• Structural Engineering and Mechanics
• /
• 제46권1호
• /
• pp.53-73
• /
• 2013

Prediction of prestressed concrete girder integral abutment bridge (IAB) load effect requires understanding of the inherent uncertainties as it relates to thermal loading, time-dependent effects, bridge material properties and soil properties. In addition, complex inelastic and hysteretic behavior must be considered over an extended, 75-year bridge life. The present study establishes IAB displacement and internal force statistics based on available material property and soil property statistical models and Monte Carlo simulations. Numerical models within the simulation were developed to evaluate the 75-year bridge displacements and internal forces based on 2D numerical models that were calibrated against four field monitored IABs. The considered input uncertainties include both resistance and load variables. Material variables are: (1) concrete elastic modulus; (2) backfill stiffness; and (3) lateral pile soil stiffness. Thermal, time dependent, and soil loading variables are: (1) superstructure temperature fluctuation; (2) superstructure concrete thermal expansion coefficient; (3) superstructure temperature gradient; (4) concrete creep and shrinkage; (5) bridge construction timeline; and (6) backfill pressure on backwall and abutment. IAB displacement and internal force statistics were established for: (1) bridge axial force; (2) bridge bending moment; (3) pile lateral force; (4) pile moment; (5) pile head/abutment displacement; (6) compressive stress at the top fiber at the mid-span of the exterior span; and (7) tensile stress at the bottom fiber at the mid-span of the exterior span. These established IAB displacement and internal force statistics provide a basis for future reliability-based design criteria development.

• 대한토목학회논문집
• /
• 제10권2호
• /
• pp.49-58
• /
• 1990

캔틸레버 시공법에 의해 가설되는 프리스트레스트 콘크리트 교량의 시간 단계별 장기 처짐을 정확하게 해석하지 위해 프리스트레스트 콘크리트의 시간 의존적 재료 특성과 캔틸레버 공법에 있어서의 분할시공 과정을 고려할 수 있는 해석 모델을 개발하고, 이에 기초하여 콤퓨터 프로그램을 작성하였다. 본 프로그램에서는 시간의 경과에 따른 콘크리트의 크리프, 건조 수축 및 탄성 계수의 변화 그리고 PS 강재의 리락세이션을 고려한다. 그리고 시공 단계별 세그먼트의 발생, 다단계 프리스트레싱 그리고 지점조건의 변화를 고려한다. 또한 철근으로 인한 단면의 강성 증가를 고려하고 전단변형의 영향을 고려하여 보다 정확하게 해석할 수 있도록 하였다. 본 프로그램을 이용하여 다경간 PS 콘크리트 교량을 해석함으로써, 프로그램의 실제 적용성과 캔틸레버공법에 의한 교량의 거동 특성을 규명하고자 하였다.

• 소성∙가공
• /
• 제25권6호
• /
• pp.359-365
• /
• 2016

The rate-controlling mechanisms for time-dependent plastic deformation of eutectoid and hyper-eutectoid pearlitic steels at low $T/T_m$ temperatures were explored. The strain rate - stress data obtained from a series of constant load tensile tests at $0.25{\sim}0.30T/T_m$ were applied to the power law, the lattice friction controlled plasticity, and the obstacle controlled plasticity. Of these models, the obstacle controlled plasticity was found to best-describe the rate-controlling mechanism for time-dependent plastic deformation of two steels at low $T/T_m$ temperatures in terms of the activation energy for overcoming the obstacles against dislocation glide in ferrite. The deformed microstructures revealed the dislocation forests of a high density as the main obstacles. In addition, the obstacle controlled plasticity well-explained the effects of cementite on the $0^{\circ}K$ flow stress of two steels.

• Computers and Concrete
• /
• 제28권5호
• /
• pp.487-495
• /
• 2021

The use of prestressed concrete box girder bridges built by segmentally balanced cantilevers has bloomed in the last decades due to its significant structural and construction advantages in complex topographies. In Colombia, this typology is the most common solution for structures with spans ranging of 80-200 m. Despite its popularity, excessive deflections in bridges worldwide evidenced that time-dependent effects were underestimated. This problem has led to the constant updating of the creep and shrinkage models in international code standards. Differences observed between design processes of box girder bridges of the Colombian code and Eurocode, led to the need for a validation of in-service status of these structures. This study analyzes the long-term behavior of the Tablazo bridge with data scarcity. The measured leveling of this structure is compared with a finite-element model that consider the most widely used creep and shrinkage models in the literature. Finally, an adjusted model evidence excessive deflection on the bridge after six years. Monitoring of this bridge typology in Colombia and updating of the current design code is recommended.

• 한국광학회:학술대회논문집
• /
• 한국광학회 1995년도 광학 및 양자전자학 워크샵 논문집
• /
• pp.138-148
• /
• 1995

A reduced description of the dynamics of carriers in excited semiconductors is presented. Fristly, a time-convolutionless equation of motion for the reduced density operator is derved from the microscopic Liouville wquation operator method. Secondly, the quantum kinetic equations for intercting electron-hole parirs near band-edge in semiconductors under an extermal optical field are obtained from the equation of motion for the reduced density operator. The non-Markovian optical gain of a driven semiconductor is derived including the many-body effects. plasma screening and excitinic effects are taken into account using as effective Hamiltonian in the time-dependent Hartree-Fock approximation. it is shown that the line shape of optical-gain spectra gain is enhanced by the exicitonic effects caused by the attrative electron-hole Coulomb interaction and the interference effects (renormalized memory effects) between the extermal driving filed and the intermal driving Filed and the stochastic reservoir of the system.

