed. The total life cycle cost functions consist of initial cost and direct/indirect damage costs considering repair/replacement costs, human losses and property damage costs, road user costs, and indirect regional economic losses. The damage costs are successfully expressed in terms of Park-Ang median global damage indices and damage probabilities. The proposed approach is successfully applied to model bridges in both regions of a moderate seismicity area like Seoul, Korea and a high one like Tokyo, Japan. It may be expected that the proposed approach can be effectively utilized for the development of cost-effective performance criteria for design and upgrading of various types of bridges as well as long span PC bridges.

• Wind and Structures
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• 제3권1호
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• pp.23-40
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• 2000

In the early morning hours of February 23rd, 1998, seven large tornadoes ravaged central Florida. A total of 42 people were killed and millions of dollars of damage was done. A strip mall and other commercial structures sustained considerable damage and several residential areas were completely destroyed. Based on field observations, the paper examines the causes and sequence of structural failure for the masonry single family homes. Wind speeds are estimated based on the observed damage, and compared to the meteorological data. Finally, recommendations are given that could help to eliminate or reduce similar failures in the future. It was found that with simple, cost effective measures, most if not all of the damage could have been prevented.

• 가족자원경영과 정책
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• 제10권3호
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• pp.149-169
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• 2006

As e-commerce is expanding rapidly, the consumer's damage in the e-commerce is also dramatically increased. This research was mainly focused on the consumer's damage experiences through the e-commerce, the consumer's behavior's when they were confronted with troubles, and the way to handle their damages in the e-commerce. This research was made with the intention of not only supplying the academic data on the consumer's damage but also understanding the consumer's basic behavior patterns in e-commerce. This research was supported by the surveys conducted to consumers who had previously experienced fashion e-commerce. Total 1230 questionnaires out of returned questionnaires were sampled for the final analysis. Main findings are as follows. 1) More than 90% of respondents answered that they had experienced troubles 2) Most consumers did complain their damages actively and tried to obtain proper cure from the seller.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2003년도 추계 학술발표회논문집
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• pp.295-302
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• 2003

A quantitative approach for the retrofit prioritization of bridges is developed based on the damage risk of seismic vulnerable components. In the developed approach, seismic damage risk is estimated in the probabilistic perspectives with an analytical bridge model, which can consider various phenomena found in the seismic behaviors of girder-type bridges and damage models of various vulnerable components. Based on the total cost due to failure of structural components, weighting factors are proposed. Finally, the ranking index and retrofit priority of bridges are estimated from the overall damage risk and weighting factors of bridges. As a result, the retrofit priority of four PSC girder bridges is evaluated by using the proposed approach. The vulnerable components in need of seismic retrofit are selected accordingly. From simulated results, the validity of the proposed approach is verified by comparison with the existing approach. In addition, the proposed approach is found to be appropriate in evaluating the priority of existing bridges.

• Earthquakes and Structures
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• 제15권5호
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• pp.529-540
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• 2018

The influences of initial damage paths and aftershock (AS) spectral shape on the assessment of AS collapse fragility are investigated. To do this, a four-story ductile reinforced concrete (RC) frame structure is employed as the study case. The far-field earthquake records recommended by FEMA P695 are used as AS ground motions. The AS incremental dynamic analyses are performed for the damaged structure. To examine the effect of initial damage paths, a total of six kinds of initial damage paths are adopted to simulate different initial damage states of the structure by pushover analysis and dynamic analysis. For the pushover-based initial damage paths, the structure is "pushed" using either uniform or triangle lateral load pattern to a specified damage state quantified by the maximum inter-story drift ratio. Among the dynamic initial damage paths, one single mainshock ground motion or a suite of mainshock ground motions are used in the incremental dynamic analyses to generate a specified initial damage state to the structure. The results show that the structure collapse capacity is reduced as the increase of initial damage, and the initial damage paths show a significant effect on the calculated collapse capacities of the damaged structure (especially at severe damage states). To account for the effect of AS spectral shape, the AS collapse fragility can be adjusted at different target values of ${\varepsilon}$ by using the linear correlation model between the collapse capacity (in term of spectral intensity) and the AS ${\varepsilon}$ values, and coefficients of this linear model is found to be associated with the initial damage states.

