• 한국산업보건학회지
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• 제20권1호
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• pp.47-52
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• 2010

Green tobacco sickness (GTS) is known as an occupational disease among tobacco harvesters, and a form of acute nicotine intoxication by the absorption of nicotine through the skin from the wet green tobacco plant. On the assumption that GTS may occur by inhalation as well as absorption of nicotine, we measured the airborne nicotine concentration in tobacco field and the processing room of tobacco leaves. We measured the airborne nicotine concentrations in the tobacco field and processing room between 13 and 30 July 2008. All sampling and analyses of airborne nicotine were conducted according to the manual of analytic methods of NIOSH 2551, and we sampled 2 times at 11 points in the tobacco field by area sampling. The sampling in the processing room of tobacco leaves was conducted at 3 points, and earlymorning dew was collected from the tobacco by wringing the moisture into specimen bottles. The airborne nicotine concentration [geometric mean (geometric standard deviation)] in the tobacco field in the P.M. was higher [49.2 mg/$m^3$ (1.3)] than the A.M. concentration [43.4 mg/$m^3$ (1.4)]. Similarly, the nicotine concentration in the processing room of tobacco leaves was 224.4 mg/$m^3$ (1.2), and the concentration of nicotine in the dew was 64.7 mg/${\ell}$ (1.7). Based on our results, the airborne nicotine concentration in the tobacco field and the processing room of tobacco leaves were 100 and 400 times higher than the occupational recommended values (TLV-TWA of 0.5 mg/$m^3$), respectively. In the future, it is hoped that epidemiologic studies and environmental measurements will be conducted for GTS which occurs by inhalation of nicotine. If GTS is confirmed to occur by inhalation of nicotine, respiratory and dermal protective equipment must be distributed.

• Journal of Preventive Medicine and Public Health
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• 제30권4호
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• pp.697-707
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• 1997

본 연구에서는 대도시 일부 사무직 근로자를 대상으로 흡연에 관한 설문조사를 통해 흡연률, 과거흡연률, 가격변동시 예상흡연률과 그에 따른 흡연의 귀속 사망수 감소 기대수를 조사, 분석하였다. 그 결과는 다음과 같았다. 1. 대도시 지역 남성 사무직 근로자의 흡연률은 59.5%였고 과거흡연률은 28.8%였으며, 과거흡연자를 제외하고 흡연률을 산출할 경우 흡연률은 67.4%였다. 2. 남성흡연자중 담배의 가격과 무관하게 금연할 의사가 있다고 응답한 사람의 분율은 55.3%였고, 담배의 가격이 4배 이상 인상될 경우 금연하겠다고 응답한 사람의 분율은 61.5%로서 반수 이상의 흡연자가 금연하겠다는 의사를 가지고 있는 것으로 나타났다. 3. 남성 흡연자의 흡연시작연령은 반수 이상(62.3%) 만 20세 미만으로, 미성년자 시기에 흡연을 시작하는 경우가 많았다. 4. 담배의 가격인상폭을 크게 할수록 금연 의사가 있는 사람의 비율이 늘어서, 4배이상 가격을 인상할 경우 예상 흡연률이 26.7%였다. 매년 20%씩 담배의 가격이 오를 경우 예상 흡연률은 46.2%였다. 5. 남성을 대상으로 흡연과 관련이 깊은 주요 8개 질환군(폐암, 위암, 췌장암, 후두암, 식도암, 뇌혈관질환, 허헐성심질환, 만성폐쇄성폐질환)의 귀속위험을 추산한 결과 매년 25,863명이 흡연에 기인해서 사망하는 것으로 추산되었다. 이는 20세 이상 총 남성 사인 분류가능 사망수 128,875명의 20.1%이다. 6. 담배의 가격인상시 기대되는 흡연률을 적용하여 계산한 결과 담뱃값을 4배 이상 올렸을 때 금연 실천률을 100%로 가정했을 때 귀속위험은 13,527명으로서 매년 홉연으로 인한 사망의 47.7%인 12,336명의 사망을 줄일 수 있는 것으로 추산되었다. 7. 담배의 가격인상시 금연하도록 동기부여가 되는 사람중에서 실제로 금연하는 사람의 비율을 10%, 25%, 50%로 가정했을 때, 기대 사망수 감소는 가격을 4배 이상 인상했을 때 각각 1,112명, 3,483명, 5,796명 이었다.

