• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3791-3794
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• 2012

CD44v, especially splice variants containing exon v6, has been shown to be related closely to development of different tumors. High levels of CD44v6/v7 have been reported to be associated with invasiveness and metastasis of many malignancies. The objective of this study was to detect expression of CD44v6-containing variants in patients with acute promyelocytic leukemia (APL) and evaluate the potential of CD44v6/v7 for risk stratification. Reverse transcription polymerase chain reaction (RT-PCR) followed by PCR product purification, ligation into T vectors and positive clone sequencing were used to detect CD44 v6-containing variant isoforms in 23 APL patients. Real-time quantitative PCR of the CD44v6/v7 gene was performed in patients with APL and in NB4 cells that were treated with all-trans retinoic acid (ATRA) or arsenic trioxide ($As_2O_3$). Sequencing results identified four isoforms (CD44v6/v7, CD44v6/v8/v10, CD44v6/v8/v9/v10, and CD44v6/v7/v8/v9/v10) in bone marrow mononuclear cells of 23 patients with APL. The level of CD44v6/v7 in high-risk cases was significantly higher than those with low-risk. Higher levels of CD44v6/v7 were found in three patients with central nervous system relapse than in other patients inthe same risk group. Furthermore, in contrast to ATRA, only $As_2O_3$ could significantly down-regulate CD44v6/v7 expression in NB4 cells. Our data suggest that CD44v6/v7 expression may be a prognostic indicator for APL.

• Geophysics and Geophysical Exploration
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• v.4 no.4
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• pp.133-144
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• 2001

An effective seismic reflection technique for mapping the cavities and bedrock surface in carbonate rocks is described. The high resolution seismic reflection images were successfully registered by using the hydrophones employed in the stream-water driven trench, and were effectively focused by applying optimal data processing sequences. The strategy included enhancement of the signal interfered with the large-amplitude scattering noise, through pre- and post stack processing such as time-variant filtering, bad-trace editing, residual statics, velocity analysis, and careful muting after NMO (normal moveout) correction. The major reflections including the bedrock surface were mapped with the desired resolution and were correlated to the seismic crosshole tomographic data. Shallow major reflectors could be identified and analyzed on the AGC (auto gain control)-applied field records. Three subhorizontal layers were identified with their distinct velocities; overburden (<3000 m/s), sediments (3000-4000 m/s), limestone bedrock (>4000 m/s). Taking into account of no diffraction effects in the field records, gravel-rich overburdens and sediments are considered to be well sorted. Based on the images mapped consistently on the whole survey line and seismic velocity increasing with depth, this area probably lacks in sizable cavities (if any, no air-filled cavities).

• New & Renewable Energy
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• v.8 no.2
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• pp.33-43
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• 2012

Why solar companies preferred vertical integration of whole value chain? Major solar companies have built internally strong vertical integration of entire PV value chain. We raise a question whether such integration increases the corporate value and whether market situation affects the result. To test these questions, we conducted multi-variant analysis where characteristic factors mainly affect the corporate value measured in terms of Tobin'Q, based on the financial and non-financial data of PV companies listed in US stock market between 2005 and 2010. We hypothesize that since integration increases the overall efficiency but decreases the flexibility to adjust to various market situation, the combined effect of the efficiency gain and the flexibility loss ultimately determines the sign of integration effect on the corporate vale. We infer that the combined effect will be influenced heavily by business cycle, as in boom market (Seller's market) the efficiency gain may be larger than the flexibility loss and vice versa in bust market. We test whether the sign of combined effect changes after the year of 2009 and which factors influence most the sign. Year of 2009 is known as the year when market shifted from Seller's to Buyer's market. We show that 1) integration increases corporate value in general but after 2009 integration significantly decreases the value, 2) the ratios such as Production/Total Cost, Cash turnover period chosen for reversal of the flexibility measure are negatively affect Tobin's Q and especially stronger after 2009. This shows the flexibility improves corporate value and stronger in the recess period (Buyer's market). These results imply that solar company should set up integration strategy considering the tradeoff between efficiency and flexibility and the impact of the business cycle on both factors. Strategy only based on the price competitiveness determined in boom time can bring undesirable outcomes to the company. In addition, Strategic alliances in some value chains as a flexible bondage should be taken in account as complementary choice to the rigid integration.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4215-4218
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• 2015

