• Journal of agricultural medicine and community health
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• v.31 no.2
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• pp.157-164
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• 2006

Objectives: Early diagnosis and treatment is the most important strategy to control malaria effectively. Microscopic examination of blood films is a traditional and standard method for diagnosing malaria, which takes a long time and needs expertise, Therefore, the alternative method, rapid diagnostic kit has been used for quick diagnosis in some counties, a highly infectious region by P. vivax. The purpose of this study was to evaluate the utility of malaria rapid diagnostic kit in Ganghwa county. Methods: The utility was evaluated by mean diagnosis time and sensitivity and specificity. For monitoring mean diagnosis time, 942 cases which were diagnosed for P. vivax were collected between 1998 and 2005, And for calculating sensitivity and specificity, 434 whole bloods in EDTA which were presented for P. vivax by microscopy and rapid diagnostic kit were collected between 2004 and 2005. Results: After malaria rapid diagnostic kit was used in 2003, mean diagnosis time has decreased to 3.36-3.14 day. The sensitivity and specificity of the rapid diagnostic kit was 98.2% and 98,5% and comparable to that of microscopic examination. Conclusions: The malaria rapid diagnostic kit is useful tool in a highly infectious region like Ganghwa county.

• Journal of Environmental Health Sciences
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• v.34 no.4
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• pp.271-278
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• 2008

Dialkylated phthalates have been commonly used as plasticizers and a variety of applications. Phthalate diesters have been shown to be developmental and reproductive toxicants. It is very difficult to exactly estimate the dose of dialkylated phthalates taken up by the general population because of environmental contamination. Urinary metabolites of phthalates enabled to estimate internal exposure. The objective of this study was quantitative determination of phthalate metabolites by LC/MS/MS with on-line cleanup method to analyze phthalate metabolites in Korean children's urine. We employed LC/MS/MS with on-line enrichment and column-switching techniques for this biological monitoring. Metabolites determined were 4 primary metabolites; MEHP, MnBP, MiBP, MEP and 2 secondary metabolites of DEHP; 5-OH-MEHP), 5-oxo-MEHP. We analyzed children's urine from 30 boys and 30 girls. The method detection limit of phthalate metabolites were 0.03 ng/mL for MEP, 1.05 ng/mL for MBP, 0.22 ng/mL for MEHP, 0.15 ng/mL for 5-OHMEHP and 0.16 ng/mL for 5-oxo-MEHP, respectively. Switching Column LC/MS/MS was proven to be a useful tool to determine metabolites of phthalate diesters in human urine. The correlation among phthalate metabolites was very high and statistically significant, except MEP. The children's age (months) was negatively correlated to the concentration of phthalate metabolites. The geometric mean concentration of phthalate metabolites (mg/g creatinine) in children's urine were 25.5 for MEP, 130.3 for MnBP, 56.8 for MiBP, 19.5 for MEHP, 85.6 for 5-OH-MEHP and 83.1 for 5-oxo-MEHP, respectively. Levels of estimated daily intake of parent phthalate compounds (${\mu}g$/kg bw/day) were 0.8 for DEP, 5.0 for DnBP, 1.9 for DiBP and $8.9{\sim}14.2$ for DEHP, respectively. Estimated daily intake for DEP and DiBP were lower than those of other studies but the value for DEHP was higher than that of other study.

• Journal of Biomedical Engineering Research
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• v.29 no.1
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• pp.32-39
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• 2008

This paper reports on a realtime OS based master-slave configuration robot control system for laparoscopic surgery robot which enables telesurgery and overcomes shortcomings with conventional laparoscopic surgery. Surgery robot system requires control system that can process large volume information such as medical image data and video signal from endoscope in real-time manner, as well as precisely control the robot with high reliability. To meet the complex requirements, the use of high-level real-time OS (Operating System) in surgery robot controller is a must, which is as common as in many of modem robot controllers that adopt real-time OS as a base system software on which specific functional modules are implemened for more reliable and stable system. The control system consists of joint controllers, host controllers, and user interface units. The robot features a compact slave robot with 5 DOF (Degree-Of-Freedom) expanding the workspace of each tool and increasing the number of tools operating simultaneously. Each master, slave and Gill (Graphical User Interface) host runs a dedicated RTOS (Real-time OS), RTLinux-Pro (FSMLabs Inc., U.S.A.) on which functional modules such as motion control, communication, video signal integration and etc, are implemented, and all the hosts are in a gigabit Ethernet network for inter-host communication. Each master and slave controller set has a dedicated CAN (Controller Area Network) channel for control and monitoring signal communication with the joint controllers. Total 4 pairs of the master/slave manipulators as current are controlled by one host controller. The system showed satisfactory performance in both position control precision and master-slave motion synchronization in both bench test and animal experiment, and is now under further development for better safety and control fidelity for clinically applicable prototype.