• Clinical and Experimental Pediatrics
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• 제59권8호
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• pp.319-327
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• 2016

Allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy, are most common chronic, noncommunicable diseases in childhood. In the past few decades, the prevalence has increased abruptly worldwide. There are 2 possible explanations for the rising prevalence of allergic diseases worldwide, that an increased disease-awareness of physician, patient, or caregivers, and an abrupt exposure to unknown hazards. Unfortunately, the underlying mechanisms remain largely unknown. Despite the continuing efforts worldwide, the etiologies and rising prevalence remain unclear. Thus, it is important to identify and control risk factors in the susceptible individual for the best prevention and management. Genetic susceptibility or environments may be a potential background for the development of allergic disease, however they alone cannot explain the rising prevalence worldwide. There is growing evidence that epigenetic change depends on the gene, environment, and their interactions, may induce a long-lasting altered gene expression and the consequent development of allergic diseases. In epigenetic mechanisms, environmental tobacco smoke (ETS) exposure during critical period (i.e., during pregnancy and early life) are considered as a potential cause of the development of childhood allergic diseases. However, the causal relationship is still unclear. This review aimed to highlight the impact of ETS exposure during the perinatal period on the development of childhood allergic diseases and to propose a future research direction.

• The Plant Pathology Journal
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• 제29권2호
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• pp.174-181
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• 2013

The plant growth-promoting rhizobacterium Ochrobactrum lupini KUDC1013 elicited induced systemic resistance (ISR) in tobacco against soft rot disease caused by Pectobacterium carotovorum subsp. carotovorum. We investigated of its factors involved in ISR elicitation. To characterize the ISR determinants, KUDC1013 cell suspension, heat-treated cells, supernatant from a culture medium, crude bacterial lipopolysaccharide (LPS) and flagella were tested for their ISR activities. Both LPS and flagella from KUDC1013 were effective in ISR elicitation. Crude cell free supernatant elicited ISR and factors with the highest ISR activity were retained in the n-butanol fraction. Analysis of the ISR-active fraction revealed the metabolites, phenylacetic acid (PAA), 1-hexadecene and linoleic acid (LA), as elicitors of ISR. Treatment of tobacco with these compounds significantly decreased the soft rot disease symptoms. This is the first report on the ISR determinants by plant growth-promoting rhizobacteria (PGPR) KUDC1013 and identifying PAA, 1-hexadecene and LA as ISR-related compounds. This study shows that KUDC1013 has a great potential as biological control agent because of its multiple factors involved in induction of systemic resistance against phytopathogens.

• 대한한의학회지
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• 제25권4호
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• pp.36-42
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• 2004

Objective : Glutathione S-transferase polymorphism (GST) were examined in 120 cases with ischemic cerebrovascular disease (ICVD) to test the hyperthesis that GST polymorphisms confer a risk to an individual to develop ICVD. Tobacco smoking is a major cause of both cancer and vascular disease. Methods : therefore We were stratified the subjects with ICVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of ICVD Results : Neither GSTM1 nor GSTT1 genotypes in the ICVD group was significantly different from the control group (n=207), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in ICVD for smoking status. No significant association observed between the combined genotypes and ICVD Conclusion : Our observation do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for ICVD, even in smokers.

• 한국연초학회지
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• 제35권1호
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• pp.13-19
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• 2013

The natural ingredient has been utilized variety of the food and medicine. The aromatherapy well known prevent disease and healthy promotion using the essential oil derived extracted plants. In this work, natural ingredient include herb granulated for application of tobacco filter. That used by granulation using fluidized bed granulator(top-spray, bottom-spray and tangential-spray) and wet granule method. According to ingredient can used granulating method selectivity. So, we used fluid-bed granulator and wet granule method. Grapefruit extract coated sugar particle using the bottom-spray method and red ginseng granule granulated red ginseng powder using the tangential-spray method in a fluidized bed. Then, these granules applied the tobacco filter after due consideration add amount and operation efficiency. As a result, wet granule was loaded dual filter because that similarity carbon granule. And it was fitted in added 3mg/mm, per tip in the tobacco end part. Another type, fuidized bed granules was filled cavity filter because it has high hardness, sphere shape.

• 한국연초학회지
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• 제16권2호
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• pp.134-138
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• 1994

Potato Virus Y(PVY), vein necrosis strain, in Korea causes severe symptoms on burley tobacco(Nicotiana tabacum L.). As the results, programs to incorporate PVY resistance into commercial cultivars were initiatEd. But the development of the homozygous fertile line resistant to PVY is time consumming. This study was conducted whether the Fl hybrid could be used to reduce the yield losses caused by PVY. Four F1 hybrids were made between male - sterile(ms) NC 107 and KB 107 as maternal parent, and TC 612 and TC 613 as Pollen donor, respectively, and were evaluated for their PVY resistance and negatively associated traits. (ms NC 107 X TC 612) F1, named as KB 109, Ivas applied to yield trial and compared with commercial cultivars for the level of disease resistance, agronomic characteristics, chemical contents and physical properties. All Fl hybrid could be used commercially as the PVY resistant cultivar. Especially KB 109 have the resistance against PVY, tobacco mosaic virus and black shank(Phytophthora parasitica var. nicotianae). It had wider leaves, flowered one day later, and yield of acceptable quality was higher than that of Burley 21, standard cultivar in Korea.

