• Journal of Pharmaceutical Investigation
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• 제30권4호
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• pp.273-278
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• 2000

Several topical preparations containing lidocaine, a widely used local anesthetic agent, have been developed and marketed recently for the treatment of premature ejaculation. In this study, microemulsion(ME)-based hydrogels containing lidocaine were prepared by dispersing ME to hydrogel bases such as Carbopol, sod. alginate, and sod. carboxymethylcellulose. Lidocaine-containing ME was thermodynamically stable over 6 months and had a diameter ranging from 10 to 100 nm. In vitro skin penetration of lidocaine from ME-based hydrogels followed apparent zero-order kinetics. ME-based hydrogel showed higher drug penetration during fifteen minutes after application than alcoholic hydrogel, reference preparation. Tail flick test in rat was introduced to compare in vivo local anesthetic effects of different hydrogels, and the results showed that ME-based hydrogels are superior to other hydrogels. In optical microscopy, recrystallization of lidocaine was observed within 5 min after application of reference hydrogel, but there was no change in ME-based hydrogels even after 30 minnute. These results indicated that ME-based hydrogels had some advantages in skin penetration, anesthetic effect and physical stability compared with alcoholic hydrogels. Finally it is possible to conclude that ME-based hydrogels containing lidocaine is a good topical drug delivery system for the treatment of premature ejaculation.

• 동의생리병리학회지
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• 제36권1호
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• pp.23-27
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• 2022

This study aims to evaluate the anti-inflammatory effect of 80% ethanol extracts of Stachys affinis (MQ) on 1-fluoro-2,4-Dinitrofluorobenzene (DNFB) induced atopic dermatitis (AD) in Balb/c mice. AD-like allergic contact dermatitis was induced by challenge of DNFB on the ear after DNFB sensitization on the back sides of mice. MQ alleivated clinical severity in AD-like skin lesions. In addition, ear thickness of epidermis and penetration of inflammatory cells in AD-like skin lesions were decreased by topical application of MQ. The the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were measured in AD mice using ELISA kits. Levels of TNF-α and IL-4 in serum were significantly decreased by topical application of MQ. Therefore, this study could give a clinical basis that MQ could be a agent to prevent AD.

• 대한화장품학회지
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• 제30권3호
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• pp.415-418
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• 2004

알부틴은 glycosylated hydroquinone으로 여러 식물들에서, 고농도로 발견되며 비교적 안정한 물질이다. 이는 멜라닌화를 억제하는 작용이 있는 것으로 보고되어 있고, 베타-글루코시다제에 의해 포도당과 hydroquinone으로 쉽게 가수분해된다. Hydroquinone 역시 우수한 항멜라닌화 작용을 가지나, 여러 가지 부작용들로 인해 그 사용이 제한적이거나 주의를 요한다. 이 연구는 알부틴과 베타-글루코시다제를 포함하는 미백 화장품이 자외선 조사로 유도된 색소 침착을 억제하는 효과를 알아보고자 하였다. 대상은 10명의 건강한 성인으로 등 부위에 자외선 B를 조사하여 색소 침착 병변을 만들었고 이 병변들은 세 그룹: 알부틴과 베타-글루코시다제를 함유하는 미백 화장품 도포군, vehicle 대조군, no-application 대조군으로 나누었다. 알부틴과 베타-글주코시다제를 함유하는 미백 화장품 도포군은 no-application 대조군에 비교하여 색소 침착을 $50.17\%$ 억제하였다(N = 10:P<0.05). 따라서 알부틴과 베타-글루코시다제를 함유하는 미백 화장품이 기미 등 자외선 조사로 유도되거나 악화되는 과색소성 질환에 효과적으로 사용될 수 있겠다.

• Journal of Oral Medicine and Pain
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• 제38권2호
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• pp.109-114
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• 2013