• 동의생리병리학회지
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• 제17권6호
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• pp.1433-1440
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• 2003

This research was performed to investigate protective effect of Sophorae subprostratae Radix and each fractions against ischemic damage using PC12 cells. To observe the protective effect of Sophorae subprostratae Radix on ischemia damage, vibility and changes in activities of Superoxide dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Production of Malondialdehyde (MDA) were observed after treating PC12 cells with Sophorae subprostratae Radix during ischemic insult. Groups were divided into five groups: no treated (Normal), hypoxia chamber for 48hrs followed by 6h at normoxic chamber (H/R), Sop horae subprostratae Radix total phase treated group with H/R (Total), Sophorae subprostratae Radix water phase treated group with H/R (Water), Sophorae subprostratae Radix BuOH phase treated group with H/R (BuOH), Sophorae subprostratae Radix alkaloid phase treated group with H/R (Alkaloid). The results showed that (1) in hypoxiajreperfusion model using PC12 cell, the Sophorae subprostratae Radix has the protective effect against ischemia in the dose of 0.2 ㎍/㎖, 2 ㎍/㎖ and 20 ㎍/㎖, (2) Sophorae subprostratae Radix increased the activities of glutathione peroxidase and catalase. (3) the activity of Superoxide Diamutase(SOD) increased by ischemic damage, which might represent the self protection. This study suggests that Sophorae subprostratae Radix has neuroprotective effect against neuronal damage following hypoxiajreperfusion cell culture model using PC12 cell and dose dependency effects. In conclusion, Sophorae subprostratae Radix has protective effects against ischemic oxidative damage at the early stage of ischemia.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2002년도 추계국제학술대회
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• pp.169-169
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• 2002

The mobilizable amount of transition metals is a fraction of the total amount of the metal from urban particulate matter. Although the fraction is small, some metals (Fe, Cu) are the major participants in a reaction that generates reactive oxygen species (ROS), which can damage various biomolecules. Damaging effects of the metals can be measured by the single strand breakage (SSB) of X174 RFI DNA or the carbonyl formation of protein. In another study, we have shown that more metals are mobilized by PM2.5 than by PM10 in general. DNA SSB of >20% for PM2.5 and >15% for PM10 was observed in the presence of chelator (EDTA or citrate)/reductant (ascorbate), compared to the control (<3%) only with the chelator. The carbonyl formation by both PMs was very similar in the presence of the chelator, regardless of the kind of proteins. Compared to the control in the absence of chelator/reductant, 3.3 times and 4.9 times more carbonyl formation for PM2.5 and PM10, respectively, was obtained with BSA in the presence of chelator/reductant, showing that PM10 induced 33% more damage than PM2.5. However, 4.8 times and 1.9 times more carbonyl formation for PM2.5 and PM10, respectively, was observed with lysozyme in the presence of chelator/reductant, showing that PM2.5 induced 250% more damage than PM10. Although different proteins showed different sensitivities toward ROS, all these results indicate that the degrees of the oxidation of or damage to the biomolecules by the mobilized metals were higher with PM2.5 than with PM10. Therefore, it is expected that more metals mobilized from PM2.5 than from PM10, more damage to the biomolecules by PM2.5 than by PM10. We suggest that when the toxicity of the dust particle is considered, the particle size as well as the mobilizable fraction of the metal should be considered in place of the total amounts.

• 한국약용작물학회지
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• 제24권6호
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• pp.464-470
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• 2016

Background: Valeriana fauriei (Valerianaceae) has been used to as a traditional medicine to treat a variety of symptoms, including headache, insomnia, hypertension, and menstrual irregularity. However, the present study investigates the species' antioxidant activity and its inhibition of oxidative DNA damage, which have yet to be studied. Methods and Results: The antioxidant activity was assessed using radical scavenging assays with 1,1-diphenyl-2-picryl hydrazyl (DPPH) and, 2, 2'-azino-bis (3-ethylbenzothiazoline-6 sulfonic acid) diammonium salt (ABTS) and a reducing power assay. The total phenol content was also analyzed, and phenolic compounds were detected using HPLC/UV, whereas the inhibitory effect of Valeriana fauriei on oxidative DNA damage was measured using ${\phi}-174$ RF I plasmid DNA cleavage assay. The DPPH and ABTS radical scavenging activity were $75.17{\pm}3.55%$ and $95.83{\pm}0.63%$, repectively, and the reducing power was $93.14{\pm}1.74$ at $200{\mu}g/m{\ell}$. The total phenol content was $10.24{\pm}0.04mg/g$, whereas chlorogenic acid, catechin, caffeic acid and epicatechin were identified using HPLC/UV, and the ${\phi}-174$ RF I plasmid DNA cleavage assay indicated that V. fauriei provided protection against oxidative damage. Conclusions: The results of the present study suggest that V. fauriei has powerful antioxidant activity that can provide protective effects against the oxidative DNA damage caused by free radicals. The species, therefore, provides a valuable resource for the development of natural pharmaceutical to treat aging, cancer, and degenerative diseases.