• Title/Summary/Keyword: Titration method

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A Case Study on Student to Student Verbal Interaction on the Acid-Base Titration Experiment Using MBL (MBL을 활용한 산-염기 적정 실험에서의 학생 간 언어적 상호작용에 대한 사례연구)

  • Ryu, Eun-Hee;Lim, Hee-Young;Kang, Seong-Joo;Choi, Byung-Soon
    • Journal of The Korean Association For Science Education
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    • v.28 no.1
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    • pp.67-74
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    • 2008
  • The purpose of this study was to investigate the effects of an MBL instrument in laboratory execution by analyzing an experimental time and student to student interactions in the MBL and traditional method of the acid-base titration experiment. The MBL method used a conductivity sensor and the traditional method used a current meter on the HCl/NaOH titrations. In comparison of the two methods, the traditional method required more time than the MBL and most of the extra time were used in the execution. In the execution, the MBL method showed more numbers of student to student interaction and higher level of verbal interaction than the traditional method.

Apparent pKa and Partition Coefficient of Tranylcypromine (Tranylcypromine의 겉보기 해리항수(解離恒數) 및 분배계수(分配係數))

  • Kang, Gun-Il;Chung, Soon-Young
    • YAKHAK HOEJI
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    • v.28 no.5
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    • pp.293-297
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    • 1984
  • The pKa' of tranylcypromine was determined by potentiometric titration and ultraviolet spectrophotometric method and found to be 8.08 and 8.15, respectively. The Papp of tranylcypromine between n-heptane and aqueous buffer solution was measured to be 0.90 at pH 7.48 and 4.50 for Pm. The pKa' of tranylcypromine obtained by means of the partition method was 8.13.

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Quantitative Analysis of Prussic Acid by "Micro-Diffusion Analsis." II Determination of Prussic Acid in Human Blood (미량확산분석법에 의한 청산의 정량법 (제2보) 혈액중(CN-Met Hb)청산의 정량)

  • 심상혁;서정현
    • YAKHAK HOEJI
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    • v.4 no.1
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    • pp.47-49
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    • 1959
  • Another application of the new quantitative analytical method of prussic acid by "Microdiffusion analysis" for the determination of prussic acid in human blood was studied. The blood containing potassium cyanide was dropped in outer room of unit, and then N-sulfuric acid was added. The liberated HCN gas was absorbed into nickel sulfate solution of inner room, afterward, absorbed prussic acid was determined with EDTA by residual titration. The result was coincided with the result of Liebig Denigs' method at ordinary temperature.

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Spectrophotometric determination of acetylsalicylic acid with copper-$\alpha$-picolin complex in tetrachloromethane ($\alpha$-picolin동에 의한 aspirin의 용매 흡광도 정량법)

  • 백남호;박만기
    • YAKHAK HOEJI
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    • v.13 no.2_3
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    • pp.80-83
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    • 1969
  • Acetylsalicylic acid gives a water-insoluble violet complex with $<\alpha>$-Picolin-Cu(II) reagent. The Complex is extractable well with a mixture of $<\alpha>$-Picolin-tetrachloromethane solution. The Complex salt dissolved in the mixed solution shows a maximum absorption at 620 m$<\mu>$. It has a melting point at $171^{\circ}C-$173^{\circ}C and molar ratio of Acetylsalicylic acid: Cu(II): $<\alpha>$-Picolin was estimated as 2:1:2 by continuous variation method and chelate titration method.

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Deconvolution of UV Spectrum for Selective Measurement of $ClO_2$ Concentration Quantitatively in Solution Containing Various Chlorine Species (다양한 염소 종이 함유된 수용액에서 자외선 흡수 파장 분해법을 이용한 이산화염소 선별 정량 분석)

  • Byun, Youngchul;Kim, Jaehoon;Jang, Yumi;Lee, Kiman;Lee, Jae Myeong;Shin, Dong Nam
    • Journal of Korean Society of Environmental Engineers
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    • v.34 no.11
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    • pp.743-750
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    • 2012
  • An ultraviolet (UV) absorption method has a difficulty to analyze $ClO_{2(aq)}$ in solutions containing various chlorine species because UV spectrum of $ClO_{2(aq)}$ overlaps with other chlorine-containing species. This study has proposed the deconvolution method of UV spectrum to analyze $ClO_{2(aq)}$ concentration quantitatively in solution containing various chlorine species. We compared results obtained from UV deconvolution method with titration method. Good agreement of $ClO_{2(aq)}$ concentration between them has been shown in about 10%. This result informs us that the deconvolution method of UV spectrum could be a feasible for the analysis of $ClO_{2(aq)}$ in solution containing various chlorine species.

Precision and Safety Comparison for SM, CRM and ATD in Phase I Clinical Trials (제 1상 임상시험의 SM, CRM, ATD에서 결정된 MTD의 정확성과 안전성 비교)

  • Kim, Dong-Uk;Kil, Sun-Kyoung
    • Communications for Statistical Applications and Methods
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    • v.16 no.1
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    • pp.51-65
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    • 2009
  • The purpose of a phase I clinical trial is to determine the maximum tolerated dose(MTD) of a new drug. This paper investigates the performance of standard method, continual reassessment method and accelerated titration designs in phase I clinical trials. Especially we study the precision and safety at the MTD of these methods. We utilize hyperbolic tangent function and power function to define dose-toxicity model. For each method, expected toxicity rate at MTD is computed and compared with target toxicity probability. We also suggest some modifications of these methods and show some improvements in performance.