• The Korean Journal of Pesticide Science
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• v.5 no.2
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• pp.1-12
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• 2001

A competitive indirect enzyme-linked immunosorbent assay (ci ELISA) for the organophosphorus insecticide acephate, O,S-dimethyl acetylphosphoramidothioate, was developed using a polyclonal antibody. Three different haptens mimicking the analyze and containing hexanoic acid moiety as a linker were synthesized, and then conjugated with the carrier proteins bovine serum albumin and keyhole limpet hemocyanin by the N-hydroxysuccinimide active ester method. Polyclonal antibodies raised against hapten-KLH conjugates in rabbits and the hapten-BSA conjugates as coating antigens were screened and selected for the assay in the homologous and/or heterologous ELISA system. The effects of various assay conditions, including blocking reagents, detergent content, organic solvents, pH, and preincubation of tile mixture of the polyclonal antibody and the analyze on the sensitivity were evaluated. The $IC_{50}$ value of acephate of 110 ng/mL was obtained in an optimized heterologous system using hapten-3-BSA as a coating antigen and a polyclonal antibody 8377, showing the detection range of 10-1000 ng/mL and the lowest detection limit of 4 ng/mL. The cross-reactivities of the structurally related insecticides, including methamidophos were less than 0.02%. These results indicate that the ELISA could be a convenient and alternative tool for monitoring acephate residues in agricultural products and environmental samples.

• Journal of Navigation and Port Research
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• v.42 no.1
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• pp.25-30
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• 2018

This study was carried out to analyze the risk attitude based on situation awareness of the Vessel Traffic Service Operator (VTSO) on the risk of collision between vessels during the monitoring of vessel traffic through the use of the VTS system. In general, when two vessels are in the close quarters situation, we analyzed the degree of risk of collision from the subjective viewpoint of the VTSOs through an administered survey. Chiefly, we analyzed the risk attitudes of each VTSO in the close quarters situation, by comparing it with the calculated value by the CoRi, which is the ship collision risk model from the VTSO's viewpoint. As a result, it was confirmed that more than 40% of the total VTSO was noted as being in a weak risk aversion type of category. Through a review of the results of analyzing the risk attitude of VTSO according to gender, age, VTS career, VTS center position, accident experience, and boarded career, it was found that there was a significant difference in the VTS career, VTS center position and accident experience. In addition, a regression model that is able to further explain the risk attitude of VTSO was derived as a factor that confirmed the significant difference and applied to CoRi to predict the collision risk according to the individual VTSO to be used as a fundamental information gathering tool for providing more accurate and safe VTS service at sea.

• Journal of Korea Water Resources Association
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• v.41 no.10
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• pp.1045-1058
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• 2008

Drought is a natural phenomena caused by long time lack of precipitation causing varying damages in several regions which increases yearly. Specifically, in 1994$\sim$1995 and 2001 severe drought occurred in almost every region of Korea. Small and medium sized water supply reservoirs exposed their bottoms and also raised considerable economic losses. In spite of this fact, damages and impacts from the drought can still be minimized by well defined drought management plans with optimal management of water supply facilities. Throughout this research, integrated drought information system is proposed to used in monitoring the drought of Korea in real time. And the expert system for the management of water supply facilities has developed using Shared Vision Model (SVM) to enable the Virtual Drought Exercise (VDE). To find a better way to manage water during drought and to develop the enhanced abilities to respond to drought, virtual drought exercise is the most effective approach and process. The proposed process of virtual drought exercise using integrated drought information system can be used as an effective tool to prepare the optimal water supply plans during the drought.

• Pediatric Infection and Vaccine
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• v.25 no.1
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• pp.17-25
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• 2018

Purpose: Blood culture is an essential diagnostic tool and requires clear indications, proper techniques, and quality control. We aimed to investigate whether blood cultures in children are appropriate for indications, are performed correctly, and receive proper quality control. Methods: We conducted an online survey targeting pediatric infectious diseases (ID) specialists working in general hospitals and neonatologists (Neo) working at hospitals operating a neonatal intensive care unit in Korea. Results: Approximately 81.1% (30/37) of pediatric ID specialists and 72.2% (52/72) of Neo responded to the survey. Some of the respondents (33.3% of ID and 59.6% of Neo) performed blood culture as a regular test irrespective of the indication. Approximately 40% of ID and 65.4% of Neo ordered only one set of blood culture in patients suspected with bacteremia. The most commonly used disinfectant for skin preparation was povidone-iodine, while the skin preparation method varied by institution. Approximately two-thirds of the institutions were monitoring the blood culture contamination rate, whereas relatively few provided staff with feedback on that rate. In addition, less than half of the institutions were providing regular staff training on blood culture (40% of ID and 28.8% of Neo). Conclusions: The indication and methods of blood culture for children varied according to institution, and few hospitals exert effort in improving the quality of blood culture. Institutions have to strive constantly toward improvement of blood culture quality and evidence-based recommendations for pediatric blood cultures should be standardized.

