• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8765-8774
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• 2014

This study aimed at summarizing epidemiological research findings on associations between tobacco, alcohol and tea consumption and risk of gastric cancer (GC) in the Chinese population. The review searched PubMed, Embase, China National Knowledge Infrastructure (CNKI) and China Biology Medicine (CBM) databases and reference lists of review papers for all studies published in English or Chinese languages. Information extracted, via two independent researchers, from retrieved articles included first author, year of publication, study design, sample size, source of controls and adjusted odds ratio (OR) or relative risk (RR) with the corresponding 95% confidence intervals (CIs) for each category. Statistical analyses used software STATA version 12.0. The systematic search found 89 articles containing 25,821 GC cases and 135,298 non-cases. The overall random effects in terms of pooled OR and 95%CI for tobacco, alcohol and tea consumption were 1.62 (95%CI: 1.50-1.74), 1.57 (95%CI: 1.41-1.76) and 0.67 (95%CI: 0.59-0.76) respectively; while the heterogeneity among included studies ranged from 80.1% to 87.5%. The majority of subgroup analyses revealed consistent results with the overall analyses. All three behavioral factors showed statistically significant dose-dependent effects on GC (P<0.05). The study revealed that tobacco smoking and alcohol drinking were associated with over 1/2 added risk of GC, while tea drinking conferred about 1/3 lower risk of GC in the Chinese population. However, these results should be interpreted with caution given the fact that most of the included studies were based on a retrospective design and heterogeneity among studies was relatively high.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.656-665
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• 2016

연구목적: 이 연구는 한국의 재림교인과 일반 인구집단간의 생활습관 및 건강행동 비교 분석 연구를 통하여 특성과 관련요인들을 도출하고자 실시하였다. 연구방법: 수도권 지역 만 20세 이상 재림교인 878명과 제4기 2차년도 국민건강영양 조사자료 중에서 수도권 지역 만 20세 이상 3,000명을 대상으로 건강행태와 관련된 건강검진, 흡연, 음주, 신체활동, 주관적 스트레스, 체중관리, 구강건강 관련 항목의 비교는 카이제곱 검정을 사용하였으며, 건강행동에 기여요인을 확인하기 위해 로지스틱회귀분석을 실시하였다. 연구결과: 건강검진율은 재림교인이 일반 인구집단보다 높게 나타났으며(p<0.001), 재림교인은 연령이 낮은 20-30대에서 검진율이 낮게 나타났다(p<0.001). 평생 흡연 경험율 및 현재 흡연율에서 재림교인이 일반 인구집단보다 현저하게 낮게 나타났으며(p<0.001), 재림교인 중 과거 흡연자의 금연 성공율은 매우 높게 나타났다. 음주율에서는 재림교인이 일반 인구집단보다 현저하게 낮게 나타났으며, 재림교인은 신앙기간이 짧을수록 음주를 많이 하는 것으로 나타났으며(p<0.001), 남자가 여자보다 음주율이 높은 것으로 나타났다(p<0.001). 중등도 신체활동 및 걷기 운동에서 재림교인은 일반 인구집단보다 실천율이 높게 나타났으며, 재림교인들의 남자가 여자보다 중등도 신체활동은 높은 것으로 나타났다(p<0.001). 결론: 이상에서 나타난 재림교인들의 건강생활습관에서 흡연 및 음주 등에서는 일반 인구집단에 보다 탁월하게 건강생활을 실천하고 있어 추후 보다 심층적인 추적관찰 연구 등이 필요해 보인다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3373-3378
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• 2012