Gastric cancer (GC) is one of the most common malignancies in the world. It is the first cause of cancer deaths in both sexes In Iranian population. Circulating insulin-like growth factor-one (IGF-1) levels have been associated for gastric cancer. IGF-1 protein has central roles involved in the regulation of epithelial cell growth, proliferation, transformation, apoptosis and metastasis. Single nucleotide polymorphism in IGF-1 regulatory elements may lead to alter in IGF-1expression level and GC susceptibility. The aim of this study was to investigate the influence of IGF-1 gene polymorphism (rs5742612) on risk of GC and clinicopathological features for the first time in Iranian population. In total, 241 subjects including 100 patients with GC and 141 healthy controls were recruited in our study. Genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of GC and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs5742612 and the risk of GC. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). The frequencies of the CC, CT, and TT genotypes were 97%, 3%, and 0%, respectively, among the cases, and 97.9%, 2.1%, and 0%, respectively, among the controls. CC genotype was more frequent in cases and controls. The frequencies of C and T alleles were 98.9% and 1.1% in controls and 98.5% and 1.5% in patient respectively. Our results provide the first evidence that this variant is rare in Iranian population and it may not be a powerful genetic predisposing biomarker for prediction GC clinicopathological features in an Iranian population.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.837-846
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• 2012

Breast cancer (BCa) is the leading type of cancer in Mexican women. Genetic factors, such as single nucleotide polymorphisms (SNP) of P450 system, have been reported in BCa. In this report, and for the first time in the literature, we analyzed the rs3735684 (7021 G>A), rs11553651 (15016 G>T) and rs56195291 (60020 C>G) polymorphisms in the CYP2W1, 4F11 and 8A1 genes in patients with BCa and in healthy Mexican women to identify a potential association between these polymorphisms and BCa risk. Patients and controls were used for polymorphism analysis using an allelic discrimination assay with TaqMan probes and confirmed by DNA sequencing. Links with clinic-pathological characteristics were also analyzed. Statistical analysis was performed using the standard ${\chi}^2$ or Fisher exact test statistic. No significant differences were observed in the distributions of CYP2W1 (OR 8.6, 95%CI 0.43-172.5 P>0.05; OR 2.0, 95%CI 0.76-5.4, P>0.05) and CYP4F11 (OR 0.3, 95%CI 0.01-8.4 P>0.05) genotypes between the patients and controls. Only the CYP8A1 CC genotype was detected in patients with BCa and the controls. All polymorphism frequencies were in Hardy-Weinberg Equilibrium (HWE) in the controls (P>0.05). We found a significant association between BCa risk and smoking, use of oral contraceptives or hormonal replacement therapy (HRT), obesity, hyperglycemia, chronic diseases, family history of cancer and menopausal status in the population studied (P<0.05). Tobacco, oral contraceptive or HRT, chronic diseases and obesity or overweight were strongly associated with almost eight, thirty-five, nine and five-fold increased risk for BCa. Tobaco, obesity and hyperglycemia significantly increased the risk of BCa in the patients carrying variant genotypes of CYP2W1 (P<0.05). These results indicate that the CYP2W1 rs3735684, CYP4F11 rs11553651 and CYP8A1 rs56195291 SNPs are not a key risk factor for BCa in Mexican women. This study did not detect an association between the CYP2W1, 4F11 and 8A1 genes polymorphisms and BCa risk in a Mexican population. However, some clinico-pathological risk factors interact with CYP2W1 genotypes and modifies susceptibility to BCa.

• Journal of Korea Spatial Information System Society
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• v.8 no.1 s.16
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• pp.1-16
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• 2006

Recently, human based computing environment for supporting users to concentrate only user task without sensing other changes from users is being progressively researched and developed. But middleware deletes steream data processed for reducing process load of massive information from RFID sensor in this computing. So, this kind of middleware have problems when user demands probability or statistics needed for data warehousing or data mining and when user demands very important stream data repeatedly but already discarded in the middleware every former time. In this paper, we designs Sensor Middleware Architecture on Multi Level Spatial DBMS with Snapshot and manage repeatedly required stream datas to solve reusing problems of historical stream data in current middleware. This system uses disk databse that manages historical stream datas filtered in middleware for requiring services using historical stream information as data mining or data warehousing from user, and uses memory database that mamages highly reuseable data as a snapshot when stream data storaged in disk database has high reuse frequency from user. For the more, this system processes memory database management policy in a cycle to maintain high reusement and rapid service for users. Our paper system solves problems of repeated requirement of stream datas, or a policy decision service using historical stream data of current middleware. Also offers variant and rapid data services maintaining high data reusement of main memory snapshot datas.

