• Journal of Nutrition and Health
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• 제42권7호
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• pp.622-630
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• 2009

The purpose of this study was to establish an association between glycemic index (GI), glycemic load (GL), dietary carbohydrates and diabetes with the context of the current population dietary practice in Korea. The subjects of 3,389 adults (male 1,430, female 1,959) were divided into normal (serum fasting glucose < 100 mg/dL), impaired glucose tolerance (100 ${\leq}$ serum fasting glucose < 126 mg/dL), diabetes (serum fasting glucose > 126 mg/dL) by serum fasting glucose. Anthropometric and hematologic factors, and nutrient intakes, dietary glycemic index (DGI), dietary glycemic load (DGL) were assessed. Multiple logistic regression model was used to determine the odds ratios (ORs) and 95% confidence intervals for relationship of DGI, DGL, carbohydrates intakes, and diabetes. DGI and DGL were not significantly correlated with impaired glucose tolerance and diabetes. However, the risk of impaired glucose tolerance and diabetes showed a tendency to increase as increase of DGI after multivariate adjustment (age, education, income, region area, diabetes family history, smoking, drinking, exercise, energy intake) in male. The risk of impaired glucose tolerance and diabetes showed a tendency to increase in the DGI 71.1-74.8 after multivariate adjustment in female. DGL was inversely related to impaired glucose tolerance and diabetes in male. In female, however, DGL was positively related to impaired glucose tolerance and diabetes. In particular, the risk of diabetes increased positively in level of DGL 260.5, and remained after multivariate adjustment (Q5 vs Q1：2.38, 0.87-6.48). When percent energy intakes from carbohydrates were more than 70%, the risk of impaired glucose tolerance and diabetes increased in both male and female. In particular, when percent energy intakes from carbohydrates were more than 69.9%, the risk of diabetes increased positively in male (Q4 vs Q1：2.34, 1.16-4.17). In conclusion, above 70% energy intakes from carbohydrates appeared to be a risk factor of diabetes. It seemed that the meal with high GI and GL value must be avoided it. And also, the macronutrients of the meal must be properly balanced. In particular, it may be said that it is a preventive way for treatment of the diabetes to avoid eating carbohydrates of much quantity.

• Animal Bioscience
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• 제34권7호
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• pp.1210-1220
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• 2021

Objective: Unlike mammals, goose fatty liver shows a strong tolerance to fatty acids without obvious injury. Stearyl-coenzyme A desaturase 1 (SCD1) serves crucial role in desaturation of saturated fatty acids (SAFs), but its role in the SAFs tolerance of goose hepatocytes has not been reported. This study was conducted to explore the role of SCD1 in regulating palmitic acid (PA) tolerance of goose primary hepatocytes. Methods: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide was examined to reflect the effect of PA on hepatocytes viability, and quantitative polymerase chain reaction was used to detect the mRNA levels of several genes related to endoplasmic reticulum (ER) stress, inflammation, and apoptosis, and the role of SCD1 in PA tolerance of goose hepatocytes was explored using RNA interfere. Results: Our results indicated that goose hepatocytes exhibited a higher tolerant capacity to PA than human hepatic cell line (LO2 cells). In goose primary hepatocytes, the mRNA levels of fatty acid desaturation-related genes (SCD1 and fatty acid desaturase 2) and fatty acid elongate enzyme-related gene (elongase of very long chain fatty acids 6) were significantly upregulated with 0.6 mM PA treatment. However, in LO2 cells, expression of ER stress-related genes (x box-binding protein, binding immunoglobulin protein, and activating transcription factor 6), inflammatory response-related genes (interleukin-6 [IL-6], interleukin-1β [IL-1β], and interferon-γ) and apoptosis-related genes (bcl-2-associated X protein, b-cell lymphoma 2, Caspase-3, and Caspase-9) was significantly enhanced with 0.6 mM PA treatment. Additionally, small interfering RNA (siRNA) mediated downregulation of SCD1 significantly reduced the PA tolerance of goose primary hepatocytes under the treatment of 0.6 mM PA; meanwhile, the mRNA levels of inflammatory-related genes (IL-6 and IL-1β) and several key genes involved in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), forkhead box O1 (FoxO1), mammalian target of rapamycin and AMPK pathways (AKT1, AKT2, FoxO1, and sirtuin 1), as well as the protein expression of cytochrome C and the apoptosis rate were upregulated. Conclusion: In conclusion, our data suggested that SCD1 was involved in enhancing the PA tolerance of goose primary hepatocytes by regulating inflammation- and apoptosis-related genes expression.