Background: Head and neck squamous cell carcinoma (HNSCC) is the 8th most common cancer worldwide. Although older age, male gender, smoking and alcohol consumption are known risk factors, an increasing number of HNSCC patients are without typical risk factors. Our aim was to define demographics of HNSCC in Iran and the potential risk factors related to Iranian ethnicity and lifestyle. Methods: We conducted a cross-sectional analytical study on 262 patients with primary SCC of the larynx, hypopharynx or tongue referred to our pathology department during 1995-2010. Patients' demographics, tumor characteristics and risk factors such as smoking, alcohol consumption and anemia were analyzed and compared in two groups of patients: over 40 years (older group) and 40 years or less (young group); Chi-square and Mann-Whitney analytical tests were employed. Results: 5.7% of patients were young adults. The male to female ratio was 1.5 in the younger group and 5.6 in the older group. In young adults, 40% of tumors were located in larynx and 40% in the tongue. Age >40 was significantly associated with laryngeal location (P<0.001). History of smoking and drinking was significantly associated with age >40 and SCC of larynx in both age groups. Cervical lymph node involvement was significantly correlated with SCC of tongue (P<0.001), however, considering young adults only, SCC of hypopharynx was most frequently accompanied by lymph node involvement (60%). The most prevalent tumor among men was SCC of larynx whereas SCC of hypopharynx was the most prevalent tumor among women (61%), of whom 18.2% were ${\leq}40$. Conclusions: The incidence of HNSCC among young adults seems to be higher in Iran compared to other countries. Reduction in exposure to known risk factors, especially tobacco smoking in forms of cigarettes and bubble pipes, and search for other causative agents of HNSCC in young population is recommended.

• 대한통합의학회지
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• 제12권1호
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• pp.27-39
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• 2024

Purpose : Smoking is a major factor in chronic obstructive pulmonary disease (COPD), but the effect of electrical cigarette smoking on COPD development is still uncertain. This study aimed to compare the functions of airways and lungs exposed to combustible cigarettes and electrical cigarettes based on the pulmonary function test (PFT) results from the Korean National Health and Nutrition Examination Survey (NHANES). Methods : This study used data from 8,942 participants with PFT results out of 47,309 total subjects from the 6th to 8th Korean NHANES (2014-2015, 2016-2018, and 2019, respectively). Individuals with diseases such as cancer, ex-smokers, and dual tobacco users were excluded. The PFT results were analyzed according to the COPD diagnostic criteria. After adjusting for confounding variables, a complex sample generalized linear model ANOVA test was performed to investigate the association between PFT results and combustible smoker or electrical cigarette user groups. Results : In an analysis based on the obstructive ventilatory disorders (forced expiratory volume in 1 second[FEV₁]/forced vital capacity[FVC]<.7), combustible cigarette smokers showed a 3.46 times higher risk of COPD compared to non-smokers, while electrical cigarette smokers exhibited no significant difference in terms of COPD-related risks compared to non-smokers. FEV₁ showed a negative relation with combustible cigarette smokers as reported elsewhere (B=-.07, p<.001). FEV₁/FVC was negatively related to both combustible cigarette smokers (B=-.03, p<.001) and electrical cigarette smokers (B=-.02, p<.001). Conclusion : FEV₁/FVC decreases were observed in the long-term exposure to both combustible and electrical cigarettes. The lower FEV₁ in the combustible cigarette group implies the worsening of the severity of COPD, suggesting more damage to the airways and lungs in the short term. Therefore, the temporary electrical cigarettes use for the transition period in order to smoking cessation potentially aids to reduce the harmful effect of combustible cigarettes in COPD development.

• 한국환경과학회지
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• 제8권3호
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• pp.319-323
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• 1999

This study was designed to evaluate the exposure to benzene by residents in neighborhoods near a major roadways, by persons waiting buses, and by drivers and service station attendants while refueling. It was confirmed that the outdoor air benzene concentrations near the major roadways were higher than those further away from the sources. However, neither the indoor air nor breath concentrations were different for two specified residential areas. Smoking was confirmed as an important factor for the indoor air benzene levels. Persons waiting buses, drivers and service station attendants were exposed to elevated benzene levels compared to even the residents in neighborhoods near a major roadways. The mean benzene concentration at bus stop was 2.7 to 6.9 times higher than the mean ambient air concentration. The mean benzene concentrations in the breathing zone of drivers and service station attendants were 95 to 160 and 120 to 202 times higher than the mean ambient air concentrations, respectively.