• The Journal of the Acoustical Society of Korea
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• v.32 no.2
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• pp.95-103
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• 2013

An underwater acoustic (UWA) communication in shallow water is strongly affected by the water surface and the seabed acoustical properties. Every reflected signal to receiver experiences a time-variant scattering in sea surface roughness and a grazing-angle-dependent reflection loss in bottom. Consequently, the performance of UWA communication systems is degraded, and high-speed digital communication is disrupted. If there is a dominant signal path such as a direct path, the received signal is modeled statistically as Rice fading but if not, it is modeled as Rayleigh fading. However, it has been known to be very difficult to reproduce the statistical estimation by real experimental evaluation in the sea. To give an insight for this scattering and grazing-angle-dependent bottom reflection loss effect in UWA communication, authors conduct experiments to quantify these effects. The image is transmitted using binary frequency shift keying (BFSK) modulation. The quality of the received image is shown to be affected by water surface scattering and grazing-angle-dependent bottom reflection loss. The analysis is based on the transmitter to receiver range and the receiver depth dependent image quality and bit error rate (BER). The results show that the received image quality is highly dependent on the transmitter-receiver range and receiver depth which characterizes the channel coherence bandwidth.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.16 no.4
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• pp.419-429
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• 2003

A three-dimensional (3-D) method of analysis is presented for determining the free vibration frequencies of thick, hyperboloidal shells of revolution. Unlike conventional shell theories, which are mathematically two-dimensional (2-D), the present method is based upon the 3-D dynamic equations of elasticity. Displacement components u/sub r/, u/sub θ/, u/sub z/ in the radial, circumferential, and axial directions, respectively, we taken to be sinusoidal in time, periodic in θ, and algebraic polynomials in the r and z directions. Potential(strain) and kinetic energies of the hyperboloidal shells are formulated, and the Ritz method is used to solve the eigenvalue problem, thus yielding upper bound values of the frequencies by minimizing the frequencies. As the degree of the polynomials is increased, frequencies converge to the exact values. Convergence to four digit exactitude is demonstrated for the first five frequencies of the hyperboloidal shells of revolution. Numerical results are tabulated for eighteen configurations of completely free hyperboloidal shells of revolution having two different shell thickness ratios, three variant axis ratios, and three types of shell height ratios. Poisson's ratio (ν) is fixed at 0.3. Comparisons we made among the frequencies for these hyperboloidal shells and ones which ate cylindrical or nearly cylindrical( small meridional curvature. ) The method is applicable to thin hyperboloidal shells, as well as thick and very thick ones.

• Food Science and Preservation
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• v.14 no.6
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• pp.565-570
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• 2007

Changes in the quality of Hallabong tangor during growth stage and with temperature pre-treatment after harvest were investigated. Soluble solids of Hallabong increased continuously until early December. The acid content of M16A, a variant species of Hallabong, decreased by 1% after October and continued to decrease until the middle of January. After ripening, treatment to reduce the acid content was required. Fruit firmness decreased gradually until November and was maintained at 1000 g-force after this time. Soluble solids and acid content were $13.3{\pm}0.83^{\circ}Brix$ and $1.07{\pm}0.52%$. Soluble solids increased in temperature-treated Hallabong with prolonged storage, but acid content did not decrease. Fruit firmness also decreased with storage period, regardless of temperature pre-treatment. Therefore, water management during cultivation, temperature treatment above $35^{\circ}C$ after harvest, and checking of the acid content and soluble solids with prolonged storage are recommended in achieving high quality Hallabong.

• Journal of KIISE:Databases
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• v.28 no.3
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• pp.468-483
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• 2001

In order to enhance the performance, cursor stability, which is a variant of isolation lvel 2 in relational DBMSs, has been widely used in place of isolation level 3, which uses strict two phase locking. However, cursor stability is much less usable in object-relational DBMSs (ORDBMSs) because navigational applications in ORDBMSs can suffer from critical inconsistency problems such as dangling pointers, lost updates, and reading inconsistent complex objects. In this paper, we propose a new isolation level, navigation stability, that prevents the inconsistency problems of cursor stability for navigational applications, while avoiding significant degradation of the concurrency of level 3. First, we analyze the inconsistency problems of cursor stability for navigational applications. Second, we define navigation stability as an extension of cursor stability and show that it solves those inconsistency problems of cursor stability in ORDBMSs. For workloads consisting of transactions of long duration, compared with level 3, the throughput of navigation stability is enhanced by up to 200%; the average response time reduced by as much as 55%; and the abort ratio reduced by as much as 77%. From these results, we conclude that navigation stability is a useful isolation level in ORDBMSs that can be used in place of isolation level 3 to improve the performance and concurrency without significantly sacrificing consistency.