• Title/Summary/Keyword: To-Tc method

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Dual Action of d-Tubocurarine on Large-Conductance $Ca^{2+}-activated$ $K^+$ Channels from Rat Brain Reconstituted into Planar Lipid Bilayer

  • Chung, Sung-Kwon;Shin, Jung-Hoon
    • The Korean Journal of Physiology and Pharmacology
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    • v.2 no.5
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    • pp.549-553
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    • 1998
  • Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance $Ca^{2+}-activated\;K^+$ channel from rat brain. When the initial open probability (Po) of the channel was relatively high, dTC decreased channel activity in a concentration dependent manner. In contrast, when the initial Po was lower, sub-micro molar dTC increased channel activity by destabilizing the closed states of the channel. Further addition of dTC up to micro molar range decreased channel activity. This dual effect of dTC implicates that there exist at least two different binding sites for dTC.

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Analysis of Hemodynamic Change in Diffuse Hepatocellular Diseases (미만성 간질환에서의 간혈류 동태의 분석에 관한 연구)

  • Lee, Sung-Yong;Chung, Soo-Kyo;Lee, Yung-Il;Kim, Jong-Woo;Bahk, Yong-Whee
    • The Korean Journal of Nuclear Medicine
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    • v.20 no.2
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    • pp.53-59
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    • 1986
  • Radionuclide angiography of the liver and spleen with rapid bolus injection of 5 mCi of $^{99m}Tc-Sn-phytate$ was performed for evaluation of dynamic flow change of the liver in 5 normal subjects and 11 patients with diffuse hepatocellular diseases. And quantification of hepatic arterial index (HAI) was generated from those TACs of the liver and compared with HAI generated from hepatic TAC with injection of $^{99m}Tc-TcO_4^-$ as previously reported method by former investigators, 67 patients with diffuse hepatocellular diseases undergoing hepatic scintigraphy were also evaluated by 2 minutes-hepatosplenic scintiangiography with 5 mCi of $^{99m}Tc-phytate$ and followed injection of 7 mCi of $^{99m}Tc-TcO_4^-$. Those heaptic and splenic TACs were analysed and compared with HAIs of 99m Tc-phytate for evaluation of relative change (%) of count at 30 seconds and 1 minuite after peaks of rapid influx phase to the peaks (100%) in T ACs of $^{99m}Tc-phytate$ and at 1 minuite and 3 minuites after in 5 minuite-TAC of $^{99m}Tc-TcO_4^-$. Correlation between HAIs with $^{99m}Tc-phytate$ and $^{99m}Tc-TcO_4^-$ was highly significant (R=0,984, P=0), and there was most significant and useful correlation (R=0,708, p<0.0001) between HAI and splenic TAC generated by $^{99m}Tc-phytate$.

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Srability Analysis Of High-Tc Superconducting Tape Through Magnetic Field Analysis Of The High-Tc Superconducting synchronous Motor (고온초전도동기모터의 자계분포해석에 따른 테이프선재의 안정도해석)

  • 송명곤;윤용수;홍계원;이산진;고태국
    • Progress in Superconductivity and Cryogenics
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    • v.1 no.2
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    • pp.25-29
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    • 1999
  • The purpose of this paper is to find the magnetic filed distribution inside the motor in order to find out if the high-Tc superconducting tapes operate stably in actual motor operation in a detailed model of the actual motor was analyzed through F.E.M.(finite Element Method). As a result, it has been proved that the high-Tc superconducting tapes can with-stand 4 A of current with staility. 4 A was the amount of current with stability. 4 A was the amount of current needed to achieve 600 A·turns which is required by the previous simulation aimed at developing this the flux damper reduces armature reactance during the motor operation. But it was observed that the flux damper generates loss by means of leakage flux and this decreases the output of the motor by about 5%.

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Assessment of Neonatal Hyperbilirubinemia Using a Transcutas Bilirubinometry (신생아에 있어 TcB[transcutaneous bilirubinometry]를 이용한 고빌리루빈혈증의 사정)

  • 안영미;김미란;이상미;전용훈
    • Journal of Korean Academy of Nursing
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    • v.33 no.1
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    • pp.51-59
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    • 2003
  • Purpose: The purpose of the study is to investigate the relationship between total serum bilirubin(TSB) and transcutaneous bilirubinometry(TcB) in neonates with jaundice. Method: TcB from various sites(forehead, sternum, abdomen, buttock, hand, dorsalis-pedia) was measured using a JM-102 in a total of 102 neonate, 42 female and 60 male, with the mean 37.5 gestational week and the mean 2,903 gram of birth weight, as well as TSB from capillary punctures. Result: The mean bilirubin was 11.73 in serum, 20.55 on the forehead, 17.23 on the sternum, 16.19 on the abdomen, 18.22 on the buttock, 15.83 on the hand and 15.49 on the dorsalis-pedia. The relationship between TSB and TcBs were formulated by simple regression with 0.406 < r < 0.668(p < .000). A higher relationship was revealed between TSB and TCB at the forehead in infants of full-term, ABO incompatibility, and Hb greater than 16 mg/dl(r =0.725, 0.790, and 0.717, retrospectively). Phototherapy altered the measurement of TcB per site. Conclusion: TcB on the forehead is a reliable, noninvasive and convenient measurement of TSB in normal infants(Institutions need to establish quantitative equations representing the specific relationship between TSB and TCB according to the hemodynamic problems of infants such as ABO incompatibility, or low Hb).