• 한국작물학회지
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• 제56권2호
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• pp.146-150
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• 2011

버어리종 잎담배 질소화합물 저감 및 이용성 향상을 위해 순지르기 시기(발뢰기, 개화시, 개화기 순지르기)와 수확시기 (미숙엽, 적숙엽, 과숙엽 수확)에 따른 건조엽의 질소화합물, 총 TSNA 함량 및 품질특성을 조사한 결과는 다음과 같다. 1. 개화기 순지르기가 발뢰기와 개화시 순지르기에 비해 전질소, 단백태 질소 등 모든 질소화합물과 총 TSNA 함량이 낮았다. 니코틴 함량은 순지르기 시기가 늦어질수록 유의적인 수준으로 감소하였고, 에텔 추출물은 증가하였다. 2. 건조엽의 색상 중 명도는 개화기 순지르기가 가장 높았고, 적색도와 황색도는 특별한 차이가 없었다. 수량은 순지르기 시기가 늦어질수록 감소하였으며, 외관품질은 순지르기 처리 간 큰 차이가 없었다. 3. 수확시기가 늦어질수록 질소화합물인 전질소, 단백태 질소, 질산태 질소, 암모니아태 질소가 감소하였고, 니코틴 함량은 증가하였다. 총 TSNA 함량도 수확시기가 늦어질수록 감소하였고, 에텔추출물은 증가하였다. 4. 전조엽의 색상 종 명도와 황색도는 수확시기가 늦어질수록 유의적인 수준으로 증가하였고, 적색도는 특별한 차이가 없었다. 수량은 수확시기가 늦어질수록 감소하였으나, 가격은 미숙엽 수확에 비해 적숙엽과 과숙엽 수확이 높았다. 5. 버어리종 잎담배 질소화합물 및 TSNA 함량 저감를 위해서는 개화기 순지르기 후 과숙엽 수확이 수량은 감소하나, 화학성분 개선 및 품질향상에 더 효과적인 것으로 조사되었다.

• 한국환경농학회지
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• 제19권2호
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• pp.147-153
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• 2000

흡연은 직접 또는 environmental tobacco smoke를 통하여 많은 위해성 물질을 인체에 유입시킨다. 이러한 위해 물질중 니코틴을 인체내의 대사에 따라서 암을 유발시키는 물질로 전이되기도 한다. 니코틴의 대사산물로 대표적인 발암물질인 nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK)가 있다. 많은 연구는 녹차의 추출물이 암을 예방하는데 탁월한 효능이 있음을 보고하고 있다. 그러나, 녹차의 암예방 효과에 대한 기작은 거의 알려져 있지 않다. 최근의 보고는 니코틴의 주요대사 산물인 코니틴이 안정한 물질임과 동시에 NNK의 활성 및 형성을 억제하는 것으로 알려져 있다. 본 연구는 세포내의 니코틴의 대사에 있어, 코티닌으로의 전이도에 녹차의 추출물이 미치는 영향에 대하여 연구하였다. 녹차의 추출물은 시험관에서 직접 혼합한 경우와 세포주를 이용한 실험에서, 니코틴이 코티닌으로 전이하는 데 긍정적 영향을 주었다. 이 결과는 녹차의 성분 중에 니코틴의 여러 대사경로중에서 코티닌의 대사를 촉진하는 물질이 함유되어 있음을 의미한다. 이 결과는 아울러, 녹차의 암 예방의 가능성에 대하여 설명할 수 있는 기전을 제시한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.111-116
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• 2013