• 대한의생명과학회지
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• 제11권4호
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• pp.539-543
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• 2005

Elevated level of serum cholesterol in humans is a risk factor correlated with the development of coronary heart disease. We have screened lactic acid bacteria from pig and human feces for the development of probiotics which have an anti-cholesterol effect. We have used special media to isolate only lactic acid bacteria and they were subjected to the experiments such as oxgal test, carbohydrate fermentation test. Results from the acid tolerance test and growth test in the presence of oxgal demonstrated that some strains would likely survive in thuman stomach, where acidity is high, and in small intestine, where bile fluid is present. In conclusion, we were able to screen lactic acid bacteria which were tolerant against bile acid and supposed to be prominent to lower the cholesterol level in human serum.

• 품질경영학회지
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• 제42권4호
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• pp.607-616
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• 2014

Purpose: This paper reviews popular measurement system indices and proposes a procedure for assessing a measurement system using two parameters with intraclass correlation and a factor for process capability. Methods: Gage Repeatability and Reproducibility(GR&R), precision-to-tolerance ratio(PTR), number of distinct categories, producer's and consumer's risks are employed to assess the measurement capabilities and discuss the relationships between measurement system metrics. Results: Two-dimensional plot by two parameters is presented to assess adequacy of the measurement system and process capability. A numerical example and previously studied case study are provided for illustration. Conclusion: The procedure proposed in this paper using two-dimension parameters provides a valuable procedure and helpful guidelines to quality and production managers in assessing the capabilities of a measurement system and choosing the needed actions to be the most benefit.

• 한국정밀공학회지
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• 제15권6호
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• pp.58-63
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• 1998

There are lots of factors that are related to the geometric characteristics of machined surface. Among them, the tool path and milling mode (up cut milling or down cut milling) are the easiest controllable machining conditions. Thus, the first objective of this research is to study the effects of them on the milled surface that is generated by an end milling tool. To get precision parts, not only the machining process but also the measurement of geometric tolerance is important. But, this measurement requires a lot of time, because the infinite surface points must be measured in the ideal case. So, the second objective is to propose a simple flatness measurement method that can be available instead of the 3-D geometric tolerance measurement method, using a scale factor and characterized points. Finally, it is also shown that the possibility of flatness improvement by shifting the consecutive fine cutting tool path as compared with the last rough cutting tool path.

• 한국식품영양학회지
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• 제6권3호
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• pp.219-230
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• 1993

This research aims to study the changes In gastrointestinal function attributed to aging In human. The thresholds for recognition and detection of flavors became elevated and salivary gland acinar cells decreased in the old age. But most esophageal function remained relatively Intact. Although gastric emptying time has been slowed with aging, the total intestinal transit time did not differ. Atropic gastritis due to H. pylori in old man decreased secretion of acid and Intrinsic factor and absorbability of calcium and iron. Pancreatic secretion is droned in older persons. Prevalence of gallstones rised with age. Liver size and portal blood flow decreased significantly with age. Mucosal surface area has been reported to be slightly diminished in the aging man. Glucose transporters decreased and Insulin tolerance Increased. Absorption of aromatic amino acid is diminished with age. Dietary protein In that aging human increased fecal nitrogen excretion. Vitamin A tolerance increased. Vitamin D receptor concentration decreased and resistance to 1,25-(OH)2D3 action increased. Permeability of aging small Intestine Increased. Zinc balance dirt not differ Copper absorption appeared not to be significantly affected by age. Neurotensin secretion decreased thus slowed colonic peristaltic movements and Intestinal mucosal growth.

