• Science of Emotion and Sensibility
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• v.5 no.4
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• pp.77-84
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• 2002

In this paper, we propose the NAVER, a general framework for multipurpose virtual environments, and introduce the case study of evaluating car prototypes using cave-like systems. As a framework to implement variant applications in virtual environment, NAVER is extensible, reconfigurable and scalable. NAVER consists of several external modules (Render Server, Control Server and Device Server), which communicate each other to share states and user-provided data and to perform their own functions. NAVER supports its own scripting language based on XML which allows a user to define variant interactions between objects in virtual environments as well as describe the scenario of an application. We used NAVER to implement the system for evaluating car prototyes in a CAVE-like virtual environment system. The CAVE-like virtual environment system at KIST consists three side screens and a floor screen (each of them is a square with side of 2.2m), four CRT projectors displays stereoscopic images to the screens, a haptic armmaster, and a 5.1 channel sound system. The system can provide a sense of reality by displaying auditory and tactile senses as well as visual images at the same time. We evaluate car prototypes in a CAVE-like system in which a user can observe, touch and manipulate the virtual installation of car interior.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4413-4416
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• 2012

Aim: Individual differences in chemosensitivity and clinical outcome in non-small cell lung cancer (NSCLC) patients treatment with platinum-based chemotherapy may be due to genetic factors. Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy. Methods: A total of 460 cases were consecutively selected from The Affiliated Hospital of Nantong University between Jan. 2003 to Nov. 2006, and all were followed-up until Nov. 2011. Genotyping of GSTP1 Ile105Val, XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was conducted by duplex polymerase-chain-reaction with confronting-two-pair primer methods. Results: Patients with GSTP Val/Val exhibited a shorter survival time, and had a 1.89 fold greater risk of death than did those with the IIe/IIe genotype. For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg. Individuals carrying XRCC1 399Gln/Gln genotype had a longer survival time, with a lowered risk of death from NSCLC. Conclusion: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population. Our findings provide information for therapeutic decisions for individualized therapy in NSCLC cases.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3551-3567
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• 2016

The Low Earth Orbit satellite network has the unique characteristics of the non-uniform and time-variant traffic load distribution, which often causes severe link congestion and thus results in poor performance for delay-sensitive flows, especially when the network is heavily loaded. To solve this problem, a novel adaptive routing algorithm, referred to as the delay-oriented adaptive routing algorithm (DOAR), is proposed. Different from current reactive schemes, DOAR employs Destination-Sequenced Distance-Vector (DSDV) routing algorithm, which is a proactive scheme. DSDV is extended to a multipath QoS version to generate alternative routes in active with real-time delay metric, which leads to two significant advantages. First, the flows can be timely and accurately detected for route adjustment. Second, it enables fast, flexible, and optimized QoS matching between the alternative routes and adjustment requiring flows and meanwhile avoids delay growth caused by increased hop number and diffused congestion range. In addition, a retrospective route adjustment requesting scheme is designed in DOAR to enlarge the alternative routes set in the severe congestion state in a large area. Simulation result suggests that DOAR performs better than typical adaptive routing algorithms in terms of the throughput and the delay in a variety of traffic intensity.

• Spatial Information Research
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• v.18 no.3
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• pp.63-72
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• 2010

The vehicle routing problem with simultaneous pick-up and delivery (VRPSPD) is a variant of the vehicle routing problem (VRP) that customers require simultaneously a pick-up and delivery service. The main objective of VRPSPD is to minimize a cost of routes satisfying many constraints. Traditional VRPSPD have been dealt with a static environment. The static environment means that a routing data and plan cannot be changed. For example, it is difficult to change a vehicle's routing plan so that a vehicle serves the pick-up demands of new customers during the delivery service. Therefore, traditional approach is not suitable for dynamic environments. To solve this problem, we propose a novel approach for finding efficient routes using a real-time re-routing heuristics based on the Location Based Service (LBS). Our re-routing heuristics can generate a new route for vehicle that satisfies a new customer's demand considering the current geographic location of a vehicle. Experimental results show that our methodology can reduce the traveling cost of vehicles comparing with other previous methods.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.5
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• pp.887-894
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• 2016

In the underwater acoustic communication channels, a multipath reflection becomes the cause of obstacle. To solve this problem, a rake receiver has been required for which one could take the time diversity. However, there is a concern about using incorrect path to recover signals with a high weighting value as underwater acoustic communication channels have severe time-variant property. In order to prevent these problem, a rake receiver is proposed which is based on BER(bit error rate) train sequence duration. The performance is evaluated through lake trials; there are three methods that are a proposed rake receiver, a conventional rake receiver, and a non-rake receiver. As a result, the number of bit errors in the proposed rake receiver, that of bit errors in the conventional rake receiver, and that of bit errors in the non-rake receiver is 8, 45, and 72, respectively.