• The Korean Journal of Physiology and Pharmacology
• /
• 제11권2호
• /
• pp.71-77
• /
• 2007

Cisplatin treatment increases the excretion of inorganic phosphate in vivo. However, the mechanism by which cisplatin reduces phosphate uptake through renal proximal tubular cells has not yet been elucidated. We examined the effect of cisplatin on $Na^+$-dependent phosphate uptake in opossum kidney (OK) cells, an established proximal tubular cell line. Cells were exposed to cisplatin for an appropriate time period and phosphate uptake was measured using $[^{32}P]$-phosphate. Changes in the number of phosphate transporter in membranes were evaluated by kinetic analysis, $[^{14}C]$phosphonoformic acid binding, and Western blot analysis. Cisplatin inhibited phosphate uptake in a time- and dose-dependent manner, and also the $Na^+$-dependent uptake without altering $Na^+$-independent uptake. The cisplatin inhibition was not affected by the hydrogen peroxide scavenger catalase, but completely prevented by the hydroxyl radical scavenger dimethylthiourea. Antioxidants were ineffective in preventing the cisplatin-induced inhibition of phosphate uptake. Kinetic analysis indicated that cisplatin decreased Vmax of $Na^+$-dependent phosphate uptake without any change in the Km value. $Na^+$-dependent phosphonoformic acid binding was decreased by cisplatin treatment. Western blot analysis showed that cisplatin caused degradation of $Na^+$-dependent phosphate transporter protein. Taken together, these data suggest that cisplatin inhibits phosphate transport in renal proximal tubular cells through the reduction in the number of functional phosphate transport units. Such effects of cisplatin are mediated by production of hydroxyl radicals.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 1998년도 가을 학술발표대회 논문집(III)
• /
• pp.656-661
• /
• 1998

This paper presents a method of statistical analysis and sensitivity analysis of creep and shrinkage effects in PSC box girder bridges. The statistical and sensitivity analyses are performed by using the numerical simulation of Latin Hypercube sampling. For each sample, the time-dependent structural analysis is performed to produce response data, which are then statistically analyzed. The probabilistic prediction of the confidence limits on long-term effects of creep and shrinkage is then expressed. Three measures are examined to quantify the sensitivity of the outputs to each of the input variables. These are rank correlation coefficient(RCC), partial rank correlation coefficient(PRCC) and standardized rank regression coefficient(SRRC) computed on the ranks of the observations. Probability band widens with time, which indicates an increase of prediction uncertainty with time. The creep model uncertainty factor and the relative humidity appear as the most dominant factors with regard to the model output uncertainty.

• The Korean Journal of Physiology and Pharmacology
• /
• 제9권6호
• /
• pp.353-361
• /
• 2005

The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at +50 mV in a reversible concentrationdependent manner with an apparent $IC_{50}$ of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA. Fast application of CsA led to a rapid and reversible block of Kv1.5, and the onset time constants of the CsA-induced block were decreased in a concentration-dependent manner. The CsA-induced block of Kv1.5 channels was voltage-dependent, with a steep increase over the voltage range of channel opening. However, the block exhibited voltage independence over the voltage range in which channels were fully activated. The rate constants for association and dissociation of CsA were $7.0{\mu}M{-1}s^{-1}$ and $8.1s^{-1}$, respectively. CsA slowed the deactivation time course, resulting in a tail crossover phenomenon. Block of Kv1.5 by CsA was use-dependent. CsA also blocked Kv1.3 currents at +50 mV in a reversible concentration-dependent manner with an apparent $IC_{50}$ of $1.1{\mu}M$. The same effects of CsA on Kv1.3 were also observed in excised inside-out patches when applied to the internal surface of the membrane. The present results suggest that CsA acts directly on Kv1.5 currents as an open-channel blocker, independently of the effects of CsA on calcineurin activity.

• Archives of Pharmacal Research
• /
• 제15권4호
• /
• pp.298-303
• /
• 1992

Synaptosomal plasma membrane vesicles (SPMV) were isolated from fresh bovine cerebral cortex. The effects of barbiturates on the rotational relaxation time of 1.6-diphenyl-1, 3, 5-hexatriene (DPH) in intact SPMV and model membranes of total lipids (SPMVTL) and phosphlipids (SPMVPL) extracted from SPMV were examined. Barbiturates decreased the rotational relaxation time of DPH in intact SPMV in a dose-dependent manner. In contrast, they did not affect the rotational relaxation time of DPH in SPMVTL and even dose-dependently increased the rotational relaxation time of DPH in SPMVPL.

• 한국시뮬레이션학회논문지
• /
• 제24권4호
• /
• pp.77-88
• /
• 2015

본 논문은 작업별 위치기반 지수학습 효과를 갖는 2-에이전트 단일기계 스케줄링 문제를 고려한다. 에이전트 A는 가중 완료 시간의 합을 최소화하며, 에이전트 B는 총소요시간에 대한 상한 값을 만족하는 조건을 갖는다. 본 연구에서는 먼저 우수해/가능해에 대한 특성을 개발하고, 이를 이용하여 최적 해를 찾기 위한 분지한계 알고리즘을 설계한다. 또한 근사 최적 해를 구하기 위해 6가지 다른 초기해 생성 방법을 이용한 시뮬레이티드 어닐링 알고리즘을 제안한다. 수치 실험을 통해 제안된 알고리즘의 우수한 성능을 검증한다. 실험 결과, 다른 초기해 생성 방법들 간에는 %errors 차이가 유의하게 발생하지 않았으며, 에이전트 A의 작업 순서를 무작위로 생성할 때 성능이 좋아짐을 발견하였다. 반면에, 에이전트 B의 초기해 생성 방법은 성능에 영향을 미치지 않았다.