• 대한기계학회논문집
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• 제19권9호
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• pp.2105-2113
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• 1995

The compressive tests under impact conditions were performed to establish a design guide for impact damage tolerance. The composition of layup was selected for the real cases of composite aircraft structure. The energy level of visible of visible damage threshold was determined as 7 Joules. It was found that the normalized bending stiffnesses in the direction of closely fixed boundary affected the area of damage. Graphite/epoxy used in the tests exhibited 60% reduction in compression strength at the energy level of visible damage threshold. Wet-conditioned specimens represented 9% reduction in residual compressive strength in comparison with room temperature ambient specimens. In this study, a design factor of 2.1 was proposed for the low velocity impact damage.

• 한국전산유체공학회지
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• 제14권2호
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• pp.1-8
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• 2009

The purposes of present work are to analyze the convective heat transfer with three-dimensional Reynolds-averaged Navier-Stokes analysis, and to optimize shape of the mixing vane taken tolerance into consideration by using the analysis results. Response surface method is employed as an optimization technique. The objective function is defined as a combination of heat transfer rate and inverse of pressure drop. Two bend angles of mixing vane are selected as design variables. Thermal-hydraulic performances have been discussed and optimum shape has been obtained as a function of weighting factor in the objective function. The results show that the optimized geometry improves the heat transfer performance far downstream of the mixing vane.

• 한국반도체및디스플레이장비학회:학술대회논문집
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• 한국반도체및디스플레이장비학회 2002년도 추계학술대회 발표 논문집
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• pp.59-63
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• 2002

This paper reports on the fabrication process and characteristics of a ceramic thin-film pressure sensor based on Ta-N strain-gauges for harsh environment applications. The Ta-N thin-film strain-gauges are sputter-deposited on a thermally oxidized micromachined Si diaphragms with buried cavities for overpressure tolerance. The proposed device takes advantage of the good mechanical properties of single-crystalline Si as a diaphragm fabricated by SDB and electrochemical etch-stop technology, and in order to extend the temperature range, it has relatively higher resistance, stability and gauge factor of Ta-N thin-films more than other gauges. The fabricated pressure sensor presents a low temperature coefficient of resistance, high-sensitivity, low non-linearity and excellent temperature stability. The sensitivity is 1.21 ~ 1.097 mV/V.kgf/$\textrm{cm}^2$ in temperature ranges of 25~ $200^{\circ}C$ and a maximum non-linearity is 0.43 %FS.

• 전자공학회논문지D
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• 제36D권7호
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• pp.80-91
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• 1999

흡수 회절결자를 가지는 복소결합 다중양자우물 구조의 DFB 레이저가 작은 문턱이득, 좋은 변조 특성 그리고 작은 선폭계수를 보이며 또한 큰 제작 공차를 가지는 최적의 복소 회절격자 구조를 보였다. 이러한 구조를 찾기 위해 확장된 새로운 층 방법을 사용하여 복소 결합계수와 복소결합계수비를 계산하였으며 흡수 회절격자 층에서의 모달 손실을 포함하는 문턱이득을 직각사각형과 사다리꼴 회절격자에 대하여 계산하였다. 제안된 여러 구조에 대한 계산 결과의 비교를 통하여 작은 문턱이득과 큰 제작 공차를 얻기 위한 설계 지침을 얻었다. 제안된 여러 구조 중에서 이중 회절격자 층 방법을 이용한 구조중 흡수 회절격자가 윗층에 있는 구조가 복소 결합계수의 크기와 문턱이득에 대한 제작 공차가 가장 컸다. 복소결합계수비에 대한 제작 공차는 모든 구조에서 매우 큰 값을 가지고 있어 회절격자 설계시 중요한 고려 대상이 아님을 볼 수 있었다.