• 한국연초학회지
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• 제22권1호
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• pp.25-30
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• 2000

Bacterial wilt(Ralstonia solanacearum) is one of the major diseases of flue-cured tobacco (Nicotiana tabacum L.) in the world. This study was conducted to investigate degree of dominance, selection, and correlation between leaf shape and degree of bacterial wilt resistance in flue-cured tobacco. The degree of disease caused by bacterial wilt was evaluated in parents, F$_1$, F$_2$ and F$_3$ populations of two crosses, BY 4 x NC 95 and BY 4 x Coker 86, in the infected field. The leaf shape index was also measured in parents and F$_2$ population of BY 4 x NC 95. The incidence of bacterial wilt was observed in the middle of June and peaked in late July, when the highest value of pathogen density reached 1.0 x 10$^{6}$ colony forming unit per gram. It was concluded that the inheritance mode of risestance to bacterial wilt in the above two crosses of susceptible and resistant varieties was recessive and polygenic. The resistance to bacterial wilt was significantly correlated with leaf shape in F2 generation of BY 4 x NC 95. But certain plants having narrower leaves were also resistant to bacterial wilt. It is considered that the bacterial wilt resistant lines having narrower leaves could be selected. The selection for bacterial wilt resistance in the F$_2$ population might be effective.

• 치위생과학회지
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• 제9권4호
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• pp.397-404
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• 2009

치과종사자의 금연에 대한 태도, 금연지도활동의 실태, 금연지도활동의 장애요인에 대한 자료를 조사 분석하여 금연지도활동을 확대하는데 필요한 자료를 얻기 위하여 강원도 원주시 구강보건지료기관에 근무하는 치과의사, 치과위생사, 간호조무사, 치과코디네이터를 대상으로 하여 설문조사법을 적용하여 다음과 같은 결과를 얻었다. 1. 치과종사자의 금연에 대한 태도점수의 평균 6점 만점에서 5.18점(${\pm}1.21$)으로 비교적 금연에 대해 긍정적인 태도를 가지고 있는 것으로 나타났다. 2. 치과종사자의 금연지도활동 점수의 평균은 12점 만점에서 6.67점(${\pm}1.85$)으로 비교적 낮게 나타났다. 3. 금연지도활동의 장애요인으로는 금연문제를 거론하기가 힘들다는 응답이 42.3%로 가장 큰 장애요인으로 나타났다. 4. 치과종사자의 금연지도활동 점수와 통계적으로 유의한 상관관계를 보인 변수는 금연에 대한 태도, 연령, 금여권유 시, 금연 가능성에 대한 인식이었다. 이상의 결과로부터 구강건강관리인력의 금연지도활동에 대한 자기효능감을 높이기 위해 정규교과과정이나 보수교육 프로그램의 개발을 통행 지속적으로 금연지도활동에 대한 이론 및 기술교육을 통해 제공해야 하며, 금연중재 프로그램의 적용과 관련하여 프로그램의 효과를 평가할 수 있는 연구가 필요하다.

• Journal of Microbiology and Biotechnology
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• 제19권10호
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• pp.1250-1258
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• 2009

Bacillus spp., as a type of plant growth-promoting rhizobacteria (PGPR), were studied with regards promoting plant growth and inducing plant systemic resistance. The results of greenhouse experiments with tobacco plants demonstrated that treatment with the Bacillus spp. significantly enhanced the plant height and fresh weight, while clearly lowering the disease severity rating of the tobacco mosaic virus (TMV) at 28 days post-inoculation (dpi). The TMV accumulation in the young non-inoculated leaves was remarkably lower for all the plants treated with the Bacillus spp. An RT-PCR analysis of the signaling regulatory genes Coil and NPR1, and defense genes PR-1a and PR-1b, in the tobacco treated with the Bacillus spp. revealed an association with enhancing the systemic resistance of tobacco to TMV. A further analysis of two expansin genes that regulate plant cell growth, NtEXP2 and NtEXP6, also verified a concomitant growth promotion in the roots and leaves of the tobacco responding to the Bacillus spp.