A study on the High Integrated 1TC SONOS Flash Memory (고집적화된 1TC SONOS 플래시 메모리에 관한 연구)

  • 김주연;이상배;한태현;안호명;서광열
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.07a
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    • pp.26-31
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    • 2002
  • To realize a high integrated Flash memory utilizing SONOS memory devices, the NOR type 1TC(one Transistor Cell) SONOS Flash arrays are fabricated and characterized. This SONOS Flash arrays with common source lines are designed and fabricated by conventional 0.35$\mu\textrm{m}$ CMOS process. The thickness of ONO for memory cell is tunnel oxide of 34${\AA}$, nitride of 73${\AA}$ and blocking oxide of 34${\AA}$. To investigate operating characteristics, CHEI(Channel Hot Electron Injection) method and Bit line erase method are selected as the write operation and the erase method, respectively. The disturbance characteristics according to the write/erase/read cycling are also examined. The degradation characteristics are investigated and then the reliability of SONOS flash memory is guaranteed.

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Design of TM/TC data protocol of Military Unmanned Aerial Vehicles (군용 무인기의 TM/TC 데이터 프로토콜 설계)

  • Hong, Su-woon;Kim, Young-kil
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.3
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    • pp.506-512
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    • 2018
  • Unmanned aerial vehicles(UAVs) operating in the military for various purposes are designed to transmit information collected according to the purpose to GCS(Ground Control System), and to transmit/receive the vehicle's operational control and status information using wireless communication(or datalink). Currently, the military UAV systems in operation in Korea use unique communication methods, protocols, and message structures for each system. Among these, the Division UAV is designed to transmit fixed size TM/TC data repeatedly and the Corps UAV is designed to transmit aperiodic TM/TC data to the variable length of the message-based. In this paper, we analyze the TM/TC data protocol of existing military UAV systems and present data protocol design method which is considered to be more efficient in wireless communication environment applied to equipment under development. And we will discuss issues to be considered for standardization of technology for ensuring interoperability with many UAVs or newly introduced UAV systems.

Camparison of the Efficiency for Tc-99m Tin-colloid and Tc-99m Phytate in Sentinel Node Detection in Breast Cancer Patients (유방암 환자의 전초림프절 검사에서 Tc-99m Tin-colloid와 Tc-99m Phytate의 효용성에 대한 비교)

  • Seok, Ju-Won;Kim, In-Ju
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.6
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    • pp.451-455
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    • 2008
  • Purpose: Lymphoscintigraphy and sentinel node biopsy has become a standard method for detection of axillary lymph node metastasis in breast cancer patients, but the standard radiopharmaceutical was not prepared. About detection of axillary lymph node metastasis by lymphoscintigraphy and sentinel node biopsy in breast cancer patient, we compared the results of Tc-99m Tin-colloid and Tc-99m Phytate by subareolar injection. Materials and Methods: This study included 382 breast cancer patients who were performed operation during 2001-2008. Three hundred forty nine patients was injected 0.8ml of Tc-99m Tin-colloid (37-185 MBq) by subareolar injection. Thirty three patients was injected 0.8ml of Tc-99m Phytate (37-185 MBq). Lymphoscintigraphy was performed in supine position and sentinel node localization was performed by hand-held gamma probe in operation. Result: Among 349 patients by Tc-99m Tin-colloid, 312 cases (89.4%) localized the sentinel node by lymphoscintigraphy, 304 cases (87.1%) localized by gamma probe. Among 33 patients by Tc-99m Phytate, 32 cases (97.0%) localized by lymphoscintigraphy, 33 cases (100%) localized by gamma probe. Detection rate by lymphoscintigraphy and gamma probe was superior for Tc-99m Phytate compared to that with Tc-99m Tin-colloid, with a statistically significant difference. (p<0.05, p<0.05) Conclusion: Tc-99m Phytate is a better choice for localization of sentinel node than Tc-99m Tin-colloid in breast cancer patients.