Determination of triflusal in raw material and capsules by HPLC

  • Pham, Thuy-Vy;Mai, Xuan-Lan;Lee, Ji-Hyeon;Lee, Jong-Ha;Jo, Hyeon-Ah;Kang, Jong-Seong;Woo, Mi Hee;Na, Dong-Hee;Chun, In-Koo;Kim, Kyeong Ho
    • Analytical Science and Technology
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    • v.31 no.4
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    • pp.143-148
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    • 2018
  • Currently, the Korean Pharmacopoeia (KP XI) recommends HPLC and potentiometric titration (which is less specific than HPLC) for the determination of triflusal content in capsules and raw materials, respectively. Additionally, the British Pharmacopoeia (BP 2017) and European Pharmacopoeia (EP 8.0), which include a monograph for triflusal in raw materials only, describe a titration method for the assay. The latest version of the United States Pharmacopoeia (USP 39) and Japanese Pharmacopoeia (JP 17) still have not published monographs for triflusal and its preparations. To improve the specificity and efficacy of the assay, we present an HPLC method to determine triflusal content in both raw materials and capsules. The proposed method was validated in accordance with the requirements of the International Conference on Harmonization. A good linear relationship was achieved for triflusal in the range of $200-1250{\mu}g/mL$ with a coefficient of determination of approximately 0.9996. The relative standard deviations (RSDs) of inter- and intraday precision were 0.73-1.12 % and 0.34-0.51 %, respectively. The recovery percentage of triflusal was in the range of 98.80-101.31 %. Because its system suitability, intermediate precision, and robustness were satisfactory, this method could be suitable for determining triflusal content in raw materials and capsules.

Characterization of bromine and chlorine in the closed combustion system (연소 반응기를 이용한 브롬 및 염소의 함량 측정에 관한 연구)

  • Choi, Ki-In;Kwon, Duck-Jun;Bae, Sung-Jin;Lee, Dong-Hoon
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.21 no.6
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    • pp.274-279
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    • 2011
  • In this study, we investigated the analytical methods for bromine (Br) and chloride (Cl) with oxygen combustion bomb, using a halogen-containing polymer materials. On measuring Cl content, it showed less reproducibility of the results applying Mohr method or potentiometric titration method than those applying acid-base titration method. In both Br and Cl tests with an oxygen combustion bomb, their concentrations in the absorption and cleaning solution with distilled water were much higher than those in the combustion gas. On the other hand, the concentration level of Br measured by the oxygen combustion bomb method were a little bit lower than those measured by XRF or combustionion chromatography.

Development of high performance liquid chromatography assay method of tramadol hydrochloride injection

  • Kim, DongHyeon;Rhee, Hee Jae;Mai, Xuan-Lan;Kang, Jong-Seong;Woo, Mi Hee;Na, Dong-Hee;Chun, In-Koo;Kim, Kyeong Ho
    • Analytical Science and Technology
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    • v.31 no.3
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    • pp.107-111
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    • 2018
  • Currently, ultraviolet-visible spectrophotometry and titration methods are used for assay tests of tramadol hydrochloride injection and raw material in the Korean Pharmacopoeia XI (KP XI). Titration has also been used in the British Pharmacopoeia (BP 2013) for the assay test of tramadol hydrochloride, and the HPLC assay for tramadol hydrochloride raw material has been used in the United States Pharmacopeia (USP 39). In this study, we developed an alternative HPLC assay method for tramadol hydrochloride injection that is up to date and specific, and employs the same method as tramadol hydrochloride capsules. Validation of the HPLC method was conducted to determine linearity, precision, accuracy, system suitability, and robustness. The linearity of the calibration curves in the desired concentration range was good ($r^2$ > 0.9999). RSDs of intra-day precision obtained were 0.05-0.08 % and inter-day precision obtained were 0.08-0.19 %. Accuracy was obtained with recoveries in the range of 98.16 % and 100.90 %. As a result of the system's suitability, the RSD of both retention time and the peak area obtained were 0.07 %. The values of the plate number and tailing factor of tramadol hydrochloride obtained were 7076 and 1.16, respectively. Because of the intermediate precision and robustness of the developed assay, it is expected to become a valuable tool for revising the Korean Pharmacopoeia (KP XI).

Inhalation Sedation with Nitrous Oxide in Dental Treatment (Nitrous Oxide를 이용한 흡입진정)

  • Yoon, Byung-Bae
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.2 no.1 s.2
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    • pp.1-6
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    • 2002
  • The usage of nitrous oxide is increased for the anxious patient to dental treatment. There are two methods to induce the sedation during dental treatment. One is sedation with drugs the other no need of drugs. We discussed here about sedation with drugs. The methods of drug administration are oral, intramuscular, intravenous, inhalation. The method of oral administration of drugs are convenient to patient and doctor but poor controllability. Intramuscular method is a parenteral technique that maintains several advantages over the enteral technique. However its pales in comparison to other parenteral technique. Intravenous method represents most effective method of ensuring predictable and adequate sedation in all patients. But it has inability to reverse the action of drugs after they have been injected except some drugs (e.g., narcotics and benzodiazepine). A variety of gaseous agents may be administered by inhalation to produce sedation. In dental practice, the inhalation administration of gas means use of nitrous oxide. There are many advantages of nitrous oxide administration. First, very short latent period and rapid onset of drug action which lead to possible titration of drug concentration. With nitrous oxide, clinical effects may become noticeable as quickly as 15 to 30 seconds after inhalation. Recovery from inhalation sedation is also quite rapid. In out patient dental practice rapid recovery is very important because it permit to discharge the patient without escort and the patient return to their ordinary life without limit. To success the conscious sedation with nitrous oxide, the administrator should be keep the mind that always titration of nitrous oxide concentration during induction and treatment. Careful observation need during treatment to prevent oversedation because the adequate nitrous oxide concentration to patients changed by environmental stress. Always begins with 100% oxygen and ends with 100% oxygen to prevent diffusion hypoxia which rare in clinical practice.

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