• Korean Journal of Ecology and Environment
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• v.42 no.1
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• pp.39-47
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• 2009

Spatial and temporal analysis of water quality was performed for eleven monitoring stations in Dongjin River watershed in order to determine the trends of monthly water quality. The monthly water quality data of biochemical oxygen demand (BOD), total nitrogen (TN) and total phosphorus (TP) during $1995{\sim}2004$, were analyzed utilizing Seasonal Mann-Kendall test, LOWESS and three-dimensional graphic approaches. The results indicated that BOD and TN concentrations had the downward trend, but TP showed the upward trend, especially in Gobucheon. This numerical and graphic analysis is the useful tool to analyze the long-term trend of water quality in a large river system.

• Journal of Food Hygiene and Safety
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• v.29 no.1
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• pp.16-20
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• 2014

The prevalence of Bacillus cereus was determined in salad and Kimbab obtained from commercial retailers. Among the 100 salad samples analyzed, 54 samples were negative for B. cereus, whereas the bacterial count was < 10 colony forming units (CFU)/g in 8 samples, < 100 CFU/g in 25 samples, < 1,000 CFU/g in 11 samples, and > 1,000 CFU/g in 2 samples. The mean (standard deviation) was 1.18 log CFU/g (${\pm}0.71$ log CFU/g). In Kimbab, B. cereus was isolated from 20 samples; the mean bacterial count was 1.01 log CFU/g (${\pm}0.71$ log CFU/g). On the basis of the monitoring data, a statistical sampling plan was determined with the NEW sampleplan program (ICMSF), which was used as an analytical tool. To identify the most suitable sampling plan, the microbial limits (m, M) and the maximum allowable number of sample units yielding unsatisfactory test results (c) were varied, but the number of samples units, n = 5, was fixed. Sampling plans showing an acceptable probability (Pa) over 0.95 were considered suitable. Two plans (A and B) were finally suggested. Parameters for plan A are n = 5, c = 0, m = 1,000, and M = 10,000 and for plan B are n = 5, c = 2, m = 100, and M = 1,000. Interestingly, the latter plan was identical to the microbial sampling plan used in New Zealand. Thus, it was concluded that the suggested plan can be used as a sampling plan that is in line with international standards.

• Journal of KIISE:Computing Practices and Letters
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• v.5 no.6
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• pp.727-737
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• 1999

프로세스 중심 소프트웨어 개발 환경(PSEE : Process-centered Software Engineering Environment)은 소프트웨어 개발자를 위한 여러가지 정보의 제공과 타스크의 수행, 소프트웨어 개발 도구의 수행 및 제어, 필수적인 규칙이나 업무의 수행등과 같은 다양한 행위를 제공하는 프로세스 모형의 수행을 통하여 소프트웨어 개발 행위를 지원한다. SEED(Software Engineering Environment for Development)는 효율적인 소프트웨어 개발과 프로세스 모형의 수행을 제어하기 위해 ETRI에서 개발된 PSEE이다.본 논문에서는 SEED에서 프로세스 모형을 설계하기 위해 사용되는 SimFlex 프로세스 프로그래밍 언어와, 수행지원시스템인 SEED Engine의 구현에 대하여 기술한다. SimFlex는 간단한 언어 구조를 가진 프로세스 프로그래밍 언어이며, 적절한 적합화를 통하여 다른 PSEE에서 사용될 수 있다. SimFlex 컴파일러는 SimFlex에 의해 기술된 프로세스 모형을 분석하고, 모형의 오류를 검사하며, SEED Engine에 의해 참조되는 중간 프로세스 모형을 생성한다. 중간 프로세스 모형을 사용하여 SEED Engine은 외부 모니터링 도구와 연관하여 사용자를 위한 유용한 정보뿐만 아니라 SimFlex에 의해 기술된 프로세스 모형의 자동적인 수행을 제공한다. SimFlex 언어와 수행지원 시스템의 지원을 통하여 소프트웨어 프로세스를 모형화하는데 드는 비용과 시간을 줄일 수 있으며, 편리하게 프로젝트를 관리하여 양질의 소프트웨어 생산물을 도출할 수 있다. Abstract Process-centered Software Engineering Environments(PSEEs) support software development activities through the enaction of process models, providing a variety of activities such as supply of various information for software developers, automation of routine tasks, invocation and control of software development tools, and enforcement of mandatory rules and practices. The SEED(Software Engineering Environment for Development) system is a PSEE which was developed for effective software process development and controlling the enactment of process models by ETRI.In this paper, we describe the implementation of the SimFlex process programming language used to design process models in SEED, and its runtime support system called by SEED Engine. SimFlex is a software process programming language to describe process models with simple language constructs, and it could be embedded into other PSEEs through appropriate customization. The SimFlex compiler analyzes process models described by SimFlex, check errors in the models, and produce intermediate process models referenced by the SEED Engine. Using the intermediate process models, the SEED Engine provides automatic enactment of the process models described by SimFlex as well as useful information for agents linked to the external monitoring tool. With the help of the SimFlex language and its runtime support system, we can reduce cost and time in modeling software processes and perform convenient project management, producing well-qualified software products.