Is $^{201}Tl-^{99m}Tc$-Subtraction Scan an Accurate Diagnostic Method to Detect Parathyroid Mass? ($^{201}Tl/^{99m}Tc$ 감영스캔으로 부갑상선종괴를 얼마나 찾을 수 있는가?)

  • Yang, Hyung-In;Kim, Deog-Yoon;Kim, Kwang-Won;Choi, Young-Kil
    • The Korean Journal of Nuclear Medicine
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    • v.28 no.1
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    • pp.31-36
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    • 1994
  • We studied 65 patients with hypercalcemia who had heed performed $^{201}Tl/^{99m}Tc$ subtraction scan, 21 of them were confirmed as parathyroid tumor (19 adenoma, 2 carcinoma). The diagnostic sensitivity of $^{201}Tl/^{99m}Tc$ subfraction scan for detecting parathyroid mass was 90.5%, specificity was 97.6%, ultrasonography was 80.6%, 58.8%, respectively. The causes of two false negative cases were relatively small size ($1.5{\times}1{\times}0.8cm$) compared to remainig cases and poor thallium uptake due to cystic necrosis of parathyroid adenoma. The one false positive case was non-functioning thyroid nodule. $^{201}Tl/^{99m}Tc$ subtraction scan was simple, effective diagnostic tool and superior to ultrasonography for evaluating the parathyroid mass with high sensitivity and specificity.

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The Clinical Role of $^{99m}Tc$-(V)-DMSA Imaging in Patients with Head and Neck Cancer (두경부 종양에서 $^{99m}Tc$-(V)-DMSA 영상술의 진단적 유용성)

  • Bae, Sun-Kun;Lee, Jae-Tae;Park, June-Sik;Park, In-Kyu;Hyun, Dong-Woo;Lee, Young-Hak;Kim, Jeong-Gyun;Ahn, Byeong-Cheal;Choi, Ji-Yong;Sohn, Sang-Gyun;Lee, Kyu-Bo
    • The Korean Journal of Nuclear Medicine
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    • v.29 no.4
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    • pp.526-532
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    • 1995
  • Introduction : $^{99m}Tc$-(V)-DMSA is a tumor seeking agent that has been used to image medullary carcinoma of thyroid, soft tissue sarcoma and lung cancer. This study was designed to assess the clinical role of $^{99m}Tc$-(V)-DMSA in the diagnosis of head and neck cancers. We has evaluated the diagnostic efficacy of planar and SPECT imaging using $^{99m}Tc$-(V)-DMSA. Patients and Method : Sixty-eight patients with head and neck mass were included in this study. All subjects were diagnosed by biopsy or surgery. Planar and SPECT images were obtained at 2 or 3 hour after intravenous injection of 740 MBq(20 mCi) $^{99m}Tc$-(V)-DMSA. Seventeen patients also underwent SPECT in aging using dual head camera. Result : The diagnostic sensitivity of $^{99m}Tc$-(V)-DMSA planar and SPECT imaging was 65% and 90%, and specificity was 80% and 66%, respectively. The sensitivity of planar imaging in squamous cell carcinoma was similar to overall sensitivity Six metastatic lesion were first diagnosed by scintigraphy. But benign lesions such as Kikuchi syndrome, tuberculous lymphadenitis also revealed increased uptake. Conclusion : $^{99m}Tc$-(V)-DMSA imaging seems to be a promising method in the evaluation of patients with head and neck mass. We recommend SPECT imaging to delineate anatomic localization of the lesion.

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Comparative Assessment of a Method for Extraction of TC-induced Rainfall Affecting the Korean Peninsula (한반도 태풍강우 추출기법 비교 평가)

  • Son, Chan-Young;Kwon, Hyun-Han;Kim, Jong-Suk;Moon, Young-Il
    • Journal of Korea Water Resources Association
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    • v.47 no.12
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    • pp.1187-1198
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    • 2014
  • Strong winds and heavy rainfall from tropical cyclones (TCs) that occur in the Northwestern Pacific cause significant human and material damage to the Korean peninsula and East Asia. Hence, it is important to establish early warning systems and conduct preparedness activities in advance of a TC. This study suggests a technique to extract the value of uniform TC-induced rainfall considering the TC track and TC size. To validate our technique, we compare it to existing TC rainfall techniques using the spatial domain. To determine the TC size required for extracting TC-induced rainfall, this research analyzed the mean of TC-induced rainfall by TC size (1973-2012). As a result of this analysis, the maximum amount of mean of TC-induced rainfall was found for a TC with a radius of 700 km. Other techniques have limitations which this new technique addresses; it can extract TC-induced rainfall in each administrative area and minimize systematic biases of other extraction methods. The result of this study can be utilized in the preparation of rainfall forecasts, designing hydraulic structures, and predicting landslide and debris flows using TC-induced rainfall and downpours.