Background: Cigarette smoking is the major risk factor for development of lung cancer. Identification of effects of tobacco on airway gene expression may provide insight into the causes. This research aimed to compare gene expression of large airway epithelium cells in normal smokers (n=13) and non-smokers (n=9) in order to find genes which discriminate the two groups and assess cigarette smoking effects on large airway epithelium cells.Materials and Methods: Genes discriminating smokers from non-smokers were identified by applying a neural network clustering method, growing self-organizing maps (GSOM), to microarray data according to class discrimination scores. An index was computed based on differentiation between each mean of gene expression in the two groups. This clustering approach provided the possibility of comparing thousands of genes simultaneously. Results: The applied approach compared the mean of 7,129 genes in smokers and non-smokers simultaneously and classified the genes of large airway epithelium cells which had differently expressed in smokers comparing with non-smokers. Seven genes were identified which had the highest different expression in smokers compared with the non-smokers group: NQO1, H19, ALDH3A1, AKR1C1, ABHD2, GPX2 and ADH7. Most (NQO1, ALDH3A1, AKR1C1, H19 and GPX2) are known to be clinically notable in lung cancer studies. Furthermore, statistical discriminate analysis showed that these genes could classify samples in smokers and non-smokers correctly with 100% accuracy. With the performed GSOM map, other nodes with high average discriminate scores included genes with alterations strongly related to the lung cancer such as AKR1C3, CYP1B1, UCHL1 and AKR1B10. Conclusions: This clustering by comparing expression of thousands of genes at the same time revealed alteration in normal smokers. Most of the identified genes were strongly relevant to lung cancer in the existing literature. The genes may be utilized to identify smokers with increased risk for lung cancer. A large sample study is now recommended to determine relations between the genes ABHD2 and ADH7 and smoking.

• Journal of Acupuncture Research
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• 제24권1호
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• pp.137-159
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• 2007

Objectives: The purpose of this study is to examine the risk factors and the genetic polymorphism of TNF-alpha associated with rheumatoid arthritis by Sasang constitution Methods : This study was planned to detect the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Constitution and to examine the risk factor such as life style and environmental stress (smoking, environmental tobacco smoke, alcohol intake and so on). The genetic polymorphism of TNF-alpha (G308A) were analyzed by PCR-RFLP in rheumatoid arthritis patients and controls. Rheumatoid arthritis patients and matched controls are assessed with QSCCII question for Sasang Typology. Then the genetic polymorphism of patients by Sasang constitution are compared to those of control, which are statistically analyzed and adjusted by age, sex, smoking status, alcohol intake, BMI, and econocmic status. Results: Differential effect of passive smoking on the association between Sasang constitution and rheumatoid arthritis risk was found. This study showed that the genetic polymorphism (TNF-${\alpha}$(G308A)) of rheumatoid arthritis patients and controls associated with the susceptibility to rheumatoid arthritis by sasang constitution was analyzed. Differential effects of TNF-${\alpha}$(G308) genetic polymorphism on the association between rheumatoid arthritis risk and Sasang constitution were found. Conclusion : It is suggested that the genetic polymorphism correlated with susceptibility to rheumatoid arthritis by specific sasang constitution used as its susceptibility marker and further as basic data to prevent the risk factors for rheumatoid arthritis. But larger studies will be needed to confirm these preliminary findings.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2439-2443
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• 2016

Purpose: To determine the risk factors, clinical symptoms and patterns of spread in laryngeal cancer. Materials and Methods: A cross sectional study was carried out in the Regional Cancer Centre, Imphal, Manipur, India. One hundred and sixteen patients with laryngeal cancer were retrospectively reviewed for epidemiological data and descriptive statistics were reported for various variables. Results: Median age at presentation was 65 years and 32.8% were undernourished at presentation. The male to female ratio was 5.4:1. Heavy smoking and tobacco chewing was associated in 91.4% and 33.6% of patients respectively. Tracheostomy was required in 21.5% leading to diagnosis of laryngeal cancer. Almost all were squamous cell carcinoma with neuroendocrine and verrucous carcinoma accounting for less than 2%. Supraglottic, glottic and trans-glottic tumors were 56.9%, 36.3% and 6.9% respectively. Nodal metastases were seen in 81.8% of supraglottic cancers and 31.6% of glottic cancers with supraglottic involvement. Level II neck nodes were the commonest site followed by level III. Distant metastases (only liver) were apparent in 1.7% at presentation. Including these liver metastases, unresectable cases were limited to 6% of the patients. Conclusions: Tobacco use is implicated in almost all of the cases and the sex ratio has also decreased due to increased female smokers. The supraglottis remains the commonest site and incidence of nodal metastases is higher than in other countries. There is also a higher requirement for tracheostomy at presentation in this region.