구강점막의 화학화상은 다양한 화학제품과의 접촉에 의해 일어날 수 있으며 국소 점막염, 각화성 백색병소, 출혈, 통증성조직 표면 등과 같은 임상적 특징을 나타낸다. Policresulen(알보칠$^{(R)}$)은 산부인과, 피부과, 이비인후과 영역에서 점막이나 피부의 소독 및 지혈 목적으로 사용되는 일반의약품이다. pH 0.6의 강산성을 띠고 있어서 강력한 부식제로 작용할 수 있으며 구강점막에 접촉될 경우 괴사나 화학화상과 같은 부작용을 나타낼 수 있기 때문에 사용상 세심한 주의를 요한다. 56세 여자 환자가 입술의 궤양과 부종 및 염증성 삼출물을 주소로 구강내과에 내원하였다. 이 환자는 약 10년 전부터 혓바늘이 가끔 발생하였으며 그런 경우에 알보칠$^{(R)}$을 종종 사용했었다고 하였다. 최근에는 혀와 입술의 통증 때문에 알보칠$^{(R)}$을 혀와 입술에 광범위하게 여러 차례 도포한 적이 있다고 하였다. 임상검사상 혀의 전방 1/2 부위에서 홍반성 미란 및 염증성 삼출물이 관찰되었고 상, 하순에 출혈성 가피 및 궤양이 형성되어 있었다. 알보칠 사용을 중단하게 한 후 구순부에 스테로이드 연고 도포 및 스테로이드 구강 가글액 사용 후 1주일 만에 병소는 현저히 줄어들었으며 2주 후 완치되었다. 본 증례를 통해서 일반의약품으로 쉽게 접할 수 있는 Policresulen(알보칠$^{(R)}$)의 오용으로 인한 구강점막의 출혈성 궤양의 발생 양상 및 치료과정을 소개하였으며, 구강점막에서 발생하는 화학화상에 대해 고찰하였다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.698-699
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• 2003

DA-3711 is a novel, anti wrinkle agent containing growth factors derived from human skin culture. In this study, effect of topical application of DA-3711 on chronic ultraviolet B (UVB)-induced skin damage was evaluated in hairless mice model. Exposure to UVB for 8 weeks induced apparent wrinkles on the back skin of the mice. The dorsal surfaces were exposed to UVB for a further 8 weeks, during which the surfaces where treated daily by topically application of a lotion containing either 35％ or 70％ of DA-3711. For comparison, lotion base, lotion base containing Cylasphere Retinol(equation omitted) (2500 I.U., Coletica) and NouriCe $l^{(R)}$ (Biozhem) were applied topically once a day for 8 weeks.(omitted))

• Biomolecules & Therapeutics
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• 제23권1호
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• pp.90-97
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• 2015

Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular $H_2O_2$-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-${\alpha}$- and interleukin-6-induced nuclear factor-${\kappa}B$ activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.

• Journal of Pharmaceutical Investigation
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• 제36권6호
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• pp.401-403
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• 2006

Topical preparations such as cream for Acyclovir(ACV), a potent anti-viral agent for the treatment of herpes simplex and herpes zoster, have been marketed in the world since 1993. However, the skin penetration rate of ACV from generic cream formulations sold in Europe has been found to be lower than the original $Zovirax^{\circledR}$ cream. In this study, we formulated ACV into a novel organogel system and compared the skin penetration characteristics with $Zovirax^{\circledR}$ cream. The rate and amount of skin penetration of ACV from the organogels were 6.3-fold greater than those obtained with $Zovirax^{\circledR}$ at an ACV concentration of 5%. The solubilizing effect of oil phase and anti-nucleation effect exhibited by sodium alginate contained in water phase are most likely attributed to enhanced ACV skin penetration property.

• Fibers and Polymers
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• 제7권3호
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• pp.255-261
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• 2006

There is increasing interest in the many beneficial aspects of green tea to human such as anti-carcinogenic, anti-aggregant, anti-allergic, anti-bacterial, anti-mutagenic, and anti-oxidant activities. Besides these beneficial aspects, it has been reported that green tea ingredients, especially polyphenolic families (i.e., catechin), have some UV protection property both in vivo and in topical applications. In this study, green tea extract was used as a dyeing stock for cotton and the UV protection property of the dyed cotton fabric was examined. To increase the affinity of cotton fiber to the polyphenolic components in the green tea extract, a natural biopolymer, chitosan, was used as mordanting agent. The effects of chitosan concentration in mordanting on the dyeing characteristics and the UV protection property were examined. Chitosan mordanted green tea dyed cotton showed better dyeing characteristic and higher UV protection property compared with the unmordanted green tea dyed cotton. As the chitosan concentration in mordanting increased, the dyeing efficiency and the UV protection property also increased. Therefore, adapting chitosan mordanting in green tea dyeing can increase the UV protection property of cotton fabrics to some extent.

• 셀메드
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• 제9권3호
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• pp.7.1-7.4
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• 2019

In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.349.1-349.1
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• 2002

Capsaicin. the pungent component of chili pepper. opens a novel cation selective ion channel in the plasma membrane of peripheral sensory neurons. Capsaicin channel agonists induce pain upon topical application in the early stage. which is followed by a period of desensitization. Although the agonists have been studied as a analgesics, their initial irritancy became sever side effect. So competive antagonists have been pursued as a novel pharmacological agent for analgesics, rather than agonists. (omitted)