• The KIPS Transactions:PartD
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• v.8D no.2
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• pp.175-180
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• 2001

This paper presents the optimal fraction of validation set to obtain a prediction accuracy of software failure count or failure time in the future by a neuro-fuzzy system. Given a fixed amount of training data, the most popular effective approach to avoiding underfitting and overfitting is early stopping, and hence getting optimal generalization. But there is unresolved practical issues : How many data do you assign to the training and validation set\ulcorner Rules of thumb abound, the solution is acquired by trial-and-error and we spend long time in this method. For the sake of optimal fraction of validation set, the variant specific fraction for the validation set be provided. It shows that minimal fraction of the validation data set is sufficient to achieve good next-step prediction. This result can be considered as a practical guideline in a prediction of software reliability by neuro-fuzzy system.

• Journal of the Korea Computer Industry Society
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• v.7 no.4
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• pp.427-436
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• 2006

State-space method for the analysis of the dynamic characteristics of a body motion is set up as mathematical tool for the solution of differential equation by computer. Representation of a system is described as a simple form of matrix calculation and unique form of model is available for the linear or nonlinear, time variant or time invariant, mono variable or multi variable system etc. For the analysis of state-space method a complicated vector calculation is required, but this analysis can be simplified with the specific functions of a software package. Recently as the Graphical User Interface softwares are well-developed, then it is very simplified to execute the simulation of the dynamic characteristics for the state-space model with the interactive graphics treatment. The purpose of this study is to developed the simulator for the educational analysis of the dynamic characteristics of body motion, and for the analysis of the longitudinal dynamic characteristics of an aircraft that is primarily to design the simulator for the analysis of the transient response of an aircraft longitudinal stability.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.2
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• pp.47-55
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• 2003

In this paper, the performance of DS-CDMA system with smart antenna is analyzed for different bandwidths (1.25MHz,5MHz) and different channel environments (rural, urban) in wideband multipath channel. For the analysis of smart antenna system, the vector channel having the spatio-temporal correlation is modeled as a time-variant linear filter in time, and each multipath is assumed as a reflective wave from only one direction (only one cluster) in space. Several multipath is within one chip are distingushed into each one and the strongest signal is selected, DS-CDMA system with smart antenna using wider bandwidth present better performance than that using narrow bandwidth. It is shown that the smart antenna is more effective in urban area when using 2D-RAKE receiver.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5211-5217
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• 2015

Background: We earlier used PCR-dHPLC for mutation analysis of BRCA1 and BRCA2. In this article we report application of targeted resequencing of 30 genes involved in hereditary cancers. Materials and Methods: A total of 91 patient samples were analysed using a panel of 30 genes in the Illumina HiScan SQ system. CLCBio was used for mapping reads to the reference sequences as well as for quality-based variant detection. All the deleterious mutations were then reconfirmed using Sanger sequencing. Kaplan Meier analysis was conducted to assess the effect of deleterious mutations on disease free and overall survival. Results: Seventy four of the 91 samples had been run earlier using the PCR-dHPLC and no deleterious mutations had been detected while 17 samples were tested for the first time. A total of 24 deleterious mutations were detected, 11 in BRCA1, 4 in BRCA2, 5 in p53, one each in RAD50, RAD52, ATM and TP53BP1. Some 19 deleterious mutations were seen in patients who had been tested earlier with PCR-dHPLC [19/74] and 5/17 in the samples tested for the first time, Together with our earlier detected 21 deleterious mutations in BRCA1 and BRCA2, we now had 45 mutations in 44 patients. BRCA1c.68_69delAG;p.Glu23ValfsX16 mutation was the most common, seen in 10/44 patients. Kaplan Meier survival analysis did not show any difference in disease free and overall survival in the patients with and without deleterious mutations. Conclusions: The NGS platform is more sensitive and cost effective in detecting mutations in genes involved in hereditary breast and/or ovarian cancers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2055-2060
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• 2016

Background: Colorectal cancer (CRC) is one of the most common causes of death worldwide and in Thailand. The X-ray repair cross-complementary protein 1 (XRCC1) is required for efficient DNA repair. The effects of this gene on survival in colorectal cancer remain controversial and have not been reported in Thailand. The aim of this study was to investigate the association of the XRCC1 gene with survival of colorectal cancer patients in a Thai population. Materials and Methods: Data and blood samples were collected from 255 newly diagnosed and pathologically confirmed CRC patients who were recruited during the period 2002 to 2006 and whose vital status was followed up until 31 October, 2014. Real-time PCR-HRM was used for genotype identification. The Kaplan-Meier method, the log-rank test, and Cox proportional hazard regression were used to estimate cumulative survival curves and compare various survival distributions and adjusted hazard ratios. Results: Most of the cases were males, and the median age was 55 years. The median survival time was 2.43 years. The cumulative 1-, 3-, 5-, 7-, and 10 year survival rates were 76.70%, 39.25%, 26.50%, 16.60% and 3.56%, respectively. After adjustment, female gender, ages 50-59 and ${\geq}60years$, tumour stage III+IV, a signet-ring cell carcinoma, and poor differentiation had significant associations with increased risk of CRC death. While the XRCC1 Arg/Arg homozygote appeared to be a risk factor for CRC death, the association was not significant. Conclusions: The genetic variant in the XRCC1 may not be associated with the survival of CRC patients in Thailand. Further studies are needed to verify our findings.